FR2367754A1 - Nouveaux derives d'hydantoine et composition pharmaceutique les contenant - Google Patents

Nouveaux derives d'hydantoine et composition pharmaceutique les contenant

Info

Publication number
FR2367754A1
FR2367754A1 FR7731216A FR7731216A FR2367754A1 FR 2367754 A1 FR2367754 A1 FR 2367754A1 FR 7731216 A FR7731216 A FR 7731216A FR 7731216 A FR7731216 A FR 7731216A FR 2367754 A1 FR2367754 A1 FR 2367754A1
Authority
FR
France
Prior art keywords
hydantoin derivatives
pharmaceutical composition
composition containing
dioxide
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7731216A
Other languages
English (en)
French (fr)
Other versions
FR2367754B1 (el
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/767,803 external-priority patent/US4117230A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2367754A1 publication Critical patent/FR2367754A1/fr
Application granted granted Critical
Publication of FR2367754B1 publication Critical patent/FR2367754B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
FR7731216A 1976-10-18 1977-10-17 Nouveaux derives d'hydantoine et composition pharmaceutique les contenant Granted FR2367754A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73306276A 1976-10-18 1976-10-18
US05/767,803 US4117230A (en) 1976-10-18 1977-02-11 Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number Publication Date
FR2367754A1 true FR2367754A1 (fr) 1978-05-12
FR2367754B1 FR2367754B1 (el) 1982-07-09

Family

ID=27112515

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7731216A Granted FR2367754A1 (fr) 1976-10-18 1977-10-17 Nouveaux derives d'hydantoine et composition pharmaceutique les contenant

Country Status (29)

Country Link
JP (3) JPS5353653A (el)
AR (1) AR220901A1 (el)
AT (1) AT356136B (el)
AU (1) AU504978B2 (el)
BG (1) BG28847A3 (el)
CA (1) CA1088945A (el)
CH (1) CH625511A5 (el)
DD (1) DD131931A5 (el)
DE (4) DE2746244C2 (el)
DK (1) DK150302C (el)
ES (1) ES463267A1 (el)
FI (1) FI62307C (el)
FR (1) FR2367754A1 (el)
GB (1) GB1566171A (el)
GR (1) GR70201B (el)
HK (1) HK53881A (el)
IE (1) IE45805B1 (el)
IL (1) IL53094A0 (el)
KE (1) KE3167A (el)
LU (1) LU78330A1 (el)
MX (1) MX4899E (el)
MY (1) MY8200157A (el)
NL (1) NL167434C (el)
NO (1) NO148453C (el)
NZ (1) NZ185358A (el)
PH (1) PH15639A (el)
PT (1) PT67164B (el)
SE (1) SE437024B (el)
YU (1) YU40821B (el)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2392024A1 (fr) * 1977-05-23 1978-12-22 Pfizer Nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et compositions pharmaceutiques les contenant
FR2415112A1 (fr) * 1978-01-18 1979-08-17 Pfizer Nouveaux derives spirothienohydantoines et composition pharmaceutique les contenant
EP0008229A1 (en) * 1978-08-11 1980-02-20 Pfizer Inc. Spiro-furanohydantoin derivatives, process for their preparation and pharmaceutical compositions containing them
FR2441627A1 (fr) * 1978-11-16 1980-06-13 Pfizer Nouvelles spiro-polycyclo-imidazolidinediones et composition pharmaceutique les contenant
EP0180421A1 (en) * 1984-10-30 1986-05-07 Pfizer Inc. Spiro-hydantoins for treatment of diabetic complications
WO2011083264A1 (fr) 2010-01-08 2011-07-14 Les Laboratoires Servier Derives thiochromanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4283409A (en) * 1979-10-29 1981-08-11 Pfizer Inc. Imidazolone derivatives
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
EP0065392B1 (en) * 1981-05-13 1985-02-13 Imperial Chemical Industries Plc Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
JPS59500617A (ja) * 1982-04-15 1984-04-12 アルコン・ラボラトリ−ズ・インコ−ポレ−テッド ヒダントイン治療剤
HU193191B (en) * 1982-12-06 1987-08-28 Pfizer Process for preparing spiro-hetero-azolones
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
HU204832B (en) * 1987-09-04 1992-02-28 Pfizer Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
CN1659136A (zh) * 2002-04-18 2005-08-24 弗吉尼亚大学专利基金会 新的钠通道阻滞剂

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
FR2287224A1 (fr) * 1974-10-11 1976-05-07 Schering Ag Derives de la pyridine et medicaments qui en contiennent
FR2392024A1 (fr) * 1977-05-23 1978-12-22 Pfizer Nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et compositions pharmaceutiques les contenant

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
FR2287224A1 (fr) * 1974-10-11 1976-05-07 Schering Ag Derives de la pyridine et medicaments qui en contiennent
FR2392024A1 (fr) * 1977-05-23 1978-12-22 Pfizer Nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et compositions pharmaceutiques les contenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1963 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2392024A1 (fr) * 1977-05-23 1978-12-22 Pfizer Nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et compositions pharmaceutiques les contenant
FR2415112A1 (fr) * 1978-01-18 1979-08-17 Pfizer Nouveaux derives spirothienohydantoines et composition pharmaceutique les contenant
EP0008229A1 (en) * 1978-08-11 1980-02-20 Pfizer Inc. Spiro-furanohydantoin derivatives, process for their preparation and pharmaceutical compositions containing them
FR2441627A1 (fr) * 1978-11-16 1980-06-13 Pfizer Nouvelles spiro-polycyclo-imidazolidinediones et composition pharmaceutique les contenant
EP0180421A1 (en) * 1984-10-30 1986-05-07 Pfizer Inc. Spiro-hydantoins for treatment of diabetic complications
WO2011083264A1 (fr) 2010-01-08 2011-07-14 Les Laboratoires Servier Derives thiochromanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
DK150302B (da) 1987-02-02
SE437024B (sv) 1985-02-04
AR220901A1 (es) 1980-12-15
NO773548L (no) 1978-04-19
DK461377A (da) 1978-04-19
MY8200157A (en) 1982-12-31
JPS5495570A (en) 1979-07-28
PT67164B (en) 1979-03-20
AU504978B2 (en) 1979-11-01
IL53094A0 (en) 1977-12-30
DE2759543C2 (el) 1987-04-09
SE7711053L (sv) 1978-04-19
JPS5940388B2 (ja) 1984-09-29
IE45805B1 (en) 1982-12-01
JPS5353653A (en) 1978-05-16
DE2759542C2 (el) 1988-07-07
YU244277A (en) 1982-08-31
ES463267A1 (es) 1978-07-16
JPS5495575A (en) 1979-07-28
DK150302C (da) 1987-09-28
DE2746244A1 (de) 1978-04-20
GR70201B (el) 1982-08-31
BG28847A3 (en) 1980-07-15
YU40821B (en) 1986-06-30
MX4899E (es) 1982-12-14
DD131931A5 (de) 1978-08-09
HK53881A (en) 1981-11-13
CA1088945A (en) 1980-11-04
NO148453C (no) 1983-10-12
ATA745977A (de) 1979-09-15
IE45805L (en) 1978-04-18
JPS5534132B2 (el) 1980-09-04
CH625511A5 (en) 1981-09-30
LU78330A1 (fr) 1979-06-01
NO148453B (no) 1983-07-04
AT356136B (de) 1980-04-10
AU2943177A (en) 1979-04-12
PT67164A (en) 1977-11-01
NL167434C (nl) 1981-12-16
DE2746244C2 (de) 1983-05-19
FI773060A (fi) 1978-04-19
PH15639A (en) 1983-03-11
FR2367754B1 (el) 1982-07-09
GB1566171A (en) 1980-04-30
NL167434B (nl) 1981-07-16
DE2759927C2 (de) 1986-12-04
NZ185358A (en) 1979-06-08
FI62307C (fi) 1982-12-10
KE3167A (en) 1981-11-06
JPS607997B2 (ja) 1985-02-28
NL7711358A (nl) 1978-04-20
FI62307B (fi) 1982-08-31

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