DE69813538D1 - Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte - Google Patents
Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukteInfo
- Publication number
- DE69813538D1 DE69813538D1 DE69813538T DE69813538T DE69813538D1 DE 69813538 D1 DE69813538 D1 DE 69813538D1 DE 69813538 T DE69813538 T DE 69813538T DE 69813538 T DE69813538 T DE 69813538T DE 69813538 D1 DE69813538 D1 DE 69813538D1
- Authority
- DE
- Germany
- Prior art keywords
- vianeue
- statines
- synthetic
- intermediate products
- producing semi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97200223 | 1997-01-28 | ||
| EP97200223 | 1997-01-28 | ||
| EP97306809 | 1997-09-03 | ||
| EP97306809 | 1997-09-03 | ||
| PCT/EP1998/000519 WO1998032751A1 (en) | 1997-01-28 | 1998-01-27 | Process for the production of semi synthetic statins via novel intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69813538D1 true DE69813538D1 (de) | 2003-05-22 |
| DE69813538T2 DE69813538T2 (de) | 2004-04-01 |
Family
ID=26146080
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69834279T Expired - Fee Related DE69834279T2 (de) | 1997-01-28 | 1998-01-27 | Verfahren zu Herstellung von halb-synthetischen Statins via neue Zwischenprodukte |
| DE69813538T Expired - Fee Related DE69813538T2 (de) | 1997-01-28 | 1998-01-27 | Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69834279T Expired - Fee Related DE69834279T2 (de) | 1997-01-28 | 1998-01-27 | Verfahren zu Herstellung von halb-synthetischen Statins via neue Zwischenprodukte |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6294680B1 (de) |
| EP (2) | EP1340752B1 (de) |
| JP (1) | JP2001508782A (de) |
| KR (1) | KR100538674B1 (de) |
| AR (1) | AR011780A1 (de) |
| AT (2) | ATE323689T1 (de) |
| AU (1) | AU747219C (de) |
| CA (1) | CA2278603A1 (de) |
| DE (2) | DE69834279T2 (de) |
| DK (1) | DK0971913T3 (de) |
| ES (2) | ES2266671T3 (de) |
| IL (1) | IL131044A (de) |
| NO (1) | NO318146B1 (de) |
| NZ (1) | NZ336993A (de) |
| PT (1) | PT971913E (de) |
| WO (1) | WO1998032751A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO991045L (no) | 1998-03-05 | 1999-09-06 | Synthon Bv | FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater |
| EP0940395A1 (de) * | 1998-03-05 | 1999-09-08 | Synthon B.V. | Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate |
| KR100672269B1 (ko) * | 1998-12-10 | 2007-01-23 | 카네카 코포레이션 | 심바스타틴의 제조 방법 |
| CO5140104A1 (es) | 1999-02-16 | 2002-03-22 | Novartis Ag | Derivados de mevinolina y preparacion farmaceuticas que los contienen |
| KR20010009846A (ko) * | 1999-07-14 | 2001-02-05 | 구광시 | 심바스타틴 제조에 유용한 중간체 및 그의 제조방법 |
| US6573385B1 (en) | 1999-11-11 | 2003-06-03 | Biocon India Limited | Process for manufacturing simvastatin and novel intermediates thereof |
| AU2127500A (en) * | 1999-11-11 | 2001-06-06 | Biocon India Limited | Process for manufacturing simvastatin and the novel intermediates |
| CN1446088A (zh) * | 2000-07-27 | 2003-10-01 | 普拉斯化学品有限公司 | 高度纯化的辛伐他汀组合物 |
| NL1017548C2 (nl) | 2001-03-09 | 2002-09-10 | Synthon Bv | Een lactonisatie proces. |
| KR20040026705A (ko) * | 2001-08-16 | 2004-03-31 | 테바 파마슈티컬 인더스트리즈 리미티드 | 스타틴의 칼슘 염 형태의 제조 방법 |
| US6472542B1 (en) | 2001-11-29 | 2002-10-29 | Fermic S.A. De C.V. | Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin |
| KR100423892B1 (ko) * | 2001-12-03 | 2004-03-22 | 씨제이 주식회사 | 스타틴의 제조에 있어서 새로운 락톤화 방법 |
| SI21187A (sl) | 2002-03-26 | 2003-10-31 | Krka, Tovarna Zdravil D.D., Novo Mesto | Postopek za pripravo 4-oksitetrahidropiran-2-onov |
| US6603022B1 (en) | 2002-05-10 | 2003-08-05 | Biocon India Limited | Process for manufacturing Simvastatin and novel intermediates thereof |
| KR20050098313A (ko) | 2003-02-11 | 2005-10-11 | 플러스 케미칼스 비.브이. | 제어된 범위의 심바스타틴 이량체 함량을 갖는심바스타틴의 제조 방법 |
| MXPA06004448A (es) * | 2003-10-21 | 2006-07-10 | Diversa Corp | Metodos para hacer simvastatina e intermediarios. |
| JP4621451B2 (ja) | 2004-08-11 | 2011-01-26 | 富士フイルム株式会社 | 液浸露光用保護膜形成組成物及びそれを用いたパターン形成方法 |
| WO2007030302A2 (en) * | 2005-09-01 | 2007-03-15 | Prescient Medical, Inc. | Drugs coated on a device to treat vulnerable plaque |
| WO2007125547A2 (en) | 2006-05-03 | 2007-11-08 | Manne Satyanarayana Reddy | Novel process for statins and its pharmaceutically acceptable salts thereof |
| US8404841B2 (en) | 2006-10-09 | 2013-03-26 | Msn Laboratories Limited | Process for the preparation of statins and their pharmaceutically acceptable salts thereof |
| WO2010089770A2 (en) | 2009-01-19 | 2010-08-12 | Msn Laboratories Limited | Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof |
| US8470805B2 (en) * | 2009-04-30 | 2013-06-25 | Kaohsiung Medical University | Processes for preparing piperazinium salts of KMUP and use thereof |
| EP2526099B1 (de) | 2010-01-18 | 2016-03-30 | MSN Laboratories Limited | Verbessertes verfahren zur herstellung von amid-zwischenprodukten und seine anwendung |
| HU229260B1 (en) * | 2010-11-29 | 2013-10-28 | Egis Gyogyszergyar Nyrt | Process for preparation of rosuvastatin salts |
| CN110483459A (zh) * | 2019-09-10 | 2019-11-22 | 山东罗欣药业集团恒欣药业有限公司 | 一种辛伐他汀的合成方法 |
| CN110563680A (zh) * | 2019-09-10 | 2019-12-13 | 山东罗欣药业集团恒欣药业有限公司 | 一种治疗高脂血症药物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| EP0415488B1 (de) | 1989-08-31 | 1994-04-20 | Merck & Co. Inc. | 7-Subsituierte HMG-CoA-Reduktase-Inhibitoren |
| US5393893A (en) | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
| EP0940395A1 (de) | 1998-03-05 | 1999-09-08 | Synthon B.V. | Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate |
-
1998
- 1998-01-27 DK DK98908031T patent/DK0971913T3/da active
- 1998-01-27 KR KR10-1999-7006745A patent/KR100538674B1/ko not_active IP Right Cessation
- 1998-01-27 AU AU66183/98A patent/AU747219C/en not_active Ceased
- 1998-01-27 EP EP03008084A patent/EP1340752B1/de not_active Expired - Lifetime
- 1998-01-27 DE DE69834279T patent/DE69834279T2/de not_active Expired - Fee Related
- 1998-01-27 EP EP98908031A patent/EP0971913B1/de not_active Expired - Lifetime
- 1998-01-27 AT AT03008084T patent/ATE323689T1/de not_active IP Right Cessation
- 1998-01-27 WO PCT/EP1998/000519 patent/WO1998032751A1/en not_active Application Discontinuation
- 1998-01-27 PT PT98908031T patent/PT971913E/pt unknown
- 1998-01-27 ES ES03008084T patent/ES2266671T3/es not_active Expired - Lifetime
- 1998-01-27 AT AT98908031T patent/ATE237605T1/de not_active IP Right Cessation
- 1998-01-27 DE DE69813538T patent/DE69813538T2/de not_active Expired - Fee Related
- 1998-01-27 ES ES98908031T patent/ES2197465T3/es not_active Expired - Lifetime
- 1998-01-27 NZ NZ336993A patent/NZ336993A/xx unknown
- 1998-01-27 US US09/341,809 patent/US6294680B1/en not_active Expired - Fee Related
- 1998-01-27 IL IL13104498A patent/IL131044A/xx not_active IP Right Cessation
- 1998-01-27 JP JP53162098A patent/JP2001508782A/ja not_active Ceased
- 1998-01-27 CA CA002278603A patent/CA2278603A1/en not_active Abandoned
- 1998-01-28 AR ARP980100381A patent/AR011780A1/es unknown
-
1999
- 1999-07-27 NO NO19993644A patent/NO318146B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO318146B1 (no) | 2005-02-07 |
| AU747219B2 (en) | 2002-05-09 |
| CA2278603A1 (en) | 1998-07-30 |
| IL131044A (en) | 2003-07-31 |
| KR20000070501A (ko) | 2000-11-25 |
| US6294680B1 (en) | 2001-09-25 |
| EP0971913B1 (de) | 2003-04-16 |
| AU747219C (en) | 2003-11-20 |
| AR011780A1 (es) | 2000-09-13 |
| ATE323689T1 (de) | 2006-05-15 |
| ES2266671T3 (es) | 2007-03-01 |
| DE69813538T2 (de) | 2004-04-01 |
| EP1340752B1 (de) | 2006-04-19 |
| DE69834279D1 (de) | 2006-05-24 |
| KR100538674B1 (ko) | 2005-12-26 |
| NO993644D0 (no) | 1999-07-27 |
| ES2197465T3 (es) | 2004-01-01 |
| NZ336993A (en) | 2000-05-26 |
| NO993644L (no) | 1999-09-28 |
| IL131044A0 (en) | 2001-01-28 |
| DE69834279T2 (de) | 2007-01-04 |
| EP1340752A1 (de) | 2003-09-03 |
| JP2001508782A (ja) | 2001-07-03 |
| EP0971913A1 (de) | 2000-01-19 |
| DK0971913T3 (da) | 2003-08-04 |
| PT971913E (pt) | 2003-08-29 |
| WO1998032751A1 (en) | 1998-07-30 |
| ATE237605T1 (de) | 2003-05-15 |
| AU6618398A (en) | 1998-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |