AU2003294830B2 - Pyridino `2, 3-D! pyrimidine derivatives as selective KDR and FGFR inhibitors - Google Patents

Pyridino `2, 3-D! pyrimidine derivatives as selective KDR and FGFR inhibitors Download PDF

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Publication number
AU2003294830B2
AU2003294830B2 AU2003294830A AU2003294830A AU2003294830B2 AU 2003294830 B2 AU2003294830 B2 AU 2003294830B2 AU 2003294830 A AU2003294830 A AU 2003294830A AU 2003294830 A AU2003294830 A AU 2003294830A AU 2003294830 B2 AU2003294830 B2 AU 2003294830B2
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substituted
lower alkyl
phenyl
pyrimidin
cor
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Expired - Fee Related
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AU2003294830A1 (en
Inventor
Jin-Jun Liu
Kin-Chun Luk
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2003294830A 2002-12-20 2003-12-11 Pyridino `2, 3-D! pyrimidine derivatives as selective KDR and FGFR inhibitors Expired - Fee Related AU2003294830B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43496902P 2002-12-20 2002-12-20
US60/434,969 2002-12-20
US51361503P 2003-10-23 2003-10-23
US60/513,615 2003-10-23
PCT/EP2003/014067 WO2004056822A1 (en) 2002-12-20 2003-12-11 Pyridino `2, 3-d! pyrimidine derivatives as selective kdr and fgfr inhibitors

Publications (2)

Publication Number Publication Date
AU2003294830A1 AU2003294830A1 (en) 2004-07-14
AU2003294830B2 true AU2003294830B2 (en) 2009-06-11

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AU2003294830A Expired - Fee Related AU2003294830B2 (en) 2002-12-20 2003-12-11 Pyridino `2, 3-D! pyrimidine derivatives as selective KDR and FGFR inhibitors

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Country Link
US (1) US7098332B2 (enExample)
EP (1) EP1581531B1 (enExample)
JP (1) JP2006511563A (enExample)
KR (1) KR100763298B1 (enExample)
AR (1) AR042532A1 (enExample)
AT (1) ATE387445T1 (enExample)
AU (1) AU2003294830B2 (enExample)
BR (1) BR0317480A (enExample)
CA (1) CA2508951A1 (enExample)
DE (1) DE60319430T2 (enExample)
ES (1) ES2300639T3 (enExample)
MX (1) MXPA05006437A (enExample)
PL (1) PL377661A1 (enExample)
RU (1) RU2345077C2 (enExample)
WO (1) WO2004056822A1 (enExample)

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Also Published As

Publication number Publication date
EP1581531A1 (en) 2005-10-05
WO2004056822A1 (en) 2004-07-08
JP2006511563A (ja) 2006-04-06
EP1581531B1 (en) 2008-02-27
DE60319430D1 (de) 2008-04-10
ATE387445T1 (de) 2008-03-15
US7098332B2 (en) 2006-08-29
RU2345077C2 (ru) 2009-01-27
RU2005122901A (ru) 2006-02-27
BR0317480A (pt) 2005-11-16
DE60319430T2 (de) 2009-02-26
KR100763298B1 (ko) 2007-10-04
ES2300639T3 (es) 2008-06-16
AU2003294830A1 (en) 2004-07-14
PL377661A1 (pl) 2006-02-06
MXPA05006437A (es) 2005-08-19
CA2508951A1 (en) 2004-07-08
KR20050088202A (ko) 2005-09-02
US20040122029A1 (en) 2004-06-24
AR042532A1 (es) 2005-06-22

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