ATE412665T1 - Reinigung von hbv-antigenen zur verwendung in impfstoffen - Google Patents

Reinigung von hbv-antigenen zur verwendung in impfstoffen

Info

Publication number
ATE412665T1
ATE412665T1 AT05077471T AT05077471T ATE412665T1 AT E412665 T1 ATE412665 T1 AT E412665T1 AT 05077471 T AT05077471 T AT 05077471T AT 05077471 T AT05077471 T AT 05077471T AT E412665 T1 ATE412665 T1 AT E412665T1
Authority
AT
Austria
Prior art keywords
vaccines
purification
hbv antigens
hbv
antigens
Prior art date
Application number
AT05077471T
Other languages
German (de)
English (en)
Inventor
Heyer Koen De
Peter Schu
Michelle Serantoni
Opstel Omer Van
Original Assignee
Glaxosmithkline Biolog Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0019728.5A external-priority patent/GB0019728D0/en
Priority claimed from GB0101334A external-priority patent/GB0101334D0/en
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Application granted granted Critical
Publication of ATE412665T1 publication Critical patent/ATE412665T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
    • A61K39/0018—Combination vaccines based on acellular diphtheria-tetanus-pertussis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT05077471T 2000-08-10 2001-08-07 Reinigung von hbv-antigenen zur verwendung in impfstoffen ATE412665T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0019728.5A GB0019728D0 (en) 2000-08-10 2000-08-10 Novel treatment
GB0101334A GB0101334D0 (en) 2001-01-18 2001-01-18 Novel compounds

Publications (1)

Publication Number Publication Date
ATE412665T1 true ATE412665T1 (de) 2008-11-15

Family

ID=26244821

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05077471T ATE412665T1 (de) 2000-08-10 2001-08-07 Reinigung von hbv-antigenen zur verwendung in impfstoffen
AT01960630T ATE313558T1 (de) 2000-08-10 2001-08-07 Reinigung von hbv-antigenen zur verwendung in impfstoffen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01960630T ATE313558T1 (de) 2000-08-10 2001-08-07 Reinigung von hbv-antigenen zur verwendung in impfstoffen

Country Status (35)

Country Link
US (3) US20030235590A1 (OSRAM)
EP (2) EP1307473B1 (OSRAM)
JP (2) JP2004505992A (OSRAM)
KR (1) KR100804922B1 (OSRAM)
CN (1) CN1468256B (OSRAM)
AP (1) AP2003002734A0 (OSRAM)
AR (1) AR030325A1 (OSRAM)
AT (2) ATE412665T1 (OSRAM)
AU (2) AU8207301A (OSRAM)
BG (1) BG66038B1 (OSRAM)
BR (1) BRPI0113155C1 (OSRAM)
CA (2) CA2427475C (OSRAM)
CY (2) CY1106310T1 (OSRAM)
CZ (1) CZ303217B6 (OSRAM)
DE (2) DE60116107T2 (OSRAM)
DK (2) DK1307473T3 (OSRAM)
DZ (1) DZ3470A1 (OSRAM)
EA (1) EA006433B1 (OSRAM)
EG (1) EG25829A (OSRAM)
ES (2) ES2314555T3 (OSRAM)
HU (1) HU228932B1 (OSRAM)
IL (2) IL154301A0 (OSRAM)
MX (1) MXPA03001235A (OSRAM)
MY (1) MY128999A (OSRAM)
NO (1) NO20030635L (OSRAM)
NZ (1) NZ524012A (OSRAM)
OA (1) OA12361A (OSRAM)
PE (1) PE20020287A1 (OSRAM)
PL (1) PL204736B1 (OSRAM)
PT (1) PT1666487E (OSRAM)
SI (2) SI1666487T1 (OSRAM)
SK (2) SK288069B6 (OSRAM)
UA (1) UA79735C2 (OSRAM)
UY (1) UY26882A1 (OSRAM)
WO (1) WO2002012287A1 (OSRAM)

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GB0202901D0 (en) * 2002-02-07 2002-03-27 Glaxosmithkline Biolog Sa Novel vaccine
US20100034840A1 (en) * 2005-07-11 2010-02-11 David Apelian Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
CA2617362A1 (en) * 2005-08-02 2007-02-08 Novartis Vaccines And Diagnostics S.R.L. Reducing interference between oil-containing adjuvants and surfactant-containing antigens
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PT2097102E (pt) 2006-09-07 2012-08-03 Glaxosmithkline Biolog Sa Vacina de combinação tendo quantidades reduzidas de antigénio de poliovírus
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GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
CN106222129A (zh) * 2016-07-29 2016-12-14 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
WO2019016654A1 (en) 2017-07-18 2019-01-24 Serum Institute Of India Pvt Ltd. IMMUNOGENIC COMPOSITION WITH IMPROVED STABILITY, ENHANCED IMMUNOGENICITY, AND LESS REACTOGENICITY, AND PREPARATION METHOD THEREOF
GB201721068D0 (en) 2017-12-15 2018-01-31 Glaxosmithkline Biologicals Sa Hepatitis B immunisation regimen and compositions
GB201721069D0 (en) 2017-12-15 2018-01-31 Glaxosmithkline Biologicals Sa Hepatitis B Immunisation regimen and compositions
EP3934687A1 (en) 2019-03-05 2022-01-12 GlaxoSmithKline Biologicals S.A. Hepatitis b immunisation regimen and compositions
BR112022011445A2 (pt) * 2019-12-13 2022-08-30 Grand Theravac Life Science Nanjing Co Ltd Composição imunoestimuladora e uso da mesma

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Also Published As

Publication number Publication date
MXPA03001235A (es) 2004-07-16
EG25829A (en) 2012-09-02
BR0113155A (pt) 2003-07-08
EP1666487A1 (en) 2006-06-07
CZ2003385A3 (cs) 2003-06-18
BG107545A (bg) 2004-01-30
DZ3470A1 (fr) 2002-02-14
HU228932B1 (en) 2013-06-28
US8624004B2 (en) 2014-01-07
DE60116107D1 (de) 2006-01-26
SI1666487T1 (sl) 2009-02-28
JP5559847B2 (ja) 2014-07-23
JP2004505992A (ja) 2004-02-26
US20060159705A1 (en) 2006-07-20
CY1106310T1 (el) 2011-10-12
UY26882A1 (es) 2002-03-22
BG66038B1 (bg) 2010-11-30
PL362322A1 (en) 2004-10-18
SK288079B6 (sk) 2013-06-03
CN1468256A (zh) 2004-01-14
UA79735C2 (uk) 2007-07-25
SI1307473T1 (sl) 2006-04-30
DE60116107T2 (de) 2006-08-03
KR20030029127A (ko) 2003-04-11
MY128999A (en) 2007-03-30
AU8207301A (en) 2002-02-18
EP1307473A1 (en) 2003-05-07
SK288069B6 (sk) 2013-05-03
DK1307473T3 (da) 2006-05-01
PT1666487E (pt) 2008-12-26
HUP0302951A2 (hu) 2003-12-29
CN1468256B (zh) 2010-10-27
EP1666487B1 (en) 2008-10-29
DE60136400D1 (de) 2008-12-11
US20030235590A1 (en) 2003-12-25
EA200300129A1 (ru) 2003-10-30
NO20030635L (no) 2003-04-01
EP1307473B1 (en) 2005-12-21
AR030325A1 (es) 2003-08-20
US20090123496A1 (en) 2009-05-14
NO20030635D0 (no) 2003-02-07
PL204736B1 (pl) 2010-02-26
ATE313558T1 (de) 2006-01-15
JP2012255015A (ja) 2012-12-27
AP2003002734A0 (en) 2003-03-31
HUP0302951A3 (en) 2004-10-28
WO2002012287A1 (en) 2002-02-14
BRPI0113155C1 (pt) 2021-05-25
PE20020287A1 (es) 2002-06-20
OA12361A (en) 2004-04-13
CA2740282A1 (en) 2002-02-11
ES2254464T3 (es) 2006-06-16
EA006433B1 (ru) 2005-12-29
SK1692003A3 (en) 2003-08-05
NZ524012A (en) 2004-02-27
CA2427475C (en) 2011-07-05
CY1108789T1 (el) 2014-04-09
BRPI0113155B1 (pt) 2018-11-21
KR100804922B1 (ko) 2008-02-20
HK1056884A1 (en) 2004-03-05
IL154301A (en) 2009-11-18
AU2001282073B2 (en) 2005-01-20
DK1666487T3 (da) 2009-01-12
BRPI0113155B8 (pt) 2019-08-13
CZ303217B6 (cs) 2012-05-30
CA2427475A1 (en) 2002-02-11
ES2314555T3 (es) 2009-03-16
IL154301A0 (en) 2003-09-17

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