ATE283849T1 - Verfahren zur herstellung eines simvastatin precursors - Google Patents
Verfahren zur herstellung eines simvastatin precursorsInfo
- Publication number
- ATE283849T1 ATE283849T1 AT99959738T AT99959738T ATE283849T1 AT E283849 T1 ATE283849 T1 AT E283849T1 AT 99959738 T AT99959738 T AT 99959738T AT 99959738 T AT99959738 T AT 99959738T AT E283849 T1 ATE283849 T1 AT E283849T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- simvastatin
- simvastatin precursor
- precursor
- lactonization
- Prior art date
Links
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 title abstract 3
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 title abstract 3
- 229960002855 simvastatin Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000020176 deacylation Effects 0.000 abstract 1
- 238000005947 deacylation reaction Methods 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
- 238000007273 lactonization reaction Methods 0.000 abstract 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 1
- 229960004844 lovastatin Drugs 0.000 abstract 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003333 secondary alcohols Chemical class 0.000 abstract 1
- 150000003509 tertiary alcohols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35186598 | 1998-12-10 | ||
| PCT/JP1999/006929 WO2000034264A1 (en) | 1998-12-10 | 1999-12-10 | Process for producing simvastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE283849T1 true ATE283849T1 (de) | 2004-12-15 |
Family
ID=18420148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99959738T ATE283849T1 (de) | 1998-12-10 | 1999-12-10 | Verfahren zur herstellung eines simvastatin precursors |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6331641B1 (enExample) |
| EP (2) | EP1055671B1 (enExample) |
| JP (2) | JP4440476B2 (enExample) |
| KR (1) | KR100672269B1 (enExample) |
| CN (2) | CN1122029C (enExample) |
| AT (1) | ATE283849T1 (enExample) |
| AU (1) | AU1683000A (enExample) |
| CA (1) | CA2320163C (enExample) |
| CZ (2) | CZ299522B6 (enExample) |
| DE (1) | DE69922348T2 (enExample) |
| ES (1) | ES2234323T3 (enExample) |
| HU (1) | HUP0103021A3 (enExample) |
| SI (1) | SI20327B (enExample) |
| WO (1) | WO2000034264A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2127500A (en) | 1999-11-11 | 2001-06-06 | Biocon India Limited | Process for manufacturing simvastatin and the novel intermediates |
| US6573385B1 (en) | 1999-11-11 | 2003-06-03 | Biocon India Limited | Process for manufacturing simvastatin and novel intermediates thereof |
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| KR100361833B1 (ko) * | 2000-06-20 | 2002-11-22 | 주식회사 엘지생명과학 | 심바스타틴의 제조방법 |
| NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| IL159741A0 (en) * | 2001-07-13 | 2004-06-20 | Astrazeneca Uk Ltd | Preparation of aminopyrimidine compounds |
| KR100435142B1 (ko) * | 2002-01-09 | 2004-06-09 | 한미약품 주식회사 | 개선된 심바스타틴의 제조방법 |
| KR100502834B1 (ko) * | 2002-03-25 | 2005-07-20 | 보령제약 주식회사 | 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법 |
| KR100502833B1 (ko) * | 2002-03-25 | 2005-07-25 | 보령제약 주식회사 | 심바스타틴 및 이의 중간체 화합물들의 개선된 제조방법 |
| US6603022B1 (en) | 2002-05-10 | 2003-08-05 | Biocon India Limited | Process for manufacturing Simvastatin and novel intermediates thereof |
| EP1375493A1 (en) * | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| US7700329B2 (en) * | 2003-10-21 | 2010-04-20 | Brian Morgan | Methods for making simvastatin and intermediates |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| AU2003289546A1 (en) * | 2003-12-16 | 2005-07-05 | Uk Chemipharm Co., Ltd. | Process for preparing simvastatin. |
| CN1754870A (zh) * | 2004-09-30 | 2006-04-05 | 淮北市辉克药业有限公司 | 辛伐他汀的制备方法 |
| GB0428328D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
| US20110059493A1 (en) * | 2007-08-27 | 2011-03-10 | Brian Morgan | Methods for Making Simvastatin and Intermediates |
| JP2009114121A (ja) * | 2007-11-06 | 2009-05-28 | Kaneka Corp | シンバスタチンの製造方法 |
| CN101575328B (zh) * | 2008-05-09 | 2012-07-04 | 上海医药工业研究院 | 一种辛伐他汀中间体的合成方法 |
| CN102690254B (zh) * | 2008-05-09 | 2014-06-04 | 上海医药工业研究院 | 辛伐他汀铵盐中间体及其制备方法 |
| CN110563680A (zh) * | 2019-09-10 | 2019-12-13 | 山东罗欣药业集团恒欣药业有限公司 | 一种治疗高脂血症药物的制备方法 |
| CN110483459A (zh) * | 2019-09-10 | 2019-11-22 | 山东罗欣药业集团恒欣药业有限公司 | 一种辛伐他汀的合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA81703B (en) * | 1980-02-04 | 1982-09-29 | Merck & Co Inc | New antihypercholesterolemic compounds,intermediates and processes |
| US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| JPS58188872A (ja) * | 1982-04-26 | 1983-11-04 | Suntory Ltd | オクタヒドロナフタレン誘導体及びその製造法 |
| US4837205A (en) * | 1986-09-02 | 1989-06-06 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
| US4916239A (en) * | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
| GB8915280D0 (en) * | 1989-07-04 | 1989-08-23 | British Bio Technology | Compounds |
| US5072002A (en) * | 1989-07-18 | 1991-12-10 | The Governors Of The University Of Alberta | Synthesis of cholesterol-lowering agents |
| US5093363A (en) * | 1989-08-22 | 1992-03-03 | Shionogi & Co., Ltd. | 2,4,6-substituted phenol derivatives |
| EP0415488B1 (en) * | 1989-08-31 | 1994-04-20 | Merck & Co. Inc. | 7-Substituted HMG-COA reductase inhibitors |
| US5393893A (en) * | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
| ES2131037T3 (es) * | 1995-12-06 | 2001-12-16 | Balkanpharma Razgrad Ad | Procedimiento de preparacion de lovastatina. |
| US5763653A (en) * | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Key intermediates in the manufacture of simvastatin |
| CA2185961A1 (en) * | 1996-09-19 | 1998-03-20 | K.S. Keshava Murthy | Process for producing simvastatin |
| SI9700202A (sl) * | 1997-01-24 | 1998-08-31 | Ranbaxy Laboratories Limited | Postopek izdelave simvastatina iz lovastatina ali mevinolinske kisline |
| US5763646A (en) * | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
| ES2197465T3 (es) * | 1997-01-28 | 2004-01-01 | Plus Chemicals B.V. | Proceso para la produccion de estatinas semisinteticas a traves de nuevos intermedios. |
| SI9800057A (sl) * | 1998-02-26 | 1999-08-31 | Krka, Tovarna Zdravil, D.D. | Postopek za pripravo simvastatina in njegovih derivatov |
| EP0940395A1 (en) * | 1998-03-05 | 1999-09-08 | Synthon B.V. | Process for producing simvastatin and/or its derivatives |
-
1999
- 1999-12-10 EP EP99959738A patent/EP1055671B1/en not_active Expired - Lifetime
- 1999-12-10 JP JP2000586711A patent/JP4440476B2/ja not_active Expired - Fee Related
- 1999-12-10 CA CA002320163A patent/CA2320163C/en not_active Expired - Fee Related
- 1999-12-10 AT AT99959738T patent/ATE283849T1/de not_active IP Right Cessation
- 1999-12-10 SI SI9920024A patent/SI20327B/sl active Search and Examination
- 1999-12-10 HU HU0103021A patent/HUP0103021A3/hu unknown
- 1999-12-10 AU AU16830/00A patent/AU1683000A/en not_active Abandoned
- 1999-12-10 KR KR1020007008648A patent/KR100672269B1/ko not_active Expired - Fee Related
- 1999-12-10 ES ES99959738T patent/ES2234323T3/es not_active Expired - Lifetime
- 1999-12-10 CN CN99802754A patent/CN1122029C/zh not_active Expired - Fee Related
- 1999-12-10 CN CNB031530451A patent/CN1226296C/zh not_active Expired - Fee Related
- 1999-12-10 EP EP04023298.5A patent/EP1533308B1/en not_active Expired - Lifetime
- 1999-12-10 WO PCT/JP1999/006929 patent/WO2000034264A1/ja not_active Ceased
- 1999-12-10 US US09/601,794 patent/US6331641B1/en not_active Expired - Lifetime
- 1999-12-10 CZ CZ20003149A patent/CZ299522B6/cs not_active IP Right Cessation
- 1999-12-10 CZ CZ20080099A patent/CZ299566B6/cs not_active IP Right Cessation
- 1999-12-10 DE DE69922348T patent/DE69922348T2/de not_active Expired - Lifetime
-
2009
- 2009-04-01 JP JP2009089110A patent/JP5048709B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69922348T2 (de) | 2005-12-01 |
| CA2320163A1 (en) | 2000-06-15 |
| US6331641B1 (en) | 2001-12-18 |
| EP1533308A2 (en) | 2005-05-25 |
| EP1533308A3 (en) | 2005-09-14 |
| JP4440476B2 (ja) | 2010-03-24 |
| CA2320163C (en) | 2008-09-23 |
| CZ20003149A3 (cs) | 2000-12-13 |
| ES2234323T3 (es) | 2005-06-16 |
| KR20010040760A (ko) | 2001-05-15 |
| SI20327B (sl) | 2015-02-27 |
| CN1122029C (zh) | 2003-09-24 |
| HUP0103021A3 (en) | 2002-04-29 |
| JP5048709B2 (ja) | 2012-10-17 |
| HUP0103021A2 (hu) | 2001-12-28 |
| EP1055671A4 (en) | 2002-05-08 |
| CZ299522B6 (cs) | 2008-08-27 |
| AU1683000A (en) | 2000-06-26 |
| EP1533308B1 (en) | 2014-01-15 |
| DE69922348D1 (de) | 2005-01-05 |
| CN1226296C (zh) | 2005-11-09 |
| CN1493570A (zh) | 2004-05-05 |
| KR100672269B1 (ko) | 2007-01-23 |
| EP1055671B1 (en) | 2004-12-01 |
| SI20327A (sl) | 2001-02-28 |
| CN1290261A (zh) | 2001-04-04 |
| CZ299566B6 (cs) | 2008-09-03 |
| WO2000034264A1 (en) | 2000-06-15 |
| JP2009185041A (ja) | 2009-08-20 |
| EP1055671A1 (en) | 2000-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |