ATE197708T1 - N-morpholino-n-nitrosaminoacetonitril- cyclodextrin-einschlussverbindungen - Google Patents

N-morpholino-n-nitrosaminoacetonitril- cyclodextrin-einschlussverbindungen

Info

Publication number
ATE197708T1
ATE197708T1 AT95918104T AT95918104T ATE197708T1 AT E197708 T1 ATE197708 T1 AT E197708T1 AT 95918104 T AT95918104 T AT 95918104T AT 95918104 T AT95918104 T AT 95918104T AT E197708 T1 ATE197708 T1 AT E197708T1
Authority
AT
Austria
Prior art keywords
sin
complexes
pct
ions
cyclodextrin
Prior art date
Application number
AT95918104T
Other languages
English (en)
Inventor
Joseph Geczy
Andrasne Vikmon
Jozsef Szejtli
Lajos Szente
Julianna Szeman
Original Assignee
Therabel Ind Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therabel Ind Sa filed Critical Therabel Ind Sa
Application granted granted Critical
Publication of ATE197708T1 publication Critical patent/ATE197708T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
AT95918104T 1994-04-26 1995-04-25 N-morpholino-n-nitrosaminoacetonitril- cyclodextrin-einschlussverbindungen ATE197708T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9401183A HU218280B (en) 1994-04-26 1994-04-26 Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes
PCT/HU1995/000011 WO1995029172A1 (en) 1994-04-26 1995-04-25 N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes

Publications (1)

Publication Number Publication Date
ATE197708T1 true ATE197708T1 (de) 2000-12-15

Family

ID=10985114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918104T ATE197708T1 (de) 1994-04-26 1995-04-25 N-morpholino-n-nitrosaminoacetonitril- cyclodextrin-einschlussverbindungen

Country Status (32)

Country Link
US (1) US5698535A (de)
EP (1) EP0705255B1 (de)
JP (1) JP3434828B2 (de)
KR (1) KR960703404A (de)
CN (1) CN1060164C (de)
AT (1) ATE197708T1 (de)
AU (1) AU694219B2 (de)
BG (1) BG61974B1 (de)
BR (1) BR9506155A (de)
CA (1) CA2163539C (de)
CZ (1) CZ316395A3 (de)
DE (1) DE69519463T2 (de)
DK (1) DK0705255T3 (de)
ES (1) ES2153897T3 (de)
FI (1) FI956156A (de)
GR (1) GR3035356T3 (de)
HR (1) HRP950249A2 (de)
HU (1) HU218280B (de)
IL (1) IL113491A (de)
LT (1) LT4167B (de)
LV (1) LV11543B (de)
MD (1) MD1419G2 (de)
NO (1) NO311030B1 (de)
NZ (1) NZ285149A (de)
PL (1) PL312183A1 (de)
PT (1) PT705255E (de)
RO (1) RO114449B1 (de)
RU (1) RU2136698C1 (de)
SI (1) SI0705255T1 (de)
SK (1) SK155195A3 (de)
WO (1) WO1995029172A1 (de)
YU (1) YU25995A (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
MXPA02004743A (es) * 1999-11-12 2003-10-14 Roquette Freres Mezclas cristalinas de eteres de metilo parciales de beta-ciclodextrina y compuestos relacionados.
FR2805462B1 (fr) * 2000-02-24 2003-08-15 Therabel Res Nouvelle forme galenique orale a liberation prolongee de la molsidomine
TWI321054B (en) * 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
EP1219306A1 (de) * 2000-12-29 2002-07-03 Nicox S.A. Zyklodextrin und NO-abgebende Arzneimittlen enthaltende Zusammensetzungen
EP1534340B1 (de) 2002-09-06 2011-11-16 Cerulean Pharma Inc. Polymere auf basis von cyclodextrin zur verabreichung von an diese kovalent gebundene arzneimittel
WO2004032862A2 (en) * 2002-10-09 2004-04-22 Insert Therapeutics, Inc. Cyclodextrin-based materials, compositions and uses related thereto
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
BR112012012210B8 (pt) * 2009-11-23 2021-05-25 Cerulean Pharma Inc conjugado de (cdp)-taxano de polímero contendo ciclodextrina, composição, composição farmacêutica, forma de dosagem, kit e uso de um conjugado de cdp-taxano
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
CN111295094A (zh) 2017-10-09 2020-06-16 泰尔茂比司特生物技术有限公司 冻干容器及使用冻干容器的方法
JP2022525742A (ja) 2019-03-14 2022-05-19 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥用ローディングトレイ組立体及びシステム
WO2022016343A1 (zh) * 2020-07-20 2022-01-27 深圳迈瑞生物医疗电子股份有限公司 一种组合物的血小板解聚用途、解聚试剂及解聚方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208233A (en) * 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5212204A (en) * 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
HU212730B (en) * 1990-03-28 1996-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them
JP3190340B2 (ja) * 1991-09-24 2001-07-23 アメリカ合衆国 酸化窒素供与体プロドラッグとしての求核試薬−酸化窒素付加物の酸素置換誘導体
US5389675A (en) * 1992-03-27 1995-02-14 The United States Of America As Represented By The Department Of Health And Human Services Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents

Also Published As

Publication number Publication date
MD950440A (en) 1997-10-31
YU25995A (sh) 1998-08-14
RU2136698C1 (ru) 1999-09-10
NO955283L (no) 1995-12-22
WO1995029172A1 (en) 1995-11-02
HUT70750A (en) 1995-10-30
US5698535A (en) 1997-12-16
SI0705255T1 (en) 2001-04-30
CZ316395A3 (en) 1996-05-15
BG61974B1 (bg) 1998-11-30
JP3434828B2 (ja) 2003-08-11
BG100313A (bg) 1996-07-31
LV11543B (en) 1996-12-20
DE69519463T2 (de) 2001-06-28
DE69519463D1 (de) 2000-12-28
GR3035356T3 (en) 2001-05-31
NO955283D0 (no) 1995-12-22
HU9401183D0 (en) 1994-07-28
IL113491A (en) 2002-03-10
NZ285149A (en) 1998-06-26
AU2415995A (en) 1995-11-16
MD1419G2 (ro) 2000-11-30
SK155195A3 (en) 1997-05-07
DK0705255T3 (da) 2000-12-11
FI956156A0 (fi) 1995-12-20
PL312183A1 (en) 1996-04-01
EP0705255B1 (de) 2000-11-22
IL113491A0 (en) 1995-07-31
HU218280B (en) 2000-07-28
RO114449B1 (ro) 1999-04-30
ES2153897T3 (es) 2001-03-16
LT4167B (en) 1997-06-25
AU694219B2 (en) 1998-07-16
NO311030B1 (no) 2001-10-01
HRP950249A2 (en) 1997-10-31
BR9506155A (pt) 1996-04-16
CN1128028A (zh) 1996-07-31
MD1419F2 (en) 2000-02-29
EP0705255A1 (de) 1996-04-10
LT95133A (en) 1996-10-25
LV11543A (lv) 1996-10-20
PT705255E (pt) 2001-05-31
CN1060164C (zh) 2001-01-03
KR960703404A (ko) 1996-08-17
CA2163539C (en) 2003-04-01
JPH09503546A (ja) 1997-04-08
CA2163539A1 (en) 1995-11-02
FI956156A (fi) 1995-12-20

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