AT332375B - Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen

Info

Publication number
AT332375B
AT332375B AT202374A AT202374A AT332375B AT 332375 B AT332375 B AT 332375B AT 202374 A AT202374 A AT 202374A AT 202374 A AT202374 A AT 202374A AT 332375 B AT332375 B AT 332375B
Authority
AT
Austria
Prior art keywords
aminobenzylamines
new
production
acid addition
addition salts
Prior art date
Application number
AT202374A
Other languages
German (de)
English (en)
Other versions
ATA202374A (de
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732318636 external-priority patent/DE2318636B2/de
Priority claimed from DE19742402989 external-priority patent/DE2402989C3/de
Priority claimed from DE19742405322 external-priority patent/DE2405322A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to AT502375A priority Critical patent/AT331212B/de
Priority to AT502875A priority patent/AT331216B/de
Priority to AT502475A priority patent/AT331213B/de
Priority to AT503175A priority patent/AT332379B/de
Priority to AT502075A priority patent/AT331211B/de
Priority to AT503075A priority patent/AT340399B/de
Priority to AT502575A priority patent/AT331214B/de
Priority to AT502975A priority patent/AT331217B/de
Priority to AT502275A priority patent/AT342027B/de
Priority to AT502175A priority patent/AT339885B/de
Priority to AT502775A priority patent/AT331215B/de
Priority to AT642975A priority patent/AT331218B/de
Publication of ATA202374A publication Critical patent/ATA202374A/de
Publication of AT332375B publication Critical patent/AT332375B/de
Application granted granted Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT202374A 1973-04-13 1974-03-12 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen AT332375B (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AT502175A AT339885B (de) 1973-04-13 1975-07-01 Verfahren zur herstellung von neuen benzylaminen und deren saureadditionssalzen
AT502775A AT331215B (de) 1974-02-05 1975-07-01 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen
AT502075A AT331211B (de) 1973-04-13 1975-07-01 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen
AT502975A AT331217B (de) 1974-02-05 1975-07-01 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen
AT502475A AT331213B (de) 1974-02-05 1975-07-01 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen
AT503175A AT332379B (de) 1973-04-13 1975-07-01 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen
AT502375A AT331212B (de) 1973-04-13 1975-07-01 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen
AT503075A AT340399B (de) 1974-02-05 1975-07-01 Verfahren zur herstellung neuer aminobenzoesaurealkylester und deren saureadditionssalze
AT502575A AT331214B (de) 1974-02-05 1975-07-01 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen
AT502875A AT331216B (de) 1974-02-05 1975-07-01 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen
AT502275A AT342027B (de) 1973-04-13 1975-07-01 Verfahren zur herstellung von neuen aminobenzoesauren sowie deren saureadditionssalzen
AT642975A AT331218B (de) 1973-04-13 1975-08-20 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19732318636 DE2318636B2 (de) 1973-04-13 1973-04-13 Neue benzylamine, sie enthaltende arzneimittel und verfahren zu ihrer herstellung
DE19742402989 DE2402989C3 (de) 1974-01-23 1974-01-23 Neue Benzylamine, sie enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19742405322 DE2405322A1 (de) 1974-02-05 1974-02-05 Neue verfahren zur herstellung von benzylaminen

Publications (2)

Publication Number Publication Date
ATA202374A ATA202374A (de) 1976-01-15
AT332375B true AT332375B (de) 1976-09-27

Family

ID=27185183

Family Applications (1)

Application Number Title Priority Date Filing Date
AT202374A AT332375B (de) 1973-04-13 1974-03-12 Verfahren zur herstellung von neuen aminobenzylaminen sowie deren saureadditionssalzen

Country Status (19)

Country Link
JP (1) JPS5634582B2 (fr)
AT (1) AT332375B (fr)
BG (1) BG25787A3 (fr)
CA (1) CA1011748A (fr)
CH (2) CH609041A5 (fr)
CS (1) CS188920B2 (fr)
DD (1) DD113748A5 (fr)
ES (1) ES424432A1 (fr)
FR (1) FR2225165B1 (fr)
GB (1) GB1469187A (fr)
HU (1) HU167971B (fr)
IE (1) IE40146B1 (fr)
IL (1) IL44623A (fr)
NL (1) NL7404965A (fr)
NO (1) NO138250C (fr)
PL (2) PL89811B1 (fr)
RO (3) RO69152A (fr)
SE (1) SE411749B (fr)
SU (2) SU517250A3 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT327876B (de) * 1974-01-19 1976-02-25 Thomae Gmbh Dr K Verfahren zur herstellung von halogenierten 2-amino-benzylaminen sowie deren saureadditionssalzen
DE2926472A1 (de) * 1979-06-30 1981-01-15 Thomae Gmbh Dr K Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
US4735959A (en) * 1981-01-10 1988-04-05 Dr. Karl Thomae Gmbh Carboxylic acid amides and pharmaceutical compositions containing them
JPS60146849A (ja) * 1984-01-09 1985-08-02 Mitsui Toatsu Chem Inc アミノベンジルアミンの製造方法
JPH0365264A (ja) * 1989-08-03 1991-03-20 Sanko Denki Seisakusho:Kk 霧化装置
DE19529431C1 (de) * 1995-08-10 1996-12-12 Boehringer Ingelheim Kg Verfahren zur Herstellung von Benzylaminderivaten
CN112279774B (zh) * 2019-07-24 2023-05-30 成都施贝康生物医药科技有限公司 二溴苄基衍生物、其立体异构体或其盐及制法和应用

Also Published As

Publication number Publication date
CH609327A5 (en) 1979-02-28
JPS5012030A (fr) 1975-02-07
FR2225165A1 (fr) 1974-11-08
PL89811B1 (fr) 1976-12-31
GB1469187A (en) 1977-03-30
DD113748A5 (fr) 1975-06-20
FR2225165B1 (fr) 1977-09-09
IL44623A (en) 1978-01-31
IL44623A0 (en) 1974-06-30
JPS5634582B2 (fr) 1981-08-11
RO70260A (fr) 1980-03-15
NL7404965A (fr) 1974-10-15
NO138250B (no) 1978-04-24
IE40146B1 (en) 1979-03-28
HU167971B (en) 1976-01-28
IE40146L (en) 1974-10-13
CS188920B2 (en) 1979-03-30
ATA202374A (de) 1976-01-15
SE411749B (sv) 1980-02-04
NO138250C (no) 1978-08-02
RO69152A (fr) 1981-01-30
PL102867B1 (pl) 1979-04-30
NO741350L (no) 1974-10-15
BG25787A3 (en) 1978-12-12
CA1011748A (en) 1977-06-07
RO69291B (ro) 1983-04-30
RO69291A (fr) 1983-04-29
CH609041A5 (en) 1979-02-15
SU521836A3 (ru) 1976-07-15
SU517250A3 (ru) 1976-06-05
ES424432A1 (es) 1976-06-01

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