AU2001283008A1 - Crystalline and pure modafinil, and process of preparing the same - Google Patents

Crystalline and pure modafinil, and process of preparing the same

Info

Publication number
AU2001283008A1
AU2001283008A1 AU2001283008A AU8300801A AU2001283008A1 AU 2001283008 A1 AU2001283008 A1 AU 2001283008A1 AU 2001283008 A AU2001283008 A AU 2001283008A AU 8300801 A AU8300801 A AU 8300801A AU 2001283008 A1 AU2001283008 A1 AU 2001283008A1
Authority
AU
Australia
Prior art keywords
modafinil
reflections
degrees
liquid
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001283008A
Other languages
English (en)
Inventor
Judith Aronhime
Arina Ceausu
Neomi Gershon
Anita Lieberman
Claude Singer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of AU2001283008A1 publication Critical patent/AU2001283008A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
AU2001283008A 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same Abandoned AU2001283008A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US60221110 2000-07-27
US22649100P 2000-08-18 2000-08-18
US60226491 2000-08-18
US22916000P 2000-08-30 2000-08-30
US60229160 2000-08-30
US23008800P 2000-09-05 2000-09-05
US60230088 2000-09-05
US25933201P 2001-01-02 2001-01-02
US60259332 2001-01-02
PCT/US2001/023689 WO2002010125A1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Publications (1)

Publication Number Publication Date
AU2001283008A1 true AU2001283008A1 (en) 2002-02-13

Family

ID=27539819

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001283008A Abandoned AU2001283008A1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Country Status (24)

Country Link
US (3) US6849120B2 (es)
EP (3) EP2168946A1 (es)
JP (2) JP4302977B2 (es)
KR (8) KR101019448B1 (es)
CN (2) CN101186590A (es)
AT (1) ATE453618T1 (es)
AU (1) AU2001283008A1 (es)
CA (3) CA2416792C (es)
CY (1) CY1110234T1 (es)
CZ (1) CZ2003529A3 (es)
DE (3) DE60126099T2 (es)
DK (2) DK1309547T3 (es)
ES (2) ES2277937T3 (es)
HR (2) HRP20030131B1 (es)
HU (1) HUP0400927A3 (es)
IL (2) IL154122A0 (es)
IS (1) IS6699A (es)
MX (1) MXPA03000747A (es)
NZ (1) NZ524359A (es)
PL (1) PL206371B1 (es)
PT (2) PT1787980E (es)
SK (1) SK2242003A3 (es)
WO (1) WO2002010125A1 (es)
ZA (1) ZA200300672B (es)

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EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
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US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1586560A1 (en) 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
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BRPI0500520A (pt) * 2005-02-16 2006-09-26 Henry Jun Suzuki uso de agentes flavorizantes aromáticos de alto ponto de fusão como agentes solubilizantes ou inibidores de cristalização em composições farmacêuticas
BRPI0501120A (pt) * 2005-02-18 2006-10-03 Henry Jun Suzuki composições farmacêuticas orais e parenterais contendo altas concentrações de agentes solubilizantes aromáticos
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
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EP1986994A2 (en) * 2006-02-21 2008-11-05 Teva Pharmaceutical Industries Ltd Novel crystalline forms of armodafinil and preparation thereof
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WO2009045488A2 (en) * 2007-10-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of armodafinil and preparation thereof
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CN102070498A (zh) * 2011-01-12 2011-05-25 华东师范大学 一种亚砜的制备方法
CN102746202B (zh) * 2012-07-04 2013-12-18 广州市博兴化工科技有限公司 一种含有甲基亚砜结构的丙烯酸酯化合物及其制备方法和应用
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CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
KR102393940B1 (ko) 2020-11-12 2022-05-09 주식회사 에스코넥 토션 타입 힌지 스프링
KR102369295B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 벤딩 타입 힌지 스프링
KR102369302B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 압축 타입 힌지 스프링

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Also Published As

Publication number Publication date
HUP0400927A2 (hu) 2004-07-28
CA2634702A1 (en) 2002-02-07
CN1466570A (zh) 2004-01-07
US8048222B2 (en) 2011-11-01
JP4980309B2 (ja) 2012-07-18
KR101098749B1 (ko) 2011-12-23
EP2168946A1 (en) 2010-03-31
ES2277937T3 (es) 2007-08-01
KR20090106661A (ko) 2009-10-09
JP4302977B2 (ja) 2009-07-29
KR20060097771A (ko) 2006-09-15
JP2004509080A (ja) 2004-03-25
EP1787980B1 (en) 2009-12-30
KR100729298B1 (ko) 2007-06-18
PT1309547E (pt) 2007-03-30
US20050038124A1 (en) 2005-02-17
ATE453618T1 (de) 2010-01-15
CA2685310C (en) 2012-10-16
EP1309547A1 (en) 2003-05-14
KR20070007970A (ko) 2007-01-16
ZA200300672B (en) 2004-02-18
KR20090103962A (ko) 2009-10-01
KR20100098462A (ko) 2010-09-06
CA2685310A1 (en) 2002-02-07
PT1787980E (pt) 2010-03-18
EP1309547A4 (en) 2005-03-02
KR20070097131A (ko) 2007-10-02
SK2242003A3 (en) 2003-10-07
KR20030029636A (ko) 2003-04-14
US20050034652A1 (en) 2005-02-17
KR100729292B1 (ko) 2007-06-18
DE60126099D1 (de) 2007-03-08
US7235691B2 (en) 2007-06-26
ES2337838T3 (es) 2010-04-29
CN101186590A (zh) 2008-05-28
CZ2003529A3 (cs) 2003-09-17
DE60140973D1 (de) 2010-02-11
US20020043207A1 (en) 2002-04-18
IL154122A0 (en) 2003-07-31
EP1309547B1 (en) 2007-01-17
EP1787980A3 (en) 2007-08-08
KR20060024028A (ko) 2006-03-15
KR101081212B1 (ko) 2011-11-07
DE60126099T2 (de) 2007-11-15
PL206371B1 (pl) 2010-07-30
PL365613A1 (en) 2005-01-10
JP2009024006A (ja) 2009-02-05
IL154122A (en) 2009-07-20
CA2416792A1 (en) 2002-02-07
MXPA03000747A (es) 2003-06-04
NZ524359A (en) 2005-06-24
EP1787980A2 (en) 2007-05-23
DK1309547T3 (da) 2007-05-21
HRP20030131A2 (en) 2005-04-30
CA2416792C (en) 2010-02-09
HRP20080373A2 (en) 2008-12-31
IS6699A (is) 2003-01-24
WO2002010125A1 (en) 2002-02-07
HRP20030131B1 (en) 2011-03-31
CN100500651C (zh) 2009-06-17
CA2634702C (en) 2011-07-19
HUP0400927A3 (en) 2007-11-28
US6849120B2 (en) 2005-02-01
DE20122504U1 (de) 2005-12-29
DK1787980T3 (da) 2010-04-26
CY1110234T1 (el) 2015-01-14
KR101019448B1 (ko) 2011-03-07

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