IL138119A - Process for producing simvastatin and/or its derivatives - Google Patents

Process for producing simvastatin and/or its derivatives

Info

Publication number
IL138119A
IL138119A IL13811999A IL13811999A IL138119A IL 138119 A IL138119 A IL 138119A IL 13811999 A IL13811999 A IL 13811999A IL 13811999 A IL13811999 A IL 13811999A IL 138119 A IL138119 A IL 138119A
Authority
IL
Israel
Prior art keywords
group
compound
formula
methyl
process according
Prior art date
Application number
IL13811999A
Other languages
English (en)
Other versions
IL138119A0 (en
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26150393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL138119(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP98201762A external-priority patent/EP0940395A1/en
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of IL138119A0 publication Critical patent/IL138119A0/xx
Publication of IL138119A publication Critical patent/IL138119A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
IL13811999A 1998-03-05 1999-03-05 Process for producing simvastatin and/or its derivatives IL138119A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL1008502 1998-03-05
EP98201762A EP0940395A1 (en) 1998-03-05 1998-05-27 Process for producing simvastatin and/or its derivatives
PCT/NL1999/000119 WO1999045003A1 (en) 1998-03-05 1999-03-05 Process for producing simvastatin and/or its derivatives

Publications (2)

Publication Number Publication Date
IL138119A0 IL138119A0 (en) 2001-10-31
IL138119A true IL138119A (en) 2004-05-12

Family

ID=26150393

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13811999A IL138119A (en) 1998-03-05 1999-03-05 Process for producing simvastatin and/or its derivatives

Country Status (14)

Country Link
EP (1) EP1064275B2 (no)
JP (1) JP2002505327A (no)
CN (2) CN1292786A (no)
AT (1) ATE227280T1 (no)
AU (1) AU759878B2 (no)
CA (1) CA2321676A1 (no)
DE (1) DE69903799T3 (no)
DK (1) DK1064275T4 (no)
ES (1) ES2182493T5 (no)
IL (1) IL138119A (no)
NO (2) NO991045L (no)
PT (1) PT1064275E (no)
SI (1) SI1064275T2 (no)
WO (1) WO1999045003A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2419206A1 (en) * 2000-07-27 2002-02-07 Plus Chemicals B.V. Highly purified simvastatin compositions
CN1277826C (zh) * 2003-12-01 2006-10-04 叶红平 辉伐他汀及其合成方法和以辉伐他汀为原料药的制剂
HUE027872T2 (en) 2006-05-03 2016-11-28 Msn Laboratories Private Ltd A novel process for statins and their pharmaceutically acceptable salts
ES2567171T3 (es) * 2006-10-09 2016-04-20 Msn Laboratories Private Limited Nuevo procedimiento para la preparación de estatinas y sus sales farmacéuticamente aceptables
CN101289440B (zh) * 2007-06-29 2010-08-25 中国热带农业科学院热带生物技术研究所 一种多烯大环类化合物及其制备方法与应用
US8487105B2 (en) 2009-01-19 2013-07-16 Msn Laboratories Limited Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof
SI2483292T1 (sl) 2009-09-30 2015-01-30 Codexis, Inc. Variantni polipeptidi lovd in njihove uporabe
US8981056B2 (en) 2009-10-08 2015-03-17 The Regents Of The University Of California Variant LovD polypeptide
EP2526099B1 (en) 2010-01-18 2016-03-30 MSN Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN103755562B (zh) * 2013-12-24 2015-11-18 深圳华润九新药业有限公司 一种洛伐他汀羟基酸化物的制备方法、组合物、组合物的制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5393893A (en) † 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
US5763646A (en) † 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
EP0971913B1 (en) 1997-01-28 2003-04-16 Plus Chemicals B.V. Process for the production of semi synthetic statins via novel intermediates

Also Published As

Publication number Publication date
ATE227280T1 (de) 2002-11-15
IL138119A0 (en) 2001-10-31
CN1292786A (zh) 2001-04-25
CA2321676A1 (en) 1999-09-10
EP1064275A1 (en) 2001-01-03
CN1232030A (zh) 1999-10-20
SI1064275T1 (en) 2003-04-30
AU759878B2 (en) 2003-05-01
NO20004357D0 (no) 2000-09-01
ES2182493T3 (es) 2003-03-01
DE69903799D1 (de) 2002-12-12
NO991045D0 (no) 1999-03-03
NO20004357L (no) 2000-11-06
WO1999045003A1 (en) 1999-09-10
EP1064275B1 (en) 2002-11-06
PT1064275E (pt) 2003-03-31
DE69903799T2 (de) 2003-09-04
JP2002505327A (ja) 2002-02-19
AU2861299A (en) 1999-09-20
SI1064275T2 (sl) 2006-08-31
NO991045L (no) 1999-09-06
DE69903799T3 (de) 2006-11-16
ES2182493T5 (es) 2006-11-16
NO321444B1 (no) 2006-05-08
DK1064275T4 (da) 2006-05-29
DK1064275T3 (da) 2003-01-27
EP1064275B2 (en) 2006-04-19

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Publication Publication Date Title
US6100407A (en) Process for producing simvastatin and/or its derivatives
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EP0864569B1 (en) Process for manufacturing simvastatin from lovastatin or mevinolinic acid
JP5048709B2 (ja) シンバスタチンの製造方法
US5393893A (en) Process for producing simvastatin and analogs thereof
AU747219C (en) Process for the production of semi synthetic statins via novel intermediates
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EP0864560B1 (en) Key intermediates in the manufacture of simvastatin
US6573392B1 (en) Process for manufacturing simvastatin and the novel intermediates
CZ20003194A3 (cs) Způsob přípravy sloučeniny simvastatinu a jejích derivátů, farmaceutický prostředek, použití sloučeniny simvastatinu a jejích derivátů pro přípravu léčiv
SK283319B6 (sk) Spôsob výroby simvastatínu z lovastatínu alebo kyseliny mevinolínovej
CA2040530A1 (en) Fluorinated derivatives of mevinic acids
WO2006072963A1 (en) Process for preparing simvastatin from lovastatin amine salts in three steps
CZ264997A3 (cs) Způsob výroby simvastatinu z lovastatinu nebo mevinolinové kyseliny
WO2002024675A1 (en) Process for manufacturing simvastatin and the novel intermediates
MXPA01010721A (es) Metodo para la obtencion de simvastatina a partir de lovastatina.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees