ATE358723T1 - Nukleinsäuresequenzen für proteine die an der isoprenoid-synthese beteiligt sind - Google Patents
Nukleinsäuresequenzen für proteine die an der isoprenoid-synthese beteiligt sindInfo
- Publication number
- ATE358723T1 ATE358723T1 AT00923461T AT00923461T ATE358723T1 AT E358723 T1 ATE358723 T1 AT E358723T1 AT 00923461 T AT00923461 T AT 00923461T AT 00923461 T AT00923461 T AT 00923461T AT E358723 T1 ATE358723 T1 AT E358723T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- acid sequences
- proteins involved
- isoprenoid
- isoprenoid synthesis
- Prior art date
Links
- 150000003505 terpenes Chemical class 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/001—Refining fats or fatty oils by a combination of two or more of the means hereafter
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/12—Refining fats or fatty oils by distillation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Nutrition Science (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12989999P | 1999-04-15 | 1999-04-15 | |
| US14646199P | 1999-07-30 | 1999-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE358723T1 true ATE358723T1 (de) | 2007-04-15 |
Family
ID=26828010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00923461T ATE358723T1 (de) | 1999-04-15 | 2000-04-14 | Nukleinsäuresequenzen für proteine die an der isoprenoid-synthese beteiligt sind |
| AT00922287T ATE316578T1 (de) | 1999-04-15 | 2000-04-14 | Nukleinsäuresequenzen für proteine, die an der tocopherolbiosynthese beteiligt sind |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00922287T ATE316578T1 (de) | 1999-04-15 | 2000-04-14 | Nukleinsäuresequenzen für proteine, die an der tocopherolbiosynthese beteiligt sind |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US6541259B1 (de) |
| EP (2) | EP1171610B1 (de) |
| JP (2) | JP2002541851A (de) |
| CN (2) | CN1318593C (de) |
| AT (2) | ATE358723T1 (de) |
| AU (3) | AU776316B2 (de) |
| BR (2) | BR0010616A (de) |
| CA (2) | CA2370616C (de) |
| DE (2) | DE60034224T2 (de) |
| DK (1) | DK1190068T3 (de) |
| ES (1) | ES2253220T3 (de) |
| MX (2) | MXPA01010486A (de) |
| PT (1) | PT1190068E (de) |
| WO (2) | WO2000063389A1 (de) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01010486A (es) | 1999-04-15 | 2002-03-27 | Calgene Llc | Secuencias de acido nucleico para proteinas implicadas en la sintesis de tocoferol. |
| US6787683B1 (en) | 1999-05-07 | 2004-09-07 | Pioneer Hi-Bred International, Inc. | Phytyl/prenyltransferase nucleic acids, polypeptides and uses thereof |
| AU6826900A (en) * | 1999-07-30 | 2001-02-19 | Bayer Aktiengesellschaft | Method of determining the activity of 1-deoxy-d-xylulose-5-phosphate reductoisomerase and 1-deoxy-d-xylulose-5-phosphate synthase |
| DE10009002A1 (de) * | 2000-02-25 | 2001-08-30 | Sungene Gmbh & Co Kgaa | Homogentisatphytyltransferase |
| US6872815B1 (en) | 2000-10-14 | 2005-03-29 | Calgene Llc | Nucleic acid sequences to proteins involved in tocopherol synthesis |
| CA2405560C (en) * | 2000-04-14 | 2014-06-17 | Calgene Llc | Nucleic acid sequences to proteins involved in tocopherol synthesis |
| AU9052201A (en) | 2000-08-07 | 2002-02-18 | Monsanto Technology Llc | Methyl-d-erythritol phosphate pathway genes |
| US6660507B2 (en) * | 2000-09-01 | 2003-12-09 | E. I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| EP1360309A2 (de) * | 2000-10-14 | 2003-11-12 | Calgene LLC | Nukleinsäuresequenzen für proteine, die an der tocopherolbiosynthese beteiligt sind |
| DE10111676A1 (de) | 2001-03-09 | 2002-09-12 | Sungene Gmbh & Co Kgaa | Erhöhung des Vitamin-E-Gehalts in Organismen durch Erhöhung der Tyrosinaminotransferase-Aktivität |
| CA2443865C (en) | 2001-05-09 | 2012-02-07 | Monsanto Technology Llc | Tyra genes and uses thereof |
| US7161061B2 (en) | 2001-05-09 | 2007-01-09 | Monsanto Technology Llc | Metabolite transporters |
| WO2003016482A2 (en) | 2001-08-17 | 2003-02-27 | Monsanto Technology Llc | Methyltransferase genes and uses thereof |
| BRPI0212339B1 (pt) * | 2001-09-05 | 2018-09-11 | Monsanto Technology Llc | método de transformação de uma planta, molécula de ácido nucleico recombinante, vetor e célula |
| ATE456657T1 (de) * | 2001-10-25 | 2010-02-15 | Monsanto Technology Llc | Aromatische methyltransferasen und ihre verwendung |
| ITMI20020147A1 (it) * | 2002-01-29 | 2003-07-29 | Indena Spa | Estrazione purificazione e modificazione di polipeptidi da seme di soia |
| US7112717B2 (en) | 2002-03-19 | 2006-09-26 | Monsanto Technology Llc | Homogentisate prenyl transferase gene (HPT2) from arabidopsis and uses thereof |
| US7230165B2 (en) * | 2002-08-05 | 2007-06-12 | Monsanto Technology Llc | Tocopherol biosynthesis related genes and uses thereof |
| US20040266862A1 (en) * | 2003-06-25 | 2004-12-30 | Wolf Fred R. | Method of improving animal tissue quality by supplementing the animal diet with mixed tocotrienols |
| US7150182B2 (en) * | 2003-10-31 | 2006-12-19 | Chevron Oronite Company, Llc | High throughput screening methods for lubricating oil compositions |
| ATE516295T1 (de) | 2004-01-20 | 2011-07-15 | Monsanto Technology Llc | Chimäre promotoren zur verwendung in pflanzen |
| CA2598792A1 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| EP2371964A1 (de) | 2006-05-16 | 2011-10-05 | Monsanto Technology LLC | Verwendung einer nichtagrobakteriellen Spezies zur Pflanzenumwandlung |
| US7838729B2 (en) | 2007-02-26 | 2010-11-23 | Monsanto Technology Llc | Chloroplast transit peptides for efficient targeting of DMO and uses thereof |
| CN105219694A (zh) | 2007-03-09 | 2016-01-06 | 孟山都技术公司 | 用于转化的植物胚外植体的制备和用途 |
| KR100901116B1 (ko) | 2007-05-28 | 2009-06-08 | 재단법인서울대학교산학협력재단 | 토코페롤 함량이 증가한 형질전환 상추 |
| CN103333894B (zh) | 2008-04-07 | 2016-11-23 | 孟山都技术公司 | 植物调控元件及其应用 |
| EP2163306A1 (de) * | 2008-09-12 | 2010-03-17 | F. Hoffmann-la Roche AG | Multiwellplatte mit maßgeschneiderten Kammern |
| US20120277117A1 (en) | 2009-02-27 | 2012-11-01 | Adel Zayed | Hydroponic apparatus and methods of use |
| EP2524045B1 (de) | 2010-01-14 | 2015-12-02 | Monsanto Technology LLC | Pflanzenregulierungselemente und verwendungen davon |
| MY185668A (en) | 2010-06-02 | 2021-05-28 | Evolva Inc | Recombinant production of steviol glycosides |
| RS57012B1 (sr) | 2010-08-30 | 2018-05-31 | Dow Agrosciences Llc | Pospešivač bakterijskog virusa šećerne repe (scbv) i njegova upotreba u funkcionalnoj genomici biljke |
| WO2012083137A1 (en) | 2010-12-17 | 2012-06-21 | Monsanto Technology Llc | Methods for improving competency of plant cells |
| MX356792B (es) | 2011-03-25 | 2018-06-12 | Monsanto Technology Llc | Elementos de regulacion de plantas y sus usos. |
| EA031636B1 (ru) | 2011-05-13 | 2019-01-31 | Монсанто Текнолоджи Ллс | Регуляторные элементы растений и их применение |
| KR102114493B1 (ko) | 2011-08-08 | 2020-05-26 | 에볼바 에스아 | 스테비올 글리코시드의 재조합 생산 |
| KR101815063B1 (ko) | 2011-08-08 | 2018-01-05 | 에볼바 에스아 | 사프란 화합물의 재조합 생성을 위한 방법 및 물질 |
| CN104411827B (zh) | 2012-02-29 | 2018-01-02 | 陶氏益农公司 | 甘蔗杆状病毒(scbv)增强子及其在植物功能基因组学中的用途 |
| US9663793B2 (en) | 2012-04-20 | 2017-05-30 | Monsanto Technology, Llc | Plant regulatory elements and uses thereof |
| KR102273360B1 (ko) | 2012-12-19 | 2021-07-06 | 몬산토 테크놀로지 엘엘씨 | 식물 조절 요소 및 그의 용도 |
| WO2014101153A1 (zh) * | 2012-12-31 | 2014-07-03 | 创世纪转基因技术有限公司 | 一种棉花异戊烯基转移酶ipt2及其编码基因与应用 |
| CN105051195B (zh) | 2013-02-06 | 2019-09-06 | 埃沃尔瓦公司 | 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法 |
| CN105189771B (zh) | 2013-02-11 | 2019-11-05 | 埃沃尔瓦公司 | 在重组宿主中有效产生甜菊醇糖苷 |
| JP2016514964A (ja) | 2013-03-14 | 2016-05-26 | モンサント テクノロジー エルエルシー | 植物調節エレメントおよびその使用 |
| EP3179869A1 (de) | 2014-08-11 | 2017-06-21 | Evolva SA | Erzeugung von steviolglycosiden in rekombinanten wirten |
| JP2017528134A (ja) | 2014-09-09 | 2017-09-28 | エヴォルヴァ エスアー.Evolva Sa. | 組み換え宿主におけるステビオールグリコシドの生産 |
| EP3250686A1 (de) | 2015-01-30 | 2017-12-06 | Evolva SA | Erzeugung von steviolglycosiden in rekombinanten wirten |
| JP6719174B2 (ja) * | 2015-02-23 | 2020-07-08 | 住友ゴム工業株式会社 | 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法 |
| JP6557990B2 (ja) * | 2015-02-23 | 2019-08-14 | 住友ゴム工業株式会社 | 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法 |
| JP6641702B2 (ja) * | 2015-02-23 | 2020-02-05 | 住友ゴム工業株式会社 | 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法 |
| JP6557989B2 (ja) * | 2015-02-23 | 2019-08-14 | 住友ゴム工業株式会社 | 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法 |
| CN115851470B (zh) | 2015-03-16 | 2025-09-02 | 帝斯曼知识产权资产管理有限公司 | Udp-糖基转移酶 |
| US11519011B2 (en) | 2015-03-26 | 2022-12-06 | The Texas A&M University System | Conversion of lignin into bioplastics and lipid fuels |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US11236347B2 (en) | 2015-08-28 | 2022-02-01 | Pioneer Hi-Bred International, Inc. | Ochrobactrum-mediated transformation of plants |
| US11732269B2 (en) | 2015-10-02 | 2023-08-22 | Monsanto Technology Llc | Recombinant maize B chromosome sequence and uses thereof |
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| SG11201808721YA (en) * | 2016-04-06 | 2018-11-29 | Greenlight Biosciences Inc | Cell-free production of ribonucleic acid |
| MY198001A (en) | 2016-04-13 | 2023-07-25 | Evolva SA | Production of steviol glycoside in recombinant hosts |
| US10815514B2 (en) | 2016-05-16 | 2020-10-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
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| CA3029271A1 (en) | 2016-06-28 | 2018-01-04 | Cellectis | Altering expression of gene products in plants through targeted insertion of nucleic acid sequences |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
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| CN108913672B (zh) * | 2018-07-26 | 2021-10-01 | 中国海洋大学 | 一种新型异戊烯转移酶及其应用 |
| BR112021003899A2 (pt) | 2019-01-10 | 2021-08-03 | Monsanto Technology Llc | elementos reguladores de plantas e seus usos |
| CA3130763A1 (en) | 2019-02-25 | 2020-09-03 | Ginkgo Bioworks, Inc. | Biosynthesis of cannabinoids and cannabinoid precursors |
| CN120718905A (zh) | 2019-05-29 | 2025-09-30 | 孟山都技术公司 | 使用基因组编辑产生显性等位基因的方法和组合物 |
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