FR2222092A1 - - Google Patents

Info

Publication number
FR2222092A1
FR2222092A1 FR7409294A FR7409294A FR2222092A1 FR 2222092 A1 FR2222092 A1 FR 2222092A1 FR 7409294 A FR7409294 A FR 7409294A FR 7409294 A FR7409294 A FR 7409294A FR 2222092 A1 FR2222092 A1 FR 2222092A1
Authority
FR
France
Prior art keywords
compounds
nucleotides
beta
salts
metal salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7409294A
Other languages
French (fr)
Other versions
FR2222092B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant Pharmaceuticals International Inc USA
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/451,639 external-priority patent/US4093714A/en
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Publication of FR2222092A1 publication Critical patent/FR2222092A1/fr
Application granted granted Critical
Publication of FR2222092B1 publication Critical patent/FR2222092B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The 9 beta-D-arabinofuranosylpurine nucleotides of the formula in which X and Y are defined in Claim 1, are prepared by deaminating corresponding 9 beta-D-arabinofuranosyladenine nucleotides in the presence of glacial acetic acid, water and sodium nitrite. These compounds can be converted into their ammonium, substituted ammonium or physiologically acceptable metal salts, in which case the alkali metal and alkaline earth metal salts are preferred. The said compounds, as well as their salts, can be used in vitro for controlling viruses, but they can also be used as starting compounds for the preparation of compounds which are employed for controlling viruses.
FR7409294A 1973-03-19 1974-03-19 Expired FR2222092B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34261773A 1973-03-19 1973-03-19
US05/451,639 US4093714A (en) 1974-03-15 1974-03-15 9β-D-Arabinofuranosylpurine nucleotides and method of use

Publications (2)

Publication Number Publication Date
FR2222092A1 true FR2222092A1 (en) 1974-10-18
FR2222092B1 FR2222092B1 (en) 1978-01-13

Family

ID=26993103

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7409294A Expired FR2222092B1 (en) 1973-03-19 1974-03-19

Country Status (7)

Country Link
JP (1) JPS5046696A (en)
CA (1) CA1023355A (en)
CH (1) CH613211A5 (en)
DE (1) DE2413226A1 (en)
FR (1) FR2222092B1 (en)
IE (1) IE39184B1 (en)
IL (1) IL44537A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2361901A1 (en) * 1975-06-17 1978-03-17 Wellcome Found NUCLEOTIDES SUBSTITUTION DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
EP0015584A2 (en) * 1979-03-12 1980-09-17 Kailash Kumar Dr. Prof. Gauri Nucleotides, methods for their preparation and medicaments

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225097A (en) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd Nucleoside 5'-alkyl or alkenylphosphate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300478A (en) * 1965-06-01 1967-01-24 Upjohn Co Arabinofuranosyl 2', 5'-and 3'-5'-dinucleoside phosphates and process therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756704A (en) * 1969-09-26 1971-03-01 Parke Davis & Co PROCESS FOR THE PRODUCTION OF 5'-PHOSPHATE OF 9- (BETA-D- ARABINOFURANOSYL) ADENINE AND ITS SALTS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300478A (en) * 1965-06-01 1967-01-24 Upjohn Co Arabinofuranosyl 2', 5'-and 3'-5'-dinucleoside phosphates and process therefor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2361901A1 (en) * 1975-06-17 1978-03-17 Wellcome Found NUCLEOTIDES SUBSTITUTION DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
EP0015584A2 (en) * 1979-03-12 1980-09-17 Kailash Kumar Dr. Prof. Gauri Nucleotides, methods for their preparation and medicaments
EP0015584A3 (en) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Nucleotides, methods for their preparation and medicaments

Also Published As

Publication number Publication date
IE39184L (en) 1974-09-19
JPS5046696A (en) 1975-04-25
AU6684974A (en) 1975-09-25
FR2222092B1 (en) 1978-01-13
IE39184B1 (en) 1978-08-16
CH613211A5 (en) 1979-09-14
IL44537A (en) 1977-05-31
IL44537A0 (en) 1974-12-31
DE2413226A1 (en) 1974-10-24
CA1023355A (en) 1977-12-27

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Legal Events

Date Code Title Description
ST Notification of lapse
AR Application made for restoration
DE Withdrawal due to an action of restoration