ATE240311T1 - Verfahren zur herstellung von 2-thienylamin- derivaten - Google Patents
Verfahren zur herstellung von 2-thienylamin- derivatenInfo
- Publication number
- ATE240311T1 ATE240311T1 AT98913841T AT98913841T ATE240311T1 AT E240311 T1 ATE240311 T1 AT E240311T1 AT 98913841 T AT98913841 T AT 98913841T AT 98913841 T AT98913841 T AT 98913841T AT E240311 T1 ATE240311 T1 AT E240311T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- general formula
- alkali metal
- metal atom
- date sep
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- GLQWRXYOTXRDNH-UHFFFAOYSA-N thiophen-2-amine Chemical class NC1=CC=CS1 GLQWRXYOTXRDNH-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 3
- 150000001340 alkali metals Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- HVLUYXIJZLDNIS-UHFFFAOYSA-N 2-thiophen-2-ylethanamine Chemical class NCCC1=CC=CS1 HVLUYXIJZLDNIS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical group 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- -1 phenylglycine ester Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9702621A FR2760456B1 (fr) | 1997-03-05 | 1997-03-05 | Procede de preparation de derives de 2-thienyl-ethylamine |
| PCT/FR1998/000441 WO1998039322A1 (fr) | 1997-03-05 | 1998-03-05 | Procede de preparation de derives de 2-thienylethylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240311T1 true ATE240311T1 (de) | 2003-05-15 |
Family
ID=9504438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98913841T ATE240311T1 (de) | 1997-03-05 | 1998-03-05 | Verfahren zur herstellung von 2-thienylamin- derivaten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6080875A (de) |
| EP (1) | EP0971915B1 (de) |
| JP (1) | JP4283896B2 (de) |
| AT (1) | ATE240311T1 (de) |
| AU (1) | AU6839498A (de) |
| BR (1) | BR9808174B1 (de) |
| CA (1) | CA2283126C (de) |
| DE (1) | DE69814608T2 (de) |
| ES (1) | ES2200332T3 (de) |
| FR (1) | FR2760456B1 (de) |
| NO (1) | NO323613B1 (de) |
| WO (1) | WO1998039322A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495691B1 (en) | 2001-07-06 | 2002-12-17 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
| US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
| US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
| IL166593A0 (en) | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
| US6800759B2 (en) | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
| WO2004081015A1 (en) * | 2003-03-10 | 2004-09-23 | Hetero Drugs Limited | Amorphous clopidogrel hydrogen sulfate |
| WO2004081016A1 (en) | 2003-03-12 | 2004-09-23 | Cadila Healthcare Limited | Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate |
| PT1680430E (pt) | 2003-11-03 | 2010-04-26 | Cadila Healthcare Ltd | Processos para a preparação da forma i de bissulfato de (s)-(+)-clopidogrel |
| WO2006003671A1 (en) * | 2004-07-02 | 2006-01-12 | Srinivasa Reddy Battula | A process for resolution of methylamino(2-chlorophenyl)acetate |
| EP1704152A2 (de) * | 2004-09-21 | 2006-09-27 | Teva Pharmaceutical Industries Ltd | Kristallines clopidogrelhydrobromid und verfahren zu dessen herstellung |
| CA2594763A1 (en) * | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries Ltd. | Clopidogrel base suitable for pharmaceutical formulation and preparation thereof |
| US20090247569A1 (en) * | 2006-08-03 | 2009-10-01 | Claude Singer | Process for Preparing Clopidogrel Bisulphate |
| EP1980563A1 (de) | 2007-04-09 | 2008-10-15 | BATTULA, Srinivasa Reddy | Verfahren zur Herstellung von Methyl (+)-(S)-Alpha-(O-Chlorophenyl)-6,7-Dihydrothieno-[3,2-C]pyridine-5(4H) Acetat |
| MX2008016012A (es) * | 2007-04-18 | 2009-03-06 | Teva Pharma | Proceso mejorado para preparar clopidogrel. |
| EP2107061A1 (de) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Herstellungsverfahren für optisch angereichertes Clopidogrel |
| US20090264460A1 (en) * | 2008-04-21 | 2009-10-22 | Mamta Mishra | Clopidogrel pharmaceutical formulations |
| KR100990949B1 (ko) | 2008-06-09 | 2010-10-29 | 엔자이텍 주식회사 | 클로피도그렐 및 그의 유도체의 제조방법 |
| WO2010046476A1 (en) * | 2008-10-24 | 2010-04-29 | Sandoz Ag | A process for the preparation of s-clopidogrel |
| US8563690B2 (en) * | 2008-11-03 | 2013-10-22 | The Board Of Trustees Of The University Of Illinois | Modulation of platelet aggregation |
| WO2012123958A1 (en) | 2011-02-14 | 2012-09-20 | Cadila Healthcare Limited | Highly pure salts of clopidogrel free of genotoxic impurities |
| CN103172527A (zh) * | 2011-12-26 | 2013-06-26 | 湖北德洲科技发展有限公司 | 一种制备氯吡格雷合成中间体-邻氯苯甘氨酸甲酯的方法 |
| RS56178B1 (sr) * | 2012-07-17 | 2017-11-30 | Sanofi Sa | Upotreba vegfr-3 inhibitora za lečenje hepatocelularnog karcinoma |
| CN106748853B (zh) * | 2016-11-25 | 2018-12-28 | 河南普瑞医药科技有限公司 | 一种（s）-邻氯苯甘氨酸甲酯盐酸盐的制备方法 |
| CN115784914B (zh) * | 2022-12-20 | 2023-05-12 | 石家庄中硕科技有限公司 | 一种邻氯苯甘氨酸的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0355170A4 (en) * | 1986-04-24 | 1990-09-05 | N-Proizv Mekh Robot Truda Sover | Vertical centrifugal casting machine |
| FR2624860B1 (fr) * | 1987-12-18 | 1990-06-01 | Sanofi Sa | Procede de preparation de la n-(chloro-2 benzyl) (thienyl-2)-2 ethylamine |
| AR245119A1 (es) * | 1988-08-22 | 1993-12-30 | Merrell Dow Pharma | Procedimiento para preparar un grupo de fenilalquiltiofenos que estan sustituidos adicionalmente con un grupo acido tiadicarboxilico. |
| FR2664276B1 (fr) * | 1990-07-04 | 1992-10-23 | Sanofi Sa | Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese. |
| FR2664596B1 (fr) * | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
-
1997
- 1997-03-05 FR FR9702621A patent/FR2760456B1/fr not_active Expired - Fee Related
-
1998
- 1998-03-05 WO PCT/FR1998/000441 patent/WO1998039322A1/fr not_active Ceased
- 1998-03-05 JP JP53824098A patent/JP4283896B2/ja not_active Expired - Fee Related
- 1998-03-05 AT AT98913841T patent/ATE240311T1/de not_active IP Right Cessation
- 1998-03-05 US US09/380,450 patent/US6080875A/en not_active Expired - Lifetime
- 1998-03-05 ES ES98913841T patent/ES2200332T3/es not_active Expired - Lifetime
- 1998-03-05 BR BRPI9808174-8A patent/BR9808174B1/pt not_active IP Right Cessation
- 1998-03-05 CA CA002283126A patent/CA2283126C/fr not_active Expired - Fee Related
- 1998-03-05 AU AU68394/98A patent/AU6839498A/en not_active Abandoned
- 1998-03-05 DE DE69814608T patent/DE69814608T2/de not_active Expired - Lifetime
- 1998-03-05 EP EP98913841A patent/EP0971915B1/de not_active Expired - Lifetime
-
1999
- 1999-09-03 NO NO19994304A patent/NO323613B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6080875A (en) | 2000-06-27 |
| DE69814608T2 (de) | 2004-04-01 |
| NO994304L (no) | 1999-11-03 |
| ES2200332T3 (es) | 2004-03-01 |
| JP4283896B2 (ja) | 2009-06-24 |
| AU6839498A (en) | 1998-09-22 |
| WO1998039322A1 (fr) | 1998-09-11 |
| DE69814608D1 (de) | 2003-06-18 |
| NO323613B1 (no) | 2007-06-18 |
| FR2760456A1 (fr) | 1998-09-11 |
| CA2283126A1 (fr) | 1998-09-11 |
| BR9808174B1 (pt) | 2010-06-29 |
| CA2283126C (fr) | 2008-09-02 |
| FR2760456B1 (fr) | 2000-05-12 |
| EP0971915A1 (de) | 2000-01-19 |
| JP2001513806A (ja) | 2001-09-04 |
| EP0971915B1 (de) | 2003-05-14 |
| BR9808174A (pt) | 2000-05-16 |
| NO994304D0 (no) | 1999-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |