KR100763298B1 - 선택적인 ｋｄｒ 및 ｆｇｆｒ 저해제로서의피리디노［２,３－ｄ］피리미딘 유도체 - Google Patents

선택적인 ｋｄｒ 및 ｆｇｆｒ 저해제로서의피리디노［２,３－ｄ］피리미딘 유도체 Download PDF

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KR100763298B1
KR100763298B1 KR1020057011681A KR20057011681A KR100763298B1 KR 100763298 B1 KR100763298 B1 KR 100763298B1 KR 1020057011681 A KR1020057011681 A KR 1020057011681A KR 20057011681 A KR20057011681 A KR 20057011681A KR 100763298 B1 KR100763298 B1 KR 100763298B1
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phenyl
pyrimidin
propionic acid
methoxy
formula
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KR20050088202A (ko
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진-쥔 류
킨-춘 뤽
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에프. 호프만-라 로슈 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020057011681A 2002-12-20 2003-12-11 선택적인 ｋｄｒ 및 ｆｇｆｒ 저해제로서의피리디노［２,３－ｄ］피리미딘 유도체 Expired - Fee Related KR100763298B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43496902P 2002-12-20 2002-12-20
US60/434,969 2002-12-20
US51361503P 2003-10-23 2003-10-23
US60/513,615 2003-10-23

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KR20050088202A KR20050088202A (ko) 2005-09-02
KR100763298B1 true KR100763298B1 (ko) 2007-10-04

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US (1) US7098332B2 (enExample)
EP (1) EP1581531B1 (enExample)
JP (1) JP2006511563A (enExample)
KR (1) KR100763298B1 (enExample)
AR (1) AR042532A1 (enExample)
AT (1) ATE387445T1 (enExample)
AU (1) AU2003294830B2 (enExample)
BR (1) BR0317480A (enExample)
CA (1) CA2508951A1 (enExample)
DE (1) DE60319430T2 (enExample)
ES (1) ES2300639T3 (enExample)
MX (1) MXPA05006437A (enExample)
PL (1) PL377661A1 (enExample)
RU (1) RU2345077C2 (enExample)
WO (1) WO2004056822A1 (enExample)

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HUE053653T2 (hu) 2014-03-26 2021-07-28 Astex Therapeutics Ltd FGFR inhibitor és IGF1R inhibitor kombinációi
MX370099B (es) 2014-03-26 2019-12-02 Astex Therapeutics Ltd Combinación que comprende un inhibidor de fgfr y un inhibidor de cmet para el tratamiento del cáncer.
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WO2004056822A1 (en) 2004-07-08
ATE387445T1 (de) 2008-03-15
KR20050088202A (ko) 2005-09-02
RU2005122901A (ru) 2006-02-27
EP1581531B1 (en) 2008-02-27
AR042532A1 (es) 2005-06-22
DE60319430D1 (de) 2008-04-10
CA2508951A1 (en) 2004-07-08
BR0317480A (pt) 2005-11-16
MXPA05006437A (es) 2005-08-19
DE60319430T2 (de) 2009-02-26
JP2006511563A (ja) 2006-04-06
AU2003294830A1 (en) 2004-07-14
RU2345077C2 (ru) 2009-01-27
EP1581531A1 (en) 2005-10-05
AU2003294830B2 (en) 2009-06-11
US20040122029A1 (en) 2004-06-24
US7098332B2 (en) 2006-08-29
PL377661A1 (pl) 2006-02-06
ES2300639T3 (es) 2008-06-16

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