DK0649907T3 - Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor - Google Patents

Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor

Info

Publication number
DK0649907T3
DK0649907T3 DK94116409T DK94116409T DK0649907T3 DK 0649907 T3 DK0649907 T3 DK 0649907T3 DK 94116409 T DK94116409 T DK 94116409T DK 94116409 T DK94116409 T DK 94116409T DK 0649907 T3 DK0649907 T3 DK 0649907T3
Authority
DK
Denmark
Prior art keywords
coa reductase
reductase inhibitors
intermediates
hydroxylation process
hmg
Prior art date
Application number
DK94116409T
Other languages
English (en)
Inventor
Brian L Davis
Paul M Cino
Laszlo Szarka
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK0649907T3 publication Critical patent/DK0649907T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94116409T 1993-10-22 1994-10-18 Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor DK0649907T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/141,316 US6043064A (en) 1993-10-22 1993-10-22 Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof

Publications (1)

Publication Number Publication Date
DK0649907T3 true DK0649907T3 (da) 2000-10-09

Family

ID=22495167

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94116409T DK0649907T3 (da) 1993-10-22 1994-10-18 Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor

Country Status (20)

Country Link
US (1) US6043064A (da)
EP (1) EP0649907B1 (da)
JP (1) JP3683606B2 (da)
KR (1) KR100342627B1 (da)
CN (1) CN1085250C (da)
AT (1) ATE196166T1 (da)
AU (1) AU679113B2 (da)
CA (1) CA2134025A1 (da)
CY (1) CY2216B1 (da)
DE (1) DE69425801T2 (da)
DK (1) DK0649907T3 (da)
ES (1) ES2150459T3 (da)
FI (1) FI113279B (da)
GR (1) GR3034835T3 (da)
HK (1) HK1014740A1 (da)
HU (1) HU217104B (da)
IL (1) IL111084A (da)
PT (1) PT649907E (da)
SG (1) SG47504A1 (da)
TW (1) TW438888B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2299634C (en) 1997-08-07 2007-10-16 Kyowa Hakko Kogyo Co., Ltd. Process for the preparation of hmg-coa reductase inhibitors
EP1015600A1 (en) * 1997-08-22 2000-07-05 Dsm N.V. Statin production by fermentation
SI9800144A (sl) * 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
CZ20012622A3 (cs) 1999-01-20 2002-01-16 Kyowa Hakko Kogyo Co. Ltd. Proces přípravy inhibitorů HMG-CoA reduktázy
US7049111B1 (en) * 1999-01-29 2006-05-23 Kyowa Hakko Kogyo Co., Ltd. Process for producing HMG-CoA reductase inhibitor
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
JP2003093045A (ja) * 2001-09-26 2003-04-02 Godo Shusei Co Ltd 有用変換微生物
ATE316146T1 (de) * 2001-09-27 2006-02-15 Biocon Ltd Verfahren zur herstellung von pravastatin- natriumsalz mittels streptomyces flavidovirens dsm 14455
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
TWI252253B (en) * 2004-01-09 2006-04-01 Chinese Petroleum Corp A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
JP5631534B2 (ja) 2005-11-29 2014-11-26 協和発酵バイオ株式会社 新規蛋白質および該蛋白質をコードするｄｎａ
WO2007137816A1 (en) * 2006-05-30 2007-12-06 Dsm Ip Assets B.V. Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP1953233A1 (en) * 2007-02-02 2008-08-06 LEK Pharmaceuticals d.d. Fermentation process for preparing pravastatin
EP3635110A2 (en) 2017-06-06 2020-04-15 Zymergen, Inc. A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (da) * 1974-06-07 1981-03-18
US4206206A (en) * 1977-03-24 1980-06-03 Kowa Company, Ltd. Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
DE3262386D1 (en) * 1981-06-06 1985-03-28 Pfizer Ltd Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60176595A (ja) * 1984-02-21 1985-09-10 Akira Endo 生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
PT85109A (en) * 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
EP0337548A3 (en) * 1988-04-15 1991-08-14 Merck & Co. Inc. HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
EP0381478A1 (en) * 1989-02-01 1990-08-08 Merck & Co. Inc. Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
EP0408806A1 (en) * 1989-07-19 1991-01-23 Merck & Co. Inc. Antihypercholesterolemic agents
TW227552B (da) * 1990-07-06 1994-08-01 Squibb & Sons Inc
CA2053000C (en) * 1990-10-15 1995-08-29 Michael J. Conder Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
HUT69959A (en) 1995-09-28
FI113279B (fi) 2004-03-31
HK1014740A1 (en) 1999-09-30
FI944926A (fi) 1995-04-23
IL111084A0 (en) 1994-11-28
CY2216B1 (en) 2003-04-18
TW438888B (en) 2001-06-07
FI944926A0 (fi) 1994-10-20
JPH07184670A (ja) 1995-07-25
HU9403061D0 (en) 1994-12-28
ATE196166T1 (de) 2000-09-15
KR100342627B1 (ko) 2002-11-18
JP3683606B2 (ja) 2005-08-17
HU217104B (hu) 1999-11-29
DE69425801T2 (de) 2001-05-03
EP0649907B1 (en) 2000-09-06
DE69425801D1 (de) 2000-10-12
IL111084A (en) 1998-01-04
AU7597294A (en) 1995-05-11
US6043064A (en) 2000-03-28
CA2134025A1 (en) 1995-04-23
PT649907E (pt) 2000-12-29
ES2150459T3 (es) 2000-12-01
EP0649907A1 (en) 1995-04-26
CN1106067A (zh) 1995-08-02
SG47504A1 (en) 1998-04-17
CN1085250C (zh) 2002-05-22
GR3034835T3 (en) 2001-02-28
KR950011616A (ko) 1995-05-15
AU679113B2 (en) 1997-06-19

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