ATE536422T1 - Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen - Google Patents

Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen

Info

Publication number
ATE536422T1
ATE536422T1 AT03075828T AT03075828T ATE536422T1 AT E536422 T1 ATE536422 T1 AT E536422T1 AT 03075828 T AT03075828 T AT 03075828T AT 03075828 T AT03075828 T AT 03075828T AT E536422 T1 ATE536422 T1 AT E536422T1
Authority
AT
Austria
Prior art keywords
protein
proteins
reagents
quantitative analysis
products
Prior art date
Application number
AT03075828T
Other languages
German (de)
English (en)
Inventor
Rudolf Hans Aebersold
Michael H Gelb
Steven P Gygi
C Ronald Scott
Frantisek Turecek
Scott A Gerber
Beate Rist
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26793647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE536422(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE536422T1 publication Critical patent/ATE536422T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/18—Sulfur containing
    • Y10T436/182—Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT03075828T 1998-08-25 1999-08-25 Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen ATE536422T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9778898P 1998-08-25 1998-08-25
US9911398P 1998-09-03 1998-09-03

Publications (1)

Publication Number Publication Date
ATE536422T1 true ATE536422T1 (de) 2011-12-15

Family

ID=26793647

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03075828T ATE536422T1 (de) 1998-08-25 1999-08-25 Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
AT99943915T ATE253126T1 (de) 1998-08-25 1999-08-25 Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99943915T ATE253126T1 (de) 1998-08-25 1999-08-25 Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen

Country Status (7)

Country Link
US (3) US6670194B1 (https=)
EP (2) EP1329513B1 (https=)
JP (3) JP3345401B2 (https=)
AT (2) ATE536422T1 (https=)
AU (1) AU755334C (https=)
DE (1) DE69912444T3 (https=)
WO (1) WO2000011208A1 (https=)

Families Citing this family (266)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6670194B1 (en) * 1998-08-25 2003-12-30 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
JP2003524394A (ja) * 1999-02-11 2003-08-19 マキシジェン， インコーポレイテッド ハイスループット質量分析法
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
EP1169641B1 (en) * 1999-04-15 2007-10-17 The University Of Virginia Patent Foundation Proteome mining
US6716636B1 (en) 1999-04-20 2004-04-06 Target Discovery, Inc. Methods for sequencing proteins
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
AU773329B2 (en) * 1999-05-14 2004-05-20 Proteomedica Ab Materials and methods relating to disease diagnosis
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US6783929B1 (en) 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
EP1246698B1 (en) * 2000-01-06 2006-09-20 Caliper Life Sciences, Inc. Ultra high throughput sampling and analysis systems and methods
CA2403296A1 (en) * 2000-04-10 2001-10-18 Benjamin F. Cravatt Proteomic analysis using activity-based probe libraries
DE10021737C2 (de) * 2000-05-04 2002-10-17 Hermann Haller Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird
EP1311858B1 (en) * 2000-05-05 2006-11-02 Purdue Research Foundation Affinity selected signature peptides for protein identification and quantification
US7153682B2 (en) 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
DE10027794A1 (de) * 2000-06-07 2001-12-13 Basf Ag Verfahren zur Analyse Enzym-katalysierter Umsetzungen mit MALDI-TOF-Massenspektrometrie
AU2001269058A1 (en) * 2000-06-07 2001-12-17 Basf Aktiengesellschaft Method for the qualitative and quantitative analysis of complex mixtures of chemical compounds, using maldi-tof mass spectrometry
AU2001270941A1 (en) 2000-06-09 2001-12-17 Mds Proteomics, Inc. Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing
AU6689401A (en) * 2000-06-12 2001-12-24 Univ Washington Selective labeling and isolation of phosphopeptides and applications to proteomeanalysis
US7567870B1 (en) 2000-07-31 2009-07-28 Institute For Systems Biology Multiparameter analysis for predictive medicine
CA2419159A1 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
US20020123055A1 (en) * 2000-08-25 2002-09-05 Estell David A. Mass spectrometric analysis of biopolymers
DE10043470B4 (de) * 2000-09-04 2006-01-19 Mpb Meltec Patent- Und Beteiligungsgesellschaft Mbh Verfahren zur Identifizierung von zellspezifischen Proteinen
WO2002029032A2 (en) * 2000-09-30 2002-04-11 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
SE0003566D0 (sv) * 2000-10-02 2000-10-02 Amersham Pharm Biotech Ab A method for the quantitative determination of one or more compounds
HK1054587A1 (zh) * 2000-10-03 2003-12-05 戴安公司 液相色谱-质谱分析仪(lc-ms)分析中的驻峰方法和系统
US6962818B2 (en) 2000-10-19 2005-11-08 Target Discovery Mass defect labeling for the determination of oligomer sequences
AU4338502A (en) 2000-10-23 2002-06-24 Genetics Inst Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures
JP4141834B2 (ja) 2000-10-23 2008-08-27 ジェネティックス インスティテュート エルエルシー マトリックス支援レーザー脱離イオン化マススペクトロメトリーを使用したハイスループットなタンパク質の同定及び定量のための同位体コードイオン化増強試薬（ｉｃｉｅｒ）
US20020164649A1 (en) * 2000-10-25 2002-11-07 Rajendra Singh Mass tags for quantitative analysis
SE0004094D0 (sv) * 2000-11-09 2000-11-09 Amersham Pharm Biotech Ab A method for the quantification of carbohudrates
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
AU2002217904A1 (en) * 2000-11-28 2002-06-11 Surromed, Inc. Methods for efficiently minig broad data sets for biological markers
US6797523B2 (en) * 2000-11-30 2004-09-28 Affinium Pharmaceuticals, Inc. Methods for systematic identification of protein—protein interactions
US20020090652A1 (en) * 2000-12-22 2002-07-11 Fu Emil Wei-Ming Inverse labeling method for the rapid identification of marker/target proteins
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US20020146743A1 (en) * 2001-01-12 2002-10-10 Xian Chen Stable isotope, site-specific mass tagging for protein identification
US6969757B2 (en) 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
US7166436B2 (en) 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
WO2002063271A2 (en) 2001-02-05 2002-08-15 Activx Biosciences, Inc. Activity based probe analysis
US6818454B2 (en) * 2001-02-16 2004-11-16 Battelle Memorial Institute Phosphoprotein binding agents and methods of their use
EP1370867B1 (en) 2001-03-02 2010-08-04 Activx Biosciences, Inc. Protein profiling platform
CA2419492C (en) * 2001-03-22 2005-07-05 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
WO2002081752A2 (en) 2001-04-03 2002-10-17 Thermo Finnigan Corporation Methods and kits useful for the simplification of complex peptide mixtures
CN1463291A (zh) * 2001-04-19 2003-12-24 赛弗根生物系统股份有限公司 用质谱法和亲和标记物鉴定生物分子的特性
US7045296B2 (en) * 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
US7183116B2 (en) 2001-05-14 2007-02-27 The Institute For Systems Biology Methods for isolation and labeling of sample molecules
JP2005502030A (ja) * 2001-05-29 2005-01-20 リージェンツ オブ ザ ユニバーシティ オブ ミシガン タンパク質解析のシステムおよび方法
CA2349265A1 (en) * 2001-05-30 2002-11-30 Andrew Emili Protein expression profile database
US6800449B1 (en) 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
WO2003006951A2 (en) * 2001-07-13 2003-01-23 Syngenta Participations Ag System and method of determining proteomic differences
WO2003092581A2 (en) * 2001-07-16 2003-11-13 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
AU2002322506A1 (en) * 2001-07-16 2003-03-03 President And Fellows Of Harvard College Non-affinity based isotope tagged peptides and methods for using the same
US7343247B2 (en) 2001-07-30 2008-03-11 The Institute For Systems Biology Methods of classifying drug responsiveness using multiparameter analysis
WO2003016861A2 (en) * 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
WO2003027682A2 (en) * 2001-09-27 2003-04-03 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US6756586B2 (en) 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
DE10153631B4 (de) * 2001-10-31 2006-04-13 Lottspeich, Friedrich, Dr. Verfahren zum Vergleich zweier Proteinzustände
WO2003040093A2 (de) * 2001-11-09 2003-05-15 Bayer Healthcare Ag Isotopencodierte affinitätsmarker 2
US6964850B2 (en) 2001-11-09 2005-11-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
WO2003040288A2 (de) * 2001-11-09 2003-05-15 Bayer Healthcare Ag Isotopencodierte affinitätsmarker 3
DE10154744A1 (de) * 2001-11-09 2003-05-22 Bayer Ag Isotopencodierte Affinitätsmarker
US20030129760A1 (en) * 2001-11-13 2003-07-10 Aguilera Frank Reinaldo Morales Mass intensity profiling system and uses thereof
US20030091976A1 (en) * 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
DE10158860B4 (de) 2001-11-30 2007-04-05 Bruker Daltonik Gmbh Massenspektrometrische Proteingemischanalyse
EP1319954A1 (en) * 2001-12-12 2003-06-18 Centre National de Genotypage Methods for protein analysis using protein capture arrays
US7623969B2 (en) 2002-01-31 2009-11-24 The Institute For Systems Biology Gene discovery for the system assignment of gene function
AU2003217385B2 (en) * 2002-02-12 2008-09-11 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
AU2003211941A1 (en) * 2002-02-14 2003-09-04 Ajinomoto Co., Inc. Method of analyzing aminofunctional compound and analytical reagent
AU2003224674A1 (en) * 2002-03-11 2003-09-29 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
US7288382B2 (en) 2002-03-14 2007-10-30 The Board Of Trustees Od The Leland Stanford Junior University Methods for structural analysis of proteins
CA2480306A1 (en) * 2002-03-25 2003-10-02 Teijin Limited Method of assaying coenzymes a in biological sample
WO2003087834A2 (en) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
US6989100B2 (en) * 2002-05-09 2006-01-24 Ppd Biomarker Discovery Sciences, Llc Methods for time-alignment of liquid chromatography-mass spectrometry data
WO2003098190A2 (en) * 2002-05-20 2003-11-27 Purdue Research Foundation Protein identification from protein product ion spectra
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7052916B2 (en) * 2002-05-24 2006-05-30 Immunex Corporation Polypeptide analyses using stable isotope labeling
GB0212522D0 (en) * 2002-05-31 2002-07-10 Shimadzu Res Lab Europe Ltd Selective binding and analysis of macromolecules
EP1514107B1 (en) 2002-06-03 2013-05-15 The Institute for Systems Biology Methods for quantitative proteome analysis of glycoproteins
AU2003259029A1 (en) 2002-06-04 2003-12-19 The Institute For Systems Biology Methods for high throughput and quantitative proteome analysis
JP2005529335A (ja) * 2002-06-10 2005-09-29 フィネクサス， インク． 開放チャンネルを使って生体分子を固体相として抽出するシステムと方法
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
AU2003236369A1 (en) * 2002-06-28 2004-01-19 Shimadzu Corporation Sulfenyl compound, labeling reagent, and method of analyzing peptide
US20060128659A1 (en) 2002-07-10 2006-06-15 Osami Habuchi Sulfotransferase inhibitors
CA2393726A1 (en) * 2002-07-16 2004-01-16 Steven J. Locke Quantitative proteomics via isotopically differentiated derivatization
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7409296B2 (en) * 2002-07-29 2008-08-05 Geneva Bioinformatics (Genebio), S.A. System and method for scoring peptide matches
EP1546364A4 (en) * 2002-07-30 2006-09-06 Univ California METHOD FOR THE AUTOMATIC MEASUREMENT OF THE MOLECULAR FLOW RATE SPEED OF THE PROTEOM OR ORGANOMA BY MEANS OF MASS SPECTROMETRY
US7501286B2 (en) 2002-08-14 2009-03-10 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US20050233307A1 (en) 2002-09-12 2005-10-20 Kyle Gee Site-specific labeling of affinity tags in fusion proteins
JP4395439B2 (ja) * 2002-09-12 2010-01-06 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） 薬物標的の同定のための方法
US7354750B2 (en) 2002-10-18 2008-04-08 Promega Corporation Methods for separating molecules
US6944549B2 (en) * 2002-10-25 2005-09-13 Syngenta Participations Ag Method and apparatus for automated detection of peaks in spectroscopic data
CA2800040C (en) 2002-10-29 2015-12-29 Target Discovery, Inc. Method for increasing ionization efficiency in mass spectroscopy
US7846748B2 (en) 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
US7425451B2 (en) 2002-12-13 2008-09-16 Agilent Technologies, Inc. Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
US7109040B2 (en) * 2002-12-13 2006-09-19 Agilent Technologies, Inc. Modular isotope coding approach to proteomic analysis
US20060105343A1 (en) * 2003-01-09 2006-05-18 Children's Medical Center Corporation Methods for diagnosis and prognosis of cancer
US7422865B2 (en) 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
WO2004064972A2 (en) 2003-01-16 2004-08-05 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US20040219685A1 (en) 2003-01-30 2004-11-04 Applera Corporation Methods and mixtures pertaining to analyte determination using electrophilic labeling reagents
WO2004079370A1 (en) * 2003-03-03 2004-09-16 Universiteit Leiden Analysis of the proteome of a living cell by labelling the proteins in the intact cell
TW200508606A (en) * 2003-03-07 2005-03-01 Nard Kenkyusho Kk Method of finding molecular weight of phosphoric acid monoester compound, and additive for mass spectrometric measurement
AU2004227362B2 (en) 2003-04-01 2008-06-26 Activx Biosciences, Inc. Acyl- phosphate and phosphonate probes and methods of their synthesis and use in proteomic analysis
WO2004097372A2 (en) 2003-04-28 2004-11-11 The Regents Of The University Of California Element-coded affinity tags
US7267994B2 (en) 2003-04-28 2007-09-11 Regents Of The University Of California Element-coded affinity tags
GB0311961D0 (en) 2003-05-23 2003-06-25 Health Prot Agency Mass-based toxin assay and substrates therefor
EP1631553A4 (en) * 2003-06-06 2008-09-10 Harvard College PEPTIDES BASED ON CAPTURE AND RELEASE BASED ISOTOPES AND METHODS OF USING PEPTIDES
EP1634083A2 (en) * 2003-06-17 2006-03-15 VIB vzw Peptide combos and their uses
GB0314209D0 (en) * 2003-06-19 2003-07-23 Amersham Biosciences Ab Novel MS reagents
WO2005007677A2 (en) 2003-07-10 2005-01-27 The Institute For Systems Biology Affinity capture of peptides by microarray and related methods
FR2857451B1 (fr) * 2003-07-11 2005-09-30 Commissariat Energie Atomique Procede et dispositif pour l'analyse de milieux reactionnels vivants
EP1673399B1 (en) * 2003-08-11 2017-04-05 Monogram BioSciences, Inc. Detecting and profiling molecular complexes
US7485435B2 (en) * 2004-08-30 2009-02-03 Perkinelmer Las, Inc. Simultaneous detection of metabolic enzyme activity and metabolite levels
JP4754352B2 (ja) * 2003-08-29 2011-08-24 株式会社リバース・プロテオミクス研究所 タンパク質の固定化方法
US20050048499A1 (en) 2003-08-29 2005-03-03 Perkin Elmer Life Sciences, Inc. Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns
US7081623B2 (en) 2003-09-05 2006-07-25 Lucent Technologies Inc. Wafer-based ion traps
US20050074895A1 (en) * 2003-09-05 2005-04-07 Bio-Rad Laboratories, Inc. Alkyl-substituted vinyl pyridines for mass-coded tagging of proteins
JP2007524844A (ja) * 2003-09-22 2007-08-30 ベクトン・ディキンソン・アンド・カンパニー デンドリマー内部標準を使用する質量分析による生体分子検体の定量化
US7145019B2 (en) * 2003-10-16 2006-12-05 Ambergen, Inc. Photocleavable isotope-coded affinity tags
EP2208992A1 (en) * 2003-11-21 2010-07-21 Eisai R&D Management Co., Ltd. Quantitation method using isotope labeled internal standard substance, analysis system for executing the quantitation method, and program for the analysis
US7348416B2 (en) * 2003-11-21 2008-03-25 Applera Corporation Selective capture and enrichment of proteins expressed on the cell surface
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
CA2553223A1 (en) * 2004-01-15 2005-08-04 Cedars-Sinai Medical Center System and method for expression proteomics based on isotope ratio modification
US20070087448A1 (en) * 2004-02-16 2007-04-19 Nelsestuen Gary L Biological profiles and methods of use
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
DE602005023286D1 (de) 2004-03-31 2010-10-14 Kazuo Shinya Verfahren zum biosubstanzeinfang, zur strukturanalyse oder/und identifizierung unter verwendung einer markierungssubstanz
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
WO2005101017A1 (en) * 2004-04-07 2005-10-27 Genentech, Inc. Mass spectrometry of antibody conjugates
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
WO2005114700A2 (en) * 2004-05-19 2005-12-01 Applera Corporation Expression quantification using mass spectrometry
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
US20060141528A1 (en) 2004-05-21 2006-06-29 Aebersold Rudolf H Compositions and methods for quantification of serum glycoproteins
US20080044857A1 (en) * 2004-05-25 2008-02-21 The Gov Of Usa As Represented By The Secretary Of Methods For Making And Using Mass Tag Standards For Quantitative Proteomics
JP5030586B2 (ja) * 2004-05-26 2012-09-19 味の素株式会社 アミノ官能性化合物の分析方法及び装置
JP4317083B2 (ja) 2004-06-04 2009-08-19 株式会社日立ハイテクノロジーズ 質量分析方法及び質量分析システム
EP1766409A2 (en) * 2004-06-18 2007-03-28 Molecular Probes, Inc. Fluorescent isotope tags and their method of use
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
WO2006017208A1 (en) * 2004-07-12 2006-02-16 Applera Corporation Mass tags for quantitative analyses
JP2008514900A (ja) 2004-07-30 2008-05-08 アデザ・バイオメデイカル・コーポレイシヨン 疾病および他の状態のマーカーとしての癌胎児性フィブロネクチンならびに癌胎児性フィブロネクチンの検出のための方法
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
JP4563764B2 (ja) * 2004-10-01 2010-10-13 丸善製薬株式会社 ペプチドの定量方法
WO2006054310A1 (en) * 2004-11-22 2006-05-26 Biosight Ltd. Activated labeling reagents and methods for preparing and using the same
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
WO2006096704A2 (en) 2005-03-07 2006-09-14 Invitrogen Corporation Isotopically-labeled proteome standards
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
DE602005004902T2 (de) * 2005-06-02 2008-10-16 Entelechon Gmbh Künstliches Protein, Verfahren für absolute Quantifizierung der Proteine und seine Benutzung
JP2006337176A (ja) * 2005-06-02 2006-12-14 Eisai R & D Management Co Ltd 代謝物の定量方法
TW200711660A (en) * 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
EP1754972A1 (en) 2005-08-17 2007-02-21 Agilent Technologies, Inc. Folded peptides containing metal binding pockets for protein tagging
EP1941280A2 (en) * 2005-10-13 2008-07-09 Applera Corporation Methods for the development of a biomolecule assay
US7998717B2 (en) 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
US8105788B2 (en) * 2005-12-08 2012-01-31 The University Of British Columbia Mucopolysaccharidosis (MPS) diagnostic methods, systems, kits and assays associated therewith
US20070140967A1 (en) * 2005-12-19 2007-06-21 Wood Nichole L Agents and methods for analyzing protein interactions
WO2007075910A2 (en) * 2005-12-23 2007-07-05 Perkinelmer Las, Inc. Methods and compositions for detecting enzymatic activity
US20070148721A1 (en) * 2005-12-28 2007-06-28 Agilent Technologies, Inc. Compositions, methods, systems, and kits for affinity purification
WO2007078229A1 (en) * 2006-01-05 2007-07-12 Ge Healthcare Bio-Sciences Ab Kit and method for mass labelling
WO2008048345A2 (en) * 2006-02-14 2008-04-24 Perkinelmer Las, Inc. Detection systems for mass labels
CA2645159A1 (en) 2006-03-10 2008-06-26 Michael S. Urdea Multiplex protein fractionation
AU2007226582B2 (en) * 2006-03-13 2012-07-05 Revvity Health Sciences, Inc. Substrates and internal standards for mass spectroscopy detection
WO2007127767A2 (en) * 2006-04-28 2007-11-08 Ludwig Institute For Cancer Research Quantification of enzyme activity by mass spectrometry
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
US8314215B2 (en) * 2006-08-04 2012-11-20 The Board Of Trustees Of The Leland Stanford Junior University Mild chemically cleavable linker system
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
EP1916526A1 (en) * 2006-10-26 2008-04-30 Koninklijke Philips Electronics N.V. Method for diagnostic and therapeutic target discovery by combining isotopic and isobaric labels
EP1921081A1 (en) * 2006-11-06 2008-05-14 Koninklijke Philips Electronics N.V. Use of arylboronic acids in protein labelling
WO2008081008A1 (en) 2007-01-05 2008-07-10 University Of Zurich Method of providing disease-specific binding molecules and targets
KR100805777B1 (ko) * 2007-02-22 2008-02-21 한국기초과학지원연구원 질량 스펙트럼 데이터 및 １차원 젤에서의 밴드 위치분석을 포함하는 단백질 수식화 분석 시스템 및 이를이용한 단백질 수식화 분석 방법
CA2690612C (en) 2007-05-14 2016-07-05 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
JP5003274B2 (ja) * 2007-05-16 2012-08-15 株式会社日立製作所 質量分析システムおよび質量分析方法
WO2008150488A1 (en) * 2007-06-01 2008-12-11 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
ES2599902T3 (es) 2007-06-15 2017-02-06 Novartis Ag Sistema y método de microscopio para obtener datos de muestra normalizados
US8071392B2 (en) 2007-06-21 2011-12-06 National University Corporation University Of Fukui Mass spectrometric analysis of proteins using stable isotopes of pyrylium derivates as labels
EP2015076A1 (en) * 2007-07-11 2009-01-14 Koninklijke Philips Electronics N.V. Protein labelling with tags comprising isotope-coded sub-tags and isobaric sub-tags
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
JP2010536347A (ja) 2007-08-17 2010-12-02 ユニヴァーシティ オブ ワシントン α−イズロニダーゼ酵素活性の検定のための方法
WO2009029810A1 (en) 2007-08-31 2009-03-05 Historx, Inc. Automatic exposure time selection for imaging tissue
JP4921302B2 (ja) * 2007-09-26 2012-04-25 株式会社日立ハイテクノロジーズ 質量分析システム
US8604692B2 (en) 2007-11-06 2013-12-10 Translational Therapeutics, Inc. Mass spectrometry assay for eIF4E and eIF4E regulon activity
AU2008323933B2 (en) * 2007-11-06 2014-12-11 Translational Therapeutics, Inc. Mass spectrometry assay for eIF4E and eIF4E regulon activity
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
JP2011514809A (ja) * 2008-03-13 2011-05-12 パーキンエルマー ラス インコーポレイテッド 多重検出システムのための酵素基質
EP2108957A1 (en) * 2008-04-07 2009-10-14 Koninklijke Philips Electronics N.V. Compounds and methods for the labelling and affinity-selection of proteins
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
US20110189680A1 (en) 2008-05-30 2011-08-04 The University Of British Columbia Methods of Diagnosing Rejection of a Kidney Allograft Using Genomic or Proteomic Expression Profiling
US20110151494A1 (en) * 2008-06-30 2011-06-23 H. Lee Moffit Cancer & Research Institute Methods and materials for monitoring myeloma using quantitative mass spectrometry
JP5551702B2 (ja) 2008-09-16 2014-07-16 ヒストロックス，インコーポレイテッド． バイオマーカー発現の再現性のある定量
US20100081926A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081927A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081928A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological Facilitation systems and methods
US20100081924A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081916A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware. Histological facilitation systems and methods
US20100081915A1 (en) * 2008-09-29 2010-04-01 Searete Llc, Alimited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US8673267B2 (en) 2009-03-02 2014-03-18 Massachusetts Institute Of Technology Methods and products for in vivo enzyme profiling
US8227251B2 (en) * 2009-04-14 2012-07-24 Institute For Systems Biology Mass spectrum-based identification and quantitation of proteins and peptides
WO2010133173A1 (en) * 2009-05-21 2010-11-25 Rongxiu Li Process for differential polypeptides detection and uses thereof
GB0916881D0 (en) * 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
EP2309262A1 (en) 2009-10-06 2011-04-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for quantifying biomolecules
EP2512639A4 (en) * 2009-12-15 2013-05-08 Dh Technologies Dev Pte Ltd ANALYSIS OF AMINO ACIDS AND AMINOUS COMPOUNDS WITH FLAG REAGENTS AND LC-MS WORKFLOW
CA2784861A1 (en) 2009-12-21 2011-07-14 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
AU2010341489A1 (en) * 2009-12-22 2012-07-19 Expression Pathology, Inc. Secreted Protein Acidic and Rich in Cysteine (SPARC) protein SRM/MRM assay
ES2555147T3 (es) * 2009-12-22 2015-12-29 Expression Pathology, Inc. Ensayo SRM/MRM de la proteína del Receptor del factor de crecimiento 1 similar a la insulina (IGF-1R)
US9453845B2 (en) * 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
US8455818B2 (en) 2010-04-14 2013-06-04 Wisconsin Alumni Research Foundation Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation
ES2676183T3 (es) 2010-07-02 2018-07-17 Ventana Medical Systems, Inc. Detección de dianas usando marcas de masa y espectrometría de masas
WO2012021733A2 (en) 2010-08-12 2012-02-16 Pacific Biosciences Of California, Inc. Photodamage mitigation compounds and systems
US8742333B2 (en) 2010-09-17 2014-06-03 Wisconsin Alumni Research Foundation Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer
CA2818169A1 (en) * 2010-11-24 2012-05-31 Dh Technologies Development Pte. Ltd. High-throughput, sensitive detection of glucose-6-phosphate dehydrogenase
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
JP6245990B2 (ja) 2011-03-15 2017-12-13 マサチューセッツ インスティテュート オブ テクノロジー 同位体によりコード化されたレポーターによる多重検出
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
US9659146B2 (en) 2011-05-02 2017-05-23 Tyler Stuart Bray Method for quantitative analysis of complex proteomic data
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
JP2014526685A (ja) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
WO2013070953A1 (en) 2011-11-08 2013-05-16 University Of Washington Lysosomal enzyme assay methods and compositions
WO2013086070A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
DE102013212179A1 (de) * 2012-07-31 2014-02-06 Agilent Technologies, Inc. Derivatisierung von PNGase F-freigesetzter Glykane auf einem HPLC-Chip
CA2913029A1 (en) * 2012-12-10 2014-06-19 Fred Hutchinson Cancer Research Center Lipocalin fusion partners
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
TWI773147B (zh) 2013-03-15 2022-08-01 美商珀金埃爾默健康科技公司 關於用於溶酶體儲積症之測試的化合物及方法
HK1221053A1 (zh) 2013-05-23 2017-05-19 艾弗诺泰普有限责任公司 用於保持或改善健康的方法和系统
CN105143872B (zh) * 2013-06-07 2019-03-01 皮尔斯生物科技有限公司 通过质谱分析用复用内标物对蛋白质和蛋白质修饰的绝对定量
JP6847660B2 (ja) 2013-06-07 2021-03-24 マサチューセッツ インスティテュート オブ テクノロジー リガンドをコードする合成バイオマーカーのアフィニティベースの検出
WO2016108267A1 (ja) * 2014-12-29 2016-07-07 株式会社日立ハイテクノロジーズ 分析方法、及び分析装置
US10989716B2 (en) 2015-05-01 2021-04-27 The University Of British Columbia Biomarkers for the detection of acute rejection in heart transplantation
WO2017040976A1 (en) * 2015-09-02 2017-03-09 Erkki Ruoslahti Compounds and compositions for targeting brain injuries and methods of use thereof
CN105384785B (zh) * 2015-11-24 2018-06-19 中国人民解放军第二军医大学 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用
EP3398201A4 (en) 2015-12-31 2019-11-06 University of Notre Dame du Lac ESI-MS VIA AN ELECTRO-KINETICALLY PUMPED INTERFACE
CN108780072B (zh) 2016-01-22 2021-11-05 普度研究基金会 带电质量标记系统
CN105911101B (zh) * 2016-04-08 2018-09-11 中南大学 一种简单灵敏的膜性能检测方法
EP3440013A4 (en) 2016-04-08 2021-03-17 Massachusetts Institute of Technology METHOD FOR SPECIFIC PROFILING OF PROTEASE ACTIVITY ON LYMPH NODES
WO2017193070A1 (en) 2016-05-05 2017-11-09 Massachusetts Institute Of Technology Methods and uses for remotely triggered protease activity measurements
WO2018003652A1 (ja) * 2016-06-29 2018-01-04 株式会社 日立ハイテクノロジーズ 酵素反応及び質量分析方法に用いる化合物
US11339434B2 (en) * 2016-07-29 2022-05-24 The Regents Of The University Of California Methods for determining gene functions
DE102017103600A1 (de) * 2017-02-22 2018-08-23 Eberhard Karls Universität Tübingen Medizinische Fakultät Radioaktiv markiertes beta-Galactosidase Substrat für PET Bildgebung der Seneszenz
CA3059358A1 (en) 2017-04-07 2018-10-11 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
WO2018213331A1 (en) * 2017-05-16 2018-11-22 Lankenau Institute For Medical Research Compositions comprising ligands to rhob protein and the uses thereof
CN107325154B (zh) * 2017-06-23 2020-11-20 广东华肽生物科技有限公司 一种具有改善记忆功效的多肽及其分离制备方法和用途
CN108169397B (zh) * 2017-11-30 2019-11-15 中国农业科学院北京畜牧兽医研究所 一种相对定量分析肉鸡谷胱甘肽s转移酶gsta2的方法
JP7028258B2 (ja) * 2018-01-09 2022-03-02 株式会社島津製作所 タンパク質同定方法
WO2019173332A1 (en) 2018-03-05 2019-09-12 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
US10656059B2 (en) 2018-03-07 2020-05-19 Alcala Pharmaceutical, Inc. Method for qualitative and quantitative multiplexing of drug analytes from biological samples
RU2678090C1 (ru) * 2018-05-28 2019-01-23 Федеральное государственное бюджетное научное учреждение "Федеральный научный центр пищевых систем им. В.М. Горбатова" РАН Способ подтверждения аутентичности вареных колбасных изделий
US12173349B2 (en) 2018-09-25 2024-12-24 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
US11835522B2 (en) 2019-01-17 2023-12-05 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
WO2020154541A1 (en) * 2019-01-24 2020-07-30 The Board Of Trustees Of The Leland Stanford Junior University Compact hydroxamate-based affinity tags for artificially tagging biological macromolecules
CN110280229B (zh) * 2019-06-28 2022-03-11 东南大学 喋呤类化合物选择性分离富集材料制备与应用方法
CA3179460A1 (en) * 2020-06-09 2021-12-16 Regeneron Pharmaceuticals, Inc. A high-throughput and mass-spectrometry-based method for quantitating antibodies
EP4229074A1 (en) 2020-10-16 2023-08-23 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Anti-tumor immunity induces the presentation of aberrant peptides
CN116829922A (zh) * 2020-12-17 2023-09-29 豪夫迈·罗氏有限公司 用于质谱法的基于蒸发的样品制备工作流程
CN113156002A (zh) * 2021-04-01 2021-07-23 河北利德检测技术有限公司 一种葡萄糖酸钙中5种有关物质的检测方法
WO2023080788A1 (en) 2021-11-05 2023-05-11 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Tryptophan depletion induces production and presentation of tryptophan to phenylalanine substitutions
WO2024238393A1 (en) * 2023-05-10 2024-11-21 Northwestern University Proteoform imaging and characterization mass spectrometry
CN117783383B (zh) * 2023-12-26 2026-04-28 深圳瑞德林生物技术有限公司 一种酶催化工艺合成lnt ii的中控检测方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4798795A (en) * 1987-02-17 1989-01-17 Hoechst Celanese Corporation Biotinylating agents
EP0390910B1 (en) * 1988-10-17 1995-12-13 Molecular Devices Corporation Hapten derivatized capture membran and assays using such membrane
US5438017A (en) * 1989-05-01 1995-08-01 The University Of Colorado Foundation, Inc. Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency
CA1340966C (en) 1989-05-19 2000-04-18 Thomas R. Covey Method of protein analysis
US5180828A (en) * 1990-02-09 1993-01-19 Molecular Devices Corporation Chromophoric reagents for incorporation of biotin or other haptens into macromolecules
US5534440A (en) 1991-02-22 1996-07-09 Biomedical Research Centre Limited Compounds and methods for sequencing amino acids
US5240859A (en) 1991-02-22 1993-08-31 B.R. Centre Limited Methods for amino acid sequencing of a polypeptide
DE4310142A1 (de) * 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung
US5496934A (en) * 1993-04-14 1996-03-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acids encoding a cellulose binding domain
US5491071A (en) 1993-08-03 1996-02-13 Abbott Laboratories Reagents and methods for the detection and quantification of testosterone in fluid samples
US5854084A (en) 1996-07-12 1998-12-29 Biotraces, Inc. Enhanced chromatography using multiphoton detection
US5527711A (en) 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
DE4343479A1 (de) 1993-12-21 1995-06-22 Boehringer Mannheim Gmbh Acylierte Proteinaggregate und deren Verwendung zur Entstörung von Immunoassays
WO1995023801A1 (de) * 1994-03-05 1995-09-08 Boehringer Mannheim Gmbh Entstörmittel zum einsatz bei immunoassays
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5534132A (en) * 1995-05-04 1996-07-09 Vreeke; Mark Electrode and method for the detection of an affinity reaction
US5686310A (en) 1995-06-06 1997-11-11 University Of Virginia Patent Foundation Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein
US5965457A (en) * 1995-06-06 1999-10-12 Magnani; John L. Methods of screening for a candidate compound able to bind to CD34+ cells
WO1996040662A2 (en) * 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
ATE458499T1 (de) * 1995-06-07 2010-03-15 Immunomedics Inc Verbesserte abgabe von diagnostischen und therapeutischen stoffen an einem zielort
US5958703A (en) 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
EP0963443B1 (en) 1996-12-10 2006-03-08 Sequenom, Inc. Releasable nonvolatile mass-label molecules
IL130949A (en) * 1997-01-23 2004-12-15 Xzillion Gmbh & Co Kg Method for characterising polypeptides
US6312904B1 (en) 1997-07-11 2001-11-06 Xzillion Gmbh & Co. Kg Characterizing nucleic acid
EP1002128A1 (en) 1997-07-11 2000-05-24 Brax Genomics Limited Characterising nucleic acids
US6670194B1 (en) * 1998-08-25 2003-12-30 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
AU6689401A (en) 2000-06-12 2001-12-24 Univ Washington Selective labeling and isolation of phosphopeptides and applications to proteomeanalysis

Also Published As

Publication number Publication date
EP1105517A1 (en) 2001-06-13
AU755334B2 (en) 2002-12-12
US20050233399A1 (en) 2005-10-20
JP3345401B2 (ja) 2002-11-18
DE69912444D1 (de) 2003-12-04
JP2002523058A (ja) 2002-07-30
EP1105517A4 (en) 2001-09-19
DE69912444T3 (de) 2010-05-06
US6670194B1 (en) 2003-12-30
EP1105517B2 (en) 2009-09-30
JP2006184290A (ja) 2006-07-13
AU5691399A (en) 2000-03-14
EP1329513B1 (en) 2011-12-07
US20030087322A9 (en) 2003-05-08
DE69912444T2 (de) 2004-07-22
JP3793124B2 (ja) 2006-07-05
US6852544B2 (en) 2005-02-08
JP4117320B2 (ja) 2008-07-16
JP2003107066A (ja) 2003-04-09
EP1105517B1 (en) 2003-10-29
WO2000011208A1 (en) 2000-03-02
EP1329513A1 (en) 2003-07-23
US7544518B2 (en) 2009-06-09
US20020076739A1 (en) 2002-06-20
ATE253126T1 (de) 2003-11-15
AU755334C (en) 2004-02-26

Similar Documents

Publication Publication Date Title
ATE253126T1 (de) Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
Wiśniewski Filter aided sample preparation–a tutorial
Issaq The role of separation science in proteomics research
EP1392848A4 (en) Process for analyzing protein samples
Dabrio et al. Recent developments in quantification methods for metallothionein
Kirkpatrick et al. The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications
Giesen et al. History of inductively coupled plasma mass spectrometry-based immunoassays
Wippel et al. Quantitative interactome analysis with chemical cross-linking and mass spectrometry
Ferranti et al. Characterisation of S‐nitrosohaemoglobin by mass spectrometry
Righetti et al. The proteome: anno Domini 2002.
EP2015076A1 (en) Protein labelling with tags comprising isotope-coded sub-tags and isobaric sub-tags
EP1356281A1 (en) Rapid and quantitative proteome analysis and related methods
Petrotchenko et al. Combining fluorescence detection and mass spectrometric analysis for comprehensive and quantitative analysis of redox-sensitive cysteines in native membrane proteins
Warwood et al. Guanidination chemistry for qualitative and quantitative proteomics
US20050164336A1 (en) Method for protein expression analysis
US7244411B2 (en) Method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixtures
CA2431864A1 (en) Elemental analysis of tagged biologically active materials
US20100317043A1 (en) MASS SPECTROMETRY ASSAY FOR eIF4E AND eIF4E REGULON ACTIVITY
Vasilieva et al. Development of a diagnostic approach based on the detection of post-translation modifications of fibrinogen associated with oxidative stress by the method of high efficiency liquid chromatography
WO2020148395A1 (en) Automatic sample workflow for lc-ms based hba1c measurement on intact protein level
Wiśniewski Dilemmas With Absolute Quantification of Pharmacologically Relevant Proteins Using Mass Spectrometry
US20210333290A1 (en) High speed sample workflow for lc-ms based hba1c measurement
Miraglia et al. Mass spectrometric identification of a candidate biomarker peptide from the in vitro interaction of epichlorohydrin with red blood cells
Basile et al. Proteomic approach for the analysis of acrylamide–hemoglobin adducts: Perspectives for biological monitoring
Amoresano et al. A rapid and selective mass spectrometric method for the identification of nitrated proteins