DE69415684T2 - Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe - Google Patents
Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufeInfo
- Publication number
- DE69415684T2 DE69415684T2 DE69415684T DE69415684T DE69415684T2 DE 69415684 T2 DE69415684 T2 DE 69415684T2 DE 69415684 T DE69415684 T DE 69415684T DE 69415684 T DE69415684 T DE 69415684T DE 69415684 T2 DE69415684 T2 DE 69415684T2
- Authority
- DE
- Germany
- Prior art keywords
- fluidized layer
- producing microspheres
- microspheres
- producing
- fluidized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000004005 microsphere Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14225793A | 1993-10-22 | 1993-10-22 | |
US14331393A | 1993-10-25 | 1993-10-25 | |
PCT/US1994/011678 WO1995011009A1 (en) | 1993-10-22 | 1994-10-13 | Method for preparing microspheres comprising a fluidized bed drying step |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69415684D1 DE69415684D1 (de) | 1999-02-11 |
DE69415684T2 true DE69415684T2 (de) | 1999-06-10 |
Family
ID=26839915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69415684T Expired - Lifetime DE69415684T2 (de) | 1993-10-22 | 1994-10-13 | Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0724433B1 (de) |
JP (1) | JP3841309B2 (de) |
AT (1) | ATE175110T1 (de) |
AU (1) | AU8017494A (de) |
CA (1) | CA2172508C (de) |
DE (1) | DE69415684T2 (de) |
DK (1) | DK0724433T3 (de) |
UY (1) | UY23846A1 (de) |
WO (1) | WO1995011009A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2153418T3 (es) * | 1993-02-23 | 2001-03-01 | Genentech Inc | Estabilizacion de polipeptidos tratados con solventes organicos por medio de excipientes. |
CZ293764B6 (cs) | 1993-11-19 | 2004-07-14 | Janssen Pharmaceutica N. V. | Farmaceutický prostředek s dostatečným a dlouhodobým uvolňováním léčiva, biodegradovatelné a biokompatibilní mikročástice, způsob jejich výroby a použití |
US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
EP0765660A3 (de) * | 1995-09-28 | 1998-09-23 | Takeda Chemical Industries, Ltd. | Mikrokapseln enthaltend 2-Piperazinon-1-essigsäure Verbindungen |
US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
EP0862419B2 (de) | 1995-11-09 | 2010-11-17 | Microbiological Research Authority | Mikroverkapselte dna zur impfung und gentherapie |
DE19545257A1 (de) * | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
GB2310801A (en) * | 1996-03-04 | 1997-09-10 | Merck & Co Inc | Process for removing an organic solvent from lactide-glycoside copolymer microspheres |
US6190702B1 (en) | 1996-03-28 | 2001-02-20 | Takeda Chemical Industries, Ltd. | Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase |
DK0904063T3 (da) * | 1996-05-07 | 2002-12-16 | Alkermes Inc | Fremgangsmåde til fremstilling af mikropartikler |
JP5220248B2 (ja) * | 1997-08-29 | 2013-06-26 | アンチジェニックス・インコーポレイテッド | アジュバントqs−21および賦形剤としてポリソルベートまたはシクロデキストリンを含む組成物 |
ATE233097T1 (de) | 1997-11-07 | 2003-03-15 | Chiron Corp | Verfahren zur herstellung von igf-i formulierungen mit verzögerter freisetzung |
SE9801288D0 (sv) | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
GB9810236D0 (en) * | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
AU1226901A (en) * | 1999-10-22 | 2001-05-08 | Amgen, Inc. | Biodegradable microparticles with novel erythropoietin stimulating protein |
EP1853228A4 (de) * | 2005-03-01 | 2012-07-18 | Sun Pharma Advanced Res Co Ltd | Verfahren zur herstellung von mikrokugeln oder mikrokapseln |
US20170079962A1 (en) | 2009-11-11 | 2017-03-23 | Rapamycin Holdings, Llc | Oral Rapamycin Preparation and Use for Stomatitus |
CA2784287C (en) * | 2009-12-22 | 2017-07-18 | Evonik Degussa Corporation | Emulsion-based process for preparing microparticles and workhead assembly for use with same |
UA111162C2 (uk) | 2010-08-04 | 2016-04-11 | Флекшен Терап'Ютікс, Інк. | Ін'єкційна композиція ацетоніду триамцинолону для лікування болю |
AU2012290683B2 (en) * | 2011-08-04 | 2017-07-13 | Flexion Therapeutics, Inc. | Corticosteroids for the treatment of joint pain |
CA2933908C (en) | 2013-12-31 | 2024-01-30 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
JPWO2023277051A1 (de) * | 2021-06-30 | 2023-01-05 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
IT1214629B (it) * | 1985-08-29 | 1990-01-18 | Formenti Farmaceutici Spa | Procedimento di microincapsulazione di un medicamento,medicamento cosi'preparato,e composizioni farmaceutiche che lo comprendono |
US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
IL84167A (en) * | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
ES2102347T3 (es) * | 1987-02-20 | 1997-08-01 | Genentech Inc | Metodos y composiciones para la utilizacion de polipeptidos env y anticuerpos anti-env de hiv. |
JP2813630B2 (ja) * | 1987-02-20 | 1998-10-22 | ジェネンテク,インコーポレイテッド | ヒト免疫不全ウイルスのエンベロープポリペプチドおよびその抗体 |
DK171073B1 (da) * | 1988-08-24 | 1996-05-28 | Allied Colloids Ltd | Polymere sammensætninger og metoder til deres fremstilling |
US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
US4990336A (en) * | 1989-02-08 | 1991-02-05 | Biosearch, Inc. | Sustained release dosage form |
US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
FR2658432B1 (fr) * | 1990-02-22 | 1994-07-01 | Medgenix Group Sa | Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation. |
AU8303691A (en) * | 1991-04-24 | 1992-12-21 | United States Of America, As Represented By The Secretary Of The Army, The | Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
US5429822A (en) * | 1992-03-13 | 1995-07-04 | Cambridge Scientific, Inc. | Biodegradable bursting release system |
FR2703927B1 (fr) * | 1993-04-13 | 1995-07-13 | Coletica | Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une polyamine pour former en milieu aqueux une membrane au moins en surface de particules gélifiées. |
JPH09504523A (ja) * | 1993-10-22 | 1997-05-06 | ジェネンテク,インコーポレイテッド | アジュバントのマイクロカプセル化方法および組成物 |
CA2172509C (en) * | 1993-10-22 | 2010-08-24 | Jeffrey L. Cleland | Methods and compositions for microencapsulation of antigens for use as vaccines |
-
1994
- 1994-10-13 AT AT94931369T patent/ATE175110T1/de active
- 1994-10-13 DE DE69415684T patent/DE69415684T2/de not_active Expired - Lifetime
- 1994-10-13 AU AU80174/94A patent/AU8017494A/en not_active Abandoned
- 1994-10-13 EP EP94931369A patent/EP0724433B1/de not_active Expired - Lifetime
- 1994-10-13 DK DK94931369T patent/DK0724433T3/da active
- 1994-10-13 CA CA002172508A patent/CA2172508C/en not_active Expired - Lifetime
- 1994-10-13 WO PCT/US1994/011678 patent/WO1995011009A1/en active IP Right Grant
- 1994-10-13 JP JP51207695A patent/JP3841309B2/ja not_active Expired - Lifetime
- 1994-10-21 UY UY23846A patent/UY23846A1/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP3841309B2 (ja) | 2006-11-01 |
AU8017494A (en) | 1995-05-08 |
DE69415684D1 (de) | 1999-02-11 |
DK0724433T3 (da) | 1999-08-30 |
CA2172508A1 (en) | 1995-04-27 |
ATE175110T1 (de) | 1999-01-15 |
JPH09504026A (ja) | 1997-04-22 |
CA2172508C (en) | 2005-08-23 |
UY23846A1 (es) | 1995-03-28 |
EP0724433A1 (de) | 1996-08-07 |
WO1995011009A1 (en) | 1995-04-27 |
EP0724433B1 (de) | 1998-12-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |