AT376208B - Verfahren zum herstellen von neuen piperidinderivaten und deren salzen - Google Patents

Verfahren zum herstellen von neuen piperidinderivaten und deren salzen

Info

Publication number
AT376208B
AT376208B AT0144880A AT144880A AT376208B AT 376208 B AT376208 B AT 376208B AT 0144880 A AT0144880 A AT 0144880A AT 144880 A AT144880 A AT 144880A AT 376208 B AT376208 B AT 376208B
Authority
AT
Austria
Prior art keywords
salts
producing new
piperide
derivatives
piperide derivatives
Prior art date
Application number
AT0144880A
Other languages
German (de)
English (en)
Other versions
ATA144880A (de
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21845568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT376208(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ATA144880A publication Critical patent/ATA144880A/de
Application granted granted Critical
Publication of AT376208B publication Critical patent/AT376208B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT0144880A 1979-04-10 1980-03-17 Verfahren zum herstellen von neuen piperidinderivaten und deren salzen AT376208B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/028,813 US4254129A (en) 1979-04-10 1979-04-10 Piperidine derivatives

Publications (2)

Publication Number Publication Date
ATA144880A ATA144880A (de) 1984-03-15
AT376208B true AT376208B (de) 1984-10-25

Family

ID=21845568

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0144880A AT376208B (de) 1979-04-10 1980-03-17 Verfahren zum herstellen von neuen piperidinderivaten und deren salzen

Country Status (19)

Country Link
US (1) US4254129A (OSRAM)
JP (1) JPS55141469A (OSRAM)
AT (1) AT376208B (OSRAM)
AU (1) AU531146B2 (OSRAM)
BE (1) BE882703A (OSRAM)
CA (1) CA1123438A (OSRAM)
CH (1) CH643245A5 (OSRAM)
DE (1) DE3007498A1 (OSRAM)
DK (1) DK153709C (OSRAM)
ES (1) ES8103735A1 (OSRAM)
FR (1) FR2453854A1 (OSRAM)
IL (1) IL59158A (OSRAM)
IT (1) IT1143960B (OSRAM)
NL (2) NL190580C (OSRAM)
NO (2) NO154521C (OSRAM)
NZ (1) NZ192653A (OSRAM)
PH (1) PH17023A (OSRAM)
SE (1) SE448726B (OSRAM)
ZA (1) ZA80332B (OSRAM)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
CN1053570C (zh) 1987-10-07 2000-06-21 默尔多药物公司 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
AR240018A1 (es) * 1987-10-07 1990-01-31 Merrell Pharma Inc Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol.
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
ZA90341B (en) * 1989-01-23 1990-10-31 Merrell Dow Pharma Liquid pharmaceutical composition for piperidinoalkanol derivatives
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
TW198008B (OSRAM) * 1991-04-08 1993-01-11 Green Cross Corp
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
ATE206119T1 (de) * 1992-02-13 2001-10-15 Merrell Pharma Inc Thiacyclische piperidinylderivate
EP0635004B1 (en) * 1992-04-10 2002-07-17 Merrell Pharmaceuticals Inc. 4-diphenylmethyl piperidine derivatives and process for their preparation
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
NZ251834A (en) * 1992-05-11 1997-07-27 Merrell Dow Pharma Use of acid derivatives of terfenadine as antihistamines
DE701443T1 (de) * 1992-08-03 1997-01-30 Georgetown University, Washington, D.C. Terfanadin Metaboliten und deren optische reine Isomeren zur Behandlung vonallegischen Krankheiten
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
ES2261871T3 (es) * 1993-06-24 2006-11-16 Amr Technology, Inc. Procedimiento para preparar compuestos utiles como intermediarios.
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
HU226037B1 (en) * 1993-06-25 2008-03-28 Aventis Inc Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
ES2153863T3 (es) * 1993-10-25 2001-03-16 Merrell Pharma Inc Composicion farmaceutica estable a base de terfenadina e ibuprofeno.
JPH10503752A (ja) * 1994-05-16 1998-04-07 メリル・フアーマシユウテイカルズ・インコーポレイテツド ラセミ形α−〔４−（１，１−ジメチルエチル）フェニル〕−４−（ヒドロキシジフェニルメチル）−１−ピペリジンブタノールおよび誘導体化合物の光学分割に有用な方法およびジアステレオマー塩
CN101337922A (zh) * 1994-05-18 2009-01-07 阿温蒂斯药物公司 抗组胺哌啶衍生物,其多晶形物和假同晶物的无水和水合物形式的制备方法
MX9605613A (es) 1994-05-18 1998-05-31 Hoechst Marion Roussel Inc Procedimiento para preparar formas anhidras e hidratadas de derivados de piperidina antihistaminica, polimorfos y pseudomorfos de los mismos.
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
ATE177095T1 (de) 1994-08-25 1999-03-15 Merrell Pharma Inc Substituierte piperidine für die behandlung von allergischen krankheiten
HUP9802086A3 (en) * 1995-02-28 2001-02-28 Aventis Pharmaceuticals Inc Br Pharmaceutical composition for piperidinoalkanol compounds
KR19990008406A (ko) * 1995-05-08 1999-01-25 스티븐엘.네스비트 알파-(치환된 알킬페닐)-4-(히드록시디페닐메틸)-1-피페리딘 부탄올 유도체들, 그들의 제조 방법 및 항히스타민제, 항알러지제및 기관지 확장제로서 그들의 용도
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
DK0864653T3 (da) * 1997-03-11 2004-07-12 Aventis Pharma Inc Fremgangsmåde til fremstilling af 4-(4-(4-(hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alfa,alfa-dimethylphenyleddikesyre og phosphorylerede derivater deraf
CA2301267C (en) * 1997-08-14 2004-07-13 Hoechst Marion Roussel, Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
US6451815B1 (en) 1997-08-14 2002-09-17 Aventis Pharmaceuticals Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
PL192079B1 (pl) * 1997-08-26 2006-08-31 Aventis Pharmaceuticals Kompozycja farmaceutyczna w postaci dwuwarstwowej tabletki
PT924196E (pt) * 1997-12-17 2003-11-28 Aventis Pharma Gmbh Procedimento para a alquilacao de derivados de alquil- ou benzilciano em presenca de trialquilaminas ou -fosfinas
ATE331522T1 (de) * 1997-12-23 2006-07-15 Schering Corp Zusammensetzung zur behandlung von atemwegs- und hauterkrankungen mit mindestens einem leukotrienantagonist und mindestens einem antihistaminikum
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
AU769284B2 (en) * 1998-07-02 2004-01-22 Aventisub Llc Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6700012B2 (en) 1998-07-02 2004-03-02 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
AU2007200674C1 (en) * 1998-07-02 2011-02-24 Aventisub Llc Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
GB9822170D0 (en) * 1998-10-13 1998-12-02 Danbioyst Uk Ltd Novel formulations of fexofenadine
IN191492B (OSRAM) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6613906B1 (en) * 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
CH695216A5 (de) * 2001-02-23 2006-01-31 Cilag Ag Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
MXPA03009259A (es) * 2001-04-09 2004-06-03 Teva Pharma Polimorfos de clorhidrato de fexofenadina.
US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
AU2001278094B2 (en) * 2001-06-18 2006-01-12 Dr. Reddy's Laboratories Ltd. Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperindinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride
AU2002357701A1 (en) * 2001-11-08 2003-05-19 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine base
US20030158227A1 (en) * 2001-11-08 2003-08-21 Barnaba Krochmal Polymorphs of fexofenadine base
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
AU2003248657A1 (en) * 2002-06-10 2003-12-22 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
CA2510158A1 (en) * 2002-12-16 2004-07-01 Ranbaxy Laboratories Limited Process for the preparation of fexofenadine
WO2004067511A1 (en) * 2003-01-31 2004-08-12 Ranbaxy Laboratories Limited Process for the preparation of fexofenadine
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
CA2560882A1 (en) * 2004-04-26 2005-11-03 Teva Pharmaceutical Industries Ltd. Crystalline forms of fexofenadine hydrochloride and processes for their preparation
WO2006008567A1 (en) * 2004-06-18 2006-01-26 Wockhardt Limited Pharmaceutical compositions for piperidinoalkanol compounds
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US20060148851A1 (en) * 2004-09-28 2006-07-06 Shlomit Wizel Fexofenadine crystal form and processes for its preparation thereof
US20070020330A1 (en) * 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
LT2522365T (lt) * 2004-11-24 2017-02-10 Meda Pharmaceuticals Inc. Kompozicijos, apimančios azelastiną, ir jų panaudojimo būdai
JP2008120684A (ja) * 2005-03-07 2008-05-29 Kumamoto Univ 抗アレルギー薬
MX2008001645A (es) * 2005-08-05 2008-04-07 Lupin Ltd Composiciones de fexofendina en suspension farmaceutica oral.
US20080292584A1 (en) * 2005-10-14 2008-11-27 Mutual Pharmaceutical Company, Inc. Metaxalone products, method of manufacture, and method of use
US20070088065A1 (en) * 2005-10-14 2007-04-19 Jie Du Metaxalone products, method of manufacture, and method of use
RU2283649C1 (ru) * 2005-10-27 2006-09-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения аллергических заболеваний
WO2007049303A2 (en) * 2005-10-28 2007-05-03 Ind-Swift Laboratories Limited An improved process for the preparation of highly pure fexofenadine
AU2006311577B2 (en) 2005-11-09 2013-02-07 Zalicus Inc. Methods, compositions, and kits for the treatment of medical conditions
DOP2006000274A (es) * 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
CN100443470C (zh) * 2006-07-21 2008-12-17 杭州保灵有限公司 一种依巴斯汀的制备方法
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20061491A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
CA2683316A1 (en) 2007-04-13 2009-02-19 Southern Research Institute Anti-angiogenic agents and methods of use
ITMI20070987A1 (it) * 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
US20090306135A1 (en) 2008-03-24 2009-12-10 Mukesh Kumar Sharma Stable amorphous fexofenadine hydrochloride
CA2724607A1 (en) * 2008-05-30 2009-12-31 Fairfield Clinical Trials, Llc Method and composition for skin inflammation and discoloration
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CN101585805B (zh) * 2009-06-06 2011-07-06 浙江大学宁波理工学院 一种抗过敏药物非索非那定盐酸盐的制备方法
EP2289867A3 (en) 2009-08-19 2012-04-25 Jubilant Organosys Limited A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof
CN101671292B (zh) * 2009-10-10 2011-09-07 浙江大学宁波理工学院 盐酸非索非那定的合成方法
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2371817A1 (en) * 2010-04-01 2011-10-05 Arevipharma GmbH Process for the preparation of 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone and acid addition salts thereof
US9216955B2 (en) 2010-06-15 2015-12-22 Chemelectiva S.R.L. Polymorphic form of Fexofenadine hydrochloride, intermediates and process for its preparation
WO2012160015A1 (en) 2011-05-23 2012-11-29 Sanofi Process for the preparation of deuterated compounds containing n-alkyl groups
EP2762141A4 (en) 2011-09-29 2015-03-25 Shionogi & Co THERAPEUTIC PHARMACEUTICAL PRODUCT AGAINST ALLERGIC RHINITIS COMPRISING A PGD2 ANTAGONIST AND A HISTAMINE ANTAGONIST
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
CN102659667B (zh) * 2012-04-20 2013-08-14 浙江启明药业有限公司 一种非索非那定关键中间体的合成方法
CN103333100B (zh) * 2013-06-06 2016-04-06 池州东升药业有限公司 一种盐酸非索非那定的合成工艺
ITMI20131652A1 (it) 2013-10-07 2015-04-08 Dipharma Francis Srl Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico
CN104557671B (zh) * 2013-10-10 2018-04-13 池州东升药业有限公司 一种非索非那定及中间体的合成方法
EP2949321A1 (en) 2014-05-26 2015-12-02 Sanovel Ilac Sanayi ve Ticaret A.S. Multilayer formulations of fexofenadine and montelukast
US10336698B2 (en) 2015-01-22 2019-07-02 Sanofi-Aventis Deutschland Gmbh Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile
RS59874B1 (sr) 2015-10-22 2020-03-31 Sanofi Aventis Deutschland Proces za pripremu feksofenadina i njegovih intermedijara
GB2629127A (en) 2022-08-31 2024-10-23 Novumgen Ltd An orodispersible tablet of fexofenadine and its process of preparation
EP4651852A1 (en) 2023-01-20 2025-11-26 Opella Healthcare Group SAS Paraben-free fexofenadine formulations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines

Also Published As

Publication number Publication date
IL59158A (en) 1984-04-30
US4254129A (en) 1981-03-03
NL8000754A (nl) 1980-10-14
DE3007498A1 (de) 1980-10-23
ZA80332B (en) 1981-01-28
JPS55141469A (en) 1980-11-05
ES489934A0 (es) 1981-03-16
AU531146B2 (en) 1983-08-11
NL190580C (nl) 1994-05-02
NO801014L (no) 1980-10-13
CH643245A5 (de) 1984-05-30
SE448726B (sv) 1987-03-16
NL980013I1 (nl) 1998-06-02
FR2453854A1 (fr) 1980-11-07
AU5501680A (en) 1980-10-16
DK153709C (da) 1988-12-27
DK132980A (da) 1980-10-11
NZ192653A (en) 1982-03-16
ES8103735A1 (es) 1981-03-16
NL190580B (nl) 1993-12-01
DK153709B (da) 1988-08-22
PH17023A (en) 1984-05-11
NL980013I2 (nl) 1998-10-01
NO154521C (no) 1986-10-08
IL59158A0 (en) 1980-05-30
SE8002634L (sv) 1980-10-11
NO154521B (no) 1986-06-30
DE3007498C2 (OSRAM) 1989-09-07
JPH0132823B2 (OSRAM) 1989-07-10
IT8048245A0 (it) 1980-03-24
BE882703A (fr) 1980-07-31
FR2453854B1 (OSRAM) 1983-06-24
ATA144880A (de) 1984-03-15
NO1998017I1 (no) 1998-05-29
IT1143960B (it) 1986-10-29
CA1123438A (en) 1982-05-11

Similar Documents

Publication Publication Date Title
AT376208B (de) Verfahren zum herstellen von neuen piperidinderivaten und deren salzen
AT376432B (de) Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditions-salzen
AT376207B (de) Verfahren zum herstellen von neuen piperidinderivaten und deren saeureadditionssalzen
AT371813B (de) Verfahren zum herstellen von neuen substituierten propanolamin- und morpholinderivaten und von deren isomeren und salzen
AT364851B (de) Verfahren zur herstellung von neuen thienothiazinderivaten und von deren salzen
AT371454B (de) Verfahren zur herstellung von neuen prostanderivaten und von deren salzen
AT366043B (de) Verfahren zur herstellung von neuen chinazolinderivaten und deren salzen
AT374458B (de) Verfahren zum herstellen von neuen piperidinderivaten und deren salzen
AT376210B (de) Verfahren zum herstellen von neuen benzimidazolderivaten und von estern und salzen hievon
AT370095B (de) Verfahren zum herstellen von neuen 1-aryl-alkyl-imidazolderivaten und deren salzen
AT371112B (de) Verfahren zur herstellung von neuen 2-imino-imidazolidin-derivaten und von deren salzen
ATA909480A (de) Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
AT363937B (de) Verfahren zur herstellung von neuen bispidinderivaten und deren salzen
AT375358B (de) Verfahren zum herstellen von neuen piperazinmethaniminderivaten und von deren saeureadditionssalzen
AT365183B (de) Verfahren zur herstellung von neuen 4-amino-2-piperidinochinazolinderivaten und deren salzen
AT372951B (de) Verfahren zum herstellen von neuen benzimidazolen bzw. benzimidazolidinen und von deren salzen
ATA507181A (de) Verfahren zum herstellen von neuen 1-arylalkyl-imidazolderivaten und deren salzen
ATA73877A (de) Verfahren zur herstellung von neuen oxadiazolopyrimidinderivaten und von deren salzen
AT376434B (de) Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen
ATA391583A (de) Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen
AT371809B (de) Verfahren zum herstellen von neuen chinazolinen und ihren salzen
AT352727B (de) Verfahren zur herstellung von neuen indol- derivaten und deren salzen
AT369730B (de) Verfahren zum herstellen von neuen basischen p-chloracetophenonoximaethern
ATA419781A (de) Verfahren zum herstellen von neuen substituierten morpholinderivaten und von deren isomeren und salzen
ATA356778A (de) Verfahren zur herstellung von neuen 4-hydroxy- thiazolidin-2-thion-derivaten und von deren salzen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
EFA Change in the company name
EZF Grant of a certificate of protection

Free format text: SZ 20/97, 970613, EXPIRES:20070315

SZA Application filed for a certificate of protection

Free format text: SZ 20/97, 970613

ELA Expired due to lapse of time