ATE228821T1 - Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung - Google Patents
Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendungInfo
- Publication number
- ATE228821T1 ATE228821T1 AT94909393T AT94909393T ATE228821T1 AT E228821 T1 ATE228821 T1 AT E228821T1 AT 94909393 T AT94909393 T AT 94909393T AT 94909393 T AT94909393 T AT 94909393T AT E228821 T1 ATE228821 T1 AT E228821T1
- Authority
- AT
- Austria
- Prior art keywords
- particles
- suspensions
- lipid
- solid lipid
- delivery systems
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/044—Suspensions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/48—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids
- B01F23/482—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids using molten solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/51—Methods thereof
- B01F23/511—Methods thereof characterised by the composition of the liquids or solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Agronomy & Crop Science (AREA)
- Medical Informatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Geometry (AREA)
- Pest Control & Pesticides (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2750193A | 1993-03-05 | 1993-03-05 | |
CA002091152A CA2091152C (en) | 1993-03-05 | 1993-03-05 | Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof |
PCT/SE1994/000185 WO1994020072A1 (en) | 1993-03-05 | 1994-03-04 | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE228821T1 true ATE228821T1 (de) | 2002-12-15 |
Family
ID=25675967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94909393T ATE228821T1 (de) | 1993-03-05 | 1994-03-04 | Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0687172B1 (de) |
JP (2) | JP3916249B2 (de) |
AT (1) | ATE228821T1 (de) |
AU (1) | AU676279B2 (de) |
CA (1) | CA2091152C (de) |
DE (1) | DE69431831T2 (de) |
DK (1) | DK0687172T3 (de) |
ES (1) | ES2190439T3 (de) |
FI (1) | FI114006B (de) |
NO (1) | NO314285B1 (de) |
NZ (1) | NZ262541A (de) |
PT (1) | PT687172E (de) |
WO (1) | WO1994020072A1 (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5785976A (en) * | 1993-03-05 | 1998-07-28 | Pharmacia & Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
US5885486A (en) * | 1993-03-05 | 1999-03-23 | Pharmaciaand Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
PT101422B (pt) * | 1993-12-06 | 1997-06-30 | Ineti Inst Biotec Q F E Tecnol | Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao |
DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
US5747001A (en) * | 1995-02-24 | 1998-05-05 | Nanosystems, L.L.C. | Aerosols containing beclomethazone nanoparticle dispersions |
EP0810853B1 (de) | 1995-02-24 | 2004-08-25 | Elan Pharma International Limited | Nanopartikel-dispersionen enthaltende aerosole |
DE19517147C2 (de) * | 1995-05-10 | 1999-07-01 | Hexal Pharmaforschung Gmbh | Aciclovir-Zubereitung |
US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
CA2263102C (en) * | 1996-08-22 | 2006-08-15 | Research Triangle Pharmaceuticals Ltd. | Compositions comprising microparticles of water-insoluble substances and method for preparing same |
DE19641259A1 (de) * | 1996-10-07 | 1998-04-16 | Kade Pharma Fab Gmbh | Arzneimittel auf Basis von Diclofenac |
US6184182B1 (en) | 1996-10-25 | 2001-02-06 | Monsanto Company | Composition and method for treating plants with exogenous chemicals |
DK0936860T3 (da) * | 1996-10-25 | 2002-06-10 | Monsanto Technology Llc | Sammensætning og fremgangsmåde til behandling af planter med exogene kemikalier |
GB9624615D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Chrystallisation process |
GB9625589D0 (en) * | 1996-12-10 | 1997-01-29 | Boots Co Plc | Therapeutic agents |
IT1292142B1 (it) * | 1997-06-12 | 1999-01-25 | Maria Rosa Gasco | Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale |
US6423363B1 (en) * | 1997-08-22 | 2002-07-23 | Lipton, Division Of Conopco, Inc. | Aqueous dispersion |
WO1999029300A1 (en) * | 1997-12-10 | 1999-06-17 | Rtp Pharma Inc. | Self-emulsifying fenofibrate formulations |
IT1298575B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
SE512958C2 (sv) † | 1998-04-30 | 2000-06-12 | Triple Crown Ab | Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning |
GB9810859D0 (en) | 1998-05-20 | 1998-07-22 | Zeneca Ltd | Crystallisation process |
DE69914327T2 (de) * | 1998-06-17 | 2004-12-23 | Uniroyal Chemical Co., Inc., Middlebury | Biologisch aktive mikrodispersionszusammensetzung |
ITMI981528A1 (it) * | 1998-07-03 | 2000-01-03 | Recordati Ind Chimica E Farma | Formulazioni topiche di aciclovir |
US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
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IT1303787B1 (it) * | 1998-11-25 | 2001-02-23 | Maria Rosa Gasco | "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule" |
DE19919770A1 (de) * | 1999-04-30 | 2000-11-02 | Henkel Kgaa | Verwendung nanoskaliger antimikrobieller Wirkstoffe in der Mund- und/oder Zahnpflege |
SE517769C2 (sv) | 1999-10-29 | 2002-07-16 | Triple Crown Ab | Kolesterol och blodfettsänkande komposition, innehållande fytosteroler, blandade med monoglycerider |
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US20040077604A1 (en) | 2001-12-19 | 2004-04-22 | Lenard Lichtenberger | Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity |
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DE10310021A1 (de) | 2002-02-28 | 2003-10-23 | Lukowski Gerold | Pharmazeutisch oder kosmetisch wirksame Mittel aus liqidhaltigen marinen Oragnismen |
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ITMI20021725A1 (it) * | 2002-08-01 | 2002-10-31 | Zambon Spa | Composizioni farmaceutiche ad attivita' antibiotica. |
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DE10312763A1 (de) * | 2003-03-21 | 2004-09-30 | IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG | Verfahren zur Herstellung einer SLN-Dispersion |
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US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
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JP2019530737A (ja) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
JP2019535829A (ja) | 2016-11-21 | 2019-12-12 | エイリオン セラピューティクス, インコーポレイテッド | 大型薬剤の経皮送達 |
MX2021013329A (es) | 2019-04-29 | 2022-03-17 | Insmed Inc | Composiciones de polvo seco de los profarmacos de treprostinil y métodos de uso de las mismas. |
JP2023506222A (ja) * | 2019-12-10 | 2023-02-15 | カプスゲル・ベルジャン・ナムローゼ・フェンノートシャップ | 脂質マトリックスコアおよび活性成分を含有する粒子 |
MX2022010050A (es) | 2020-02-21 | 2022-09-05 | Akouos Inc | Composiciones y metodos para tratar deficiencia auditiva no asociada con la edad en un sujeto humano. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3421468A1 (de) * | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
DE3702029A1 (de) * | 1987-01-24 | 1988-08-04 | Basf Ag | Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung |
KR960005137B1 (ko) * | 1989-11-13 | 1996-04-22 | 노바 파머수티컬 코포레이션 | 물질 전달용 리포스피어 |
AU658608B2 (en) * | 1991-03-25 | 1995-04-27 | Astellas Pharma Europe B.V. | Topical preparation containing a suspension of solid lipid particles |
-
1993
- 1993-03-05 CA CA002091152A patent/CA2091152C/en not_active Expired - Fee Related
-
1994
- 1994-03-04 EP EP94909393A patent/EP0687172B1/de not_active Expired - Lifetime
- 1994-03-04 PT PT94909393T patent/PT687172E/pt unknown
- 1994-03-04 AU AU62253/94A patent/AU676279B2/en not_active Ceased
- 1994-03-04 ES ES94909393T patent/ES2190439T3/es not_active Expired - Lifetime
- 1994-03-04 AT AT94909393T patent/ATE228821T1/de not_active IP Right Cessation
- 1994-03-04 NZ NZ262541A patent/NZ262541A/en unknown
- 1994-03-04 WO PCT/SE1994/000185 patent/WO1994020072A1/en active IP Right Grant
- 1994-03-04 DE DE69431831T patent/DE69431831T2/de not_active Expired - Fee Related
- 1994-03-04 JP JP51988794A patent/JP3916249B2/ja not_active Expired - Fee Related
- 1994-03-04 DK DK94909393T patent/DK0687172T3/da active
-
1995
- 1995-09-04 FI FI954143A patent/FI114006B/fi not_active IP Right Cessation
- 1995-09-04 NO NO19953461A patent/NO314285B1/no unknown
-
2006
- 2006-09-27 JP JP2006261728A patent/JP2007023051A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO314285B1 (no) | 2003-03-03 |
FI954143A0 (fi) | 1995-09-04 |
ES2190439T3 (es) | 2003-08-01 |
FI114006B (fi) | 2004-07-30 |
JP2007023051A (ja) | 2007-02-01 |
JP3916249B2 (ja) | 2007-05-16 |
CA2091152C (en) | 2005-05-03 |
EP0687172B1 (de) | 2002-12-04 |
DE69431831D1 (de) | 2003-01-16 |
NZ262541A (en) | 1997-04-24 |
PT687172E (pt) | 2003-04-30 |
CA2091152A1 (en) | 1994-09-06 |
DK0687172T3 (da) | 2003-03-17 |
FI954143A (fi) | 1995-10-19 |
AU676279B2 (en) | 1997-03-06 |
AU6225394A (en) | 1994-09-26 |
NO953461L (no) | 1995-11-06 |
WO1994020072A1 (en) | 1994-09-15 |
JPH08507515A (ja) | 1996-08-13 |
DE69431831T2 (de) | 2003-04-10 |
NO953461D0 (no) | 1995-09-04 |
EP0687172A1 (de) | 1995-12-20 |
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