BR0011445A - Processo para a produção de tiazolidina - Google Patents

Processo para a produção de tiazolidina

Info

Publication number
BR0011445A
BR0011445A BR0011445-6A BR0011445A BR0011445A BR 0011445 A BR0011445 A BR 0011445A BR 0011445 A BR0011445 A BR 0011445A BR 0011445 A BR0011445 A BR 0011445A
Authority
BR
Brazil
Prior art keywords
salts
production
thiazolidine
formula
relates
Prior art date
Application number
BR0011445-6A
Other languages
English (en)
Inventor
Hans-Ulrich Demuth
Susanne Kruber
Original Assignee
Probiodrug Ges Fuer Arzneim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiodrug Ges Fuer Arzneim filed Critical Probiodrug Ges Fuer Arzneim
Publication of BR0011445A publication Critical patent/BR0011445A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: "PROCESSO PARA A PRODUçãO DE TIAZOLIDINA". A invenção se refere a um processo simples para a produção de uma base de tiazolidina e os seus sais, que é tecnicamente fácil de executar. A invenção se refere, especificamente, a um processo para a produção de uma base de tiazolidina e os seus sais, que é caracterizado pelo fato de que hexametilenotetramina de fórmula (I) é reagida com cisteamina ou os seus sais de fórmula (II) em que X^ (-)^ representa um resíduo ácido, de preferência, um halogeneto ou um sulfato.
BR0011445-6A 1999-06-10 2000-04-11 Processo para a produção de tiazolidina BR0011445A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19926233A DE19926233C1 (de) 1999-06-10 1999-06-10 Verfahren zur Herstellung von Thiazolidin
PCT/EP2000/003213 WO2000076986A1 (de) 1999-06-10 2000-04-11 Verfahren zur herstellung von thiazolidin

Publications (1)

Publication Number Publication Date
BR0011445A true BR0011445A (pt) 2002-03-19

Family

ID=7910641

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011445-6A BR0011445A (pt) 1999-06-10 2000-04-11 Processo para a produção de tiazolidina

Country Status (18)

Country Link
US (1) US6559314B2 (pt)
EP (1) EP1185520B1 (pt)
JP (1) JP3803292B2 (pt)
KR (1) KR100467898B1 (pt)
CN (1) CN1169799C (pt)
AT (1) ATE261946T1 (pt)
AU (1) AU758605B2 (pt)
BR (1) BR0011445A (pt)
CA (1) CA2373834C (pt)
DE (2) DE19926233C1 (pt)
DK (1) DK1185520T3 (pt)
ES (1) ES2215045T3 (pt)
HK (1) HK1042483B (pt)
MX (1) MXPA01012237A (pt)
NZ (1) NZ515561A (pt)
PT (1) PT1185520E (pt)
RU (1) RU2218336C2 (pt)
WO (1) WO2000076986A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2304206A1 (en) * 1997-09-29 1999-04-08 Point Therapeutics, Inc. Stimulation of hematopoietic cells in vitro
US6979697B1 (en) * 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US20040242566A1 (en) * 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN1867560A (zh) 2003-08-13 2006-11-22 武田药品工株式会社 4－嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EP1699777B1 (en) 2003-09-08 2012-12-12 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN102127053A (zh) 2004-03-15 2011-07-20 武田药品工业株式会社 二肽基肽酶抑制剂
US7687638B2 (en) * 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
ATE553077T1 (de) * 2004-07-23 2012-04-15 Nuada Llc Peptidaseinhibitoren
US20060063719A1 (en) * 2004-09-21 2006-03-23 Point Therapeutics, Inc. Methods for treating diabetes
EP2805953B1 (en) 2004-12-21 2016-03-09 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US20070060529A1 (en) * 2005-09-14 2007-03-15 Christopher Ronald J Administration of dipeptidyl peptidase inhibitors
ES2445180T5 (es) * 2005-09-14 2022-02-01 Takeda Pharmaceuticals Co Administración de inhibidores de dipeptidil peptidasa
ME02005B (me) 2005-09-14 2012-08-31 Takeda Pharmaceuticals Co Inhibitori dipeptidil peptidaze za lečenje dijabetesa
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
CA2622642C (en) 2005-09-16 2013-12-31 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200745080A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7833260B2 (en) * 2006-07-20 2010-11-16 Orbusneich Medical, Inc. Bioabsorbable polymeric medical device
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
CA2663279C (en) * 2006-09-13 2016-05-17 Takeda Pharmaceutical Company Limited Use of 2-6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile for treating diabetes, cancer, autoimmune disorders and hiv infection
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
CN104910128A (zh) * 2015-06-02 2015-09-16 安徽兴东化工有限公司 一种2,2-二甲基四氢噻唑的制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2961377A (en) 1957-08-05 1960-11-22 Us Vitamin Pharm Corp Oral anti-diabetic compositions and methods
US3594377A (en) * 1967-11-07 1971-07-20 Uniroyal Inc Condensation products of n - (3 -thiazolidinylmethyl) - nitrogen base compounds
DE2009743A1 (de) 1970-03-03 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Substituierte Biguanide mit antihyperglykämischer Wirkung
US3960949A (en) 1971-04-02 1976-06-01 Schering Aktiengesellschaft 1,2-Biguanides
CH590857A5 (en) * 1973-05-30 1977-08-31 Givaudan & Cie Sa Substd. thiazolidine odourants flavourants - having a wide aroma spectrum and usable in small concns.
CH602612A5 (pt) 1974-10-11 1978-07-31 Hoffmann La Roche
DE3172383D1 (en) * 1980-12-12 1985-10-24 Fine Organics Ltd Preparation of thiazolidine derivatives
US4935493A (en) 1987-10-06 1990-06-19 E. I. Du Pont De Nemours And Company Protease inhibitors
JPH01272570A (ja) * 1988-04-26 1989-10-31 Nippon Shokubai Kagaku Kogyo Co Ltd ４−メチル−５−［（２−アミノエチル）−チオメチル］−イミダゾールの製法
US5433955A (en) 1989-01-23 1995-07-18 Akzo N.V. Site specific in vivo activation of therapeutic drugs
JPH04334357A (ja) 1991-05-02 1992-11-20 Fujirebio Inc 酵素阻害作用を有するアシル誘導体
DE69231674T2 (de) 1991-10-22 2001-08-09 New England Medical Center Inc Inhibitoren der dipeptidyl-aminopeptidase vom typ-iv
IL106998A0 (en) 1992-09-17 1993-12-28 Univ Florida Brain-enhanced delivery of neuroactive peptides by sequential metabolism
FR2696740B1 (fr) 1992-10-13 1994-12-30 Dospharma Sa Dérivés prodrogués de la diméthylbiguanide et applications comme médicaments.
WO1995011689A1 (en) 1993-10-29 1995-05-04 Trustees Of Tufts College Use of inhibitors of dipeptidyl-aminopeptidase to block entry of hiv into cells
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
US5543396A (en) 1994-04-28 1996-08-06 Georgia Tech Research Corp. Proline phosphonate derivatives
DE4427569A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Verfahren zur Herstellung von Cyanimino-1,3-thiazolidin
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5614379A (en) 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
CA2256669A1 (en) 1996-05-29 1997-12-04 Prototek, Inc. Prodrugs of thalidomide and methods for using same as modulators of t-cell function
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
AR016751A1 (es) 1996-11-22 2001-08-01 Athena Neurosciences Inc Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo
AU4854999A (en) 1998-07-02 2000-01-24 Invitro Diagnostics, Inc. Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule
WO2000053171A1 (en) 1999-03-05 2000-09-14 Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Use of metformin in the preparation of pharmaceutical compositions capable of inhibiting the enzyme dipeptidyl peptidase iv
WO2001062266A2 (en) 2000-02-25 2001-08-30 Novo Nordisk A/S Use of dpp-iv inhibitors for the treatment of diabetes

Also Published As

Publication number Publication date
DE50005699D1 (de) 2004-04-22
DK1185520T3 (da) 2004-06-28
JP3803292B2 (ja) 2006-08-02
CN1169799C (zh) 2004-10-06
AU758605B2 (en) 2003-03-27
US6559314B2 (en) 2003-05-06
PT1185520E (pt) 2004-08-31
CN1355795A (zh) 2002-06-26
MXPA01012237A (es) 2002-08-12
KR100467898B1 (ko) 2005-02-21
HK1042483B (zh) 2004-09-10
HK1042483A1 (en) 2002-08-16
DE19926233C1 (de) 2000-10-19
CA2373834A1 (en) 2000-12-21
US20020082427A1 (en) 2002-06-27
ATE261946T1 (de) 2004-04-15
ES2215045T3 (es) 2004-10-01
EP1185520A1 (de) 2002-03-13
EP1185520B1 (de) 2004-03-17
JP2003502319A (ja) 2003-01-21
NZ515561A (en) 2003-06-30
RU2218336C2 (ru) 2003-12-10
CA2373834C (en) 2005-11-08
AU4399600A (en) 2001-01-02
WO2000076986A1 (de) 2000-12-21
KR20020022688A (ko) 2002-03-27

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: PROSIDION LIMITED (GB)

Free format text: TRANSFERIDO DE: PROBIODRUG AG

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: PROBIODRUG AG (DE)

Free format text: REFERENTE A RPI 1902 DE19/06/2007, POR TER SIDO INDEVIDO.

B25A Requested transfer of rights approved

Owner name: PROSIDION LIMITED (GB)

Free format text: TRANSFERIDO DE: PROBIODRUG AG

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2156 DE 02/05/2012.