AU2006235735C1 - Hydroxybenzamide derivatives and their use as inhibitors of Hsp90 - Google Patents

Hydroxybenzamide derivatives and their use as inhibitors of Hsp90 Download PDF

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Publication number
AU2006235735C1
AU2006235735C1 AU2006235735A AU2006235735A AU2006235735C1 AU 2006235735 C1 AU2006235735 C1 AU 2006235735C1 AU 2006235735 A AU2006235735 A AU 2006235735A AU 2006235735 A AU2006235735 A AU 2006235735A AU 2006235735 C1 AU2006235735 C1 AU 2006235735C1
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Australia
Prior art keywords
dihydro
phenyl
isopropyl
dihydroxy
methanone
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Ceased
Application number
AU2006235735A
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English (en)
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AU2006235735B2 (en
AU2006235735A1 (en
Inventor
Maria Grazia Carr
Gianni Chessari
Miles Stuart Congreve
Robert Downham
Martyn Frederickson
Christopher Murray
Eva Figueroa Navarro
Michael Alistair O'brien
Theresa Rachel Phillips
Andrew James Woodhead
Alison Jo-Anne Woolford
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36808863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2006235735(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0507474A external-priority patent/GB0507474D0/en
Priority claimed from GB0604111A external-priority patent/GB0604111D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of AU2006235735A1 publication Critical patent/AU2006235735A1/en
Application granted granted Critical
Publication of AU2006235735B2 publication Critical patent/AU2006235735B2/en
Publication of AU2006235735C1 publication Critical patent/AU2006235735C1/en
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Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P11/06—Antiasthmatics
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
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    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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AU2006235735A 2005-04-13 2006-04-13 Hydroxybenzamide derivatives and their use as inhibitors of Hsp90 Ceased AU2006235735C1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US67089705P 2005-04-13 2005-04-13
US60/670,897 2005-04-13
GB0507474.5 2005-04-13
GB0507474A GB0507474D0 (en) 2005-04-13 2005-04-13 Pharmaceutical compounds
US77798906P 2006-03-01 2006-03-01
GB0604111A GB0604111D0 (en) 2006-03-01 2006-03-01 Pharmaceutical compounds
GB0604111.5 2006-03-01
US60/777,989 2006-03-01
PCT/GB2006/001382 WO2006109085A1 (en) 2005-04-13 2006-04-13 Hydroxybenzamide derivatives and their use as inhibitors of hsp90

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AU2006235735A1 AU2006235735A1 (en) 2006-10-19
AU2006235735B2 AU2006235735B2 (en) 2012-05-24
AU2006235735C1 true AU2006235735C1 (en) 2013-10-31

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AU2006235735A Ceased AU2006235735C1 (en) 2005-04-13 2006-04-13 Hydroxybenzamide derivatives and their use as inhibitors of Hsp90

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US (7) US8101648B2 (enExample)
EP (3) EP2332909B1 (enExample)
JP (2) JP5154406B2 (enExample)
KR (1) KR101411167B1 (enExample)
CN (1) CN101193862B (enExample)
AU (1) AU2006235735C1 (enExample)
CA (1) CA2604042C (enExample)
DK (2) DK2332909T3 (enExample)
ES (2) ES2402469T3 (enExample)
ME (2) ME02051B (enExample)
MX (1) MX2007012659A (enExample)
NO (1) NO341631B1 (enExample)
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PT (2) PT1877379E (enExample)
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RU (1) RU2458919C2 (enExample)
SI (2) SI2332909T1 (enExample)
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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2601936C (en) * 2005-02-24 2014-06-17 Amgen Inc. Epidermal growth factor receptor mutations
CN101193862B (zh) * 2005-04-13 2013-08-21 阿斯特克斯治疗有限公司 羟基苯甲酰胺衍生物和其作为hsp90抑制剂的用途
JP2008540395A (ja) * 2005-05-03 2008-11-20 ファイザー・インク アミドレソルシノール化合物
US7754725B2 (en) * 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US7893264B2 (en) * 2006-07-07 2011-02-22 Gilead Sciences, Inc. Antiviral phosphinate compounds
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