GB1469187A - Substituted aminobenzylamines - Google Patents

Substituted aminobenzylamines

Info

Publication number
GB1469187A
GB1469187A GB1625474A GB1625474A GB1469187A GB 1469187 A GB1469187 A GB 1469187A GB 1625474 A GB1625474 A GB 1625474A GB 1625474 A GB1625474 A GB 1625474A GB 1469187 A GB1469187 A GB 1469187A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
effect
carboxyl group
aminobenzylamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1625474A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732318636 external-priority patent/DE2318636B2/en
Priority claimed from DE19742402989 external-priority patent/DE2402989C3/en
Priority claimed from DE19742405322 external-priority patent/DE2405322A1/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB1469187A publication Critical patent/GB1469187A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

The preparation of novel benzylamines of the formula I <IMAGE> in which the symbols R1 to R5 have the meanings stated in Claim 1, as well as their physiologically tolerated acid addition salts with inorganic or organic acids is described. The compounds of the formula I have valuable pharmacological properties, especially an antiulcer effect, a secretolytic, cough-suppressant effect and an effect enhancing the production of the surfactant or antiatelectasis factor in the alveoli. The compounds of the formula I are prepared by hydrolysing corresponding compounds which, in place of the carboxyl group R3, have a functional derivative of the carboxyl group as substituent.
GB1625474A 1973-04-13 1974-04-11 Substituted aminobenzylamines Expired GB1469187A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19732318636 DE2318636B2 (en) 1973-04-13 1973-04-13 NEW BENZYLAMINES, MEDICINAL PRODUCTS AND THE METHOD OF MANUFACTURING THEM
DE19742402989 DE2402989C3 (en) 1974-01-23 1974-01-23 New benzylamines, pharmaceuticals containing them and processes for their manufacture
DE19742405322 DE2405322A1 (en) 1974-02-05 1974-02-05 NEW METHODS FOR MANUFACTURING BENZYLAMINES

Publications (1)

Publication Number Publication Date
GB1469187A true GB1469187A (en) 1977-03-30

Family

ID=27185183

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1625474A Expired GB1469187A (en) 1973-04-13 1974-04-11 Substituted aminobenzylamines

Country Status (19)

Country Link
JP (1) JPS5634582B2 (en)
AT (1) AT332375B (en)
BG (1) BG25787A3 (en)
CA (1) CA1011748A (en)
CH (2) CH609041A5 (en)
CS (1) CS188920B2 (en)
DD (1) DD113748A5 (en)
ES (1) ES424432A1 (en)
FR (1) FR2225165B1 (en)
GB (1) GB1469187A (en)
HU (1) HU167971B (en)
IE (1) IE40146B1 (en)
IL (1) IL44623A (en)
NL (1) NL7404965A (en)
NO (1) NO138250C (en)
PL (2) PL89811B1 (en)
RO (3) RO70260A (en)
SE (1) SE411749B (en)
SU (2) SU517250A3 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024282A1 (en) * 1979-06-30 1981-03-04 Dr. Karl Thomae GmbH Benzoyl derivatives, their preparation and their use as medicines
WO1997006131A1 (en) * 1995-08-10 1997-02-20 Boehringer Ingelheim Kg Method of preparing benzylamine derivatives

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU167562B (en) * 1974-01-19 1975-11-28
DE3100575A1 (en) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "NEW BENZOESAEURS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
US4735959A (en) * 1981-01-10 1988-04-05 Dr. Karl Thomae Gmbh Carboxylic acid amides and pharmaceutical compositions containing them
JPS60146849A (en) * 1984-01-09 1985-08-02 Mitsui Toatsu Chem Inc Preparation of aminobenzylamine
JPH0365264A (en) * 1989-08-03 1991-03-20 Sanko Denki Seisakusho:Kk Spraying device
CN112279774B (en) * 2019-07-24 2023-05-30 成都施贝康生物医药科技有限公司 Dibromobenzyl derivative, stereoisomer or salt thereof, preparation method and application

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024282A1 (en) * 1979-06-30 1981-03-04 Dr. Karl Thomae GmbH Benzoyl derivatives, their preparation and their use as medicines
WO1997006131A1 (en) * 1995-08-10 1997-02-20 Boehringer Ingelheim Kg Method of preparing benzylamine derivatives

Also Published As

Publication number Publication date
NO138250C (en) 1978-08-02
PL102867B1 (en) 1979-04-30
NO741350L (en) 1974-10-15
SU517250A3 (en) 1976-06-05
HU167971B (en) 1976-01-28
SU521836A3 (en) 1976-07-15
CH609041A5 (en) 1979-02-15
IL44623A (en) 1978-01-31
FR2225165A1 (en) 1974-11-08
IE40146B1 (en) 1979-03-28
CA1011748A (en) 1977-06-07
FR2225165B1 (en) 1977-09-09
SE411749B (en) 1980-02-04
ES424432A1 (en) 1976-06-01
RO69291B (en) 1983-04-30
RO69152A (en) 1981-01-30
AT332375B (en) 1976-09-27
PL89811B1 (en) 1976-12-31
RO69291A (en) 1983-04-29
NO138250B (en) 1978-04-24
NL7404965A (en) 1974-10-15
CH609327A5 (en) 1979-02-28
ATA202374A (en) 1976-01-15
JPS5634582B2 (en) 1981-08-11
DD113748A5 (en) 1975-06-20
IL44623A0 (en) 1974-06-30
RO70260A (en) 1980-03-15
CS188920B2 (en) 1979-03-30
IE40146L (en) 1974-10-13
JPS5012030A (en) 1975-02-07
BG25787A3 (en) 1978-12-12

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee