ES2150459T3 - Procedimiento de hidroxilacion enzimatico para la preparacion de inhibidores de la hmg-coa reductasa e intermedios para la preparacion de los mismos. - Google Patents

Procedimiento de hidroxilacion enzimatico para la preparacion de inhibidores de la hmg-coa reductasa e intermedios para la preparacion de los mismos.

Info

Publication number
ES2150459T3
ES2150459T3 ES94116409T ES94116409T ES2150459T3 ES 2150459 T3 ES2150459 T3 ES 2150459T3 ES 94116409 T ES94116409 T ES 94116409T ES 94116409 T ES94116409 T ES 94116409T ES 2150459 T3 ES2150459 T3 ES 2150459T3
Authority
ES
Spain
Prior art keywords
preparation
hmg
coa reductase
reductase inhibitors
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94116409T
Other languages
English (en)
Inventor
Brian L Davis
Paul M Cino
Laszlo Szarka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2150459T3 publication Critical patent/ES2150459T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCESO DE HIDROXILACION ENZIMATICA PARA LA PREPARACION DE COMPUESTOS UTILES COMO INHIBIDORES DE REDUCTASA HMG-COA Y/O COMO INTERMEDIARIOS EN LA PREPARACION DE INHIBIDORES DE REDUCTASA HMG-COA USA UN MICROORGANISMO O UNA ENZIMA DERIVADA DE EL, O TENIENDO LA ESTRUCTURA DE UNA ENZIMA DERIVADA DE EL, DICHO MICROORGANISMO, EL CUAL ES CAPAZ DE CATALIZAR EL PROCESO DE HIDROXILACION.
ES94116409T 1993-10-22 1994-10-18 Procedimiento de hidroxilacion enzimatico para la preparacion de inhibidores de la hmg-coa reductasa e intermedios para la preparacion de los mismos. Expired - Lifetime ES2150459T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/141,316 US6043064A (en) 1993-10-22 1993-10-22 Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof

Publications (1)

Publication Number Publication Date
ES2150459T3 true ES2150459T3 (es) 2000-12-01

Family

ID=22495167

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94116409T Expired - Lifetime ES2150459T3 (es) 1993-10-22 1994-10-18 Procedimiento de hidroxilacion enzimatico para la preparacion de inhibidores de la hmg-coa reductasa e intermedios para la preparacion de los mismos.

Country Status (20)

Country Link
US (1) US6043064A (es)
EP (1) EP0649907B1 (es)
JP (1) JP3683606B2 (es)
KR (1) KR100342627B1 (es)
CN (1) CN1085250C (es)
AT (1) ATE196166T1 (es)
AU (1) AU679113B2 (es)
CA (1) CA2134025A1 (es)
CY (1) CY2216B1 (es)
DE (1) DE69425801T2 (es)
DK (1) DK0649907T3 (es)
ES (1) ES2150459T3 (es)
FI (1) FI113279B (es)
GR (1) GR3034835T3 (es)
HK (1) HK1014740A1 (es)
HU (1) HU217104B (es)
IL (1) IL111084A (es)
PT (1) PT649907E (es)
SG (1) SG47504A1 (es)
TW (1) TW438888B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69839248T2 (de) 1997-08-07 2009-04-02 Kyowa Hakko Kogyo Co., Ltd. VERFAHREN FÜR DIE HERSTELLUNG VON INHIBITOREN DER HMG-CoA-REDUKTASE.
WO1999010499A1 (en) * 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
SI9800144A (sl) 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
JP4428866B2 (ja) 1999-01-20 2010-03-10 協和発酵バイオ株式会社 ＨＭＧ−ＣｏＡレダクターゼ阻害剤の製造法
HUP0105145A3 (en) * 1999-01-29 2006-02-28 Kyowa Hakko Kogyo Kk Process for producing hmg-coa reductase inhibitor
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
JP2003093045A (ja) * 2001-09-26 2003-04-02 Godo Shusei Co Ltd 有用変換微生物
KR100725559B1 (ko) * 2001-09-27 2007-06-08 바이오콘 리미티드 스트렙토마이세스 플라비도비렌스 ｄｓｍ 14455를 이용한프라바스타틴 나트륨염의 제조 방법
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
TWI252253B (en) * 2004-01-09 2006-04-01 Chinese Petroleum Corp A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
CN101351551A (zh) 2005-11-29 2009-01-21 协和发酵工业株式会社 新型蛋白质和编码该蛋白质的dna
WO2007137816A1 (en) * 2006-05-30 2007-12-06 Dsm Ip Assets B.V. Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP1953233A1 (en) * 2007-02-02 2008-08-06 LEK Pharmaceuticals d.d. Fermentation process for preparing pravastatin
JP7350659B2 (ja) 2017-06-06 2023-09-26 ザイマージェン インコーポレイテッド Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａ ｓｐｉｎｏｓａの改良のためのハイスループット（ＨＴＰ）ゲノム操作プラットフォーム

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (es) * 1974-06-07 1981-03-18
US4206206A (en) * 1977-03-24 1980-06-03 Kowa Company, Ltd. Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0069442B1 (en) * 1981-06-06 1985-02-20 Pfizer Limited Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60176595A (ja) * 1984-02-21 1985-09-10 Akira Endo 生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
PT85109A (en) * 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
EP0337548A3 (en) * 1988-04-15 1991-08-14 Merck & Co. Inc. HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
JPH02245191A (ja) * 1989-02-01 1990-09-28 Merck & Co Inc ６―α―ヒドロキシメチルロバスタチン誘導体の製造方法
EP0408806A1 (en) * 1989-07-19 1991-01-23 Merck & Co. Inc. Antihypercholesterolemic agents
MY106564A (en) * 1990-07-06 1995-06-30 Squibb & Sons Inc Sulfur-substituted mevinic acid derivatives.
CA2053000C (en) * 1990-10-15 1995-08-29 Michael J. Conder Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
US6043064A (en) 2000-03-28
DE69425801T2 (de) 2001-05-03
CY2216B1 (en) 2003-04-18
KR950011616A (ko) 1995-05-15
HU9403061D0 (en) 1994-12-28
FI113279B (fi) 2004-03-31
CN1085250C (zh) 2002-05-22
EP0649907B1 (en) 2000-09-06
TW438888B (en) 2001-06-07
CN1106067A (zh) 1995-08-02
SG47504A1 (en) 1998-04-17
KR100342627B1 (ko) 2002-11-18
GR3034835T3 (en) 2001-02-28
AU7597294A (en) 1995-05-11
IL111084A0 (en) 1994-11-28
FI944926A (fi) 1995-04-23
HUT69959A (en) 1995-09-28
JP3683606B2 (ja) 2005-08-17
PT649907E (pt) 2000-12-29
EP0649907A1 (en) 1995-04-26
JPH07184670A (ja) 1995-07-25
AU679113B2 (en) 1997-06-19
CA2134025A1 (en) 1995-04-23
DE69425801D1 (de) 2000-10-12
HK1014740A1 (en) 1999-09-30
IL111084A (en) 1998-01-04
DK0649907T3 (da) 2000-10-09
FI944926A0 (fi) 1994-10-20
HU217104B (hu) 1999-11-29
ATE196166T1 (de) 2000-09-15

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