AU2001283008A1 - Crystalline and pure modafinil, and process of preparing the same - Google Patents

Crystalline and pure modafinil, and process of preparing the same

Info

Publication number
AU2001283008A1
AU2001283008A1 AU2001283008A AU8300801A AU2001283008A1 AU 2001283008 A1 AU2001283008 A1 AU 2001283008A1 AU 2001283008 A AU2001283008 A AU 2001283008A AU 8300801 A AU8300801 A AU 8300801A AU 2001283008 A1 AU2001283008 A1 AU 2001283008A1
Authority
AU
Australia
Prior art keywords
modafinil
reflections
degrees
liquid
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001283008A
Other languages
English (en)
Inventor
Judith Aronhime
Arina Ceausu
Neomi Gershon
Anita Lieberman
Claude Singer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of AU2001283008A1 publication Critical patent/AU2001283008A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Metallurgy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Laminated Bodies (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Glass Compositions (AREA)
AU2001283008A 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same Abandoned AU2001283008A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US60221110 2000-07-27
US22649100P 2000-08-18 2000-08-18
US60226491 2000-08-18
US22916000P 2000-08-30 2000-08-30
US60229160 2000-08-30
US23008800P 2000-09-05 2000-09-05
US60230088 2000-09-05
US25933201P 2001-01-02 2001-01-02
US60259332 2001-01-02
PCT/US2001/023689 WO2002010125A1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Publications (1)

Publication Number Publication Date
AU2001283008A1 true AU2001283008A1 (en) 2002-02-13

Family

ID=27539819

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001283008A Abandoned AU2001283008A1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Country Status (24)

Country Link
US (3) US6849120B2 (es)
EP (3) EP1309547B1 (es)
JP (2) JP4302977B2 (es)
KR (8) KR100729292B1 (es)
CN (2) CN101186590A (es)
AT (1) ATE453618T1 (es)
AU (1) AU2001283008A1 (es)
CA (3) CA2685310C (es)
CY (1) CY1110234T1 (es)
CZ (1) CZ2003529A3 (es)
DE (3) DE20122504U1 (es)
DK (2) DK1309547T3 (es)
ES (2) ES2337838T3 (es)
HR (2) HRP20030131B1 (es)
HU (1) HUP0400927A3 (es)
IL (2) IL154122A0 (es)
IS (1) IS6699A (es)
MX (1) MXPA03000747A (es)
NZ (1) NZ524359A (es)
PL (1) PL206371B1 (es)
PT (2) PT1309547E (es)
SK (1) SK2242003A3 (es)
WO (1) WO2002010125A1 (es)
ZA (1) ZA200300672B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1309547T3 (da) * 2000-07-27 2007-05-21 Teva Pharma Krystallinsk og ren modafinil og fremgangsmåde til fremstilling af samme
HU229409B1 (en) 2000-10-11 2013-12-30 Cephalon Compositions comprising modafinil compounds
BR0114814A (pt) * 2000-10-11 2005-01-25 Cephalon Inc Composições compreendendo composto de modafinila e seu uso
US20050025791A1 (en) 2002-06-21 2005-02-03 Julius Remenar Pharmaceutical compositions with improved dissolution
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
ITMI20020991A1 (it) * 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
US6875893B2 (en) 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
TW200413296A (en) * 2002-08-09 2004-08-01 Cephalon France Modafinil polymorphic forms
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
FR2849029B1 (fr) * 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
MXPA05008088A (es) * 2003-02-24 2005-09-21 Mallinckrodt Inc Proceso mejorado para preparar benzhidril tioacetamida.
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
DE60329167D1 (de) * 2003-05-16 2009-10-22 Cephalon France Verfahren zur Herstellung von Modafinil
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
EP1670753A4 (en) * 2003-09-04 2008-01-02 Cephalon Inc MODAFINIL COMPOSITIONS
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP2292213A1 (en) 2004-02-06 2011-03-09 Cephalon, Inc. Compositions comprising a polymorphic form of armodafinil
CN1980888B (zh) * 2004-02-06 2011-04-13 赛福伦公司 莫达芬尼组合物
US20090018202A1 (en) 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
EA009949B1 (ru) * 2004-02-06 2008-04-28 Сефалон, Инк. Композиции модафинила
US7314875B2 (en) 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1586560A1 (en) 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
BRPI0500520A (pt) * 2005-02-16 2006-09-26 Henry Jun Suzuki uso de agentes flavorizantes aromáticos de alto ponto de fusão como agentes solubilizantes ou inibidores de cristalização em composições farmacêuticas
BRPI0501120A (pt) * 2005-02-18 2006-10-03 Henry Jun Suzuki composições farmacêuticas orais e parenterais contendo altas concentrações de agentes solubilizantes aromáticos
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
CA2632722A1 (en) * 2005-12-09 2007-06-21 Mallinckrodt Inc. Processes for the preparation of modafinil and analogs thereof
US20070293702A1 (en) * 2006-02-21 2007-12-20 Viviana Braude Novel crystalline forms of armodafinil and preparation thereof
BRPI0714173A2 (pt) * 2006-07-12 2012-12-25 Elan Pharma Int Ltd composiÇço nanoparticulada estÁvel,mÉtodos para preparar a composiÇço, para prevenir e/ou tratar estados de doenÇas, sintomas, sÍndromes e condiÇÕes do sistema nervoso central, para melhorar ou manter a biodisponibilidade de modafinil, e para tratar distérbio com base neurolàgica, composiÇço farmacÊutica, e forma de dosagem
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
US20100234468A1 (en) * 2007-06-04 2010-09-16 Abhay Gaitonde Novel process
WO2009025791A2 (en) * 2007-08-16 2009-02-26 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
FR2923482B1 (fr) * 2007-11-09 2010-01-29 Servier Lab Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
US20090105346A1 (en) * 2007-10-02 2009-04-23 Alexandr Jegorov Novel crystalline forms of armodafinil and preparation thereof
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
US8551887B2 (en) 2009-12-22 2013-10-08 Air Products And Chemicals, Inc. Method for chemical mechanical planarization of a copper-containing substrate
CN102070498A (zh) * 2011-01-12 2011-05-25 华东师范大学 一种亚砜的制备方法
CN102746202B (zh) * 2012-07-04 2013-12-18 广州市博兴化工科技有限公司 一种含有甲基亚砜结构的丙烯酸酯化合物及其制备方法和应用
KR102495018B1 (ko) 2013-11-15 2023-02-06 아케비아 테라퓨틱스 인코포레이티드 ｛[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노｝아세트산의 고체형, 이의 조성물 및 용도
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
KR102369295B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 벤딩 타입 힌지 스프링
KR102393940B1 (ko) 2020-11-12 2022-05-09 주식회사 에스코넥 토션 타입 힌지 스프링
KR102369302B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 압축 타입 힌지 스프링

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098824A (en) 1975-10-02 1978-07-04 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
FR2606015B1 (fr) 1986-08-13 1989-05-19 Lafon Labor Derives du benzhydrylthiomethane, leurs procedes de preparation et leurs applications en therapeutique
FR2611709B1 (fr) 1987-02-26 1989-06-09 Lafon Labor 2-(benzhydrylsulfonyl)acetamide, son procede de preparation et son application en therapeutique
US5843347A (en) 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
FR2707637B1 (fr) * 1993-06-30 1995-10-06 Lafon Labor Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique.
US5618845A (en) 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
FR2771004B1 (fr) 1997-11-19 2000-02-18 Inst Curie Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
US6346548B1 (en) 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation
CN1249932A (zh) * 1999-09-29 2000-04-12 付俊昌 一种莫达芬尼及其光学对映体l及d异构体的新用途
FR2804322B1 (fr) 2000-01-31 2002-04-19 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies
DK1309547T3 (da) * 2000-07-27 2007-05-21 Teva Pharma Krystallinsk og ren modafinil og fremgangsmåde til fremstilling af samme
US6919378B2 (en) 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
US7297346B2 (en) 2001-05-25 2007-11-20 Cephalon Inc. Pharmaceutical formulations of modafinil
ITMI20020991A1 (it) 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
US6875893B2 (en) 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
US7229644B2 (en) 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US7115281B2 (en) 2002-07-08 2006-10-03 Ranbaxy Laboratories Limited Processes for the preparation of oral dosage formulations of modafinil
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
CA2409429A1 (en) * 2002-10-17 2004-04-17 Bayer Inc. Hydrogenated nitrile rubber composites with improved proccesability
IL153098A0 (en) 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
WO2004075827A2 (en) 2003-01-31 2004-09-10 Alembic Limited Process for the preparation of 2-[(diphenylmethyl) thio] acetamide
MXPA05008088A (es) 2003-02-24 2005-09-21 Mallinckrodt Inc Proceso mejorado para preparar benzhidril tioacetamida.
CA2420180A1 (en) 2003-02-28 2004-08-28 Bernard Charles Sherman Tablets comprising modafinil
AR045314A1 (es) 2003-05-13 2005-10-26 Cephalon Inc Composiciones farmaceuticas de analepticos y antidepresivos
US20040229941A1 (en) 2003-05-13 2004-11-18 Cephalon, Inc. Analeptic and antidepressant combinations
AR045423A1 (es) 2003-05-13 2005-10-26 Cephalon Inc Combinaciones de analiticos y antidepresivos
US20040229943A1 (en) 2003-05-16 2004-11-18 Cephalon Inc Analeptic and drug combinations
ITMI20031298A1 (it) 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).

Also Published As

Publication number Publication date
JP2004509080A (ja) 2004-03-25
ATE453618T1 (de) 2010-01-15
EP2168946A1 (en) 2010-03-31
DE60126099T2 (de) 2007-11-15
ES2337838T3 (es) 2010-04-29
US20050038124A1 (en) 2005-02-17
US8048222B2 (en) 2011-11-01
KR100729298B1 (ko) 2007-06-18
PT1309547E (pt) 2007-03-30
JP2009024006A (ja) 2009-02-05
WO2002010125A1 (en) 2002-02-07
KR100729292B1 (ko) 2007-06-18
EP1309547A1 (en) 2003-05-14
CA2416792C (en) 2010-02-09
US6849120B2 (en) 2005-02-01
HRP20080373A2 (en) 2008-12-31
HRP20030131B1 (en) 2011-03-31
US20020043207A1 (en) 2002-04-18
PL206371B1 (pl) 2010-07-30
PT1787980E (pt) 2010-03-18
CA2685310C (en) 2012-10-16
US20050034652A1 (en) 2005-02-17
CA2416792A1 (en) 2002-02-07
IL154122A (en) 2009-07-20
KR20070097131A (ko) 2007-10-02
EP1309547B1 (en) 2007-01-17
MXPA03000747A (es) 2003-06-04
KR101098749B1 (ko) 2011-12-23
NZ524359A (en) 2005-06-24
CZ2003529A3 (cs) 2003-09-17
PL365613A1 (en) 2005-01-10
DE60140973D1 (de) 2010-02-11
KR20060097771A (ko) 2006-09-15
DE20122504U1 (de) 2005-12-29
EP1787980B1 (en) 2009-12-30
ES2277937T3 (es) 2007-08-01
SK2242003A3 (en) 2003-10-07
DE60126099D1 (de) 2007-03-08
KR20070007970A (ko) 2007-01-16
KR20090103962A (ko) 2009-10-01
EP1309547A4 (en) 2005-03-02
IL154122A0 (en) 2003-07-31
CY1110234T1 (el) 2015-01-14
DK1309547T3 (da) 2007-05-21
CA2634702C (en) 2011-07-19
CN100500651C (zh) 2009-06-17
CN1466570A (zh) 2004-01-07
KR20100098462A (ko) 2010-09-06
KR20060024028A (ko) 2006-03-15
KR101019448B1 (ko) 2011-03-07
KR20090106661A (ko) 2009-10-09
IS6699A (is) 2003-01-24
DK1787980T3 (da) 2010-04-26
HUP0400927A3 (en) 2007-11-28
HRP20030131A2 (en) 2005-04-30
KR101081212B1 (ko) 2011-11-07
HUP0400927A2 (hu) 2004-07-28
ZA200300672B (en) 2004-02-18
JP4980309B2 (ja) 2012-07-18
CN101186590A (zh) 2008-05-28
CA2685310A1 (en) 2002-02-07
US7235691B2 (en) 2007-06-26
EP1787980A2 (en) 2007-05-23
CA2634702A1 (en) 2002-02-07
EP1787980A3 (en) 2007-08-08
JP4302977B2 (ja) 2009-07-29
KR20030029636A (ko) 2003-04-14

Similar Documents

Publication Publication Date Title
US6849120B2 (en) Oxidation method for preparing highly pure modafinil, crystalline forms of modafinil, and methods of preparing the crystalline forms
EP2679578B1 (fr) Procédé de préparation et une forme cristalline des énantiomères optiques du modafinil
CA2634133A1 (en) An improved process for the preparation of armodafinil
JPH0586042A (ja) ２−メルカプト−フエノチアジンの製造方法

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application