ATE229013T1 - Verfahren zur herstellung von hydroxysubstituierten gamma-butyrolactonen - Google Patents
Verfahren zur herstellung von hydroxysubstituierten gamma-butyrolactonenInfo
- Publication number
- ATE229013T1 ATE229013T1 AT98948584T AT98948584T ATE229013T1 AT E229013 T1 ATE229013 T1 AT E229013T1 AT 98948584 T AT98948584 T AT 98948584T AT 98948584 T AT98948584 T AT 98948584T AT E229013 T1 ATE229013 T1 AT E229013T1
- Authority
- AT
- Austria
- Prior art keywords
- butyrolactones
- preparation
- substituted gamma
- producing hydroxy
- methyl ester
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- ARXKVVRQIIOZGF-UHFFFAOYSA-N 1,2,4-butanetriol Chemical compound OCCC(O)CO ARXKVVRQIIOZGF-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical class O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 abstract 1
- FUDDLSHBRSNCBV-UHFFFAOYSA-N 4-hydroxyoxolan-2-one Chemical compound OC1COC(=O)C1 FUDDLSHBRSNCBV-UHFFFAOYSA-N 0.000 abstract 1
- NSISJFFVIMQBRN-UHFFFAOYSA-N 5-(hydroxymethyl)oxolan-2-one Chemical compound OCC1CCC(=O)O1 NSISJFFVIMQBRN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 229930188620 butyrolactone Natural products 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- DKRLDWPGYHOBCX-UHFFFAOYSA-N methyl 4,5-dihydroxypentanoate Chemical compound COC(=O)CCC(O)CO DKRLDWPGYHOBCX-UHFFFAOYSA-N 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D315/00—Heterocyclic compounds containing rings having one oxygen atom as the only ring hetero atom according to more than one of groups C07D303/00 - C07D313/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/962,365 US5808107A (en) | 1997-10-31 | 1997-10-31 | Process for the preparation of hydroxy substituted gamma butyrolactones |
| PCT/US1998/020448 WO1999023086A1 (en) | 1997-10-31 | 1998-09-29 | Process for the preparation of hydroxy substituted gamma butyrolactones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229013T1 true ATE229013T1 (de) | 2002-12-15 |
Family
ID=25505755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98948584T ATE229013T1 (de) | 1997-10-31 | 1998-09-29 | Verfahren zur herstellung von hydroxysubstituierten gamma-butyrolactonen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5808107A (de) |
| EP (1) | EP1027343B2 (de) |
| JP (1) | JP3527706B2 (de) |
| KR (1) | KR100369857B1 (de) |
| AT (1) | ATE229013T1 (de) |
| CA (1) | CA2304809C (de) |
| DE (1) | DE69809962T3 (de) |
| DK (1) | DK1027343T3 (de) |
| ES (1) | ES2188017T5 (de) |
| PT (1) | PT1027343E (de) |
| WO (1) | WO1999023086A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618099D0 (en) | 1996-08-30 | 1996-10-09 | Zeneca Ltd | Process |
| IT1297120B1 (it) * | 1997-12-16 | 1999-08-03 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina |
| CA2322480A1 (en) * | 1998-03-03 | 1999-09-10 | Daiso Co., Ltd. | Process for producing 1,2,4-butanetriol |
| US6949684B2 (en) | 1998-03-03 | 2005-09-27 | Daiso Co., Ltd. | Process for preparing 1,2,4-butanetriol |
| US6084131A (en) * | 1998-06-01 | 2000-07-04 | Board Of Trustees Operating Michigan State University | Process for the preparation of protected dihydroxypropyl trialkylammonium salts and derivatives thereof |
| US6040464A (en) * | 1998-06-01 | 2000-03-21 | Board Of Trustees Operating Michigan State University | Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof |
| US6288272B1 (en) * | 1998-07-24 | 2001-09-11 | Samsung Fine Chemicals Co., Ltd. | Continuous process for preparing optically pure (s)-3,4-dihydroxybutyric acid derivatives |
| US6713290B2 (en) * | 1998-07-24 | 2004-03-30 | Samsung Fine Chemicals Co., Ltd. | Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone |
| US6423850B1 (en) * | 1999-06-18 | 2002-07-23 | E.I. Du Pont De Nemours And Company | Preparation and use of gamma-butyrolactones as cross-linking agents |
| KR100645665B1 (ko) | 2000-07-27 | 2006-11-13 | 에스케이 주식회사 | (s)-베타-하이드록시-감마-부티로락톤의 연속 제조방법 |
| US6288238B1 (en) | 2000-09-19 | 2001-09-11 | Board Of Trustees Operating Michigan State University | Process for the preparation of 5-hydroxymethyl 2-oxazolidinone and novel intermediate |
| US6288239B1 (en) | 2000-09-19 | 2001-09-11 | Board Of Trustees Operating Michigan State University | 5-trityloxymethyl-oxazolidinones and process for the preparation thereof |
| JP4824874B2 (ja) * | 2001-07-19 | 2011-11-30 | 高砂香料工業株式会社 | 光学活性γ−ブチロラクトンの製造方法 |
| EP1398312A1 (de) * | 2002-09-13 | 2004-03-17 | Hong-Sun Uh | Beta-substituierte gamma-Butyrolactone und Verfahren ihrer Herstellung |
| WO2004026223A2 (en) * | 2002-09-18 | 2004-04-01 | Sk Corporation | CONTINUOUS PROCESS FOR THE PRODUCTION OF OPTICALLY PURE (S)-β HYDROXY-Ϝ-BUTYROLACTONE |
| WO2005068642A2 (en) | 2003-10-01 | 2005-07-28 | Board Of Trustees Operating Michigan State University | Bacterial synthesis of 1,2,4-butanetriol enantiomers |
| CN100335457C (zh) * | 2005-09-08 | 2007-09-05 | 上海交通大学 | 3-位手性羟基被保护的3,4-二羟基丁酸酯及其制备方法 |
| KR20070090833A (ko) * | 2006-03-02 | 2007-09-06 | 주식회사 엘지화학 | 가수분해효소를 이용한 s-hgb의 제조방법 |
| US20110165641A1 (en) * | 2006-03-31 | 2011-07-07 | The Board Of Trustees Of Michigan State University | Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates |
| US20110076730A1 (en) * | 2006-07-19 | 2011-03-31 | Board Of Trustees Of Michigan State University | Microbial synthesis of d-1,2,4-butanetriol |
| CN100441573C (zh) * | 2006-07-20 | 2008-12-10 | 厦门大学 | 一种合成s-(3)-羟基四氢呋喃的方法 |
| CN102439133B (zh) * | 2009-03-06 | 2015-02-25 | 麻省理工学院 | 由葡萄糖和乙醇酸进行3-羟基酸的微生物生产 |
| US8669379B2 (en) | 2011-02-25 | 2014-03-11 | Massachusetts Institute Of Technology | Microbial production of 3,4-dihydroxybutyrate (3,4-DHBA), 2,3-dihydroxybutyrate (2,3-DHBA) and 3-hydroxybutyrolactone (3-HBL) |
| KR102377433B1 (ko) * | 2016-03-15 | 2022-03-23 | 시오노기 앤드 컴파니, 리미티드 | 페녹시에탄올 유도체의 제조 방법 |
| CA3086153A1 (en) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release |
| WO2019126215A1 (en) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system |
| US12514818B2 (en) | 2017-12-18 | 2026-01-06 | Tris Pharma, Inc. | Pharmaceutical compositions comprising a floating interpenetrating polymer network forming system |
| US11337920B2 (en) | 2017-12-18 | 2022-05-24 | Tris Pharma, Inc. | Pharmaceutical composition comprising GHB gastro-retentive raft forming systems having trigger pulse drug release |
| FR3088324B1 (fr) * | 2018-11-08 | 2020-10-09 | Inst Des Sciences Et Industries Du Vivant Et De Lenvironnement Agroparistech | Procede biocatalytique de production de 2h-hbo a partir de lgo utilisant une cyclohexanone monooxygenase |
| CN112939901B (zh) * | 2021-02-09 | 2023-05-09 | 中国科学院福建物质结构研究所 | 一种α-羟基-γ-丁内酯的制备方法 |
| EP4658242A1 (de) | 2023-02-03 | 2025-12-10 | Tris Pharma, Inc. | Natriumarmes oxybat zur einmaligen nacht |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3024250A (en) * | 1962-03-06 | Certificate of correction | ||
| US2683721A (en) * | 1952-01-17 | 1954-07-13 | Hermann I Schlesinger | Method of reducing and hydrogenating chemical compounds by reacting with alkali metal borohydrides |
| US3997569A (en) * | 1972-11-08 | 1976-12-14 | Texaco Inc. | Method for preparing a lactone reaction product |
| US3868370A (en) * | 1973-02-09 | 1975-02-25 | Gen Electric | Process for making 4-butyrolactone |
| US4083809A (en) * | 1976-08-20 | 1978-04-11 | Gaf Corporation | Hydrogenation catalyst and method of producing same |
| GB1587198A (en) * | 1976-11-23 | 1981-04-01 | Ucb Sa | Process for the production of butane-1,4 diol and tetrahydrofuran |
| US4772729A (en) * | 1987-01-23 | 1988-09-20 | E. I. Du Pont De Nemours And Company | Hydrogenation of citric acid and substituted citric acids to 3-substituted tetrahydrofuran, 3- and 4-substituted butyrolactones and mixtures thereof |
| EP0304696B1 (de) * | 1987-08-08 | 1992-04-29 | BASF Aktiengesellschaft | Verfahren zur Herstellung von 1,4-Butandiol und/oder Tetrahydrofuran |
| CA1307796C (en) * | 1988-04-27 | 1992-09-22 | Kenji Inoue | Method for preparing optically active 3,4-dihydroxy butyric acid derivatives |
| US5087751A (en) * | 1988-04-27 | 1992-02-11 | Kanegafuchi Kagaku Kogyo K.K. | Method of preparing optically active 3,4-dihydroxy butyric acid derivatives |
| CA2049536C (en) * | 1991-05-13 | 1999-07-06 | Rawle I. Hollingsworth | Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof |
| EP0543340B1 (de) * | 1991-11-18 | 1998-05-20 | Tosoh Corporation | Verfahren zur Herstellung von Lactonen |
| GB9618099D0 (en) † | 1996-08-30 | 1996-10-09 | Zeneca Ltd | Process |
-
1997
- 1997-10-31 US US08/962,365 patent/US5808107A/en not_active Ceased
-
1998
- 1998-09-29 DK DK98948584T patent/DK1027343T3/da active
- 1998-09-29 ES ES98948584T patent/ES2188017T5/es not_active Expired - Lifetime
- 1998-09-29 WO PCT/US1998/020448 patent/WO1999023086A1/en not_active Ceased
- 1998-09-29 EP EP98948584A patent/EP1027343B2/de not_active Expired - Lifetime
- 1998-09-29 KR KR10-2000-7004510A patent/KR100369857B1/ko not_active Expired - Fee Related
- 1998-09-29 CA CA002304809A patent/CA2304809C/en not_active Expired - Fee Related
- 1998-09-29 AT AT98948584T patent/ATE229013T1/de not_active IP Right Cessation
- 1998-09-29 JP JP2000518957A patent/JP3527706B2/ja not_active Expired - Fee Related
- 1998-09-29 PT PT98948584T patent/PT1027343E/pt unknown
- 1998-09-29 DE DE69809962T patent/DE69809962T3/de not_active Expired - Fee Related
-
2002
- 2002-03-28 US US10/109,487 patent/USRE38324E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69809962T3 (de) | 2006-12-14 |
| ES2188017T5 (es) | 2006-07-16 |
| USRE38324E1 (en) | 2003-11-18 |
| KR100369857B1 (ko) | 2003-02-05 |
| ES2188017T3 (es) | 2003-06-16 |
| DE69809962T2 (de) | 2003-04-24 |
| CA2304809C (en) | 2006-08-01 |
| EP1027343B2 (de) | 2006-01-11 |
| WO1999023086A1 (en) | 1999-05-14 |
| JP2001521931A (ja) | 2001-11-13 |
| CA2304809A1 (en) | 1999-05-14 |
| EP1027343B1 (de) | 2002-12-04 |
| US5808107A (en) | 1998-09-15 |
| PT1027343E (pt) | 2003-04-30 |
| JP3527706B2 (ja) | 2004-05-17 |
| EP1027343A4 (de) | 2001-08-22 |
| EP1027343A1 (de) | 2000-08-16 |
| DE69809962D1 (de) | 2003-01-16 |
| DK1027343T3 (da) | 2003-03-31 |
| KR20010031475A (ko) | 2001-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1027343 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |