ATA128191A - Gemische von polysacchariden mit niedrigem molekulargewicht, deren herstellungsverfahren und verwendung - Google Patents

Gemische von polysacchariden mit niedrigem molekulargewicht, deren herstellungsverfahren und verwendung

Info

Publication number
ATA128191A
ATA128191A AT0128191A AT128191A ATA128191A AT A128191 A ATA128191 A AT A128191A AT 0128191 A AT0128191 A AT 0128191A AT 128191 A AT128191 A AT 128191A AT A128191 A ATA128191 A AT A128191A
Authority
AT
Austria
Prior art keywords
mixtures
molecular weight
production method
low molecular
weight polysaccharides
Prior art date
Application number
AT0128191A
Other languages
English (en)
Other versions
AT398976B (de
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9398013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATA128191(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of ATA128191A publication Critical patent/ATA128191A/de
Application granted granted Critical
Publication of AT398976B publication Critical patent/AT398976B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0128191A 1990-06-26 1991-06-26 Gemische von polysacchariden mit niedrigem molekulargewicht, deren herstellungsverfahren und verwendung AT398976B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9008013A FR2663639B1 (fr) 1990-06-26 1990-06-26 Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.

Publications (2)

Publication Number Publication Date
ATA128191A true ATA128191A (de) 1994-07-15
AT398976B AT398976B (de) 1995-02-27

Family

ID=9398013

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0128191A AT398976B (de) 1990-06-26 1991-06-26 Gemische von polysacchariden mit niedrigem molekulargewicht, deren herstellungsverfahren und verwendung

Country Status (26)

Country Link
US (1) US5389618A (de)
JP (1) JP3287363B2 (de)
KR (1) KR0185586B1 (de)
AT (1) AT398976B (de)
AU (1) AU643531B2 (de)
BE (1) BE1006827A3 (de)
CA (1) CA2045433C (de)
CH (1) CH682236A5 (de)
DK (1) DK176524B1 (de)
ES (1) ES2036922B9 (de)
FI (1) FI104490B (de)
FR (1) FR2663639B1 (de)
GB (1) GB2245898B (de)
GR (1) GR1000763B (de)
HU (1) HU210925B (de)
IE (1) IE66341B1 (de)
IL (1) IL98604A (de)
IT (1) IT1248557B (de)
LU (1) LU87957A1 (de)
MX (1) MX25829A (de)
NL (1) NL194947C (de)
NO (1) NO304991B1 (de)
NZ (1) NZ238691A (de)
PT (1) PT98102B (de)
SE (1) SE506267C2 (de)
ZA (1) ZA914869B (de)

Families Citing this family (58)

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USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
FR2687158B1 (fr) * 1992-02-07 1995-06-30 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
US5849721A (en) * 1992-02-07 1998-12-15 Rhone-Poulenc Rorer S.A. Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
PL177245B1 (pl) * 1993-09-30 1999-10-29 Seikagaku Kogyo Co Ltd Środek przeciwzakrzepowy
RU2179445C2 (ru) * 1996-08-13 2002-02-20 Бейкер Нортон Фармасьютикалз, Инк. Способ и композиция для лечения астмы
CA2370539C (en) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
NZ516229A (en) * 1999-06-30 2004-08-27 Hamilton Civic Hospitals Res Heparin compositions that inhibit clot associated coagulation factors
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
WO2001034114A1 (en) * 1999-11-12 2001-05-17 Emisphere Technologies, Inc. Liquid heparin formulation
US6608042B2 (en) 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
KR20030069990A (ko) * 2000-09-08 2003-08-27 해밀톤 시빅 호스피탈즈 리서치 디벨로프먼트 인코포레이티드 항혈전 조성물
PT1345612E (pt) 2000-12-16 2005-06-30 Aventis Pharma Gmbh Utilizacao de heparina de massa molecular reduzida para o tratamento de osteoartrose
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
CA2458852A1 (en) * 2001-08-28 2003-03-06 Leo Pharma A/S Antithrombotic compositions comprising low molecular weight heparin and low molecular weight dermatan sulphate
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
EP2284535A1 (de) * 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Heparine mit niedrigem Molekulargewicht
US20030236221A1 (en) * 2002-06-20 2003-12-25 Chemi Spa Process for the preparation of esters of heparin
ATE356150T1 (de) * 2002-06-20 2007-03-15 Chemi Spa Verfahren zur herstellung von heparinestern
US20040265943A1 (en) * 2002-09-23 2004-12-30 Aventis Pharma S.A. Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins
FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
WO2004066808A2 (en) * 2002-12-20 2004-08-12 Momenta Pharmaceuticals, Inc. Glycan markers for diagnosing and monitoring disease
JP2006526592A (ja) * 2003-06-05 2006-11-24 センテリオン 血管由来の欠損に関連する高コレステロール血症または糖尿病の治療のための、線維芽細胞成長因子をコードするプラスミド
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US20050186679A1 (en) * 2004-02-24 2005-08-25 Christian Viskov Method for determining specific groups constituting heparins or low molecular weight heparins
EP1582531A1 (de) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
GB0509433D0 (en) * 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
EP1792621B1 (de) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Oral verabreichbare Heparinderivate
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
CN100436483C (zh) * 2006-05-24 2008-11-26 杭州九源基因工程有限公司 一种依诺肝素钠的纯化生产方法
CN101495517B (zh) 2006-05-25 2012-10-10 莫曼塔医药品有限公司 低分子量肝素及其用途
US8101733B1 (en) 2006-06-27 2012-01-24 Momenta Pharmaceuticals, Inc. Methods of evaluating mixtures of polysaccharides
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
US7790466B1 (en) 2007-01-26 2010-09-07 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US20110112050A1 (en) * 2008-05-20 2011-05-12 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
EP2233145A1 (de) 2009-03-19 2010-09-29 Sanofi-Aventis AVE5026-Dosis zur Behandlung von venöser Thromboembolie bei Patienten mit starker Nierenfunktionsstörung
EP2526122B1 (de) * 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Beurteilung von heparinzubereitungen
CN102792158B (zh) 2011-01-28 2013-07-10 杭州九源基因工程有限公司 一种基于毛细管电泳的依诺肝素钠精细结构测定方法
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
AR085961A1 (es) 2011-04-11 2013-11-06 Sanofi Sa Polisacaridos que poseen dos sitios de union a la antitrombina iii, metodo para prepararlos y composiciones farmaceuticas que los contienen
CN102603925B (zh) * 2012-03-21 2013-12-11 东营天东制药有限公司 一种由粗品肝素钠直接生产依诺肝素钠的方法
CN102603926B (zh) * 2012-03-27 2014-04-30 烟台东诚生化股份有限公司 一种高效价肝素钠制备新工艺
CN102633908A (zh) * 2012-05-02 2012-08-15 雷晓刚 一种高品质超低分子量肝素的制备方法
RU2512768C1 (ru) * 2012-12-18 2014-04-10 Федеральное бюджетное учреждение "Государственный институт кровезаменителей и медицинских препаратов (ФБУ "ГИКиМП") Способ получения низкомолекулярного гепарина
CN103145868B (zh) * 2013-01-07 2015-09-16 中国科学院昆明植物研究所 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用
CN103175925B (zh) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 依诺肝素钠生产过程中肝素苄基酯的酯化率的检测方法
CN103214591B (zh) * 2013-04-12 2015-11-04 中国科学院昆明植物研究所 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
US10668015B2 (en) 2015-01-20 2020-06-02 Incarda Therapeutics, Inc. Unit aerosol doses for anticoagulation
CN109666086B (zh) * 2018-11-05 2020-12-22 上海宝维医药技术有限公司 一种高纯度肝素季铵盐的制备方法及其应用
CA3144968A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
EP4182452A4 (de) 2020-07-14 2024-07-31 Optimvia, LLC Verfahren zur synthese von nicht-antikoagulierendem heparansulfat

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DK108622C (da) * 1963-01-18 1968-01-15 Roussel Uclaf Fremgangsmåde til fremstilling af benzylheparinat eller dets alkalimetalsalte.
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
DE3265781D1 (en) * 1981-05-21 1985-10-03 Akzo Nv New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
DK196886D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0337327A1 (de) * 1988-04-09 1989-10-18 Bioiberica, S.A. Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
ES2006891A6 (es) * 1988-04-09 1989-05-16 Bioiberica Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina

Also Published As

Publication number Publication date
GR910100270A (en) 1992-08-25
FI104490B (fi) 2000-02-15
NO912485L (no) 1991-12-27
PT98102B (pt) 1998-11-30
HUT57796A (en) 1991-12-30
KR0185586B1 (ko) 1999-04-01
ITMI911757A1 (it) 1992-12-26
FI913101L (fi) 1991-12-27
GB2245898A (en) 1992-01-15
FI913101A0 (fi) 1991-06-25
CH682236A5 (de) 1993-08-13
NZ238691A (en) 1992-07-28
NO304991B1 (no) 1999-03-15
ES2036922B9 (es) 2012-07-30
CA2045433C (fr) 2002-07-30
GR1000763B (el) 1992-12-30
PT98102A (pt) 1992-03-31
NL194947B (nl) 2003-04-01
NL194947C (nl) 2003-08-04
AU643531B2 (en) 1993-11-18
ES2036922A1 (es) 1993-06-01
DK176524B1 (da) 2008-07-14
NO912485D0 (no) 1991-06-25
ZA914869B (en) 1992-04-29
IL98604A0 (en) 1992-07-15
IE912216A1 (en) 1992-01-01
FR2663639A1 (fr) 1991-12-27
JP3287363B2 (ja) 2002-06-04
HU210925B (en) 1995-09-28
GB2245898B (en) 1993-10-06
IE66341B1 (en) 1995-12-27
IL98604A (en) 1998-08-15
CA2045433A1 (fr) 1991-12-27
SE506267C2 (sv) 1997-11-24
SE9101957D0 (sv) 1991-06-25
KR920000792A (ko) 1992-01-29
AT398976B (de) 1995-02-27
LU87957A1 (fr) 1993-01-15
JPH04226101A (ja) 1992-08-14
AU7928891A (en) 1992-01-02
FR2663639B1 (fr) 1994-03-18
MX25829A (es) 1993-10-01
NL9101049A (nl) 1992-01-16
ITMI911757A0 (it) 1991-06-26
DK124391D0 (da) 1991-06-25
US5389618A (en) 1995-02-14
BE1006827A3 (fr) 1995-01-03
ES2036922B1 (es) 1994-03-01
GB9113589D0 (en) 1991-08-14
DK124391A (da) 1991-12-27
SE9101957L (sv) 1991-12-27
IT1248557B (it) 1995-01-19

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Effective date: 20110626