BR9808174B1 - processo de preparação de derivados de 2-tienil-etilamina. - Google Patents
processo de preparação de derivados de 2-tienil-etilamina.Info
- Publication number
- BR9808174B1 BR9808174B1 BRPI9808174-8A BR9808174A BR9808174B1 BR 9808174 B1 BR9808174 B1 BR 9808174B1 BR 9808174 A BR9808174 A BR 9808174A BR 9808174 B1 BR9808174 B1 BR 9808174B1
- Authority
- BR
- Brazil
- Prior art keywords
- pct
- general formula
- alkali metal
- metal atom
- date sep
- Prior art date
Links
- BYGZVEKTHREAGM-UHFFFAOYSA-N n-ethylthiophen-2-amine Chemical class CCNC1=CC=CS1 BYGZVEKTHREAGM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 3
- 150000001340 alkali metals Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- HVLUYXIJZLDNIS-UHFFFAOYSA-N 2-thiophen-2-ylethanamine Chemical class NCCC1=CC=CS1 HVLUYXIJZLDNIS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical group 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- -1 phenylglycine ester Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9702621A FR2760456B1 (fr) | 1997-03-05 | 1997-03-05 | Procede de preparation de derives de 2-thienyl-ethylamine |
PCT/FR1998/000441 WO1998039322A1 (fr) | 1997-03-05 | 1998-03-05 | Procede de preparation de derives de 2-thienylethylamine |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9808174A BR9808174A (pt) | 2000-05-16 |
BR9808174B1 true BR9808174B1 (pt) | 2010-06-29 |
Family
ID=9504438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9808174-8A BR9808174B1 (pt) | 1997-03-05 | 1998-03-05 | processo de preparação de derivados de 2-tienil-etilamina. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6080875A (pt) |
EP (1) | EP0971915B1 (pt) |
JP (1) | JP4283896B2 (pt) |
AT (1) | ATE240311T1 (pt) |
AU (1) | AU6839498A (pt) |
BR (1) | BR9808174B1 (pt) |
CA (1) | CA2283126C (pt) |
DE (1) | DE69814608T2 (pt) |
ES (1) | ES2200332T3 (pt) |
FR (1) | FR2760456B1 (pt) |
NO (1) | NO323613B1 (pt) |
WO (1) | WO1998039322A1 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495691B1 (en) | 2001-07-06 | 2002-12-17 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
US6800759B2 (en) | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
IL166593A0 (en) | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
AU2003216707A1 (en) * | 2003-03-10 | 2004-09-30 | Hetero Drugs Limited | Amorphous clopidogrel hydrogen sulfate |
US7872019B2 (en) | 2003-03-12 | 2011-01-18 | Cadila Healthcare Limited | Polymorphs and amorphous form of (S)-(+)-clopidogrel bisulfate |
KR101050105B1 (ko) | 2003-11-03 | 2011-07-19 | 카딜라 핼쓰캐어 리미티드 | (s)-(+)-클로피도그렐 비설페이트의 상이한 형태의 제조방법 |
WO2006003671A1 (en) * | 2004-07-02 | 2006-01-12 | Srinivasa Reddy Battula | A process for resolution of methylamino(2-chlorophenyl)acetate |
KR20070052780A (ko) * | 2004-09-21 | 2007-05-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | 결정질 클로피도그렐 브롬산염 및 이의 제조 방법 |
JP2008526896A (ja) * | 2005-02-24 | 2008-07-24 | テバ ファーマシューティカル インダストリーズ リミティド | 医薬製剤に適したグロピドグレル塩基及びその調製 |
US20090247569A1 (en) * | 2006-08-03 | 2009-10-01 | Claude Singer | Process for Preparing Clopidogrel Bisulphate |
EP1980563A1 (en) | 2007-04-09 | 2008-10-15 | BATTULA, Srinivasa Reddy | Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate |
EP2084164A2 (en) * | 2007-04-18 | 2009-08-05 | Teva Pharmaceutical Industries Ltd. | Improved process for preparing clopidogrel |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
US20090264460A1 (en) * | 2008-04-21 | 2009-10-22 | Mamta Mishra | Clopidogrel pharmaceutical formulations |
KR100990949B1 (ko) * | 2008-06-09 | 2010-10-29 | 엔자이텍 주식회사 | 클로피도그렐 및 그의 유도체의 제조방법 |
CN102186858A (zh) * | 2008-10-24 | 2011-09-14 | 桑多斯股份公司 | 制备s-氯吡格雷的方法 |
US8563690B2 (en) * | 2008-11-03 | 2013-10-22 | The Board Of Trustees Of The University Of Illinois | Modulation of platelet aggregation |
WO2012123958A1 (en) | 2011-02-14 | 2012-09-20 | Cadila Healthcare Limited | Highly pure salts of clopidogrel free of genotoxic impurities |
CN103172527A (zh) * | 2011-12-26 | 2013-06-26 | 湖北德洲科技发展有限公司 | 一种制备氯吡格雷合成中间体-邻氯苯甘氨酸甲酯的方法 |
BR112015000942A2 (pt) * | 2012-07-17 | 2017-06-27 | Sanofi Sa | uso de inibidores de vegfr-3 para tratamento de carcinoma hepatocelular |
CN106748853B (zh) * | 2016-11-25 | 2018-12-28 | 河南普瑞医药科技有限公司 | 一种(s)-邻氯苯甘氨酸甲酯盐酸盐的制备方法 |
CN115784914B (zh) * | 2022-12-20 | 2023-05-12 | 石家庄中硕科技有限公司 | 一种邻氯苯甘氨酸的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989006169A1 (en) * | 1986-04-24 | 1989-07-13 | Nauchno-Proizvodstvennoe Obiedinenie Po Mekhanizat | Vertical centrifugal casting machine |
FR2624860B1 (fr) * | 1987-12-18 | 1990-06-01 | Sanofi Sa | Procede de preparation de la n-(chloro-2 benzyl) (thienyl-2)-2 ethylamine |
ZA896260B (en) * | 1988-08-22 | 1990-05-30 | Merrell Dow Pharma | Phenylalkylthiophenes and related compounds |
FR2664276B1 (fr) * | 1990-07-04 | 1992-10-23 | Sanofi Sa | Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese. |
FR2664596B1 (fr) * | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
-
1997
- 1997-03-05 FR FR9702621A patent/FR2760456B1/fr not_active Expired - Fee Related
-
1998
- 1998-03-05 BR BRPI9808174-8A patent/BR9808174B1/pt not_active IP Right Cessation
- 1998-03-05 US US09/380,450 patent/US6080875A/en not_active Expired - Lifetime
- 1998-03-05 CA CA002283126A patent/CA2283126C/fr not_active Expired - Fee Related
- 1998-03-05 AT AT98913841T patent/ATE240311T1/de not_active IP Right Cessation
- 1998-03-05 EP EP98913841A patent/EP0971915B1/fr not_active Expired - Lifetime
- 1998-03-05 JP JP53824098A patent/JP4283896B2/ja not_active Expired - Fee Related
- 1998-03-05 ES ES98913841T patent/ES2200332T3/es not_active Expired - Lifetime
- 1998-03-05 WO PCT/FR1998/000441 patent/WO1998039322A1/fr active IP Right Grant
- 1998-03-05 DE DE69814608T patent/DE69814608T2/de not_active Expired - Lifetime
- 1998-03-05 AU AU68394/98A patent/AU6839498A/en not_active Abandoned
-
1999
- 1999-09-03 NO NO19994304A patent/NO323613B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2283126A1 (fr) | 1998-09-11 |
ES2200332T3 (es) | 2004-03-01 |
DE69814608D1 (de) | 2003-06-18 |
WO1998039322A1 (fr) | 1998-09-11 |
FR2760456B1 (fr) | 2000-05-12 |
CA2283126C (fr) | 2008-09-02 |
US6080875A (en) | 2000-06-27 |
EP0971915B1 (fr) | 2003-05-14 |
FR2760456A1 (fr) | 1998-09-11 |
JP4283896B2 (ja) | 2009-06-24 |
EP0971915A1 (fr) | 2000-01-19 |
ATE240311T1 (de) | 2003-05-15 |
AU6839498A (en) | 1998-09-22 |
NO994304L (no) | 1999-11-03 |
JP2001513806A (ja) | 2001-09-04 |
NO323613B1 (no) | 2007-06-18 |
BR9808174A (pt) | 2000-05-16 |
NO994304D0 (no) | 1999-09-03 |
DE69814608T2 (de) | 2004-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS (FR) Free format text: ALTERADO DE: SANOFI-SYNTHELABO |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT. CL: C07D 333/20; B01J 31/14. Ipc: C07D 333/20 (2008.04), B01J 31/14 (2008.04) |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/06/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2307 DE 24-03-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |