AU2005319305B2 - Pyrrolidine inhibitors of IAP - Google Patents

Pyrrolidine inhibitors of IAP Download PDF

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Publication number
AU2005319305B2
AU2005319305B2 AU2005319305A AU2005319305A AU2005319305B2 AU 2005319305 B2 AU2005319305 B2 AU 2005319305B2 AU 2005319305 A AU2005319305 A AU 2005319305A AU 2005319305 A AU2005319305 A AU 2005319305A AU 2005319305 B2 AU2005319305 B2 AU 2005319305B2
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AU
Australia
Prior art keywords
mmol
compound
mixture
alkyl
pct
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Expired
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AU2005319305A
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English (en)
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AU2005319305A1 (en
Inventor
Frederick Cohen
John A. Flygare
Cuong Ly
Vickie Hsiao-Wei Tsui
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Genentech Inc
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AU2005319305A1 publication Critical patent/AU2005319305A1/en
Application granted granted Critical
Publication of AU2005319305B2 publication Critical patent/AU2005319305B2/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2005319305A 2004-12-20 2005-12-19 Pyrrolidine inhibitors of IAP Expired AU2005319305B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63820204P 2004-12-20 2004-12-20
US60/638,202 2004-12-20
PCT/US2005/046161 WO2006069063A1 (en) 2004-12-20 2005-12-19 Pyrrolidine inhibitors of iap

Publications (2)

Publication Number Publication Date
AU2005319305A1 AU2005319305A1 (en) 2006-06-29
AU2005319305B2 true AU2005319305B2 (en) 2012-08-23

Family

ID=36129810

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005319305A Expired AU2005319305B2 (en) 2004-12-20 2005-12-19 Pyrrolidine inhibitors of IAP

Country Status (18)

Country Link
US (4) US20060167066A1 (enExample)
EP (1) EP1836201B2 (enExample)
JP (2) JP5007235B2 (enExample)
KR (2) KR20120127754A (enExample)
CN (1) CN101146803A (enExample)
AT (1) ATE477254T1 (enExample)
AU (1) AU2005319305B2 (enExample)
CA (1) CA2588921C (enExample)
DE (1) DE602005022936D1 (enExample)
DK (1) DK1836201T4 (enExample)
EA (1) EA019420B1 (enExample)
ES (1) ES2349110T5 (enExample)
IL (1) IL183514A (enExample)
MX (1) MX2007007195A (enExample)
NO (1) NO339157B1 (enExample)
NZ (1) NZ589670A (enExample)
WO (1) WO2006069063A1 (enExample)
ZA (1) ZA200704910B (enExample)

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