DK0649907T3 - Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor - Google Patents
Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derforInfo
- Publication number
- DK0649907T3 DK0649907T3 DK94116409T DK94116409T DK0649907T3 DK 0649907 T3 DK0649907 T3 DK 0649907T3 DK 94116409 T DK94116409 T DK 94116409T DK 94116409 T DK94116409 T DK 94116409T DK 0649907 T3 DK0649907 T3 DK 0649907T3
- Authority
- DK
- Denmark
- Prior art keywords
- coa reductase
- reductase inhibitors
- intermediates
- hydroxylation process
- hmg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/141,316 US6043064A (en) | 1993-10-22 | 1993-10-22 | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0649907T3 true DK0649907T3 (da) | 2000-10-09 |
Family
ID=22495167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94116409T DK0649907T3 (da) | 1993-10-22 | 1994-10-18 | Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor |
Country Status (20)
Country | Link |
---|---|
US (1) | US6043064A (da) |
EP (1) | EP0649907B1 (da) |
JP (1) | JP3683606B2 (da) |
KR (1) | KR100342627B1 (da) |
CN (1) | CN1085250C (da) |
AT (1) | ATE196166T1 (da) |
AU (1) | AU679113B2 (da) |
CA (1) | CA2134025A1 (da) |
CY (1) | CY2216B1 (da) |
DE (1) | DE69425801T2 (da) |
DK (1) | DK0649907T3 (da) |
ES (1) | ES2150459T3 (da) |
FI (1) | FI113279B (da) |
GR (1) | GR3034835T3 (da) |
HK (1) | HK1014740A1 (da) |
HU (1) | HU217104B (da) |
IL (1) | IL111084A (da) |
PT (1) | PT649907E (da) |
SG (1) | SG47504A1 (da) |
TW (1) | TW438888B (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2299634C (en) | 1997-08-07 | 2007-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Process for the preparation of hmg-coa reductase inhibitors |
EP1015600A1 (en) * | 1997-08-22 | 2000-07-05 | Dsm N.V. | Statin production by fermentation |
SI9800144A (sl) * | 1998-05-21 | 1999-12-31 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4' |
CZ20012622A3 (cs) | 1999-01-20 | 2002-01-16 | Kyowa Hakko Kogyo Co. Ltd. | Proces přípravy inhibitorů HMG-CoA reduktázy |
US7049111B1 (en) * | 1999-01-29 | 2006-05-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing HMG-CoA reductase inhibitor |
HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
JP2003093045A (ja) * | 2001-09-26 | 2003-04-02 | Godo Shusei Co Ltd | 有用変換微生物 |
ATE316146T1 (de) * | 2001-09-27 | 2006-02-15 | Biocon Ltd | Verfahren zur herstellung von pravastatin- natriumsalz mittels streptomyces flavidovirens dsm 14455 |
EP1452602A1 (en) * | 2003-02-25 | 2004-09-01 | Antibiotic Co., | Method for production of pravastatin by fermentation |
TWI252253B (en) * | 2004-01-09 | 2006-04-01 | Chinese Petroleum Corp | A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same |
JP5631534B2 (ja) | 2005-11-29 | 2014-11-26 | 協和発酵バイオ株式会社 | 新規蛋白質および該蛋白質をコードするdna |
WO2007137816A1 (en) * | 2006-05-30 | 2007-12-06 | Dsm Ip Assets B.V. | Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins |
EP1953233A1 (en) * | 2007-02-02 | 2008-08-06 | LEK Pharmaceuticals d.d. | Fermentation process for preparing pravastatin |
EP3635110A2 (en) | 2017-06-06 | 2020-04-15 | Zymergen, Inc. | A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (da) * | 1974-06-07 | 1981-03-18 | ||
US4206206A (en) * | 1977-03-24 | 1980-06-03 | Kowa Company, Ltd. | Antibiotics of the KA-6606 series and pharmaceutical compositions thereof |
US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
US4450171A (en) * | 1980-08-05 | 1984-05-22 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
DE3262386D1 (en) * | 1981-06-06 | 1985-03-28 | Pfizer Ltd | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
JPS5889191A (ja) * | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | 3−ヒドロキシ−ml−236b誘導体の製造法 |
JPS60176595A (ja) * | 1984-02-21 | 1985-09-10 | Akira Endo | 生理活性物質ml−236a及びモナコリンjの製造法 |
PT85109A (en) * | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
US4857547A (en) * | 1988-01-07 | 1989-08-15 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
EP0337548A3 (en) * | 1988-04-15 | 1991-08-14 | Merck & Co. Inc. | HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695) |
EP0381478A1 (en) * | 1989-02-01 | 1990-08-08 | Merck & Co. Inc. | Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives |
EP0408806A1 (en) * | 1989-07-19 | 1991-01-23 | Merck & Co. Inc. | Antihypercholesterolemic agents |
TW227552B (da) * | 1990-07-06 | 1994-08-01 | Squibb & Sons Inc | |
CA2053000C (en) * | 1990-10-15 | 1995-08-29 | Michael J. Conder | Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula |
IL108432A (en) * | 1993-01-29 | 1997-09-30 | Sankyo Co | DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1993
- 1993-10-22 US US08/141,316 patent/US6043064A/en not_active Expired - Fee Related
-
1994
- 1994-09-29 IL IL111084A patent/IL111084A/en not_active IP Right Cessation
- 1994-10-01 TW TW083109094A patent/TW438888B/zh not_active IP Right Cessation
- 1994-10-18 SG SG1996002486A patent/SG47504A1/en unknown
- 1994-10-18 PT PT94116409T patent/PT649907E/pt unknown
- 1994-10-18 DK DK94116409T patent/DK0649907T3/da active
- 1994-10-18 ES ES94116409T patent/ES2150459T3/es not_active Expired - Lifetime
- 1994-10-18 AT AT94116409T patent/ATE196166T1/de not_active IP Right Cessation
- 1994-10-18 DE DE69425801T patent/DE69425801T2/de not_active Expired - Fee Related
- 1994-10-18 EP EP94116409A patent/EP0649907B1/en not_active Expired - Lifetime
- 1994-10-20 FI FI944926A patent/FI113279B/fi not_active IP Right Cessation
- 1994-10-21 KR KR1019940026933A patent/KR100342627B1/ko not_active IP Right Cessation
- 1994-10-21 HU HU9403061A patent/HU217104B/hu not_active IP Right Cessation
- 1994-10-21 CA CA002134025A patent/CA2134025A1/en not_active Abandoned
- 1994-10-21 AU AU75972/94A patent/AU679113B2/en not_active Ceased
- 1994-10-21 JP JP25654894A patent/JP3683606B2/ja not_active Expired - Fee Related
- 1994-10-22 CN CN94117167A patent/CN1085250C/zh not_active Expired - Fee Related
-
1998
- 1998-12-28 HK HK98116039A patent/HK1014740A1/xx not_active IP Right Cessation
-
2000
- 2000-11-13 GR GR20000402523T patent/GR3034835T3/el not_active IP Right Cessation
- 2000-11-28 CY CY0000057A patent/CY2216B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
HUT69959A (en) | 1995-09-28 |
FI113279B (fi) | 2004-03-31 |
HK1014740A1 (en) | 1999-09-30 |
FI944926A (fi) | 1995-04-23 |
IL111084A0 (en) | 1994-11-28 |
CY2216B1 (en) | 2003-04-18 |
TW438888B (en) | 2001-06-07 |
FI944926A0 (fi) | 1994-10-20 |
JPH07184670A (ja) | 1995-07-25 |
HU9403061D0 (en) | 1994-12-28 |
ATE196166T1 (de) | 2000-09-15 |
KR100342627B1 (ko) | 2002-11-18 |
JP3683606B2 (ja) | 2005-08-17 |
HU217104B (hu) | 1999-11-29 |
DE69425801T2 (de) | 2001-05-03 |
EP0649907B1 (en) | 2000-09-06 |
DE69425801D1 (de) | 2000-10-12 |
IL111084A (en) | 1998-01-04 |
AU7597294A (en) | 1995-05-11 |
US6043064A (en) | 2000-03-28 |
CA2134025A1 (en) | 1995-04-23 |
PT649907E (pt) | 2000-12-29 |
ES2150459T3 (es) | 2000-12-01 |
EP0649907A1 (en) | 1995-04-26 |
CN1106067A (zh) | 1995-08-02 |
SG47504A1 (en) | 1998-04-17 |
CN1085250C (zh) | 2002-05-22 |
GR3034835T3 (en) | 2001-02-28 |
KR950011616A (ko) | 1995-05-15 |
AU679113B2 (en) | 1997-06-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0649907T3 (da) | Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor | |
AU659550B2 (en) | Dual action inhibitors | |
AU3075697A (en) | Enzymatic process for the manufacture of ascorbic acid, 2-keto-l-gulonic acid and esters of 2-keto-l-gulonic acid | |
AU2002354696A1 (en) | Method for purifying an enzyme, a purified enzyme produced thereby, and use of this enzyme | |
DK0625571T3 (da) | Mikroorganismer, deres anvendelse samt fremgangsmåde til fremstilling af L-alfa-aminosyrer | |
DE69329719D1 (de) | Stereoselektive mikrobielle oder enzymatische Reduktion von 3,5-Dioxoestern zu 3,5-Dihydroxyestern | |
DK0826773T3 (da) | Fremgangsmåde til fremstilling af trans-4-hydroxy-L-prolin | |
IL101996A (en) | Regulation of enzyme activities by contacting them with noble gases | |
CA2253977A1 (en) | Process for the preparation of amino alcohols and derivatives thereof | |
DK0498316T3 (da) | Mikrobiologisk fremgangsmåde til fremstilling af 6-hydroxypicolinsyre | |
EP0927755A3 (en) | Haloaccloacetate reductase, method for producing said enzyme, and method for producing alcohols using said enzyme | |
DK0698111T3 (da) | Fremgangsmåde til syntese af HMG-CoA-reduktaseinhibitorer | |
AU3610299A (en) | Novel method for preparing synthesis intermediates | |
HUP9903941A2 (hu) | Racém tetralon sztereoszelektív mikrobiális redukciója | |
ATE161584T1 (de) | Esterase und ihre verwendung in bioumwandlung | |
AU2818392A (en) | Method for enhancing enzyme activities and the synthetic performance of organisms | |
DK148361C (da) | Fremgangsmaade til fremstilling af kolesterinesterase | |
WO2002061094A3 (de) | Mikrobiologisches verfahren zur herstellung von l-carnitin | |
WO1999007199A3 (de) | Verfahren zur herstellung von l-alaninol und gamma-glutamylisopropylamid und mikroorganismusstamm des genus pseudomonas | |
ATE164628T1 (de) | L-proline-3-hydroxylase und verfahren zur herstellung von cis-3-hydroxy-l-prolin | |
HU911038D0 (en) | Enzime inhibitors substituted with a halogenethyl group | |
ATE243194T1 (de) | Substituierte dithio-bis-nitrobenzole und ihre anwendungen | |
ATE345394T1 (de) | Verfahren zur enzymatischen umsetzung von verbindungen mit mindestens einer nitrilfunktion und/oder mindestens einer amidfunktion | |
DK0711350T3 (da) | Clavulansyre dehydrogenase, fremstilling og anvendelse af produktion af clavulansyre | |
IT1255470B (it) | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |