ATE409693T1 - Verfahren zur herstellung von 2-(4- chlorbenzoylamino-3- 2(1h)-chinolinon-4-yl propionsäure - Google Patents
Verfahren zur herstellung von 2-(4- chlorbenzoylamino-3- 2(1h)-chinolinon-4-yl propionsäureInfo
- Publication number
- ATE409693T1 ATE409693T1 AT02700867T AT02700867T ATE409693T1 AT E409693 T1 ATE409693 T1 AT E409693T1 AT 02700867 T AT02700867 T AT 02700867T AT 02700867 T AT02700867 T AT 02700867T AT E409693 T1 ATE409693 T1 AT E409693T1
- Authority
- AT
- Austria
- Prior art keywords
- chlorobenzoylamino
- propionic acid
- quinolinone
- producing
- quinolinon
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- ALLWOAVDORUJLA-UHFFFAOYSA-N Rebamipida Chemical compound C=1C(=O)NC2=CC=CC=C2C=1CC(C(=O)O)NC(=O)C1=CC=C(Cl)C=C1 ALLWOAVDORUJLA-UHFFFAOYSA-N 0.000 abstract 2
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 229950004535 rebamipide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20010008407 | 2001-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE409693T1 true ATE409693T1 (de) | 2008-10-15 |
Family
ID=19705995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02700867T ATE409693T1 (de) | 2001-02-20 | 2002-02-20 | Verfahren zur herstellung von 2-(4- chlorbenzoylamino-3- 2(1h)-chinolinon-4-yl propionsäure |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6680386B2 (de) |
| EP (1) | EP1274686B1 (de) |
| JP (1) | JP4048119B2 (de) |
| KR (1) | KR100669823B1 (de) |
| AT (1) | ATE409693T1 (de) |
| DE (1) | DE60229087D1 (de) |
| WO (1) | WO2002066436A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020038466A (ko) * | 2001-09-14 | 2002-05-23 | 김용옥 | 카르보스티릴 유도체의 제조방법 |
| KR100439733B1 (ko) * | 2002-01-04 | 2004-07-12 | 신풍제약주식회사 | (±)-2-(4-클로로벤조일아미노)-3-[2(1ｈ)-퀴놀리논-4-일]프로피오닉산의 제조 방법 |
| KR100520184B1 (ko) * | 2002-10-11 | 2005-10-10 | 한미약품 주식회사 | 레바미파이드의 개선된 제조방법 |
| CN100537541C (zh) * | 2004-12-01 | 2009-09-09 | 大塚制药株式会社 | 制备瑞巴派特的改进的方法 |
| JP3892894B2 (ja) * | 2005-04-28 | 2007-03-14 | 大塚製薬株式会社 | カルボスチリル化合物の製造法 |
| KR101032600B1 (ko) | 2008-08-11 | 2011-05-06 | 동우신테크 주식회사 | 고순도 레바미피드의 제조방법 |
| KR101365849B1 (ko) | 2012-03-28 | 2014-02-24 | 경동제약 주식회사 | 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체 |
| SA113340675B1 (ar) * | 2012-06-26 | 2015-08-16 | استيش. كو.، ليمتد | أدوية ريباميبايد تحضيرية جديدة، طريقة تحضيرها واستخدامها |
| CN103076421B (zh) * | 2012-12-31 | 2014-10-01 | 北京元延医药科技有限公司 | 瑞巴派特有关物质检查的分析方法 |
| CN103113294B (zh) * | 2013-03-11 | 2016-04-27 | 浙江远力健药业有限责任公司 | 瑞巴派特的合成方法 |
| CN104418802B (zh) * | 2013-09-07 | 2017-02-22 | 重庆汇智药物研究院有限公司 | 瑞巴派特一水合物晶型及其制备方法 |
| KR102132162B1 (ko) * | 2013-12-25 | 2020-07-10 | 삼진제약주식회사 | 신규 레바미피드 전구체의 염 및 이의 용도 |
| WO2016108319A1 (ko) * | 2015-01-02 | 2016-07-07 | 삼진제약 주식회사 | 신규 레바미피드 전구체의 염 및 이의 용도 |
| KR20170094584A (ko) * | 2016-02-11 | 2017-08-21 | 삼진제약주식회사 | 레바미피드 전구체를 포함하는 면역질환 및 대사성질환의 예방 또는 치료를 위한 경구투여용 약제학적 조성물 |
| CN108069901B (zh) * | 2016-11-16 | 2020-12-11 | 重庆圣华曦药业股份有限公司 | 一种瑞巴派特合成新工艺 |
| CN106632029A (zh) * | 2016-12-29 | 2017-05-10 | 大桐制药（中国）有限责任公司 | 瑞巴派特的合成工艺 |
| CN107674023A (zh) * | 2017-11-16 | 2018-02-09 | 重庆理工大学 | 一种瑞巴派特的合成方法 |
| CN113336700A (zh) * | 2021-06-15 | 2021-09-03 | 大桐制药（中国）有限责任公司 | 一种瑞巴派特的制备方法 |
| CN115028579B (zh) * | 2022-06-21 | 2023-07-18 | 福建海西新药创制股份有限公司 | 一种瑞巴派特原料药的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI80022C (fi) | 1982-07-05 | 1990-04-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat. |
| JPS6019767A (ja) | 1983-07-11 | 1985-01-31 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体を有効成分とする抗潰瘍剤 |
| JPH0249774A (ja) | 1988-05-10 | 1990-02-20 | Meiji Seika Kaisha Ltd | ベンズイミダゾール誘導体および抗潰瘍剤 |
| GB8820129D0 (en) * | 1988-08-24 | 1988-09-28 | Schering Agrochemicals Ltd | Fungicides |
| JPH0565273A (ja) * | 1989-04-27 | 1993-03-19 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JPH01308258A (ja) | 1989-04-27 | 1989-12-12 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JP2820739B2 (ja) * | 1989-10-28 | 1998-11-05 | 大塚製薬株式会社 | カルボスチリル誘導体の製造法 |
| JP2989689B2 (ja) * | 1991-06-25 | 1999-12-13 | ダイセル化学工業株式会社 | キノリノン誘導体の製造方法 |
| JP3621463B2 (ja) * | 1995-04-26 | 2005-02-16 | 大塚製薬株式会社 | カルボスチリル誘導体ビスマス塩 |
-
2002
- 2002-02-19 KR KR1020020008829A patent/KR100669823B1/ko not_active Expired - Fee Related
- 2002-02-20 EP EP02700867A patent/EP1274686B1/de not_active Expired - Lifetime
- 2002-02-20 AT AT02700867T patent/ATE409693T1/de not_active IP Right Cessation
- 2002-02-20 WO PCT/KR2002/000262 patent/WO2002066436A1/en not_active Ceased
- 2002-02-20 JP JP2002565953A patent/JP4048119B2/ja not_active Expired - Fee Related
- 2002-02-20 US US10/240,728 patent/US6680386B2/en not_active Expired - Lifetime
- 2002-02-20 DE DE60229087T patent/DE60229087D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1274686A1 (de) | 2003-01-15 |
| EP1274686B1 (de) | 2008-10-01 |
| DE60229087D1 (de) | 2008-11-13 |
| US6680386B2 (en) | 2004-01-20 |
| EP1274686A4 (de) | 2004-09-15 |
| JP4048119B2 (ja) | 2008-02-13 |
| KR100669823B1 (ko) | 2007-01-17 |
| US20030087930A1 (en) | 2003-05-08 |
| JP2004518737A (ja) | 2004-06-24 |
| WO2002066436A1 (en) | 2002-08-29 |
| KR20020068287A (ko) | 2002-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE409693T1 (de) | Verfahren zur herstellung von 2-(4- chlorbenzoylamino-3- 2(1h)-chinolinon-4-yl propionsäure | |
| DE60103995D1 (de) | Perzychinin, verfahren zu seiner herstellung und seine verwendung als pharmazeutisches produkt | |
| ATE478084T1 (de) | Verfahren zur herstellung von 4'- azidocytidinderivaten | |
| DE60229041D1 (de) | Verfahren zur erhöhung der leptinspiegel unter verwendung von nikotinsäureverbindungen | |
| ATE240311T1 (de) | Verfahren zur herstellung von 2-thienylamin- derivaten | |
| ATE370131T1 (de) | Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten | |
| ATE519747T1 (de) | Verfahren zur herstellung von cyclopentaägüchinazolin-derivaten | |
| DE69915713D1 (de) | Verfahren zur herstellung von citalopram | |
| DE60228724D1 (de) | Verfahren zur herstellung von beraprost und dessen salzen | |
| ATE521600T1 (de) | Verfahren zur herstellung von statinen | |
| ATE343385T1 (de) | Verfahren zur herstellung von donepezil | |
| ATE250057T1 (de) | Verfahren zur herstellung von 1-(1h)- benzoquinolizin-3-on derivaten | |
| ATE303377T1 (de) | Verfahren zur racemizierung | |
| DE60105441D1 (de) | Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens | |
| ATE281434T1 (de) | Verfahren zur herstellung von benzoperhydroisoindolen | |
| DE602005026827D1 (de) | Verfahren zur herstellung von isoindolderivaten | |
| DE60107292D1 (de) | Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin | |
| ATE390400T1 (de) | Verfahren zur herstellung von alpha'-chlorketonen | |
| ATE282589T1 (de) | Verfahren zur herstellung eines chiralen-beta- aminosäureesters | |
| DE69936350D1 (de) | Verfahren zur herstellung fluorierter benzoesäuren | |
| ATE205211T1 (de) | Benzopyranopyridoncarbonsäuren und verfahren zu ihrer herstellung | |
| ATE150451T1 (de) | Stereoselektives verfahren zur herstellung eines beta-phenylisoserin-derivates sowie seine verwendung zur herstellung von taxan-derivaten | |
| ATE425972T1 (de) | Verfahren zur herstellung substituierter imidazolderivate und in dem verfahren verwendete zwischenprodukte | |
| TR200200307T2 (tr) | Alfa-Kloroepoksi esterleri vasıtasıyla asit hazırlama prosesi | |
| DE50101761D1 (de) | Verfahren zur herstellung von 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-yl-essigsäure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |