CN101146803A - Iap的吡咯烷抑制剂 - Google Patents

Iap的吡咯烷抑制剂 Download PDF

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Publication number
CN101146803A
CN101146803A CNA2005800484668A CN200580048466A CN101146803A CN 101146803 A CN101146803 A CN 101146803A CN A2005800484668 A CNA2005800484668 A CN A2005800484668A CN 200580048466 A CN200580048466 A CN 200580048466A CN 101146803 A CN101146803 A CN 101146803A
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CN
China
Prior art keywords
mmol
alkyl
heterocycle
compound
mixture
Prior art date
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Pending
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CNA2005800484668A
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English (en)
Chinese (zh)
Inventor
弗雷德里克·科恩
崔晓薇
李国强
约翰·A·弗莱加雷
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Genentech Inc
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Genentech Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36129810&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101146803(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CN101146803A publication Critical patent/CN101146803A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA2005800484668A 2004-12-20 2005-12-19 Iap的吡咯烷抑制剂 Pending CN101146803A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63820204P 2004-12-20 2004-12-20
US60/638,202 2004-12-20

Publications (1)

Publication Number Publication Date
CN101146803A true CN101146803A (zh) 2008-03-19

Family

ID=36129810

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800484668A Pending CN101146803A (zh) 2004-12-20 2005-12-19 Iap的吡咯烷抑制剂

Country Status (18)

Country Link
US (4) US20060167066A1 (enExample)
EP (1) EP1836201B2 (enExample)
JP (2) JP5007235B2 (enExample)
KR (2) KR20120127754A (enExample)
CN (1) CN101146803A (enExample)
AT (1) ATE477254T1 (enExample)
AU (1) AU2005319305B2 (enExample)
CA (1) CA2588921C (enExample)
DE (1) DE602005022936D1 (enExample)
DK (1) DK1836201T4 (enExample)
EA (1) EA019420B1 (enExample)
ES (1) ES2349110T5 (enExample)
IL (1) IL183514A (enExample)
MX (1) MX2007007195A (enExample)
NO (1) NO339157B1 (enExample)
NZ (1) NZ589670A (enExample)
WO (1) WO2006069063A1 (enExample)
ZA (1) ZA200704910B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102757426A (zh) * 2011-04-28 2012-10-31 中国医学科学院医药生物技术研究所 一种苯并异恶唑基取代的噻唑类化合物、制备方法及用途
WO2019091492A1 (zh) * 2017-11-13 2019-05-16 南京明德新药研发股份有限公司 用作iap抑制剂的smac模拟物及其用途
WO2020228642A1 (zh) * 2019-05-10 2020-11-19 正大天晴药业集团股份有限公司 一种用作iap抑制剂的smac模拟物的结晶及其制备方法
CN113354530A (zh) * 2020-03-07 2021-09-07 东莞市东阳光动物保健药品有限公司 一种制备4-乙酰基-1-萘甲酸的方法

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