ATE277931T1 - Bicyclische stickstoffheteroaryl verbindungen - Google Patents

Bicyclische stickstoffheteroaryl verbindungen

Info

Publication number
ATE277931T1
ATE277931T1 AT99953796T AT99953796T ATE277931T1 AT E277931 T1 ATE277931 T1 AT E277931T1 AT 99953796 T AT99953796 T AT 99953796T AT 99953796 T AT99953796 T AT 99953796T AT E277931 T1 ATE277931 T1 AT E277931T1
Authority
AT
Austria
Prior art keywords
lower alkyl
heteroaryl
aryl
cycloalkyl
alkyl
Prior art date
Application number
AT99953796T
Other languages
English (en)
Inventor
William Harris
Christopher Huw Hill
Ian Edward David Smith
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE277931(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9823277.0A external-priority patent/GB9823277D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE277931T1 publication Critical patent/ATE277931T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Inorganic Insulating Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT99953796T 1998-10-23 1999-10-13 Bicyclische stickstoffheteroaryl verbindungen ATE277931T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9823277.0A GB9823277D0 (en) 1998-10-23 1998-10-23 Bicycle nitrogen heterocycles
GBGB9920044.6A GB9920044D0 (en) 1998-10-23 1999-08-24 Biciclic nitrogen heterocycles
PCT/EP1999/007675 WO2000024744A1 (en) 1998-10-23 1999-10-13 Bicyclic nitrogen heterocycles

Publications (1)

Publication Number Publication Date
ATE277931T1 true ATE277931T1 (de) 2004-10-15

Family

ID=26314565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99953796T ATE277931T1 (de) 1998-10-23 1999-10-13 Bicyclische stickstoffheteroaryl verbindungen

Country Status (25)

Country Link
US (1) US6150373A (de)
EP (1) EP1123295B1 (de)
JP (1) JP3593035B2 (de)
CN (1) CN1150195C (de)
AT (1) ATE277931T1 (de)
AU (1) AU769989B2 (de)
BR (1) BR9914677A (de)
CA (1) CA2347474C (de)
CZ (1) CZ20011394A3 (de)
DE (1) DE69920732T2 (de)
ES (1) ES2228123T3 (de)
HK (1) HK1041483B (de)
HR (1) HRP20010274A2 (de)
HU (1) HUP0104199A3 (de)
ID (1) ID28276A (de)
MA (1) MA27678A1 (de)
MY (1) MY126478A (de)
NO (1) NO318802B1 (de)
NZ (1) NZ510760A (de)
PL (1) PL347432A1 (de)
PT (1) PT1123295E (de)
RU (1) RU2256662C2 (de)
TR (1) TR200101102T2 (de)
TW (1) TWI227235B (de)
WO (1) WO2000024744A1 (de)

Families Citing this family (73)

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JP2001526230A (ja) 1997-12-19 2001-12-18 スミスクライン・ビーチャム・コーポレイション ヘテロアリール置換イミダゾール化合物、その医薬組成物および使用
ES2310039T3 (es) 1998-05-26 2008-12-16 Warner-Lambert Company Llc Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular.
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
US20040044012A1 (en) * 1998-05-26 2004-03-04 Dobrusin Ellen Myra Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
US6599910B1 (en) 1998-08-20 2003-07-29 Smithkline Beecham Corporation Substituted triazole compounds
ES2212657T3 (es) 1998-11-04 2004-07-16 Smithkline Beecham Corporation Pirazinas sustituidas piridin-4-il o pirimidin-4-il.
JP3961830B2 (ja) * 1999-10-21 2007-08-22 エフ.ホフマン−ラ ロシュ アーゲー p38プロテインキナーゼのインヒビターとしてのヘテロアルキルアミノ置換二環式窒素複素環
MXPA02003841A (es) 1999-10-21 2002-09-30 Hoffmann La Roche Heterociclos de nitrogeno biciclicos alquilamino substituidos como inhibidores de proteina p38.
JP2003514900A (ja) 1999-11-23 2003-04-22 スミスクライン・ビーチャム・コーポレイション CSBP/p38キナーゼ阻害剤としての3,4−ジヒドロ−(1H)−キナゾリン−2−オン化合物
ATE305787T1 (de) 1999-11-23 2005-10-15 Smithkline Beecham Corp 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
ES2230171T3 (es) 1999-11-23 2005-05-01 Smithkline Beecham Corporation Compuestos 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p38 quinasa.
US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7101869B2 (en) 1999-11-30 2006-09-05 Pfizer Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
MY141144A (en) * 2000-03-02 2010-03-15 Smithkline Beecham Corp 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
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US7119111B2 (en) 2002-05-29 2006-10-10 Amgen, Inc. 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use
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US7897762B2 (en) * 2006-09-14 2011-03-01 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of proliferative diseases
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CN105307657B (zh) 2013-03-15 2020-07-10 西建卡尔有限责任公司 杂芳基化合物和其用途
CN105263931B (zh) 2013-04-19 2019-01-25 因赛特公司 作为fgfr抑制剂的双环杂环
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Also Published As

Publication number Publication date
BR9914677A (pt) 2001-07-17
AU1036300A (en) 2000-05-15
MY126478A (en) 2006-10-31
MA27678A1 (fr) 2006-01-02
TR200101102T2 (tr) 2002-01-21
HK1041483B (zh) 2004-12-24
PL347432A1 (en) 2002-04-08
AU769989B2 (en) 2004-02-12
EP1123295B1 (de) 2004-09-29
NO20011929D0 (no) 2001-04-19
DE69920732D1 (de) 2004-11-04
NO318802B1 (no) 2005-05-09
TWI227235B (en) 2005-02-01
CN1324360A (zh) 2001-11-28
HUP0104199A3 (en) 2002-12-28
JP3593035B2 (ja) 2004-11-24
HUP0104199A2 (hu) 2002-04-29
JP2002528455A (ja) 2002-09-03
CA2347474C (en) 2008-08-26
DE69920732T2 (de) 2006-02-23
NZ510760A (en) 2003-08-29
ES2228123T3 (es) 2005-04-01
ID28276A (id) 2001-05-10
PT1123295E (pt) 2005-01-31
HRP20010274A2 (en) 2002-06-30
RU2256662C2 (ru) 2005-07-20
CZ20011394A3 (cs) 2001-12-12
CA2347474A1 (en) 2000-05-04
EP1123295A1 (de) 2001-08-16
HK1041483A1 (en) 2002-07-12
NO20011929L (no) 2001-04-19
WO2000024744A1 (en) 2000-05-04
CN1150195C (zh) 2004-05-19
US6150373A (en) 2000-11-21

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