AT356136B - Verfahren zur herstellung von neuen spiro- hydantoinen - Google Patents
Verfahren zur herstellung von neuen spiro- hydantoinenInfo
- Publication number
- AT356136B AT356136B AT745977A AT745977A AT356136B AT 356136 B AT356136 B AT 356136B AT 745977 A AT745977 A AT 745977A AT 745977 A AT745977 A AT 745977A AT 356136 B AT356136 B AT 356136B
- Authority
- AT
- Austria
- Prior art keywords
- hydantoines
- producing new
- new spiro
- spiro
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73306276A | 1976-10-18 | 1976-10-18 | |
| US05/767,803 US4117230A (en) | 1976-10-18 | 1977-02-11 | Hydantoin derivatives as therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA745977A ATA745977A (de) | 1979-09-15 |
| AT356136B true AT356136B (de) | 1980-04-10 |
Family
ID=27112515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT745977A AT356136B (de) | 1976-10-18 | 1977-10-18 | Verfahren zur herstellung von neuen spiro- hydantoinen |
Country Status (29)
| Country | Link |
|---|---|
| JP (3) | JPS5353653A (el) |
| AR (1) | AR220901A1 (el) |
| AT (1) | AT356136B (el) |
| AU (1) | AU504978B2 (el) |
| BG (1) | BG28847A3 (el) |
| CA (1) | CA1088945A (el) |
| CH (1) | CH625511A5 (el) |
| DD (1) | DD131931A5 (el) |
| DE (4) | DE2746244C2 (el) |
| DK (1) | DK150302C (el) |
| ES (1) | ES463267A1 (el) |
| FI (1) | FI62307C (el) |
| FR (1) | FR2367754A1 (el) |
| GB (1) | GB1566171A (el) |
| GR (1) | GR70201B (el) |
| HK (1) | HK53881A (el) |
| IE (1) | IE45805B1 (el) |
| IL (1) | IL53094A0 (el) |
| KE (1) | KE3167A (el) |
| LU (1) | LU78330A1 (el) |
| MX (1) | MX4899E (el) |
| MY (1) | MY8200157A (el) |
| NL (1) | NL167434C (el) |
| NO (1) | NO148453C (el) |
| NZ (1) | NZ185358A (el) |
| PH (1) | PH15639A (el) |
| PT (1) | PT67164B (el) |
| SE (1) | SE437024B (el) |
| YU (1) | YU40821B (el) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
| US4127665A (en) * | 1978-01-18 | 1978-11-28 | Pfizer Inc. | Thienohydantoin derivatives |
| US4147797A (en) * | 1978-08-11 | 1979-04-03 | Pfizer Inc. | Spiro-furanohydantoin derivatives |
| US4200642A (en) * | 1978-08-21 | 1980-04-29 | Pfizer Inc. | Spiro-oxazolidindiones |
| US4181728A (en) * | 1978-11-16 | 1980-01-01 | Pfizer Inc. | Spiro-polycyclicimidazolidinedione derivatives |
| US4181729A (en) * | 1979-03-21 | 1980-01-01 | Pfizer Inc. | Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives |
| US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
| US4283409A (en) * | 1979-10-29 | 1981-08-11 | Pfizer Inc. | Imidazolone derivatives |
| US4286098A (en) * | 1980-03-28 | 1981-08-25 | Pfizer Inc. | Process for the preparation of chiral hydantoins |
| JPS5745185A (en) * | 1980-07-21 | 1982-03-13 | Eisai Co Ltd | Hydantoin derivative and its preparation |
| EP0065392B1 (en) * | 1981-05-13 | 1985-02-13 | Imperial Chemical Industries Plc | Pharmaceutical compositions containing spiro succinimide derivatives |
| JPS58213717A (ja) * | 1982-01-20 | 1983-12-12 | Eisai Co Ltd | ヒダントイン誘導体を含有する治療用薬剤 |
| JPS59500617A (ja) * | 1982-04-15 | 1984-04-12 | アルコン・ラボラトリ−ズ・インコ−ポレ−テッド | ヒダントイン治療剤 |
| HU193191B (en) * | 1982-12-06 | 1987-08-28 | Pfizer | Process for preparing spiro-hetero-azolones |
| US4474967A (en) * | 1983-04-27 | 1984-10-02 | Pfizer Inc. | 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione |
| WO1986002647A1 (en) * | 1984-10-30 | 1986-05-09 | Pfizer Inc. | Spiro-heteroazolones for treatment of diabetes complications |
| JPS61200991A (ja) * | 1985-03-04 | 1986-09-05 | Sanwa Kagaku Kenkyusho:Kk | スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤 |
| US4575507A (en) * | 1985-05-29 | 1986-03-11 | Pfizer Inc. | Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use |
| JPS6357588A (ja) * | 1986-08-28 | 1988-03-12 | Sanwa Kagaku Kenkyusho Co Ltd | ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤 |
| HU204832B (en) * | 1987-09-04 | 1992-02-28 | Pfizer | Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same |
| GB2355264A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
| CN1659136A (zh) * | 2002-04-18 | 2005-08-24 | 弗吉尼亚大学专利基金会 | 新的钠通道阻滞剂 |
| FR2955107B1 (fr) | 2010-01-08 | 2012-03-02 | Servier Lab | Nouveaux derives thiochromanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB818724A (en) * | 1956-10-18 | 1959-08-19 | Ici Ltd | Hydantoin derivatives |
| DE1135915B (de) * | 1961-06-29 | 1962-09-06 | Asta Werke Ag Chem Fab | Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine |
| US3532744A (en) * | 1967-07-28 | 1970-10-06 | American Home Prod | 1- and 2-amino substituted indane and tetralene carboxylic acids |
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
| DE2449030A1 (de) * | 1974-10-11 | 1976-05-20 | Schering Ag | Neue pyridin-derivate |
| US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
-
1977
- 1977-09-30 CA CA287,868A patent/CA1088945A/en not_active Expired
- 1977-10-03 SE SE7711053A patent/SE437024B/sv not_active IP Right Cessation
- 1977-10-04 GR GR54503A patent/GR70201B/el unknown
- 1977-10-05 NZ NZ185358A patent/NZ185358A/xx unknown
- 1977-10-06 AU AU29431/77A patent/AU504978B2/en not_active Expired
- 1977-10-10 IL IL53094A patent/IL53094A0/xx not_active IP Right Cessation
- 1977-10-10 YU YU2442/77A patent/YU40821B/xx unknown
- 1977-10-14 DE DE2746244A patent/DE2746244C2/de not_active Expired
- 1977-10-14 FI FI773060A patent/FI62307C/fi not_active IP Right Cessation
- 1977-10-14 DE DE2759542A patent/DE2759542C2/de not_active Expired
- 1977-10-14 DE DE2759927A patent/DE2759927C2/de not_active Expired
- 1977-10-14 DE DE2759543A patent/DE2759543C2/de not_active Expired
- 1977-10-14 PH PH20335A patent/PH15639A/en unknown
- 1977-10-15 ES ES463267A patent/ES463267A1/es not_active Expired
- 1977-10-17 CH CH1262677A patent/CH625511A5/fr not_active IP Right Cessation
- 1977-10-17 JP JP12437177A patent/JPS5353653A/ja active Granted
- 1977-10-17 NL NL7711358.A patent/NL167434C/xx not_active IP Right Cessation
- 1977-10-17 PT PT67164A patent/PT67164B/pt unknown
- 1977-10-17 DK DK461377A patent/DK150302C/da not_active IP Right Cessation
- 1977-10-17 GB GB43122/77A patent/GB1566171A/en not_active Expired
- 1977-10-17 MX MX776490U patent/MX4899E/es unknown
- 1977-10-17 NO NO773548A patent/NO148453C/no unknown
- 1977-10-17 FR FR7731216A patent/FR2367754A1/fr active Granted
- 1977-10-17 LU LU78330A patent/LU78330A1/xx unknown
- 1977-10-17 IE IE2114/77A patent/IE45805B1/en not_active IP Right Cessation
- 1977-10-18 BG BG7737604A patent/BG28847A3/xx unknown
- 1977-10-18 AT AT745977A patent/AT356136B/de not_active IP Right Cessation
- 1977-10-18 AR AR269623A patent/AR220901A1/es active
- 1977-10-18 DD DD7700201582A patent/DD131931A5/xx unknown
-
1978
- 1978-11-25 JP JP53145925A patent/JPS5940388B2/ja not_active Expired
- 1978-11-25 JP JP53145926A patent/JPS607997B2/ja not_active Expired
-
1981
- 1981-10-09 KE KE3167A patent/KE3167A/xx unknown
- 1981-11-05 HK HK538/81A patent/HK53881A/xx unknown
-
1982
- 1982-12-30 MY MY157/82A patent/MY8200157A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |