DE50005699D1 - Verfahren zur herstellung von thiazolidin - Google Patents

Verfahren zur herstellung von thiazolidin

Info

Publication number
DE50005699D1
DE50005699D1 DE50005699T DE50005699T DE50005699D1 DE 50005699 D1 DE50005699 D1 DE 50005699D1 DE 50005699 T DE50005699 T DE 50005699T DE 50005699 T DE50005699 T DE 50005699T DE 50005699 D1 DE50005699 D1 DE 50005699D1
Authority
DE
Germany
Prior art keywords
salts
producing
thiazolidine
formula
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50005699T
Other languages
English (en)
Inventor
Hans-Ulrich Demuth
Susanne Kruber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prosidion Ltd
Original Assignee
Probiodrug AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiodrug AG filed Critical Probiodrug AG
Priority to DE50005699T priority Critical patent/DE50005699D1/de
Application granted granted Critical
Publication of DE50005699D1 publication Critical patent/DE50005699D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE50005699T 1999-06-10 2000-04-11 Verfahren zur herstellung von thiazolidin Expired - Lifetime DE50005699D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50005699T DE50005699D1 (de) 1999-06-10 2000-04-11 Verfahren zur herstellung von thiazolidin

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19926233A DE19926233C1 (de) 1999-06-10 1999-06-10 Verfahren zur Herstellung von Thiazolidin
DE50005699T DE50005699D1 (de) 1999-06-10 2000-04-11 Verfahren zur herstellung von thiazolidin
PCT/EP2000/003213 WO2000076986A1 (de) 1999-06-10 2000-04-11 Verfahren zur herstellung von thiazolidin

Publications (1)

Publication Number Publication Date
DE50005699D1 true DE50005699D1 (de) 2004-04-22

Family

ID=7910641

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19926233A Expired - Lifetime DE19926233C1 (de) 1999-06-10 1999-06-10 Verfahren zur Herstellung von Thiazolidin
DE50005699T Expired - Lifetime DE50005699D1 (de) 1999-06-10 2000-04-11 Verfahren zur herstellung von thiazolidin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19926233A Expired - Lifetime DE19926233C1 (de) 1999-06-10 1999-06-10 Verfahren zur Herstellung von Thiazolidin

Country Status (18)

Country Link
US (1) US6559314B2 (de)
EP (1) EP1185520B1 (de)
JP (1) JP3803292B2 (de)
KR (1) KR100467898B1 (de)
CN (1) CN1169799C (de)
AT (1) ATE261946T1 (de)
AU (1) AU758605B2 (de)
BR (1) BR0011445A (de)
CA (1) CA2373834C (de)
DE (2) DE19926233C1 (de)
DK (1) DK1185520T3 (de)
ES (1) ES2215045T3 (de)
HK (1) HK1042483B (de)
MX (1) MXPA01012237A (de)
NZ (1) NZ515561A (de)
PT (1) PT1185520E (de)
RU (1) RU2218336C2 (de)
WO (1) WO2000076986A1 (de)

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DE69837393T2 (de) * 1997-09-29 2007-12-06 Point Therapeutics, Inc., Boston Stimulierung von hämatopoietischen zellen im vitro
US6979697B1 (en) * 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US7687625B2 (en) 2003-03-25 2010-03-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
BRPI0413452A (pt) 2003-08-13 2006-10-17 Takeda Pharmaceutical composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7790734B2 (en) 2003-09-08 2010-09-07 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
AU2004318013B8 (en) 2004-03-15 2011-10-06 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2005118555A1 (en) * 2004-06-04 2005-12-15 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US7842707B2 (en) * 2004-07-23 2010-11-30 Nuada, Llc Peptidase inhibitors
US20060063719A1 (en) * 2004-09-21 2006-03-23 Point Therapeutics, Inc. Methods for treating diabetes
EP2805953B1 (de) 2004-12-21 2016-03-09 Takeda Pharmaceutical Company Limited Dipeptidyl-Peptidase-Hemmer
US20070060529A1 (en) * 2005-09-14 2007-03-15 Christopher Ronald J Administration of dipeptidyl peptidase inhibitors
EP1942898B2 (de) 2005-09-14 2014-05-14 Takeda Pharmaceutical Company Limited Dipeptidyl-peptidase-hemmer zur behandlung von diabetes
CN102908351B (zh) * 2005-09-14 2014-07-23 武田药品工业株式会社 用于治疗糖尿病的二肽基肽酶抑制剂
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
JP5122462B2 (ja) 2005-09-16 2013-01-16 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
TW200745080A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8460364B2 (en) * 2006-07-20 2013-06-11 Orbusneich Medical, Inc. Bioabsorbable polymeric medical device
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
PE20081150A1 (es) * 2006-09-13 2008-10-03 Takeda Pharmaceutical Inhibidores de dipetidilpeptidasa
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
CN104910128A (zh) * 2015-06-02 2015-09-16 安徽兴东化工有限公司 一种2,2-二甲基四氢噻唑的制备方法

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US2961377A (en) 1957-08-05 1960-11-22 Us Vitamin Pharm Corp Oral anti-diabetic compositions and methods
US3594377A (en) * 1967-11-07 1971-07-20 Uniroyal Inc Condensation products of n - (3 -thiazolidinylmethyl) - nitrogen base compounds
DE2009743A1 (de) 1970-03-03 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Substituierte Biguanide mit antihyperglykämischer Wirkung
US3960949A (en) 1971-04-02 1976-06-01 Schering Aktiengesellschaft 1,2-Biguanides
CH590857A5 (en) * 1973-05-30 1977-08-31 Givaudan & Cie Sa Substd. thiazolidine odourants flavourants - having a wide aroma spectrum and usable in small concns.
CH602612A5 (de) 1974-10-11 1978-07-31 Hoffmann La Roche
EP0054409B1 (de) * 1980-12-12 1985-09-18 Fine Organics Limited Verfahren zur Herstellung von Thiazolidin-Derivaten
US4935493A (en) 1987-10-06 1990-06-19 E. I. Du Pont De Nemours And Company Protease inhibitors
JPH01272570A (ja) * 1988-04-26 1989-10-31 Nippon Shokubai Kagaku Kogyo Co Ltd ４−メチル−５−［（２−アミノエチル）−チオメチル］−イミダゾールの製法
US5433955A (en) 1989-01-23 1995-07-18 Akzo N.V. Site specific in vivo activation of therapeutic drugs
JPH04334357A (ja) 1991-05-02 1992-11-20 Fujirebio Inc 酵素阻害作用を有するアシル誘導体
EP1050540B1 (de) 1991-10-22 2006-12-27 New England Medical Center Hospitals, Inc. Inhibitoren der Dipeptidyl-Aminopeptidase vom Typ IV
IL106998A0 (en) 1992-09-17 1993-12-28 Univ Florida Brain-enhanced delivery of neuroactive peptides by sequential metabolism
FR2696740B1 (fr) 1992-10-13 1994-12-30 Dospharma Sa Dérivés prodrogués de la diméthylbiguanide et applications comme médicaments.
WO1995011689A1 (en) 1993-10-29 1995-05-04 Trustees Of Tufts College Use of inhibitors of dipeptidyl-aminopeptidase to block entry of hiv into cells
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
US5543396A (en) 1994-04-28 1996-08-06 Georgia Tech Research Corp. Proline phosphonate derivatives
DE4427569A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Verfahren zur Herstellung von Cyanimino-1,3-thiazolidin
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5614379A (en) 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
WO1997045117A1 (en) 1996-05-29 1997-12-04 Prototek, Inc. Prodrugs of thalidomide and methods for using same as modulators of t-cell function
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
AR016751A1 (es) 1996-11-22 2001-08-01 Athena Neurosciences Inc Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo
AU4854999A (en) 1998-07-02 2000-01-24 Invitro Diagnostics, Inc. Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule
AU3960400A (en) 1999-03-05 2000-09-28 Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Use of metformin in the preparation of pharmaceutical compositions capable of inhibiting the enzyme dipeptidyl peptidase iv
EP1259246A2 (de) 2000-02-25 2002-11-27 Novo Nordisk A/S Verwendung von dpp-iv inhibitoren zur behandlung von diabetes

Also Published As

Publication number Publication date
RU2218336C2 (ru) 2003-12-10
CA2373834C (en) 2005-11-08
ATE261946T1 (de) 2004-04-15
JP3803292B2 (ja) 2006-08-02
PT1185520E (pt) 2004-08-31
CN1355795A (zh) 2002-06-26
CA2373834A1 (en) 2000-12-21
US20020082427A1 (en) 2002-06-27
DE19926233C1 (de) 2000-10-19
KR20020022688A (ko) 2002-03-27
EP1185520A1 (de) 2002-03-13
BR0011445A (pt) 2002-03-19
CN1169799C (zh) 2004-10-06
WO2000076986A1 (de) 2000-12-21
DK1185520T3 (da) 2004-06-28
KR100467898B1 (ko) 2005-02-21
HK1042483B (zh) 2004-09-10
ES2215045T3 (es) 2004-10-01
US6559314B2 (en) 2003-05-06
AU4399600A (en) 2001-01-02
HK1042483A1 (en) 2002-08-16
MXPA01012237A (es) 2002-08-12
NZ515561A (en) 2003-06-30
JP2003502319A (ja) 2003-01-21
EP1185520B1 (de) 2004-03-17
AU758605B2 (en) 2003-03-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PROSIDION LTD., OXFORD, GB

8328 Change in the person/name/address of the agent

Representative=s name: BOETERS & LIECK, 81541 MUENCHEN