ATE283849T1 - Verfahren zur herstellung eines simvastatin precursors - Google Patents

Verfahren zur herstellung eines simvastatin precursors

Info

Publication number
ATE283849T1
ATE283849T1 AT99959738T AT99959738T ATE283849T1 AT E283849 T1 ATE283849 T1 AT E283849T1 AT 99959738 T AT99959738 T AT 99959738T AT 99959738 T AT99959738 T AT 99959738T AT E283849 T1 ATE283849 T1 AT E283849T1
Authority
AT
Austria
Prior art keywords
producing
simvastatin
simvastatin precursor
precursor
lactonization
Prior art date
Application number
AT99959738T
Other languages
English (en)
Inventor
Naoaki Taoka
Kenji Inoue
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of ATE283849T1 publication Critical patent/ATE283849T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AT99959738T 1998-12-10 1999-12-10 Verfahren zur herstellung eines simvastatin precursors ATE283849T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35186598 1998-12-10
PCT/JP1999/006929 WO2000034264A1 (fr) 1998-12-10 1999-12-10 Procede de production de simvastatine

Publications (1)

Publication Number Publication Date
ATE283849T1 true ATE283849T1 (de) 2004-12-15

Family

ID=18420148

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99959738T ATE283849T1 (de) 1998-12-10 1999-12-10 Verfahren zur herstellung eines simvastatin precursors

Country Status (14)

Country Link
US (1) US6331641B1 (de)
EP (2) EP1055671B1 (de)
JP (2) JP4440476B2 (de)
KR (1) KR100672269B1 (de)
CN (2) CN1226296C (de)
AT (1) ATE283849T1 (de)
AU (1) AU1683000A (de)
CA (1) CA2320163C (de)
CZ (2) CZ299566B6 (de)
DE (1) DE69922348T2 (de)
ES (1) ES2234323T3 (de)
HU (1) HUP0103021A3 (de)
SI (1) SI20327B (de)
WO (1) WO2000034264A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
US6573392B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
KR100361833B1 (ko) * 2000-06-20 2002-11-22 주식회사 엘지생명과학 심바스타틴의 제조방법
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
DK1417180T3 (da) * 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
KR100435142B1 (ko) * 2002-01-09 2004-06-09 한미약품 주식회사 개선된 심바스타틴의 제조방법
KR100502834B1 (ko) * 2002-03-25 2005-07-20 보령제약 주식회사 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
KR100502833B1 (ko) * 2002-03-25 2005-07-25 보령제약 주식회사 심바스타틴 및 이의 중간체 화합물들의 개선된 제조방법
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
EP1375493A1 (de) * 2002-06-17 2004-01-02 Dsm N.V. Verfahren zur Herstellung von Dioxanessigsäureester
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
CA2543348A1 (en) * 2003-10-21 2005-05-06 Diversa Corporation Methods for making simvastatin and intermediates
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
WO2005058861A1 (en) * 2003-12-16 2005-06-30 Uk Chemipharm Co., Ltd. Process for preparing simvastatin.
CN1754870A (zh) * 2004-09-30 2006-04-05 淮北市辉克药业有限公司 辛伐他汀的制备方法
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
US20110059493A1 (en) * 2007-08-27 2011-03-10 Brian Morgan Methods for Making Simvastatin and Intermediates
JP2009114121A (ja) * 2007-11-06 2009-05-28 Kaneka Corp シンバスタチンの製造方法
CN102690254B (zh) * 2008-05-09 2014-06-04 上海医药工业研究院 辛伐他汀铵盐中间体及其制备方法
CN101575328B (zh) * 2008-05-09 2012-07-04 上海医药工业研究院 一种辛伐他汀中间体的合成方法
CN110563680A (zh) * 2019-09-10 2019-12-13 山东罗欣药业集团恒欣药业有限公司 一种治疗高脂血症药物的制备方法
CN110483459A (zh) * 2019-09-10 2019-11-22 山东罗欣药业集团恒欣药业有限公司 一种辛伐他汀的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes
JPS58188872A (ja) * 1982-04-26 1983-11-04 Suntory Ltd オクタヒドロナフタレン誘導体及びその製造法
US4837205A (en) * 1986-09-02 1989-06-06 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
GB8915280D0 (en) * 1989-07-04 1989-08-23 British Bio Technology Compounds
US5072002A (en) * 1989-07-18 1991-12-10 The Governors Of The University Of Alberta Synthesis of cholesterol-lowering agents
US5093363A (en) * 1989-08-22 1992-03-03 Shionogi & Co., Ltd. 2,4,6-substituted phenol derivatives
DE69008277D1 (de) * 1989-08-31 1994-05-26 Merck & Co Inc 7-Subsituierte HMG-CoA-Reduktase-Inhibitoren.
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
UA44922C2 (uk) * 1995-12-06 2002-03-15 Балканфарма-Разград Ад Спосіб одержання ловастатину
US5763653A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Key intermediates in the manufacture of simvastatin
CA2185961A1 (en) * 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US5763646A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
SI9700202A (sl) * 1997-01-24 1998-08-31 Ranbaxy Laboratories Limited Postopek izdelave simvastatina iz lovastatina ali mevinolinske kisline
IL131044A (en) * 1997-01-28 2003-07-31 Plus Chemicals Bv Process for the production of semi synthetic statins via novel intermediates
SI9800057A (sl) * 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
EP0940395A1 (de) * 1998-03-05 1999-09-08 Synthon B.V. Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate

Also Published As

Publication number Publication date
EP1533308A3 (de) 2005-09-14
EP1055671B1 (de) 2004-12-01
JP4440476B2 (ja) 2010-03-24
KR100672269B1 (ko) 2007-01-23
CN1493570A (zh) 2004-05-05
CZ299522B6 (cs) 2008-08-27
JP2009185041A (ja) 2009-08-20
HUP0103021A3 (en) 2002-04-29
JP5048709B2 (ja) 2012-10-17
EP1533308B1 (de) 2014-01-15
US6331641B1 (en) 2001-12-18
CZ20003149A3 (cs) 2000-12-13
CN1290261A (zh) 2001-04-04
SI20327B (sl) 2015-02-27
SI20327A (sl) 2001-02-28
CN1226296C (zh) 2005-11-09
DE69922348T2 (de) 2005-12-01
ES2234323T3 (es) 2005-06-16
KR20010040760A (ko) 2001-05-15
AU1683000A (en) 2000-06-26
EP1055671A4 (de) 2002-05-08
CA2320163C (en) 2008-09-23
DE69922348D1 (de) 2005-01-05
CN1122029C (zh) 2003-09-24
WO2000034264A1 (fr) 2000-06-15
CZ299566B6 (cs) 2008-09-03
HUP0103021A2 (hu) 2001-12-28
EP1055671A1 (de) 2000-11-29
EP1533308A2 (de) 2005-05-25
CA2320163A1 (en) 2000-06-15

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