JP3345401B2 - 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析 - Google Patents

複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析

Info

Publication number
JP3345401B2
JP3345401B2 JP2000566460A JP2000566460A JP3345401B2 JP 3345401 B2 JP3345401 B2 JP 3345401B2 JP 2000566460 A JP2000566460 A JP 2000566460A JP 2000566460 A JP2000566460 A JP 2000566460A JP 3345401 B2 JP3345401 B2 JP 3345401B2
Authority
JP
Japan
Prior art keywords
protein
affinity
reagent
group
tagged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2000566460A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002523058A (ja
Inventor
ルドルフ ハンス アエバーソールド，
マイケル エイチ． ゲルブ，
スティーブン ピー． ジジ，
シー． ロナルド スコット，
フランティセック トゥレセック，
スコット エイ． ガーバー，
ビート リスト，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26793647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3345401(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Washington filed Critical University of Washington
Publication of JP2002523058A publication Critical patent/JP2002523058A/ja
Application granted granted Critical
Publication of JP3345401B2 publication Critical patent/JP3345401B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/18—Sulfur containing
    • Y10T436/182—Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000566460A 1998-08-25 1999-08-25 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析 Expired - Lifetime JP3345401B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9778898P 1998-08-25 1998-08-25
US9911398P 1998-09-03 1998-09-03
US60/099,113 1998-09-03
US60/097,788 1998-09-03
PCT/US1999/019415 WO2000011208A1 (en) 1998-08-25 1999-08-25 Rapid quantitative analysis of proteins or protein function in complex mixtures

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2002208687A Division JP3793124B2 (ja) 1998-08-25 2002-07-17 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析

Publications (2)

Publication Number Publication Date
JP2002523058A JP2002523058A (ja) 2002-07-30
JP3345401B2 true JP3345401B2 (ja) 2002-11-18

Family

ID=26793647

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2000566460A Expired - Lifetime JP3345401B2 (ja) 1998-08-25 1999-08-25 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析
JP2002208687A Expired - Lifetime JP3793124B2 (ja) 1998-08-25 2002-07-17 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析
JP2006043216A Expired - Lifetime JP4117320B2 (ja) 1998-08-25 2006-02-20 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2002208687A Expired - Lifetime JP3793124B2 (ja) 1998-08-25 2002-07-17 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析
JP2006043216A Expired - Lifetime JP4117320B2 (ja) 1998-08-25 2006-02-20 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析

Country Status (7)

Country Link
US (3) US6670194B1 (https=)
EP (2) EP1105517B2 (https=)
JP (3) JP3345401B2 (https=)
AT (2) ATE253126T1 (https=)
AU (1) AU755334C (https=)
DE (1) DE69912444T3 (https=)
WO (1) WO2000011208A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7180056B2 (en) 2004-06-04 2007-02-20 Hitachi, Ltd. Mass spectrometry and mass spectrometry system

Families Citing this family (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
DE69912444T3 (de) * 1998-08-25 2010-05-06 University Of Washington, Seattle Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
JP2003524394A (ja) * 1999-02-11 2003-08-19 マキシジェン， インコーポレイテッド ハイスループット質量分析法
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
AU774776B2 (en) * 1999-04-15 2004-07-08 University Of Virginia Patent Foundation Proteome mining
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6716636B1 (en) 1999-04-20 2004-04-06 Target Discovery, Inc. Methods for sequencing proteins
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
AU773329B2 (en) * 1999-05-14 2004-05-20 Proteomedica Ab Materials and methods relating to disease diagnosis
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US6783929B1 (en) 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
DE60030882T2 (de) * 2000-01-06 2007-04-05 Caliper Life Sciences, Inc., Mountain View Vorrichtungen und verfahren für hochdurchsatz-probenentnahme und analyse
CA2403296A1 (en) * 2000-04-10 2001-10-18 Benjamin F. Cravatt Proteomic analysis using activity-based probe libraries
DE10021737C2 (de) * 2000-05-04 2002-10-17 Hermann Haller Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird
ATE344456T1 (de) * 2000-05-05 2006-11-15 Purdue Research Foundation Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7153682B2 (en) 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
DE10027794A1 (de) * 2000-06-07 2001-12-13 Basf Ag Verfahren zur Analyse Enzym-katalysierter Umsetzungen mit MALDI-TOF-Massenspektrometrie
WO2001094910A2 (de) * 2000-06-07 2001-12-13 Basf Aktiengesellschaft Verfahren zur qualitativen und quantitativen analyse komplexer gemische chemischer verbindungen mit maldi-tof-massenspektrometrie
WO2001094935A2 (en) 2000-06-09 2001-12-13 Mds Proteomics, Inc. Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing
JP2004503780A (ja) 2000-06-12 2004-02-05 ユニバーシティ　オブ　ワシントン リンペプチドの選択的標識および単離ならびにプロテオーム分析への適用
US7567870B1 (en) 2000-07-31 2009-07-28 Institute For Systems Biology Multiparameter analysis for predictive medicine
WO2002014867A2 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
US20020123055A1 (en) * 2000-08-25 2002-09-05 Estell David A. Mass spectrometric analysis of biopolymers
DE10043470B4 (de) * 2000-09-04 2006-01-19 Mpb Meltec Patent- Und Beteiligungsgesellschaft Mbh Verfahren zur Identifizierung von zellspezifischen Proteinen
WO2002029032A2 (en) * 2000-09-30 2002-04-11 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
SE0003566D0 (sv) * 2000-10-02 2000-10-02 Amersham Pharm Biotech Ab A method for the quantitative determination of one or more compounds
EP1325322A2 (en) * 2000-10-03 2003-07-09 Dionex Corporation Method and system for peak parking in liquid chromatography-mass spectrometer (lc-ms) analysis
WO2002066952A2 (en) 2000-10-19 2002-08-29 Target Discovery, Inc Mass defect labeling for the determination of oligomer sequences
CA2426731A1 (en) 2000-10-23 2002-06-20 Genetics Institute, Llc. Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures
ATE405839T1 (de) 2000-10-23 2008-09-15 Genetics Inst Llc Isotop-kodierte ionisierung-förderende reagenzien zur hochdurchsatz protein identifikation und quantifikation mit massenspectrometrie
US20020164649A1 (en) * 2000-10-25 2002-11-07 Rajendra Singh Mass tags for quantitative analysis
SE0004094D0 (sv) * 2000-11-09 2000-11-09 Amersham Pharm Biotech Ab A method for the quantification of carbohudrates
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
US20020095260A1 (en) * 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
US6797523B2 (en) 2000-11-30 2004-09-28 Affinium Pharmaceuticals, Inc. Methods for systematic identification of protein—protein interactions
US20020090652A1 (en) * 2000-12-22 2002-07-11 Fu Emil Wei-Ming Inverse labeling method for the rapid identification of marker/target proteins
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
AU2002248323A1 (en) * 2001-01-12 2002-07-24 The Regents Of The University Of California Stable isotope, site-specific mass tagging for protein identification
US7166436B2 (en) * 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
US6969757B2 (en) 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
US7083987B2 (en) 2001-02-05 2006-08-01 Activx Biosciences, Inc. Activity based probe analysis
US6818454B2 (en) 2001-02-16 2004-11-16 Battelle Memorial Institute Phosphoprotein binding agents and methods of their use
ATE476654T1 (de) 2001-03-02 2010-08-15 Activx Biosciences Inc Plattform für protein-profiling
ES2242864T3 (es) * 2001-03-22 2005-11-16 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Procedimientos y aparatos para el analisis cualitativo y cuantitativo sin gel de proteoma, y sus usos.
CN1273615C (zh) * 2001-04-03 2006-09-06 塞莫费尼根股份有限公司 用于简化复合肽混合物的方法和试剂盒
KR20030031911A (ko) * 2001-04-19 2003-04-23 싸이퍼젠 바이오시스템즈, 인코포레이티드 질량 분석법과 친화성 태그를 이용한 생물분자 특성화
US7045296B2 (en) * 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
US7183116B2 (en) * 2001-05-14 2007-02-27 The Institute For Systems Biology Methods for isolation and labeling of sample molecules
JP2005502030A (ja) * 2001-05-29 2005-01-20 リージェンツ オブ ザ ユニバーシティ オブ ミシガン タンパク質解析のシステムおよび方法
CA2349265A1 (en) * 2001-05-30 2002-11-30 Andrew Emili Protein expression profile database
US20030068825A1 (en) * 2001-07-13 2003-04-10 Washburn Michael P. System and method of determining proteomic differences
US6800449B1 (en) 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
ATE305938T1 (de) * 2001-07-16 2005-10-15 Harvard College Nicht auf affinität basierende, isotopenmarkierte peptide und verfahren zu deren anwendung
JP3935487B2 (ja) 2001-07-16 2007-06-20 フーベルト・ケスター 捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法
US7343247B2 (en) 2001-07-30 2008-03-11 The Institute For Systems Biology Methods of classifying drug responsiveness using multiparameter analysis
ATE508361T1 (de) * 2001-08-14 2011-05-15 Harvard College Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
CA2461587C (en) * 2001-09-27 2011-04-26 Purdue Research Foundation Materials and methods for controlling isotope effects during fractionation of analytes
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US6756586B2 (en) 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
DE10153631B4 (de) * 2001-10-31 2006-04-13 Lottspeich, Friedrich, Dr. Verfahren zum Vergleich zweier Proteinzustände
WO2003040288A2 (de) * 2001-11-09 2003-05-15 Bayer Healthcare Ag Isotopencodierte affinitätsmarker 3
DE10154744A1 (de) * 2001-11-09 2003-05-22 Bayer Ag Isotopencodierte Affinitätsmarker
CN1612936A (zh) 2001-11-09 2005-05-04 苏尔斯精细医药公司 利用基因表达分布图识别、监控和治疗疾病以及鉴定生物学状态
CA2466356A1 (en) * 2001-11-09 2003-05-15 Bayer Healthcare Ag Isotopically coded affinity marker 2
US20030129760A1 (en) * 2001-11-13 2003-07-10 Aguilera Frank Reinaldo Morales Mass intensity profiling system and uses thereof
US20030091976A1 (en) * 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
DE10158860B4 (de) 2001-11-30 2007-04-05 Bruker Daltonik Gmbh Massenspektrometrische Proteingemischanalyse
EP1319954A1 (en) * 2001-12-12 2003-06-18 Centre National de Genotypage Methods for protein analysis using protein capture arrays
US7623969B2 (en) 2002-01-31 2009-11-24 The Institute For Systems Biology Gene discovery for the system assignment of gene function
WO2003068919A2 (en) * 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
EP2317307B1 (en) * 2002-02-14 2013-11-20 Ajinomoto Co., Inc. Method of analyzing amino- and/or imino-functional compounds, and analytical reagent
EP1502102B1 (en) * 2002-03-11 2009-01-14 caprotec bioanalytics GmbH Compounds and methods for analyzing the proteome
US7288382B2 (en) 2002-03-14 2007-10-30 The Board Of Trustees Od The Leland Stanford Junior University Methods for structural analysis of proteins
EP1489411A4 (en) * 2002-03-25 2007-03-14 Teijin Ltd TECHNIQUE FOR DETERMINING COENZYMES IN A BIOLOGICAL SAMPLE
WO2003087834A2 (en) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
WO2003095978A2 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
US20050221500A1 (en) * 2002-05-20 2005-10-06 Purdue Research Foundation Protein identification from protein product ion spectra
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7052916B2 (en) * 2002-05-24 2006-05-30 Immunex Corporation Polypeptide analyses using stable isotope labeling
GB0212522D0 (en) * 2002-05-31 2002-07-10 Shimadzu Res Lab Europe Ltd Selective binding and analysis of macromolecules
US7183118B2 (en) 2002-06-03 2007-02-27 The Institute For Systems Biology Methods for quantitative proteome analysis of glycoproteins
US7655433B2 (en) 2002-06-04 2010-02-02 The Institute For Systems Biology Methods for high-throughput and quantitative proteome analysis
AU2003233498A1 (en) * 2002-06-10 2003-12-22 Phynexus, Inc. Biomolecule open channel solid phase extraction systems and methods
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
WO2004002950A1 (ja) * 2002-06-28 2004-01-08 Shimadzu Corporation スルフェニル化合物、ラベル化試薬、及びペプチドの解析方法
EP1541580B1 (en) 2002-07-10 2013-02-27 Seikagaku Corporation Sulfotransferase inhibitors
CA2393726A1 (en) * 2002-07-16 2004-01-16 Steven J. Locke Quantitative proteomics via isotopically differentiated derivatization
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7409296B2 (en) * 2002-07-29 2008-08-05 Geneva Bioinformatics (Genebio), S.A. System and method for scoring peptide matches
US20060094057A1 (en) * 2002-07-30 2006-05-04 Maro K. Hellerstein Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
US7501286B2 (en) 2002-08-14 2009-03-10 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US7473535B2 (en) 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
CA2498352C (en) * 2002-09-12 2011-05-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw A method for the identification of drug targets
US20050233307A1 (en) * 2002-09-12 2005-10-20 Kyle Gee Site-specific labeling of affinity tags in fusion proteins
AU2003286553A1 (en) 2002-10-18 2004-05-04 Promega Corporation Methods for separating molecules
US6944549B2 (en) * 2002-10-25 2005-09-13 Syngenta Participations Ag Method and apparatus for automated detection of peaks in spectroscopic data
EP1579187B1 (en) 2002-10-29 2012-12-19 Target Discovery, Inc. Method for increasing ionization efficiency in mass spectroscopy
US7846748B2 (en) 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
US7109040B2 (en) * 2002-12-13 2006-09-19 Agilent Technologies, Inc. Modular isotope coding approach to proteomic analysis
US7425451B2 (en) 2002-12-13 2008-09-16 Agilent Technologies, Inc. Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
US20060105343A1 (en) * 2003-01-09 2006-05-18 Children's Medical Center Corporation Methods for diagnosis and prognosis of cancer
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
EP2259068B1 (en) * 2003-01-16 2013-08-14 caprotec bioanalytics GmbH Capture compounds and methods for analyzing the proteome
JP4613299B2 (ja) * 2003-01-30 2011-01-12 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 分析物分析に関する方法、混合物、キット、および組成物
WO2004079370A1 (en) * 2003-03-03 2004-09-16 Universiteit Leiden Analysis of the proteome of a living cell by labelling the proteins in the intact cell
TW200508606A (en) * 2003-03-07 2005-03-01 Nard Kenkyusho Kk Method of finding molecular weight of phosphoric acid monoester compound, and additive for mass spectrometric measurement
EP1616034A4 (en) 2003-04-01 2008-12-03 Activx Biosciences Inc ACYL PHOSPHATE AND PHOSPHONATE EASTS AND PROCESSES FOR THEIR SYNTHESIS AND USE IN PROTEAM ANALYSIS
WO2004097372A2 (en) 2003-04-28 2004-11-11 The Regents Of The University Of California Element-coded affinity tags
US7267994B2 (en) 2003-04-28 2007-09-11 Regents Of The University Of California Element-coded affinity tags
GB0311961D0 (en) 2003-05-23 2003-06-25 Health Prot Agency Mass-based toxin assay and substrates therefor
WO2005042559A2 (en) * 2003-06-06 2005-05-12 President And Fellows Of Harvard College Capture and release based isotope tagged peptides and methods for using the same
CA2529863A1 (en) * 2003-06-17 2004-12-23 Vib Vzw Peptide combos and their uses
GB0314209D0 (en) * 2003-06-19 2003-07-23 Amersham Biosciences Ab Novel MS reagents
US7794947B2 (en) 2003-07-10 2010-09-14 Institute For Systems Biology Affinity capture of peptides by microarray and related methods
FR2857451B1 (fr) * 2003-07-11 2005-09-30 Commissariat Energie Atomique Procede et dispositif pour l'analyse de milieux reactionnels vivants
WO2005019470A2 (en) * 2003-08-11 2005-03-03 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US7485435B2 (en) * 2004-08-30 2009-02-03 Perkinelmer Las, Inc. Simultaneous detection of metabolic enzyme activity and metabolite levels
WO2005022156A1 (ja) * 2003-08-29 2005-03-10 Reverse Proteomics Research Institute Co., Ltd. タンパク質の固定化方法
US20050048499A1 (en) * 2003-08-29 2005-03-03 Perkin Elmer Life Sciences, Inc. Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns
US7081623B2 (en) 2003-09-05 2006-07-25 Lucent Technologies Inc. Wafer-based ion traps
US20050074895A1 (en) * 2003-09-05 2005-04-07 Bio-Rad Laboratories, Inc. Alkyl-substituted vinyl pyridines for mass-coded tagging of proteins
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards
US7145019B2 (en) 2003-10-16 2006-12-05 Ambergen, Inc. Photocleavable isotope-coded affinity tags
US7348416B2 (en) * 2003-11-21 2008-03-25 Applera Corporation Selective capture and enrichment of proteins expressed on the cell surface
EP1686372A4 (en) * 2003-11-21 2009-04-01 Eisai R&D Man Co Ltd QUANTIFICATION METHOD USING AN ISOTOPE-MARKED INTERNAL CALIBRATION, ANALYSIS SYSTEM FOR EXECUTING THE QUANTIFICATION METHOD AND ASSOCIATED SEPARATION PROGRAM
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
EP1708758A4 (en) * 2004-01-15 2008-04-02 Cedars Sinai Medical Center System and method for expression proteomics based on isotope ratio modification
US20070087448A1 (en) * 2004-02-16 2007-04-19 Nelsestuen Gary L Biological profiles and methods of use
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
DE602005023286D1 (de) * 2004-03-31 2010-10-14 Kazuo Shinya Verfahren zum biosubstanzeinfang, zur strukturanalyse oder/und identifizierung unter verwendung einer markierungssubstanz
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
WO2005101017A1 (en) * 2004-04-07 2005-10-27 Genentech, Inc. Mass spectrometry of antibody conjugates
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
CA2567459A1 (en) * 2004-05-19 2005-12-01 Applera Corporation Expression quantification using mass spectrometry
ATE427499T1 (de) 2004-05-21 2009-04-15 Inst Systems Biology Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen
US20080044857A1 (en) * 2004-05-25 2008-02-21 The Gov Of Usa As Represented By The Secretary Of Methods For Making And Using Mass Tag Standards For Quantitative Proteomics
EP1750126B1 (en) * 2004-05-26 2015-09-16 Ajinomoto Co., Inc. Method and apparatus for analyzing aminofunctional compound
WO2006091214A2 (en) * 2004-06-18 2006-08-31 Molecular Probes, Inc. Fluorescent isotope tags and their method of use
WO2006017208A1 (en) * 2004-07-12 2006-02-16 Applera Corporation Mass tags for quantitative analyses
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
DK2299275T3 (en) 2004-07-30 2018-05-07 Adeza Biomedical Corp Classification of oncofetal fetronectin level for pregnancy-related indications
US7592139B2 (en) * 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
JP4563764B2 (ja) * 2004-10-01 2010-10-13 丸善製薬株式会社 ペプチドの定量方法
WO2006054310A1 (en) * 2004-11-22 2006-05-26 Biosight Ltd. Activated labeling reagents and methods for preparing and using the same
US20060183238A1 (en) * 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
WO2006096704A2 (en) 2005-03-07 2006-09-14 Invitrogen Corporation Isotopically-labeled proteome standards
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
DE602005004902T2 (de) * 2005-06-02 2008-10-16 Entelechon Gmbh Künstliches Protein, Verfahren für absolute Quantifizierung der Proteine und seine Benutzung
JP2006337176A (ja) * 2005-06-02 2006-12-14 Eisai R & D Management Co Ltd 代謝物の定量方法
TW200711660A (en) * 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
EP1754972A1 (en) 2005-08-17 2007-02-21 Agilent Technologies, Inc. Folded peptides containing metal binding pockets for protein tagging
WO2007044935A2 (en) * 2005-10-13 2007-04-19 Applera Corporation Methods for the development of a biomolecule assay
US7998717B2 (en) * 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
WO2007065273A1 (en) * 2005-12-08 2007-06-14 The University Of British Columbia Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith
US20070140967A1 (en) * 2005-12-19 2007-06-21 Wood Nichole L Agents and methods for analyzing protein interactions
WO2007075910A2 (en) * 2005-12-23 2007-07-05 Perkinelmer Las, Inc. Methods and compositions for detecting enzymatic activity
US20070148721A1 (en) * 2005-12-28 2007-06-28 Agilent Technologies, Inc. Compositions, methods, systems, and kits for affinity purification
WO2007078229A1 (en) * 2006-01-05 2007-07-12 Ge Healthcare Bio-Sciences Ab Kit and method for mass labelling
US20080026480A1 (en) * 2006-02-14 2008-01-31 Perkinelmer Las, Inc. Detection systems for mass labels
CA2645159A1 (en) 2006-03-10 2008-06-26 Michael S. Urdea Multiplex protein fractionation
CN102943106A (zh) * 2006-03-13 2013-02-27 珀金埃尔默健康科学股份有限公司 用于质谱法检测的底物和内标
EP2021492A2 (en) * 2006-04-28 2009-02-11 Ludwig Institute For Cancer Research Quantification of enzyme activity by mass spectrometry
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
US8314215B2 (en) * 2006-08-04 2012-11-20 The Board Of Trustees Of The Leland Stanford Junior University Mild chemically cleavable linker system
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
EP1916526A1 (en) * 2006-10-26 2008-04-30 Koninklijke Philips Electronics N.V. Method for diagnostic and therapeutic target discovery by combining isotopic and isobaric labels
EP1921081A1 (en) * 2006-11-06 2008-05-14 Koninklijke Philips Electronics N.V. Use of arylboronic acids in protein labelling
KR20120017469A (ko) 2007-01-05 2012-02-28 유니버시티 오브 취리히 질환 특이적 결합 분자 및 표적을 제공하는 방법
KR100805777B1 (ko) * 2007-02-22 2008-02-21 한국기초과학지원연구원 질량 스펙트럼 데이터 및 １차원 젤에서의 밴드 위치분석을 포함하는 단백질 수식화 분석 시스템 및 이를이용한 단백질 수식화 분석 방법
WO2008143849A2 (en) 2007-05-14 2008-11-27 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
JP5003274B2 (ja) * 2007-05-16 2012-08-15 株式会社日立製作所 質量分析システムおよび質量分析方法
WO2008150488A1 (en) * 2007-06-01 2008-12-11 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
WO2008156669A1 (en) 2007-06-15 2008-12-24 Historx, Inc. Method and system for standardizing microscope instruments
JP4883540B2 (ja) * 2007-06-21 2012-02-22 国立大学法人福井大学 同位体化合物を標識として使用するタンパク質の分析方法
EP2015076A1 (en) * 2007-07-11 2009-01-14 Koninklijke Philips Electronics N.V. Protein labelling with tags comprising isotope-coded sub-tags and isobaric sub-tags
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
PT2191006E (pt) * 2007-08-17 2013-01-04 Univ Washington Métodos para ensaiar a actividade enzimática de alfa-liduronidase
WO2009029810A1 (en) 2007-08-31 2009-03-05 Historx, Inc. Automatic exposure time selection for imaging tissue
JP4921302B2 (ja) * 2007-09-26 2012-04-25 株式会社日立ハイテクノロジーズ 質量分析システム
WO2009061904A2 (en) * 2007-11-06 2009-05-14 Translational Therapeutics, Inc. MASS SPECTROMETRY ASSAY FOR eIF4E AND eIF4E REGULON ACTIVITY
US8604692B2 (en) 2007-11-06 2013-12-10 Translational Therapeutics, Inc. Mass spectrometry assay for eIF4E and eIF4E regulon activity
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
AU2009223222A1 (en) 2008-03-13 2009-09-17 Perkinelmer Health Sciences, Inc. Enzymatic substrates for multiple detection systems
EP2108957A1 (en) * 2008-04-07 2009-10-14 Koninklijke Philips Electronics N.V. Compounds and methods for the labelling and affinity-selection of proteins
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
WO2009143624A1 (en) 2008-05-30 2009-12-03 The University Of British Columbia Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling
US20110151494A1 (en) 2008-06-30 2011-06-23 H. Lee Moffit Cancer & Research Institute Methods and materials for monitoring myeloma using quantitative mass spectrometry
WO2010033508A1 (en) 2008-09-16 2010-03-25 Historx, Inc. Reproducible quantification of biomarker expression
US20100081915A1 (en) * 2008-09-29 2010-04-01 Searete Llc, Alimited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081916A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware. Histological facilitation systems and methods
US20100081928A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological Facilitation systems and methods
US20100081924A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081927A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081926A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
ES2890501T3 (es) 2009-03-02 2022-01-20 Massachusetts Inst Technology Métodos y productos para la creación de perfiles enzimáticos in vivo
US8227251B2 (en) * 2009-04-14 2012-07-24 Institute For Systems Biology Mass spectrum-based identification and quantitation of proteins and peptides
WO2010133173A1 (en) * 2009-05-21 2010-11-25 Rongxiu Li Process for differential polypeptides detection and uses thereof
GB0916881D0 (en) 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
EP2309262A1 (en) 2009-10-06 2011-04-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for quantifying biomolecules
US20110143445A1 (en) * 2009-12-15 2011-06-16 Dh Technologies Development Pte. Ltd. Analysis of Amino Acids And Amine-Containing Compounds Using Tagging Reagents and LC-MS Workflow
JP2013526840A (ja) 2009-12-21 2013-06-27 ファーマシーネ，インコーポレイテッド 組み換えブチリルコリンエステラーゼおよびその切断型
AU2010341488C1 (en) * 2009-12-22 2017-09-28 Expression Pathology, Inc. Insulin-like growth factor 1 receptor (IGF-1R) protein SRM/MRM assay
WO2011087869A1 (en) * 2009-12-22 2011-07-21 Expression Pathology, Inc. Secreted protein acidic and rich in cysteine (sparc) protein srm/mrm assay
US9453845B2 (en) 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
DE102011017084B4 (de) 2010-04-14 2020-07-09 Wisconsin Alumni Research Foundation Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung
EP2588144B1 (en) 2010-07-02 2018-05-09 Ventana Medical Systems, Inc. Detecting targets using mass tags and mass spectrometry
WO2012021733A2 (en) 2010-08-12 2012-02-16 Pacific Biosciences Of California, Inc. Photodamage mitigation compounds and systems
US8742333B2 (en) 2010-09-17 2014-06-03 Wisconsin Alumni Research Foundation Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer
CN103547679A (zh) * 2010-11-24 2014-01-29 Dh科技发展私人贸易有限公司 葡萄糖-6-磷酸脱氢酶的高产量、灵敏检测
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
CA2830235C (en) 2011-03-15 2023-10-24 Massachusetts Institute Of Technology Multiplexed detection with isotope-coded reporters
US9040903B2 (en) 2011-04-04 2015-05-26 Wisconsin Alumni Research Foundation Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility
US9659146B2 (en) 2011-05-02 2017-05-23 Tyler Stuart Bray Method for quantitative analysis of complex proteomic data
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
WO2013036885A1 (en) 2011-09-08 2013-03-14 The Regents Of The University Of California Metabolic flux measurement, imaging and microscopy
JP6180423B2 (ja) 2011-11-08 2017-08-16 ユニヴァーシティ オブ ワシントン リソソーム酵素アッセイ法および組成物
US20140353486A1 (en) 2011-12-07 2014-12-04 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
DE102013212179A1 (de) * 2012-07-31 2014-02-06 Agilent Technologies, Inc. Derivatisierung von PNGase F-freigesetzter Glykane auf einem HPLC-Chip
CN105008393A (zh) * 2012-12-10 2015-10-28 弗莱德哈钦森癌症研究中心 用于筛选的方法
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
CA2906839A1 (en) 2013-03-15 2014-09-18 Perkinelmer Health Sciences, Inc. Compounds and methods relating to testing for lysosomal storage disorders
CN105431853B (zh) 2013-05-23 2018-12-28 艾弗诺泰普有限责任公司 表型整合的社会研究数据库和方法
WO2014197754A1 (en) * 2013-06-07 2014-12-11 Pierce Biotechnology, Inc. Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards
JP6847660B2 (ja) 2013-06-07 2021-03-24 マサチューセッツ インスティテュート オブ テクノロジー リガンドをコードする合成バイオマーカーのアフィニティベースの検出
US20170343540A1 (en) * 2014-12-29 2017-11-30 Hitachi High-Technologies Corporation Analysis method and analysis device
WO2016178121A1 (en) 2015-05-01 2016-11-10 The University Of British Columbia Biomarkers for the detection of acute rejection in heart transplantation
US10653797B2 (en) * 2015-09-02 2020-05-19 Sanford Burnham Prebys Medical Discovery Institute Compounds and compositions for targeting brain injuries and methods of use thereof
CN105384785B (zh) * 2015-11-24 2018-06-19 中国人民解放军第二军医大学 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用
EP3398201A4 (en) * 2015-12-31 2019-11-06 University of Notre Dame du Lac ESI-MS VIA AN ELECTRO-KINETICALLY PUMPED INTERFACE
CN113970589B (zh) * 2016-01-22 2025-04-11 普度研究基金会 带电质量标记系统
CN105911101B (zh) * 2016-04-08 2018-09-11 中南大学 一种简单灵敏的膜性能检测方法
WO2017177115A1 (en) 2016-04-08 2017-10-12 Massachusetts Institute Of Technology Methods to specifically profile protease activity at lymph nodes
US11428689B2 (en) 2016-05-05 2022-08-30 Massachusetts Institute Of Technology Methods and uses for remotely triggered protease activity measurements
US20190330140A1 (en) * 2016-06-29 2019-10-31 Hitachi High-Technologies Corporation Compound for Use in Enzymatic Reaction and Mass Spectrometry Method
US11339434B2 (en) * 2016-07-29 2022-05-24 The Regents Of The University Of California Methods for determining gene functions
DE102017103600A1 (de) * 2017-02-22 2018-08-23 Eberhard Karls Universität Tübingen Medizinische Fakultät Radioaktiv markiertes beta-Galactosidase Substrat für PET Bildgebung der Seneszenz
CA3059358A1 (en) 2017-04-07 2018-10-11 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
US20200200760A1 (en) * 2017-05-16 2020-06-25 Lankenau Institute Of Medical Research Compositions comprising ligands to rhob protein and the uses thereof
CN107325154B (zh) * 2017-06-23 2020-11-20 广东华肽生物科技有限公司 一种具有改善记忆功效的多肽及其分离制备方法和用途
CN108169397B (zh) * 2017-11-30 2019-11-15 中国农业科学院北京畜牧兽医研究所 一种相对定量分析肉鸡谷胱甘肽s转移酶gsta2的方法
JP7028258B2 (ja) * 2018-01-09 2022-03-02 株式会社島津製作所 タンパク質同定方法
US11054428B2 (en) 2018-03-05 2021-07-06 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
US10656059B2 (en) 2018-03-07 2020-05-19 Alcala Pharmaceutical, Inc. Method for qualitative and quantitative multiplexing of drug analytes from biological samples
RU2678090C1 (ru) * 2018-05-28 2019-01-23 Федеральное государственное бюджетное научное учреждение "Федеральный научный центр пищевых систем им. В.М. Горбатова" РАН Способ подтверждения аутентичности вареных колбасных изделий
EP3856921B1 (en) 2018-09-25 2026-04-29 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
WO2020150560A1 (en) 2019-01-17 2020-07-23 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
US12472448B2 (en) * 2019-01-24 2025-11-18 The Board Of Trustees Of The Leland Stanford Junior University Compact hydroxamate-based affinity tags for artificially tagging biological macromolecules
CN110280229B (zh) * 2019-06-28 2022-03-11 东南大学 喋呤类化合物选择性分离富集材料制备与应用方法
CA3179460A1 (en) * 2020-06-09 2021-12-16 Regeneron Pharmaceuticals, Inc. A high-throughput and mass-spectrometry-based method for quantitating antibodies
WO2022081015A1 (en) 2020-10-16 2022-04-21 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Anti-tumor immunity induces the presentation of aberrant peptides
ES3006019T3 (en) * 2020-12-17 2025-03-17 Hoffmann La Roche Evaporation-based sample preparation workflow for mass spectrometry
CN113156002A (zh) * 2021-04-01 2021-07-23 河北利德检测技术有限公司 一种葡萄糖酸钙中5种有关物质的检测方法
WO2023080788A1 (en) 2021-11-05 2023-05-11 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Tryptophan depletion induces production and presentation of tryptophan to phenylalanine substitutions
WO2024238393A1 (en) * 2023-05-10 2024-11-21 Northwestern University Proteoform imaging and characterization mass spectrometry

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614368A (en) 1990-02-09 1997-03-25 Molecular Devices Corporation Chromophoric reagents for incorporation of biotin or other haptens into macromolecules
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798795A (en) 1987-02-17 1989-01-17 Hoechst Celanese Corporation Biotinylating agents
ATE131617T1 (de) 1988-10-17 1995-12-15 Molecular Devices Corp Haptenderivatisierte aufnahmemembran und diagnostische tests, die eine solche membran verwenden
US5438017A (en) * 1989-05-01 1995-08-01 The University Of Colorado Foundation, Inc. Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency
CA1340966C (en) 1989-05-19 2000-04-18 Thomas R. Covey Method of protein analysis
US5534440A (en) 1991-02-22 1996-07-09 Biomedical Research Centre Limited Compounds and methods for sequencing amino acids
US5240859A (en) 1991-02-22 1993-08-31 B.R. Centre Limited Methods for amino acid sequencing of a polypeptide
DE4310142A1 (de) 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung
US5496934A (en) * 1993-04-14 1996-03-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acids encoding a cellulose binding domain
US5491071A (en) * 1993-08-03 1996-02-13 Abbott Laboratories Reagents and methods for the detection and quantification of testosterone in fluid samples
US5854084A (en) 1996-07-12 1998-12-29 Biotraces, Inc. Enhanced chromatography using multiphoton detection
US5527711A (en) * 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
DE4343479A1 (de) 1993-12-21 1995-06-22 Boehringer Mannheim Gmbh Acylierte Proteinaggregate und deren Verwendung zur Entstörung von Immunoassays
WO1995023801A1 (de) 1994-03-05 1995-09-08 Boehringer Mannheim Gmbh Entstörmittel zum einsatz bei immunoassays
US6017693A (en) 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5534132A (en) * 1995-05-04 1996-07-09 Vreeke; Mark Electrode and method for the detection of an affinity reaction
US5965457A (en) 1995-06-06 1999-10-12 Magnani; John L. Methods of screening for a candidate compound able to bind to CD34+ cells
US5686310A (en) 1995-06-06 1997-11-11 University Of Virginia Patent Foundation Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein
WO1996040662A2 (en) 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
EP0837696B1 (en) * 1995-06-07 2010-02-24 Immunomedics, Inc. Improved delivery of diagnostic and therapeutic agents to a target site
US5958703A (en) 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
DE69735445T2 (de) 1996-12-10 2006-08-10 Sequenom, Inc., San Diego Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
DE69817211T2 (de) * 1997-01-23 2004-06-03 Xzillion Gmbh & Co. Kg Charakterisierung von polypeptiden
IL133948A0 (en) 1997-07-11 2001-04-30 Brax Group Ltd Characterising nucleic acids
AU8234898A (en) 1997-07-11 1999-02-08 Brax Group Limited Characterising nucleic acid
DE69912444T3 (de) * 1998-08-25 2010-05-06 University Of Washington, Seattle Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
JP2004503780A (ja) 2000-06-12 2004-02-05 ユニバーシティ　オブ　ワシントン リンペプチドの選択的標識および単離ならびにプロテオーム分析への適用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5614368A (en) 1990-02-09 1997-03-25 Molecular Devices Corporation Chromophoric reagents for incorporation of biotin or other haptens into macromolecules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈ．，Ｖｏｌ．１７，Ｎｏ．１０，Ｐ．９９４−９９９（Ｏｃｔ．１９９９）

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7180056B2 (en) 2004-06-04 2007-02-20 Hitachi, Ltd. Mass spectrometry and mass spectrometry system

Also Published As

Publication number Publication date
ATE253126T1 (de) 2003-11-15
US20030087322A9 (en) 2003-05-08
US7544518B2 (en) 2009-06-09
EP1105517A1 (en) 2001-06-13
JP2002523058A (ja) 2002-07-30
US6852544B2 (en) 2005-02-08
AU5691399A (en) 2000-03-14
JP2006184290A (ja) 2006-07-13
EP1105517B2 (en) 2009-09-30
EP1329513A1 (en) 2003-07-23
US20050233399A1 (en) 2005-10-20
DE69912444D1 (de) 2003-12-04
DE69912444T2 (de) 2004-07-22
JP2003107066A (ja) 2003-04-09
DE69912444T3 (de) 2010-05-06
AU755334C (en) 2004-02-26
EP1329513B1 (en) 2011-12-07
JP3793124B2 (ja) 2006-07-05
AU755334B2 (en) 2002-12-12
ATE536422T1 (de) 2011-12-15
US6670194B1 (en) 2003-12-30
WO2000011208A1 (en) 2000-03-02
EP1105517A4 (en) 2001-09-19
JP4117320B2 (ja) 2008-07-16
US20020076739A1 (en) 2002-06-20
EP1105517B1 (en) 2003-10-29

Similar Documents

Publication Publication Date Title
JP3345401B2 (ja) 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析
US7052915B2 (en) Selective labeling and isolation of phosphopeptides and applications to proteome analysis
EP1311858B1 (en) Affinity selected signature peptides for protein identification and quantification
AU2003249692B2 (en) Methods for quantitative proteome analysis of glycoproteins
EP1456632B1 (en) Methods for isolating and labeling sample molecules
US7449170B2 (en) Materials and methods for controlling isotope effects during fractionation of analytes
WO2008056290A9 (en) Use of arylboronic acids in protein labelling

Legal Events

Date Code Title Description
TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20020815

R150 Certificate of patent or registration of utility model

Ref document number: 3345401

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080830

Year of fee payment: 6

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090830

Year of fee payment: 7

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100830

Year of fee payment: 8

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110830

Year of fee payment: 9

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110830

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120830

Year of fee payment: 10

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120830

Year of fee payment: 10

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130830

Year of fee payment: 11

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term