AT396250B - Verfahren zur herstellung von neuen antibiotisch wirkenden verbindungen - Google Patents

Verfahren zur herstellung von neuen antibiotisch wirkenden verbindungen Download PDF

Info

Publication number
AT396250B
AT396250B AT0268485A AT268485A AT396250B AT 396250 B AT396250 B AT 396250B AT 0268485 A AT0268485 A AT 0268485A AT 268485 A AT268485 A AT 268485A AT 396250 B AT396250 B AT 396250B
Authority
AT
Austria
Prior art keywords
compounds
ncib
factor
partial
formulas
Prior art date
Application number
AT0268485A
Other languages
German (de)
English (en)
Other versions
ATA268485A (de
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848423278A external-priority patent/GB8423278D0/en
Priority claimed from GB848432519A external-priority patent/GB8432519D0/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ATA268485A publication Critical patent/ATA268485A/de
Application granted granted Critical
Publication of AT396250B publication Critical patent/AT396250B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT0268485A 1984-09-14 1985-09-13 Verfahren zur herstellung von neuen antibiotisch wirkenden verbindungen AT396250B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848423278A GB8423278D0 (en) 1984-09-14 1984-09-14 Antibiotic compounds
GB848432519A GB8432519D0 (en) 1984-12-21 1984-12-21 Antibiotic compounds

Publications (2)

Publication Number Publication Date
ATA268485A ATA268485A (de) 1992-11-15
AT396250B true AT396250B (de) 1993-07-26

Family

ID=26288220

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0268485A AT396250B (de) 1984-09-14 1985-09-13 Verfahren zur herstellung von neuen antibiotisch wirkenden verbindungen

Country Status (33)

Country Link
US (2) US4898821A (en, 2012)
JP (2) JPH07116199B2 (en, 2012)
KR (1) KR940004098B1 (en, 2012)
AT (1) AT396250B (en, 2012)
AU (1) AU596565B2 (en, 2012)
BE (1) BE903232A (en, 2012)
BG (1) BG44205A3 (en, 2012)
BR (1) BR8504457A (en, 2012)
CA (1) CA1313155C (en, 2012)
CH (1) CH666690A5 (en, 2012)
CS (1) CS268803B2 (en, 2012)
DE (1) DE3532794A1 (en, 2012)
DK (1) DK162099C (en, 2012)
ES (2) ES8704545A1 (en, 2012)
FI (1) FI87366C (en, 2012)
FR (1) FR2570390B1 (en, 2012)
GB (1) GB2166436B (en, 2012)
GR (1) GR852232B (en, 2012)
HU (1) HU197046B (en, 2012)
IE (1) IE59394B1 (en, 2012)
IL (1) IL76385A (en, 2012)
IT (1) IT1182857B (en, 2012)
LU (1) LU86074A1 (en, 2012)
NL (1) NL8502511A (en, 2012)
NZ (1) NZ213463A (en, 2012)
PH (2) PH21995A (en, 2012)
PL (1) PL152148B1 (en, 2012)
PT (1) PT81125B (en, 2012)
RO (1) RO92478A (en, 2012)
SE (2) SE502748C2 (en, 2012)
SU (1) SU1738090A3 (en, 2012)
UA (1) UA19162A (en, 2012)
ZW (1) ZW15585A1 (en, 2012)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV5536A3 (lv) * 1984-09-14 1994-03-10 American Cyanamid Co Panemiens antibiotikas s-541 iegusanai streptomicetu celmi-antibiotikas s-541 producenti
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
AT399441B (de) * 1985-04-30 1995-05-26 American Cyanamid Co Schädlingsbekämpfungsmittel und verfahren zur bekämpfung von schädlingen
AU596586B2 (en) * 1985-04-30 1990-05-10 American Cyanamid Company Chemical derivatives of antibiotics S541
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
AU598204B2 (en) * 1985-09-13 1990-06-21 American Cyanamid Company Chemical derivatives of antibiotics S541
DK168866B1 (da) * 1986-03-12 1994-06-27 American Cyanamid Co 5-Keto-S541-macrolidforbindelse; krystallinsk produkt indeholdende over 90 % af forbindelsen; præparater indeholdende forbindelsen til anvendelse inden for human- og veterinærmedicin; skadedyrsbekæmpelsespræparat indeholdende forbindelsen; ikke-terapeutisk fremgangsmåde til bekæmpelse af skadedyr under anvendelse af forbindelsen; fremgangsmåde til fremstilling af et fermentationsmedium indeholdend
DE3787548T2 (de) * 1986-03-12 1994-03-31 American Cyanamid Co Makrolid-Verbindungen.
GB8606116D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
AT398312B (de) * 1986-03-12 1994-11-25 American Cyanamid Co Verfahren zur herstellung einer neuen makroliden verbindung
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
GB8606105D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
GB8613790D0 (en) * 1986-06-06 1986-07-09 Glaxo Group Ltd Chemical compounds
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
EP0253378A3 (de) * 1986-07-18 1988-03-23 Ciba-Geigy Ag 13Beta-Alkyl-derivate von S541-Antibiotika zur Bekämpfung von Parasiten an Nutztieren und Pflanzen
EP0254583B1 (en) * 1986-07-24 1994-09-07 Beecham Group Plc Parasiticidal milbemycin derivatives, a process for their production, and compositions containing the same
US5019589A (en) * 1986-09-12 1991-05-28 American Cyanamid Company Δ23 -LL-F28249 compounds
US4886828A (en) * 1986-09-12 1989-12-12 American Cyanamid Company Δ22 -derivatives of LL-F28249 compounds
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
DE3750355T2 (de) * 1986-09-12 1995-04-06 American Cyanamid Co 23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen.
DE3782481T2 (de) * 1986-09-12 1993-05-19 American Cyanamid Co 23-deoxy-derivate von ll-f28249-verbindungen.
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5183749A (en) * 1987-02-04 1993-02-02 Sankyo Company, Ltd. Microbial process for the preparation of milbemycin derivatives
US4897416A (en) * 1987-02-18 1990-01-30 Ciba-Geigy Corporation Insecticides and parasiticides
US4886830A (en) * 1987-03-06 1989-12-12 American Cyanamid Company Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
US4876272A (en) * 1987-03-06 1989-10-24 American Cyanamid Company Mono- and diepoxide derivatives of LL-F28249 compounds
US4855317A (en) * 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4956479A (en) * 1987-03-06 1990-09-11 American Cyanamid Company 23-deoxy-27-chloro derivatives of LL-F28249 compounds
US4851428A (en) * 1987-03-06 1989-07-25 American Cyanamid Company Mono- and diepoxide derivatives of Δ22-LL-F28249 compounds
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
EP0285561A3 (de) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Parasitizide und insektizide Milbemycin-Derivate
GB8721375D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721378D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
CA1340771C (en) * 1987-11-09 1999-09-28 Shih-Jen Edward Lee Ethylated avermectins
GB8726730D0 (en) 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
GB8803836D0 (en) * 1988-02-18 1988-03-16 Glaxo Group Ltd Compositions
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
GB8805978D0 (en) * 1988-03-14 1988-04-13 Glaxo Group Ltd Process
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
US5322692A (en) * 1989-02-28 1994-06-21 American Cyanamid Company Sustained release bolus effective for the prolonged prevention, treatment or control of nematode, acarid and endo- and ectoparasitic infestations of ruminants
US6001822A (en) * 1989-04-11 1999-12-14 Pfizer Inc. Antiparasitic formulations
ES2052173T3 (es) * 1989-04-11 1994-07-01 Pfizer Composiciones inyectables que contienen 25-cyclohexil-avermectina b1.
DK0426948T3 (da) 1989-08-11 1996-05-28 American Cyanamid Co Arylpyrroler som insekticide, acaricide og nematodicide midler samt fremgangsmåder til deres fremstilling
NZ234802A (en) * 1989-08-14 1992-11-25 Merck & Co Inc Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals
US5055454A (en) * 1989-10-30 1991-10-08 Merck & Co., Inc. 13-epi-avermectin derivatives useful as antiparasitic agents
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
MD24B1 (ro) * 1991-07-09 1994-05-31 Parfumerii Si Cosmetice Vioric Compozitie de substante odorante
GB9205007D0 (en) * 1992-03-07 1992-04-22 Pfizer Ltd Antiparasitic agents
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US6486195B1 (en) * 1993-08-19 2002-11-26 Merck & Co., Inc. Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
JP2855181B2 (ja) 1993-12-10 1999-02-10 敏雄 鈴木 松類の枯損防止用組成物及び防止方法
WO1999017760A2 (en) 1997-10-02 1999-04-15 Microcide Pharmaceuticals, Inc. Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug
PT1197215E (pt) 2000-10-10 2006-07-31 Wyeth Corp Composicoes antelminticas
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
US20080299212A1 (en) * 2005-02-25 2008-12-04 Medigenes Co., Ltd Pharmaceutical Composition for Treating Avellino Cornea Dystrophy Comprising Blood Plasma or Serum
CN100394983C (zh) * 2006-01-09 2008-06-18 浙江海正药业股份有限公司 含有大豆油的多拉菌素注射液

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914624A (en, 2012) * 1972-06-08 1974-02-08
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
IL56149A (en) * 1977-12-19 1989-09-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds,their preparation and method for the treatment of parasitic infections in animals therewith
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
DK165119C (da) * 1984-06-05 1993-03-01 American Cyanamid Co Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling
AU596586B2 (en) * 1985-04-30 1990-05-10 American Cyanamid Company Chemical derivatives of antibiotics S541
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina

Also Published As

Publication number Publication date
GR852232B (en, 2012) 1986-01-14
SU1738090A3 (ru) 1992-05-30
PL255360A1 (en) 1988-02-18
FR2570390A1 (fr) 1986-03-21
DK162099C (da) 1992-02-24
GB2166436B (en) 1989-05-24
PH24247A (en) 1990-05-04
DK162099B (da) 1991-09-16
ZW15585A1 (en) 1986-04-23
IL76385A0 (en) 1986-01-31
JP2566385B2 (ja) 1996-12-25
DK418085A (da) 1986-03-15
PT81125B (pt) 1987-10-20
AU4742685A (en) 1986-03-20
IE59394B1 (en) 1994-02-23
SE469173B (sv) 1993-05-24
ES557237A0 (es) 1988-08-01
FR2570390B1 (fr) 1987-11-27
HUT39779A (en) 1986-10-29
SE8504254L (sv) 1986-03-15
US4898821A (en) 1990-02-06
FI853520A0 (fi) 1985-09-13
US4935531A (en) 1990-06-19
NZ213463A (en) 1993-04-28
RO92478A (ro) 1987-09-30
KR940004098B1 (ko) 1994-05-13
BE903232A (fr) 1986-03-13
ES8704545A1 (es) 1987-04-01
BG44205A3 (en) 1988-10-14
LU86074A1 (fr) 1986-04-03
SE8504254D0 (sv) 1985-09-13
IT8548551A0 (it) 1985-09-13
CS654685A2 (en) 1989-08-14
IT1182857B (it) 1987-10-05
CA1313155C (en) 1993-01-26
HU197046B (en) 1989-02-28
BR8504457A (pt) 1986-07-15
CS268803B2 (en) 1990-04-11
FI87366B (fi) 1992-09-15
UA19162A (uk) 1997-12-25
IE852263L (en) 1986-03-14
KR860002576A (ko) 1986-04-26
DK418085D0 (da) 1985-09-13
IL76385A (en) 1990-09-17
DE3532794A1 (de) 1986-04-17
ES546962A0 (es) 1987-04-01
NL8502511A (nl) 1986-04-01
FI87366C (fi) 1992-12-28
SE8802985L (sv) 1988-08-25
PH21995A (en) 1988-05-02
FI853520L (fi) 1986-03-15
SE8802985D0 (sv) 1988-08-25
GB8522699D0 (en) 1985-10-16
JPH07116199B2 (ja) 1995-12-13
ATA268485A (de) 1992-11-15
PT81125A (en) 1985-10-01
JPS61118387A (ja) 1986-06-05
JPH07213278A (ja) 1995-08-15
ES8802555A1 (es) 1988-08-01
AU596565B2 (en) 1990-05-10
SE502748C2 (sv) 1995-12-18
CH666690A5 (de) 1988-08-15
PL152148B1 (en) 1990-11-30
GB2166436A (en) 1986-05-08

Similar Documents

Publication Publication Date Title
AT396250B (de) Verfahren zur herstellung von neuen antibiotisch wirkenden verbindungen
AT397095B (de) Verfahren zur herstellung neuer antibiotischer makrolite
DE2717040C2 (de) Als Anthelmintica C-076 bezeichnete α-L-Oleandrosyl-α-L-oleandroside, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE69422526T2 (de) Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung
DE69733715T2 (de) Antiparasitäre mittel
CH645899A5 (de) Verbindung mit anthelminthischer und akarizider wirkung.
DE3519834A1 (de) Neue antibiotische wirkstoffe, verfahren zu ihrer gewinnung und ihre anwendung zur bekaempfung von infektionen bei tieren und pflanzen
DE3745133C2 (de) Verwendung von Macrolid-Verbindungen zur Schädlingsbekämpfung
JPS6357591A (ja) 新規化合物、その製法及びそれを含む医薬組成物
DE69005935T2 (de) Antiparasitisches Mittel.
DE3878535T2 (de) Antiparasit-derivate.
US5182207A (en) Strains of streptomyces thermoarchaensis
DD296929A5 (de) Verfahren zur herstellung von macrolidverbindungen und deren verwendung als pestizide
DE3686011T2 (de) Anthelmintisches avermectin-derivat, welches durch ein fermentatives verfahren hergestellt werden kann.
DE3707859A1 (de) Makrolidverbindung
DE3879792T2 (de) Gerichtete-Biosynthese eines Milbemycinanaloges.
DE3785480T2 (de) Macrolid-derivate.
AT398312B (de) Verfahren zur herstellung einer neuen makroliden verbindung
RU2029783C1 (ru) Способ получения антибиотика
RU2100354C1 (ru) Макроциклический лактон, фармацевтическая композиция, обладающая антибиотической активностью, и инсектоакарицидная композиция
JPS63227590A (ja) 抗生物質ミルベマイシン化合物およびその製造法
AT397096B (de) Macrolid-verbindungen, diese enthaltende mittel und verfahren zu deren herstellung

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee