ATE417037T1 - Diarylharnstoffderivate, die sich zur behandlung von proteinkinaseabhängigen krankheiten eignen - Google Patents
Diarylharnstoffderivate, die sich zur behandlung von proteinkinaseabhängigen krankheiten eignenInfo
- Publication number
- ATE417037T1 ATE417037T1 AT03755147T AT03755147T ATE417037T1 AT E417037 T1 ATE417037 T1 AT E417037T1 AT 03755147 T AT03755147 T AT 03755147T AT 03755147 T AT03755147 T AT 03755147T AT E417037 T1 ATE417037 T1 AT E417037T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- protein kinase
- dependent diseases
- derivatives suitable
- diarylurea derivatives
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/40—Acylated substituent nitrogen atom
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0212413A GB0212413D0 (en) | 2002-05-29 | 2002-05-29 | Organic Compounds |
| GB0305684A GB0305684D0 (en) | 2003-03-12 | 2003-03-12 | Organic compounds |
| GB0309219 | 2003-04-23 |
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| Publication Number | Publication Date |
|---|---|
| ATE417037T1 true ATE417037T1 (de) | 2008-12-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03755147T ATE417037T1 (de) | 2002-05-29 | 2003-05-28 | Diarylharnstoffderivate, die sich zur behandlung von proteinkinaseabhängigen krankheiten eignen |
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|---|---|
| US (1) | US7652022B2 (de) |
| EP (1) | EP1511730B8 (de) |
| JP (1) | JP4608312B2 (de) |
| KR (1) | KR101036394B1 (de) |
| CN (1) | CN1656073B (de) |
| AR (1) | AR037647A1 (de) |
| AT (1) | ATE417037T1 (de) |
| AU (1) | AU2003242591B2 (de) |
| BR (1) | BR0311313A (de) |
| CA (1) | CA2484288A1 (de) |
| DE (1) | DE60325209D1 (de) |
| ES (1) | ES2318158T3 (de) |
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| EP4540252A1 (de) | 2022-06-14 | 2025-04-23 | Incyte Corporation | Feste formen eines jak-hemmers und verfahren zur herstellung davon |
| WO2023250430A1 (en) | 2022-06-22 | 2023-12-28 | Incyte Corporation | Bicyclic amine cdk12 inhibitors |
| WO2024015731A1 (en) | 2022-07-11 | 2024-01-18 | Incyte Corporation | Fused tricyclic compounds as inhibitors of kras g12v mutants |
| CN115108998B (zh) * | 2022-07-19 | 2023-06-30 | 重庆医科大学 | 用于抗乙型肝炎病毒的化合物及其应用 |
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| WO2024220532A1 (en) | 2023-04-18 | 2024-10-24 | Incyte Corporation | Pyrrolidine kras inhibitors |
| WO2024254245A1 (en) | 2023-06-09 | 2024-12-12 | Incyte Corporation | Bicyclic amines as cdk2 inhibitors |
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| US20250195536A1 (en) | 2023-12-13 | 2025-06-19 | Incyte Corporation | Bicyclooctane kras inhibitors |
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| WO1993015043A1 (fr) * | 1992-01-24 | 1993-08-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose arylalkananilide et utilisation pharmaceutique |
| AU7526798A (en) | 1997-04-18 | 1998-11-27 | Smithkline Beecham Plc | Acetamide and urea derivatives, process for their preparation and their use in the treatment of cns disorders |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| EP1449834A3 (de) | 1997-12-22 | 2004-12-22 | Bayer Corporation | Hemmung der RAF-Kinase unter Verwendung von symmetrisch und unsymmetrisch substituierten Harnstoffen |
| IL136737A0 (en) * | 1997-12-22 | 2001-06-14 | Bayer Ag | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US6462036B1 (en) | 1998-11-06 | 2002-10-08 | Basf Aktiengesellschaft | Tricyclic pyrazole derivatives |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| CZ299125B6 (cs) * | 1999-01-13 | 2008-04-30 | Bayer Corporation | Difenylové mocoviny substituované omega-karboxyarylovou skupinou jako inhibitory rafkinázy, jejich použití a farmaceutické kompozice s jejich obsahem |
| EP1140840B1 (de) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituierte diphenyl harnstoffe als raf kinase inhibitoren |
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| ATE419239T1 (de) | 2000-10-20 | 2009-01-15 | Eisai R&D Man Co Ltd | Verfahren zur herstellung von 4-phenoxy chinolin derivaten |
| US6706751B2 (en) | 2000-12-21 | 2004-03-16 | Hoffman-La Roche Inc. | Dihydroindole and tetrahydroquinoline derivatives |
| EP1562905A2 (de) | 2002-10-24 | 2005-08-17 | MERCK PATENT GmbH | Methylenharnstoffderivate als raf-kinase inhibitoren |
| AR041992A1 (es) | 2002-11-06 | 2005-06-08 | Smithkline Beecham Corp | Compuesto de piridinil benzoheterociclico, composicion farmaceutica que lo comprende y su uso para prepararla |
-
2003
- 2003-05-27 AR ARP030101848A patent/AR037647A1/es not_active Application Discontinuation
- 2003-05-27 PE PE2003000513A patent/PE20040522A1/es not_active Application Discontinuation
- 2003-05-27 TW TW092114271A patent/TW200406374A/zh unknown
- 2003-05-28 PL PL03372426A patent/PL372426A1/xx not_active Application Discontinuation
- 2003-05-28 PT PT03755147T patent/PT1511730E/pt unknown
- 2003-05-28 ES ES03755147T patent/ES2318158T3/es not_active Expired - Lifetime
- 2003-05-28 JP JP2004507429A patent/JP4608312B2/ja not_active Expired - Fee Related
- 2003-05-28 EP EP03755147A patent/EP1511730B8/de not_active Expired - Lifetime
- 2003-05-28 US US10/515,113 patent/US7652022B2/en not_active Expired - Fee Related
- 2003-05-28 CA CA002484288A patent/CA2484288A1/en not_active Abandoned
- 2003-05-28 MX MXPA04011789A patent/MXPA04011789A/es active IP Right Grant
- 2003-05-28 NZ NZ536781A patent/NZ536781A/en unknown
- 2003-05-28 KR KR1020047019245A patent/KR101036394B1/ko not_active Expired - Fee Related
- 2003-05-28 WO PCT/EP2003/005634 patent/WO2003099771A2/en not_active Ceased
- 2003-05-28 AU AU2003242591A patent/AU2003242591B2/en not_active Ceased
- 2003-05-28 CN CN038122804A patent/CN1656073B/zh not_active Expired - Fee Related
- 2003-05-28 DE DE60325209T patent/DE60325209D1/de not_active Expired - Lifetime
- 2003-05-28 AT AT03755147T patent/ATE417037T1/de active
- 2003-05-28 BR BR0311313-2A patent/BR0311313A/pt not_active IP Right Cessation
-
2004
- 2004-10-21 IL IL16478404A patent/IL164784A0/xx unknown
- 2004-12-17 NO NO20045521A patent/NO20045521L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ536781A (en) | 2007-12-21 |
| JP4608312B2 (ja) | 2011-01-12 |
| EP1511730A2 (de) | 2005-03-09 |
| PL372426A1 (en) | 2005-07-25 |
| PE20040522A1 (es) | 2004-09-28 |
| PT1511730E (pt) | 2009-02-18 |
| EP1511730B1 (de) | 2008-12-10 |
| WO2003099771A3 (en) | 2004-04-01 |
| US7652022B2 (en) | 2010-01-26 |
| MXPA04011789A (es) | 2005-03-31 |
| AR037647A1 (es) | 2004-12-01 |
| EP1511730B8 (de) | 2009-04-08 |
| AU2003242591B2 (en) | 2007-07-26 |
| CN1656073A (zh) | 2005-08-17 |
| TW200406374A (en) | 2004-05-01 |
| IL164784A0 (en) | 2005-12-18 |
| CN1656073B (zh) | 2010-05-26 |
| AU2003242591A1 (en) | 2003-12-12 |
| BR0311313A (pt) | 2005-02-15 |
| KR20050006281A (ko) | 2005-01-15 |
| NO20045521L (no) | 2004-12-17 |
| DE60325209D1 (de) | 2009-01-22 |
| KR101036394B1 (ko) | 2011-05-23 |
| JP2005527622A (ja) | 2005-09-15 |
| ES2318158T3 (es) | 2009-05-01 |
| WO2003099771A2 (en) | 2003-12-04 |
| US20060128734A1 (en) | 2006-06-15 |
| CA2484288A1 (en) | 2003-12-04 |
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