GB1469521A - Antimicrobial preparations - Google Patents

Antimicrobial preparations

Info

Publication number
GB1469521A
GB1469521A GB69073A GB69073A GB1469521A GB 1469521 A GB1469521 A GB 1469521A GB 69073 A GB69073 A GB 69073A GB 69073 A GB69073 A GB 69073A GB 1469521 A GB1469521 A GB 1469521A
Authority
GB
United Kingdom
Prior art keywords
sulphonamides
compounds
carbon atoms
aqueous solutions
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB69073A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB69073A priority Critical patent/GB1469521A/en
Priority to ZM201/73A priority patent/ZM20173A1/en
Priority to AR251788A priority patent/AR204521A1/en
Priority to HU74WE00000498A priority patent/HU171200B/en
Priority to FI8/74A priority patent/FI55296C/en
Priority to AT2274*#A priority patent/AT331986B/en
Priority to DD175822A priority patent/DD111156A5/xx
Priority to NO740022A priority patent/NO140578C/en
Priority to BE139505A priority patent/BE809378A/en
Priority to CA189,371A priority patent/CA1014067A/en
Priority to CH3574A priority patent/CH616930A5/en
Priority to IN19/CAL/1974A priority patent/IN138511B/en
Priority to AU64136/74A priority patent/AU472758B2/en
Priority to DK4074AA priority patent/DK138006B/en
Priority to FR7400111A priority patent/FR2213060B1/fr
Priority to IL43954A priority patent/IL43954A/en
Priority to IE10/74A priority patent/IE38713B1/en
Priority to CS7435A priority patent/CS212740B2/en
Priority to DE2400218A priority patent/DE2400218A1/en
Priority to DD182544A priority patent/DD115120A5/xx
Priority to SE7400031A priority patent/SE430847B/en
Priority to ZA00740061A priority patent/ZA7461B/en
Priority to JP450774A priority patent/JPS5344531B2/ja
Priority to NLAANVRAGE7400094,A priority patent/NL183927C/en
Priority to MW1/74*UA priority patent/MW174A1/en
Priority to PH7415374A priority patent/PH12388A/en
Priority to CY1070A priority patent/CY1070A/en
Priority to ES427078A priority patent/ES427078A1/en
Priority to US05/575,142 priority patent/US3985876A/en
Publication of GB1469521A publication Critical patent/GB1469521A/en
Priority to CH279379A priority patent/CH616931A5/en
Priority to CH279579A priority patent/CH616932A5/en
Priority to CH279479A priority patent/CH628335A5/en
Priority to IT8047967A priority patent/IT8047967A0/en
Priority to KE3065A priority patent/KE3065A/en
Priority to HK442/80A priority patent/HK44280A/en
Priority to MY146/81A priority patent/MY8100146A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Compounds of the formula 10 in which R<7>, R<8> and R<9>, which can be identical or different, are each an alkyl or alkoxy group with 1 to 4 carbon atoms, or R<7> and R<8> together are an alkylenedioxy group with 1 to 4 carbon atoms, are prepared by reacting correspondingly substituted benzylacrylo- or benzylpropionitrile with guanidine. The compounds are intended in the form of their pharmaceutically acceptable monoacid addition salts as potentiator for sulphonamides in the preparation of clear aqueous solutions of sulphonamides in a medicinally acceptable, water-miscible organic solvent and water. The clear aqueous solutions are suitable for injection and infusion purposes and are distinguished by being well tolerated and having high stability. They can, for example, be injected directly into the veins without causing clot formation or tissue damage. <IMAGE>
GB69073A 1973-01-05 1973-01-05 Antimicrobial preparations Expired GB1469521A (en)

Priority Applications (36)

Application Number Priority Date Filing Date Title
GB69073A GB1469521A (en) 1973-01-05 1973-01-05 Antimicrobial preparations
ZM201/73A ZM20173A1 (en) 1973-01-05 1973-12-27 Pharmaceutical formulation
AR251788A AR204521A1 (en) 1973-01-05 1974-01-01 METHOD FOR PREPARING AN INJECTABLE CHEMOTHERAPEUTIC SOLUTION OF SULFONAMIDE
HU74WE00000498A HU171200B (en) 1973-01-05 1974-01-02 Process for preparing parenterally applicable pharmaceutical preparations containing sulphonamides
FI8/74A FI55296C (en) 1973-01-05 1974-01-02 FOERFARANDE FOER FRAMSTAELLNING AV EN ENFASIG KLAR INJEKTIONSLOESNING AV SULPHONAMID OCH SULPHONAMIDE POTENTIATOR FOR PARENTERAL ADMINISTRATION, VARVID TOTALMAENGDEN AV AKTIVA KOMPONENTER I LOESNINGEN AER MINST 6% I
AT2274*#A AT331986B (en) 1973-01-05 1974-01-02 METHOD FOR MANUFACTURING CHEMOTHERAPEUTIC SOLUTIONS
CS7435A CS212740B2 (en) 1973-01-05 1974-01-03 Method of preparing clear solutions for parenteral administration
ZA00740061A ZA7461B (en) 1973-01-05 1974-01-03 Pharmaceutical formulation
BE139505A BE809378A (en) 1973-01-05 1974-01-03 PHARMACEUTICAL COMPOSITIONS CONTAINING SULFONAMIDES
CA189,371A CA1014067A (en) 1973-01-05 1974-01-03 Solutions of sulfonamides with potentiators
CH3574A CH616930A5 (en) 1973-01-05 1974-01-03 Process for the preparation of 2,4-diamino-5-benzylpyrimidines acting as potentiator for sulphonamides.
IN19/CAL/1974A IN138511B (en) 1973-01-05 1974-01-03
AU64136/74A AU472758B2 (en) 1973-01-05 1974-01-03 Improvements in or relating to injectable therapeutic formulations
DK4074AA DK138006B (en) 1973-01-05 1974-01-03 Process for preparing a clear solution containing a sulfonamide and a sulfonamide potentiator.
FR7400111A FR2213060B1 (en) 1973-01-05 1974-01-03
IL43954A IL43954A (en) 1973-01-05 1974-01-03 Chemotherapeutic solutions containing a sulfonamide and a 5-benzyl-2,4-diaminopyrimidine mono acid addition salt sulfonamide potentiator
IE10/74A IE38713B1 (en) 1973-01-05 1974-01-03 Antimicrobial preparations
DD175822A DD111156A5 (en) 1973-01-05 1974-01-03
DE2400218A DE2400218A1 (en) 1973-01-05 1974-01-03 PHARMACEUTICAL FORMULATIONS
DD182544A DD115120A5 (en) 1973-01-05 1974-01-03
SE7400031A SE430847B (en) 1973-01-05 1974-01-03 PREPARING A CLEAR SOLUTION FOR PARENTERAL ADMINISTRATION, INCLUDING A SULPHONAMIDE AND A SULPHONAMIDE POTENTIATOR
NO740022A NO140578C (en) 1973-01-05 1974-01-03 PROCEDURE FOR PREPARING A CLEAR INJECTIBLE SOLUTION
JP450774A JPS5344531B2 (en) 1973-01-05 1974-01-04
NLAANVRAGE7400094,A NL183927C (en) 1973-01-05 1974-01-04 PROCESS FOR PREPARING A THERAPEUTICALLY USEFUL SOLUTION OF A SULFONAMIDE AND A PYRIMIDINE DERIVATIVE.
MW1/74*UA MW174A1 (en) 1973-01-05 1974-01-04 Pharmaceutical formulation
PH7415374A PH12388A (en) 1973-01-05 1974-01-05 Injectable pharmaceutical solution containing a sulphonamide and a sulphonamide potentiator and its method of use
CY1070A CY1070A (en) 1973-01-05 1974-03-22 Antimicrobial preparations
ES427078A ES427078A1 (en) 1973-01-05 1974-06-07 Antimicrobial preparations
US05/575,142 US3985876A (en) 1973-01-05 1975-05-07 Chemotherapeutic solutions containing a sulphur and a salt of a 2,4-diamino-5-benzylpyrimidine
CH279479A CH628335A5 (en) 1973-01-05 1979-03-26 Process for the preparation of 2,4-diamino-5-benzylpyrimidines which act as potentiators for sulphonamides
CH279379A CH616931A5 (en) 1973-01-05 1979-03-26 Process for the preparation of 2,4-diamino-5-benzylpyrimidines acting as potentiator for sulphonamides.
CH279579A CH616932A5 (en) 1973-01-05 1979-03-26 Process for the preparation of 2,4-diamino-5-benzylpyrimidines acting as potentiator for sulphonamides.
IT8047967A IT8047967A0 (en) 1973-01-05 1980-02-21 PHARMACEUTICAL COMPOSITION BASED ON SULFONAMIDE AND ITS ENHANCER
KE3065A KE3065A (en) 1973-01-05 1980-07-12 Antimicrobial preparations
HK442/80A HK44280A (en) 1973-01-05 1980-08-14 Antimicrobial preparations
MY146/81A MY8100146A (en) 1973-01-05 1981-12-30 Antimicrobial preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB69073A GB1469521A (en) 1973-01-05 1973-01-05 Antimicrobial preparations

Publications (1)

Publication Number Publication Date
GB1469521A true GB1469521A (en) 1977-04-06

Family

ID=9708818

Family Applications (1)

Application Number Title Priority Date Filing Date
GB69073A Expired GB1469521A (en) 1973-01-05 1973-01-05 Antimicrobial preparations

Country Status (31)

Country Link
JP (1) JPS5344531B2 (en)
AR (1) AR204521A1 (en)
AT (1) AT331986B (en)
AU (1) AU472758B2 (en)
BE (1) BE809378A (en)
CA (1) CA1014067A (en)
CH (4) CH616930A5 (en)
CS (1) CS212740B2 (en)
CY (1) CY1070A (en)
DD (2) DD111156A5 (en)
DE (1) DE2400218A1 (en)
DK (1) DK138006B (en)
ES (1) ES427078A1 (en)
FI (1) FI55296C (en)
FR (1) FR2213060B1 (en)
GB (1) GB1469521A (en)
HK (1) HK44280A (en)
HU (1) HU171200B (en)
IE (1) IE38713B1 (en)
IL (1) IL43954A (en)
IN (1) IN138511B (en)
IT (1) IT8047967A0 (en)
KE (1) KE3065A (en)
MW (1) MW174A1 (en)
MY (1) MY8100146A (en)
NL (1) NL183927C (en)
NO (1) NO140578C (en)
PH (1) PH12388A (en)
SE (1) SE430847B (en)
ZA (1) ZA7461B (en)
ZM (1) ZM20173A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3044753A1 (en) * 1979-11-27 1981-06-19 Egyt Gyógyszervegyészeti Gyár, Budapest INJECTABLE MEDICINAL PRODUCTS WITH EXTENDED EFFECT

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1596044A (en) * 1977-04-14 1981-08-19 Wellcome Found Veterinary compositions
DE2731013C2 (en) * 1977-07-08 1982-07-15 Lentia Gmbh Process for the preparation of an aqueous solution for infusion
DE2963408D1 (en) 1978-08-01 1982-09-16 Ciba Geigy Ag Stable medicinal solution on the basis of 2,6-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine(trimethoprim) and a sulphonamide, process for preparing and using it
CH647412A5 (en) * 1980-03-25 1985-01-31 Hoffmann La Roche PHARMACEUTICAL PREPARATIONS.
HU212498B (en) * 1992-11-06 1996-07-29 Egyt Gyogyszervegyeszeti Gyar Process for producing water-soluble pharmaceutical compositions, containing sulfachlorpyridazin-sodium and trimethoprim
DE4331147A1 (en) 1993-09-14 1995-03-16 Nycomed Arzneimittel Gmbh Aqueous solution which can be administered intravenously
WO2018229659A1 (en) 2017-06-13 2018-12-20 3M Innovative Properties Company Modified polytetrafluoroethylene and aqueous dispersion containing the same
EP3527634A1 (en) 2018-02-15 2019-08-21 3M Innovative Properties Company Fluoropolymers and fluoropolymer dispersions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1028204A (en) * 1963-06-28 1966-05-04 May & Baker Ltd Veterinary coccidiostatic compositions
BR6915082D0 (en) * 1969-05-16 1973-03-08 Wellcome Found PROCESS OF PREPARATION OF BENZYL-PYRIMIDINES
RO67383A (en) * 1970-10-22 1981-07-30 The Wellcome Foundation Ltd,Gb PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPIRIMIDINE
GB1407971A (en) * 1971-04-16 1975-10-01 Wellcome Found 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor
BE787236A (en) * 1971-08-05 1973-02-05 Wellcome Found POTENTIALIZATION COMPOSITIONS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3044753A1 (en) * 1979-11-27 1981-06-19 Egyt Gyógyszervegyészeti Gyár, Budapest INJECTABLE MEDICINAL PRODUCTS WITH EXTENDED EFFECT

Also Published As

Publication number Publication date
FR2213060A1 (en) 1974-08-02
DD115120A5 (en) 1975-09-12
MY8100146A (en) 1981-12-31
DK138006C (en) 1979-01-08
BE809378A (en) 1974-07-03
JPS49100215A (en) 1974-09-21
FI55296B (en) 1979-03-30
CY1070A (en) 1980-10-24
NL183927C (en) 1989-03-01
CA1014067A (en) 1977-07-19
CH616931A5 (en) 1980-04-30
HU171200B (en) 1977-11-28
FR2213060B1 (en) 1976-09-03
CH628335A5 (en) 1982-02-26
NO140578C (en) 1979-10-03
JPS5344531B2 (en) 1978-11-29
DK138006B (en) 1978-06-26
AU472758B2 (en) 1976-06-03
DD111156A5 (en) 1975-02-05
KE3065A (en) 1980-07-25
MW174A1 (en) 1975-08-13
CH616930A5 (en) 1980-04-30
NL183927B (en) 1988-10-03
NL7400094A (en) 1974-07-09
CH616932A5 (en) 1980-04-30
CS212740B2 (en) 1982-03-26
ES427078A1 (en) 1976-07-16
FI55296C (en) 1979-07-10
IL43954A (en) 1977-05-31
AR204521A1 (en) 1976-02-12
IL43954A0 (en) 1974-05-16
NO740022L (en) 1974-07-08
AU6413674A (en) 1975-07-03
IE38713B1 (en) 1978-05-24
DE2400218A1 (en) 1974-07-18
ZM20173A1 (en) 1974-09-23
IT8047967A0 (en) 1980-02-21
IE38713L (en) 1975-07-03
IN138511B (en) 1976-02-14
NO140578B (en) 1979-06-25
ZA7461B (en) 1975-08-27
PH12388A (en) 1979-01-29
AT331986B (en) 1976-09-10
SE430847B (en) 1983-12-19
HK44280A (en) 1980-08-22
ATA2274A (en) 1975-12-15

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Legal Events

Date Code Title Description
416 Proceeding under section 16 patents act 1949
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee