GB1484345A - Water-soluble derivatives of 6-deoxytetracyclines and process for the preparation thereof - Google Patents

Water-soluble derivatives of 6-deoxytetracyclines and process for the preparation thereof

Info

Publication number
GB1484345A
GB1484345A GB41918/74A GB4191874A GB1484345A GB 1484345 A GB1484345 A GB 1484345A GB 41918/74 A GB41918/74 A GB 41918/74A GB 4191874 A GB4191874 A GB 4191874A GB 1484345 A GB1484345 A GB 1484345A
Authority
GB
United Kingdom
Prior art keywords
deoxy
water
product
antibiotic
tetracyclins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41918/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxochem SpA
Original Assignee
Ankerfarm SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ankerfarm SpA filed Critical Ankerfarm SpA
Publication of GB1484345A publication Critical patent/GB1484345A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The novel antibiotic product of the general formula <IMAGE> has a high solubility in water at neutral pH and can be administered by the oral, intramuscular or intravenous route. The antibiotic activity of the doxycyclin is preserved unchanged. The product shows higher tolerance, stability and blood levels superior to those of 6-deoxy-tetracyclins and derivatives thereof, lower toxicity, yet retains the antibiotic properties of the 6-deoxy-tetracyclins. The product is prepared by contacting a 6-deoxy-tetracyclin with an equimolar quantity of methionine in the presence of formaldehyde in a polar solvent at a temperature of 10-80 DEG C.
GB41918/74A 1973-09-28 1974-09-26 Water-soluble derivatives of 6-deoxytetracyclines and process for the preparation thereof Expired GB1484345A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2948673 1973-09-28

Publications (1)

Publication Number Publication Date
GB1484345A true GB1484345A (en) 1977-09-01

Family

ID=11227072

Family Applications (1)

Application Number Title Priority Date Filing Date
GB41918/74A Expired GB1484345A (en) 1973-09-28 1974-09-26 Water-soluble derivatives of 6-deoxytetracyclines and process for the preparation thereof

Country Status (15)

Country Link
JP (1) JPS6044293B2 (en)
AT (1) AT337359B (en)
BE (1) BE820474A (en)
CA (1) CA1031774A (en)
CH (1) CH614190A5 (en)
DE (1) DE2446586A1 (en)
DK (1) DK153784C (en)
ES (1) ES430512A1 (en)
FR (1) FR2246275B1 (en)
GB (1) GB1484345A (en)
IL (1) IL45741A (en)
NL (1) NL7412764A (en)
NO (1) NO140345C (en)
SE (1) SE398875B (en)
ZA (1) ZA746147B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6442586U (en) * 1987-09-07 1989-03-14
CN102688492A (en) * 2007-03-23 2012-09-26 分子研究中心公司 Compositions and methods for anti-inflammatory treatments

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES262241A1 (en) * 1959-11-23 1961-02-01 Erba Carlo Spa Procedure for preparing new derivatives of tetracycline antibiotics (Machine-translation by Google Translate, not legally binding)
BE615425A (en) * 1961-03-24 1962-07-16 Erba Carlo Spa New salts of derivatives of tetracycline antibiotics

Also Published As

Publication number Publication date
SE7412215L (en) 1975-03-29
NO140345B (en) 1979-05-07
AU7381274A (en) 1976-04-01
IL45741A0 (en) 1974-11-29
NL7412764A (en) 1975-04-02
DE2446586A1 (en) 1975-04-03
IL45741A (en) 1977-12-30
FR2246275A1 (en) 1975-05-02
NO140345C (en) 1979-08-15
JPS6044293B2 (en) 1985-10-02
AT337359B (en) 1977-06-27
JPS5062970A (en) 1975-05-29
NO743489L (en) 1975-04-28
DK153784C (en) 1989-01-23
DK501674A (en) 1975-05-26
SE398875B (en) 1978-01-23
DK153784B (en) 1988-09-05
CA1031774A (en) 1978-05-23
CH614190A5 (en) 1979-11-15
BE820474A (en) 1975-01-16
FR2246275B1 (en) 1978-07-21
ES430512A1 (en) 1977-01-16
ATA776274A (en) 1976-10-15
ZA746147B (en) 1975-11-26

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee