ATE237605T1 - Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte - Google Patents

Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte

Info

Publication number
ATE237605T1
ATE237605T1 AT98908031T AT98908031T ATE237605T1 AT E237605 T1 ATE237605 T1 AT E237605T1 AT 98908031 T AT98908031 T AT 98908031T AT 98908031 T AT98908031 T AT 98908031T AT E237605 T1 ATE237605 T1 AT E237605T1
Authority
AT
Austria
Prior art keywords
vianew
intermediate products
producing semi
synthetic statins
statins
Prior art date
Application number
AT98908031T
Other languages
English (en)
Inventor
Ton Rene Vries
Hans Wijnberg
Wijnand Sjourd Faber
Venetka Ivanova Kalkman-Agayn
Mieke Sibeyn
Original Assignee
Plus Chemicals Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plus Chemicals Bv filed Critical Plus Chemicals Bv
Application granted granted Critical
Publication of ATE237605T1 publication Critical patent/ATE237605T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574Esters of oxyacids of phosphorus
    • C07F9/65742Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
AT98908031T 1997-01-28 1998-01-27 Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte ATE237605T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97200223 1997-01-28
EP97306809 1997-09-03
PCT/EP1998/000519 WO1998032751A1 (en) 1997-01-28 1998-01-27 Process for the production of semi synthetic statins via novel intermediates

Publications (1)

Publication Number Publication Date
ATE237605T1 true ATE237605T1 (de) 2003-05-15

Family

ID=26146080

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03008084T ATE323689T1 (de) 1997-01-28 1998-01-27 Verfahren zu herstellung von halb-synthetischen statins via neue zwischenprodukte
AT98908031T ATE237605T1 (de) 1997-01-28 1998-01-27 Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03008084T ATE323689T1 (de) 1997-01-28 1998-01-27 Verfahren zu herstellung von halb-synthetischen statins via neue zwischenprodukte

Country Status (16)

Country Link
US (1) US6294680B1 (de)
EP (2) EP0971913B1 (de)
JP (1) JP2001508782A (de)
KR (1) KR100538674B1 (de)
AR (1) AR011780A1 (de)
AT (2) ATE323689T1 (de)
AU (1) AU747219C (de)
CA (1) CA2278603A1 (de)
DE (2) DE69834279T2 (de)
DK (1) DK0971913T3 (de)
ES (2) ES2197465T3 (de)
IL (1) IL131044A (de)
NO (1) NO318146B1 (de)
NZ (1) NZ336993A (de)
PT (1) PT971913E (de)
WO (1) WO1998032751A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0940395A1 (de) * 1998-03-05 1999-09-08 Synthon B.V. Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate
NO991045L (no) 1998-03-05 1999-09-06 Synthon Bv FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
EP1533308B1 (de) * 1998-12-10 2014-01-15 Kaneka Corporation Verfahren zur Herstellung eines Simvastatin Precursors
CO5140104A1 (es) 1999-02-16 2002-03-22 Novartis Ag Derivados de mevinolina y preparacion farmaceuticas que los contienen
KR20010009846A (ko) * 1999-07-14 2001-02-05 구광시 심바스타틴 제조에 유용한 중간체 및 그의 제조방법
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
WO2001034590A1 (en) * 1999-11-11 2001-05-17 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
AU2001282981B2 (en) * 2000-07-27 2004-08-05 Plus Chemicals, B.V. Highly purified simvastatin compositions
US6777552B2 (en) * 2001-08-16 2004-08-17 Teva Pharmaceutical Industries, Ltd. Processes for preparing calcium salt forms of statins
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
US6472542B1 (en) 2001-11-29 2002-10-29 Fermic S.A. De C.V. Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
KR100423892B1 (ko) * 2001-12-03 2004-03-22 씨제이 주식회사 스타틴의 제조에 있어서 새로운 락톤화 방법
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
US6995277B2 (en) 2003-02-11 2006-02-07 Plus Chemicals, B.V. Process for preparing simvastatin having controlled ranges of simvastatin dimer content
KR20060129196A (ko) * 2003-10-21 2006-12-15 다이버사 코포레이션 심바스타틴 및 중간체의 제조 방법
JP4621451B2 (ja) 2004-08-11 2011-01-26 富士フイルム株式会社 液浸露光用保護膜形成組成物及びそれを用いたパターン形成方法
US20070048351A1 (en) * 2005-09-01 2007-03-01 Prescient Medical, Inc. Drugs coated on a device to treat vulnerable plaque
WO2007125547A2 (en) 2006-05-03 2007-11-08 Manne Satyanarayana Reddy Novel process for statins and its pharmaceutically acceptable salts thereof
US8404841B2 (en) 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
EP2387561A4 (de) 2009-01-19 2012-07-25 Msn Lab Ltd Verbessertes verfahren zur herstellung von hochreiner (3r,5s)-7-[2-cyclopropyl-4-(4-fluorphenyl) chinolin-3-yl]-3,5-dihydroxy-6(e)-heptensäure und pharmazeutisch akzeptable salze daraus
US8470805B2 (en) * 2009-04-30 2013-06-25 Kaohsiung Medical University Processes for preparing piperazinium salts of KMUP and use thereof
US8987444B2 (en) 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN110563680A (zh) * 2019-09-10 2019-12-13 山东罗欣药业集团恒欣药业有限公司 一种治疗高脂血症药物的制备方法
CN110483459A (zh) * 2019-09-10 2019-11-22 山东罗欣药业集团恒欣药业有限公司 一种辛伐他汀的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
DE69008277D1 (de) * 1989-08-31 1994-05-26 Merck & Co Inc 7-Subsituierte HMG-CoA-Reduktase-Inhibitoren.
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
EP0940395A1 (de) 1998-03-05 1999-09-08 Synthon B.V. Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate

Also Published As

Publication number Publication date
AU747219B2 (en) 2002-05-09
ES2197465T3 (es) 2004-01-01
NO993644L (no) 1999-09-28
AU6618398A (en) 1998-08-18
NZ336993A (en) 2000-05-26
PT971913E (pt) 2003-08-29
DE69813538T2 (de) 2004-04-01
AU747219C (en) 2003-11-20
EP1340752A1 (de) 2003-09-03
IL131044A0 (en) 2001-01-28
NO993644D0 (no) 1999-07-27
DE69834279T2 (de) 2007-01-04
DK0971913T3 (da) 2003-08-04
JP2001508782A (ja) 2001-07-03
AR011780A1 (es) 2000-09-13
DE69813538D1 (de) 2003-05-22
EP0971913A1 (de) 2000-01-19
KR100538674B1 (ko) 2005-12-26
IL131044A (en) 2003-07-31
EP1340752B1 (de) 2006-04-19
NO318146B1 (no) 2005-02-07
EP0971913B1 (de) 2003-04-16
ATE323689T1 (de) 2006-05-15
KR20000070501A (ko) 2000-11-25
CA2278603A1 (en) 1998-07-30
US6294680B1 (en) 2001-09-25
WO1998032751A1 (en) 1998-07-30
DE69834279D1 (de) 2006-05-24
ES2266671T3 (es) 2007-03-01

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