ATE263563T1 - Mittel gegen juckreiz - Google Patents

Mittel gegen juckreiz

Info

Publication number
ATE263563T1
ATE263563T1 AT03001740T AT03001740T ATE263563T1 AT E263563 T1 ATE263563 T1 AT E263563T1 AT 03001740 T AT03001740 T AT 03001740T AT 03001740 T AT03001740 T AT 03001740T AT E263563 T1 ATE263563 T1 AT E263563T1
Authority
AT
Austria
Prior art keywords
remedies
itching
morphinian
antipruritic
opiate
Prior art date
Application number
AT03001740T
Other languages
English (en)
Inventor
Hiroshi Nagase
Jun Utsumi
Takashi Endoh
Toshiaki Tanaka
Kuniaki Kawamura
Junzo Kamei
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18041771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE263563(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE263563T1 publication Critical patent/ATE263563T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Magnetic Record Carriers (AREA)
  • Elimination Of Static Electricity (AREA)
  • Table Equipment (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03001740T 1996-11-25 1997-11-21 Mittel gegen juckreiz ATE263563T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31347696 1996-11-25

Publications (1)

Publication Number Publication Date
ATE263563T1 true ATE263563T1 (de) 2004-04-15

Family

ID=18041771

Family Applications (3)

Application Number Title Priority Date Filing Date
AT03001740T ATE263563T1 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
AT03001739T ATE291429T1 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
AT97912539T ATE359076T1 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT03001739T ATE291429T1 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
AT97912539T ATE359076T1 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz

Country Status (15)

Country Link
US (2) US6174891B1 (de)
EP (5) EP1310255B1 (de)
KR (1) KR100557801B1 (de)
CN (3) CN1291717C (de)
AT (3) ATE263563T1 (de)
AU (1) AU738743B2 (de)
CA (1) CA2244256C (de)
DE (3) DE69737592T2 (de)
DK (1) DK0897726T3 (de)
ES (3) ES2285733T3 (de)
NO (1) NO316309B1 (de)
NZ (1) NZ331001A (de)
PT (1) PT897726E (de)
TW (1) TW542838B (de)
WO (1) WO1998023290A1 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
AU1290797A (en) * 1996-12-24 1998-07-17 George F. El Khoury Topical application of opioid drugs such as morphine for relief of itching and skin disease or irritation
MXPA99011298A (es) * 1997-07-14 2004-10-28 Adolor Corp Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas.
JP3211027B2 (ja) * 1998-11-13 2001-09-25 丸石製薬株式会社 カプサイシン含有外用剤
WO2001014382A1 (fr) * 1999-08-23 2001-03-01 Toray Industries, Inc. Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif
CA2383146C (en) * 1999-08-24 2010-11-16 Hiroshi Nagase Therapeutic agent for neuropathic pain and neuropathic pain animal model
WO2001074819A1 (fr) * 2000-04-03 2001-10-11 Toray Industries, Inc. Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif
JP2002249442A (ja) * 2001-02-21 2002-09-06 Fumakilla Ltd アレルギー減感作治療薬
DE60231388D1 (de) 2001-03-30 2009-04-16 Toray Industries Mittel zur behandlung des syndroms der unruhigen beine
US7294688B2 (en) 2001-04-30 2007-11-13 Nanogen Inc. Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons
US6617308B2 (en) 2001-04-30 2003-09-09 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons
CN1283317C (zh) * 2001-05-08 2006-11-08 东丽株式会社 类鸦片κ受体激动性化合物在制备治疗败血症的药物中的应用
US6844438B2 (en) * 2001-08-15 2005-01-18 Mclean Hospital Corporation N-substituted derivatives of morphinan and uses thereof
US20030125347A1 (en) * 2001-11-02 2003-07-03 Elan Corporation Plc Pharmaceutical composition
EP2042173A3 (de) 2002-03-29 2010-02-24 Santen Pharmaceutical Co., Ltd. Ein 2-Phenylbenzothiazolin-Derivat enthaltender Kappa-Opioidrezeptoragonist
WO2004026262A2 (en) * 2002-09-23 2004-04-01 Verion, Inc. Abuse-resistant pharmaceutical compositions
DE60313478T2 (de) * 2002-09-25 2008-01-03 Euro-Celtique S.A. N-substituierte hydromorphone und ihre anwendung
ATE414516T1 (de) 2004-03-30 2008-12-15 Toray Industries Morphinanderivate als mittel gegen juckreiz
US7704522B2 (en) * 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP1809104A4 (de) * 2004-09-23 2009-04-29 Alexander Michalow Verfahren zum regeln von neurotransmittersystemen durch gegenadaptationen
US20060159748A1 (en) * 2004-12-23 2006-07-20 Rajesh Jain Oral immediate release formulation of a poorly water-soluble active substance
US7453122B2 (en) * 2005-02-08 2008-11-18 Taiwan Semiconductor Manufacturing Co., Ltd. SOI MOSFET device with reduced polysilicon loading on active area
CA2604071C (en) * 2005-03-10 2013-10-08 Toray Industries, Inc. Antipruritic agent for pruritus caused by multiple sclerosis
KR101333620B1 (ko) 2005-04-06 2013-11-27 도레이 카부시키가이샤 모르피난 유도체의 결정 및 그 제조법
KR20080065664A (ko) * 2005-11-09 2008-07-14 도레이 가부시끼가이샤 기능성 장장해의 치료 또는 예방제
WO2007072749A1 (ja) * 2005-12-21 2007-06-28 Toray Industries, Inc. 鎮咳剤
JP2010504325A (ja) * 2006-09-20 2010-02-12 マリンクロット インコーポレイテッド 置換モルフィナン−６−オン、並びにその塩および中間体の調製
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2137189B1 (de) * 2007-03-06 2015-05-06 Mallinckrodt LLC Verfahren zur herstellung quaternärer n-alkyl-morphinin-alkaloid-derivate
WO2008133297A1 (ja) 2007-04-24 2008-11-06 Toray Industries, Inc. ジスキネジアの治療または予防剤
JP5099127B2 (ja) * 2007-04-26 2012-12-12 東レ株式会社 ４，５−エポキシモルヒナン誘導体を含有する安定な固形製剤
AU2008268202B2 (en) 2007-06-22 2012-12-20 Toray Industries, Inc. Remedy or preventive for integration dysfunction syndrome
EP2196206B8 (de) * 2007-10-05 2019-11-13 Toray Industries, Inc. Heilmittel zur linderung von hautproblemen mit einem morphinanderivat oder pharmakologisch verträglichen säuradditionssalz daraus als wirkstoff
WO2009138734A2 (en) * 2008-05-14 2009-11-19 Serentis Limited Use of opioid compounds in peripheral pain, wound healing and scar formation
NZ589496A (en) * 2008-05-27 2013-02-22 Mallinckrodt Llc Processes and compounds for the preparation of normorphinans
US9458109B2 (en) * 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP5784507B2 (ja) * 2009-02-23 2015-09-24 マリンクロッド エルエルシー （＋）−モルフィナニウム第四級塩およびその生成方法
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
MY173491A (en) 2010-01-29 2020-01-29 Toray Industries Therapeutic or prophylactic agent for biliary tract diseases
MX2013008749A (es) 2011-01-31 2013-10-17 Toray Industries Agente terapeutico o profilactico para caquexia.
MX2014002630A (es) 2011-09-08 2014-04-14 Mallinckrodt Llc Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
JP6064252B2 (ja) * 2012-01-19 2017-01-25 三笠製薬株式会社 そう痒症改善経皮吸収貼付剤
CN104981246A (zh) * 2012-12-14 2015-10-14 特雷维治疗股份有限公司 治疗瘙痒的方法
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
WO2016052617A1 (ja) * 2014-09-30 2016-04-07 国立大学法人筑波大学 ナルフラフィン含有局所適用製剤
TW201707703A (zh) * 2015-06-04 2017-03-01 Tokai Capsule Co Ltd 軟膠囊劑
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
WO2017165409A1 (en) * 2016-03-21 2017-09-28 Trevi Therapeutics, Inc. Treatment of uremic pruritus
CN108883185B (zh) * 2016-12-06 2021-10-08 江苏恒瑞医药股份有限公司 一种κ阿片受体激动剂在制备治疗法尼醇X受体激动剂引起的瘙痒的药物中的用途
EP3761982A4 (de) 2018-03-08 2021-12-15 Victoria Link Ltd Behandlung von demyelinisierungskrankheiten
JP2021531299A (ja) 2018-07-23 2021-11-18 トレビ セラピューティクス インコーポレイテッド 慢性咳嗽、息切れ、及び呼吸困難の治療
US20220226299A1 (en) * 2019-03-29 2022-07-21 Nippon Chemiphar Co., Ltd. Use of t-type calcium channel blocker for treating pruritus
WO2022004788A1 (ja) 2020-06-30 2022-01-06 東レ株式会社 代謝異常を伴う疾患又は症候群における筋力低下症状の改善剤又は予防剤
KR20240035395A (ko) 2021-06-14 2024-03-15 스코르피온 테라퓨틱스, 인코퍼레이티드 암 치료에 사용할 수 있는 요소 유도체

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196376B (en) * 1985-05-23 1988-11-28 Sandoz Ag Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
US5021413B1 (en) * 1988-08-24 1994-12-13 Sankyo Co Analgesic thiomorpholins, their preparation, and pharmaceutical compositions containing them
US5116842A (en) * 1989-05-18 1992-05-26 Glaxo Group Limited Chemical compounds
ATE172201T1 (de) * 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung
JPH06122677A (ja) * 1992-08-28 1994-05-06 Sankyo Co Ltd 光学活性なカルボン酸アミド誘導体
CA2143318A1 (en) * 1993-06-30 1995-01-12 Hiroshi Nagase Antitussive agents
AU690155B2 (en) * 1993-10-20 1998-04-23 Boots Company Plc, The Ibuprofen and flurbiprofen as anti-pruritic agents
IT1273751B (it) 1994-02-11 1997-07-10 Smithkline Beecham Farma Derivati azaciclici
US5760023A (en) 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
MXPA99011298A (es) * 1997-07-14 2004-10-28 Adolor Corp Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas.

Also Published As

Publication number Publication date
ES2215158T3 (es) 2004-10-01
ATE291429T1 (de) 2005-04-15
DK0897726T3 (da) 2007-08-13
NO983431L (no) 1998-09-24
KR19990081978A (ko) 1999-11-15
AU738743B2 (en) 2001-09-27
US6316461B1 (en) 2001-11-13
DE69737592D1 (de) 2007-05-24
CA2244256C (en) 2006-07-11
EP1327444B1 (de) 2005-03-23
EP0897726A4 (de) 2003-05-28
EP0897726B1 (de) 2007-04-11
CA2244256A1 (en) 1998-06-04
DE69728585D1 (de) 2004-05-13
CN1214634A (zh) 1999-04-21
CN1291717C (zh) 2006-12-27
CN1535687A (zh) 2004-10-13
EP0897726A1 (de) 1999-02-24
EP1310255B1 (de) 2004-04-07
DE69732868D1 (de) 2005-04-28
KR100557801B1 (ko) 2006-04-21
JP3531170B2 (ja) 2004-05-24
EP1310251A1 (de) 2003-05-14
TW542838B (en) 2003-07-21
ATE359076T1 (de) 2007-05-15
AU4968397A (en) 1998-06-22
DE69737592T2 (de) 2008-01-03
PT897726E (pt) 2007-07-09
NO316309B1 (no) 2004-01-12
WO1998023290A1 (fr) 1998-06-04
EP1312361A1 (de) 2003-05-21
NO983431D0 (no) 1998-07-24
DE69728585T2 (de) 2004-08-05
CN1180844C (zh) 2004-12-22
DE69732868T2 (de) 2006-04-13
US6174891B1 (en) 2001-01-16
ES2285733T3 (es) 2007-11-16
EP1310255A1 (de) 2003-05-14
NZ331001A (en) 2000-05-26
CN1530111A (zh) 2004-09-22
ES2236630T3 (es) 2005-07-16
EP1327444A1 (de) 2003-07-16

Similar Documents

Publication Publication Date Title
ATE291429T1 (de) Mittel gegen juckreiz
AU2002213336A1 (en) Substituted heterocyclic compounds for treating multidrug resistance
ID18883A (id) Pesaing 5-ht 1f
ES2155601T3 (es) Compuestos de benzolactama sustituidos como antagonistas de la sustancia p.
DE60133029D1 (de) Mittel zur prävention oder behandlung von psoriasi
ATE252560T1 (de) Steroidrezeptor-modulator verbindungen und methoden
IL138476A0 (en) Method for treating pharmaceutical compositions by special use of anti-oxidant
DE69616480D1 (de) Piperidinderivate als neurokininantagonisten
EA200300566A1 (ru) Применение cci-779 в качестве противоопухолевого средства
ATE231872T1 (de) Thiazolopyrimidinderivate
DE69928655D1 (de) Substituierte porphyrine
ATE256671T1 (de) 2-phenyl-substituierte 1-(n-phenylaminoalkyl)- piperazin-derivate
PT1117403E (pt) Antagonistas de mglurs para o tratamento da dor e ansiedade
CU23088A3 (es) Compuestos de tetra-hidropiridina.
IL152097A0 (en) Use of pyrazole derivatives for treating infertility
BRPI0507987A (pt) métodos e compostos moduladores receptor de glicocorticóide
PT977716E (pt) Utilizacao de alcoois como aditivos para rebocos e/ou argamassas
ATE290857T1 (de) Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen
BR0206917A (pt) Uso de antagonistas de mglur5 para o tratamento de condições prurìticas
EA200000522A1 (ru) 5-htагонисты
TR200100240T2 (tr) Anksiyete bozukluklarının tedavisi
NO20005548D0 (no) Mykobakterieinhibitorer
ATE267194T1 (de) Medikamente geeignet zur behandlung von proliferativen erkrankungen
MXPA05009428A (es) Composiciones y metodos para prevenir y tratar enfermedades relacionadas con endotoxinas.
ID27052A (id) Pengobatan arthritis dan keadaan-keadaan lain yang sekupa

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties