NO991045L - FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater - Google Patents

FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater

Info

Publication number
NO991045L
NO991045L NO991045A NO991045A NO991045L NO 991045 L NO991045 L NO 991045L NO 991045 A NO991045 A NO 991045A NO 991045 A NO991045 A NO 991045A NO 991045 L NO991045 L NO 991045L
Authority
NO
Norway
Prior art keywords
compound
formula
iii
general formula
agent
Prior art date
Application number
NO991045A
Other languages
English (en)
Other versions
NO991045D0 (no
Inventor
Frans Van Dalen
Jacobus Maria Lemmens
Gertruda Antonetta Ph Helvoirt
Theodorus Hendricus Ant Peters
Frantisek Pycha
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26150393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO991045(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP98201762A external-priority patent/EP0940395A1/en
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of NO991045D0 publication Critical patent/NO991045D0/no
Publication of NO991045L publication Critical patent/NO991045L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

Fremgangsmåte ved fremstilling av en forbindelse med formel VI: omfattende trinnene å: - omsette en forbindelse av den generelle formel (I): med et ring-åpnede middel for å gi en forbindelse som har den generelle formel II: og, beskytte hydroksygruppene av den således dannede forbin- delse (II) med et beskyttende middle for i hovedsak å nedsette reaktiviteten derav og gi forbindelse (III) eller (VII) , CO-NH-Rj VlO-Rj * 0" ks*^ (III) .CO-NH-R, (VII) hvori det beskyttende midlet nedsetter reaktiviteten av i det minste forbindelse (II) ved å erstatte hydrogenatomet av minst en av hydroksygruppene derav med en karbon-termi- nert gruppe, hvorved i tilfellet med forbindelse (III) minst en av R3 og R4 ikke er hydrogen. - omsette forbindelse (III) og/eller (VII) med et alky- leringsmiddel av formel R,X for å gi en forbindelse hen- holdsvis med formel (IV) eller (VIII), (IV) .CO-NH-R, (VIII) hvor R, fortrinnsvis representerer en metyl- eller etyl- gruppe og X representerer et halid, fortrinnsvis klor, brom eller jod; - hydrolysere de beskyttende gruppene R3, R4 og R5, R6 av forbindelser henholdsvis (IV) og (VIII) for å gi en forbindelse med formel (V) - CO-NH-R, : c: (V) relaktonisere forbindelse (V) for å gi forbindelse (VI).
NO991045A 1998-03-05 1999-03-03 FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater NO991045L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1008502 1998-03-05
EP98201762A EP0940395A1 (en) 1998-03-05 1998-05-27 Process for producing simvastatin and/or its derivatives

Publications (2)

Publication Number Publication Date
NO991045D0 NO991045D0 (no) 1999-03-03
NO991045L true NO991045L (no) 1999-09-06

Family

ID=26150393

Family Applications (2)

Application Number Title Priority Date Filing Date
NO991045A NO991045L (no) 1998-03-05 1999-03-03 FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
NO20004357A NO321444B1 (no) 1998-03-05 2000-09-01 Fremgangsmate ved fremstilling av simvastatin-derivater samt intermediater egnet for fremstillingen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20004357A NO321444B1 (no) 1998-03-05 2000-09-01 Fremgangsmate ved fremstilling av simvastatin-derivater samt intermediater egnet for fremstillingen.

Country Status (14)

Country Link
EP (1) EP1064275B2 (no)
JP (1) JP2002505327A (no)
CN (2) CN1232030A (no)
AT (1) ATE227280T1 (no)
AU (1) AU759878B2 (no)
CA (1) CA2321676A1 (no)
DE (1) DE69903799T3 (no)
DK (1) DK1064275T4 (no)
ES (1) ES2182493T5 (no)
IL (1) IL138119A (no)
NO (2) NO991045L (no)
PT (1) PT1064275E (no)
SI (1) SI1064275T2 (no)
WO (1) WO1999045003A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1446088A (zh) * 2000-07-27 2003-10-01 普拉斯化学品有限公司 高度纯化的辛伐他汀组合物
CN1277826C (zh) * 2003-12-01 2006-10-04 叶红平 辉伐他汀及其合成方法和以辉伐他汀为原料药的制剂
US8455640B2 (en) 2006-05-03 2013-06-04 Msn Laboratories Limited Process for statins and its pharmaceutically acceptable salts thereof
ES2567171T3 (es) * 2006-10-09 2016-04-20 Msn Laboratories Private Limited Nuevo procedimiento para la preparación de estatinas y sus sales farmacéuticamente aceptables
CN101289440B (zh) * 2007-06-29 2010-08-25 中国热带农业科学院热带生物技术研究所 一种多烯大环类化合物及其制备方法与应用
WO2010089770A2 (en) 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
CN102712678B (zh) 2009-09-30 2015-05-06 科德克希思公司 改进的lov-d酰基转移酶介导的酰化作用
CN102695792B (zh) 2009-10-08 2015-02-18 加利福尼亚大学董事会 对辛伐他汀合成表现出改善性质的LovD突变体
EP2526099B1 (en) 2010-01-18 2016-03-30 MSN Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN103755562B (zh) * 2013-12-24 2015-11-18 深圳华润九新药业有限公司 一种洛伐他汀羟基酸化物的制备方法、组合物、组合物的制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5393893A (en) † 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
US5763646A (en) † 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
ES2197465T3 (es) * 1997-01-28 2004-01-01 Plus Chemicals B.V. Proceso para la produccion de estatinas semisinteticas a traves de nuevos intermedios.

Also Published As

Publication number Publication date
NO991045D0 (no) 1999-03-03
EP1064275A1 (en) 2001-01-03
SI1064275T2 (sl) 2006-08-31
DE69903799T3 (de) 2006-11-16
DE69903799D1 (de) 2002-12-12
ES2182493T5 (es) 2006-11-16
NO20004357L (no) 2000-11-06
EP1064275B2 (en) 2006-04-19
CN1292786A (zh) 2001-04-25
DK1064275T3 (da) 2003-01-27
IL138119A0 (en) 2001-10-31
CA2321676A1 (en) 1999-09-10
DE69903799T2 (de) 2003-09-04
SI1064275T1 (en) 2003-04-30
NO321444B1 (no) 2006-05-08
AU2861299A (en) 1999-09-20
DK1064275T4 (da) 2006-05-29
AU759878B2 (en) 2003-05-01
WO1999045003A1 (en) 1999-09-10
EP1064275B1 (en) 2002-11-06
ES2182493T3 (es) 2003-03-01
IL138119A (en) 2004-05-12
CN1232030A (zh) 1999-10-20
ATE227280T1 (de) 2002-11-15
JP2002505327A (ja) 2002-02-19
NO20004357D0 (no) 2000-09-01
PT1064275E (pt) 2003-03-31

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