AR246253A1 - Procedimiento para obtener derivados de dideshidro-vitamina d3. - Google Patents

Procedimiento para obtener derivados de dideshidro-vitamina d3.

Info

Publication number
AR246253A1
AR246253A1 AR89313012A AR31301289A AR246253A1 AR 246253 A1 AR246253 A1 AR 246253A1 AR 89313012 A AR89313012 A AR 89313012A AR 31301289 A AR31301289 A AR 31301289A AR 246253 A1 AR246253 A1 AR 246253A1
Authority
AR
Argentina
Prior art keywords
didehydro
vitamin
derivatives
hydrogen
sililo
Prior art date
Application number
AR89313012A
Other languages
English (en)
Spanish (es)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of AR246253A1 publication Critical patent/AR246253A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
AR89313012A 1988-01-20 1989-01-18 Procedimiento para obtener derivados de dideshidro-vitamina d3. AR246253A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/145,867 US4804502A (en) 1988-01-20 1988-01-20 Vitamin D compounds

Publications (1)

Publication Number Publication Date
AR246253A1 true AR246253A1 (es) 1994-07-29

Family

ID=22514903

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89313012A AR246253A1 (es) 1988-01-20 1989-01-18 Procedimiento para obtener derivados de dideshidro-vitamina d3.

Country Status (23)

Country Link
US (1) US4804502A (OSRAM)
EP (1) EP0326875B1 (OSRAM)
JP (1) JPH0764805B2 (OSRAM)
KR (1) KR960009118B1 (OSRAM)
AR (1) AR246253A1 (OSRAM)
AT (1) ATE74125T1 (OSRAM)
AU (1) AU621851B2 (OSRAM)
CA (1) CA1314906C (OSRAM)
DE (1) DE58901003D1 (OSRAM)
DK (1) DK171966B1 (OSRAM)
ES (1) ES2032613T3 (OSRAM)
FI (1) FI92193C (OSRAM)
GR (1) GR3004785T3 (OSRAM)
HU (1) HU201736B (OSRAM)
IE (1) IE60920B1 (OSRAM)
IL (1) IL88988A (OSRAM)
MC (1) MC1997A1 (OSRAM)
NO (1) NO174547C (OSRAM)
NZ (1) NZ227642A (OSRAM)
PH (1) PH24442A (OSRAM)
PT (1) PT89485B (OSRAM)
YU (1) YU47204B (OSRAM)
ZA (1) ZA8922B (OSRAM)

Families Citing this family (55)

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US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5258559A (en) * 1990-11-27 1993-11-02 Hoffmann-La Roche Inc. Process for the preparation of [1R-(1β(R*), 3aα, 4β, 7aβ)] octahydro-1-(5-hydroxy-1,5-dimethylhexyl)-7a-methyl-4H-inden-4-one
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
WO1992012165A1 (en) * 1991-01-08 1992-07-23 Lunar Corporation METHODS FOR PREPARATION AND USE OF 1α,24-DIHYDROXY VITAMIN D¿2?
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
EP0521550B1 (en) * 1991-07-05 1996-09-18 Duphar International Research B.V Vitamin D compound, method of preparing this compound and intermediate therefor
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
ES2091515T3 (es) * 1992-05-20 1996-11-01 Hoffmann La Roche Analogos fluorados de la vitamina d3.
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
GB9214202D0 (en) * 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
TW267161B (OSRAM) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
US6121469A (en) * 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
AU7295696A (en) * 1995-10-27 1997-05-22 F. Hoffmann-La Roche Ag Pharmaceutical composition for treating osteoporosis
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
AU7497798A (en) * 1997-05-16 1998-12-08 F. Hoffmann-La Roche Ag 3-epi compounds of vitamin d3 and uses thereof
CA2289209C (en) 1997-05-16 2006-07-25 Women & Infants Hospital Cyclic ether vitamin d3 compounds, 1.alpha. (oh) 3-epi-vitamin d3 compounds and uses thereof
AU744471B2 (en) * 1997-05-16 2002-02-21 Women & Infants Hospital 3-epi vitamin D2 compounds and uses thereof
US6087350A (en) 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
ES2196614T3 (es) 1997-09-08 2003-12-16 Hoffmann La Roche Analogos de la 1-3-dihidroxi-20,20-dialquil-vitamina d3.
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
AU762481C (en) 1998-03-27 2004-08-19 Oregon Health Sciences University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
AU2001278744A1 (en) * 2000-08-17 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Remedial agent for osteoporosis
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
GB0422929D0 (en) * 2004-10-15 2004-11-17 Leuven K U Res & Dev Bioactive vitamin D analogues
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
JP2008519808A (ja) 2004-11-12 2008-06-12 ビオエクセル エスピーエー 膀胱癌治療のためのビタミンｄ誘導体及び抗増殖薬の併用
JP2008540513A (ja) * 2005-05-10 2008-11-20 ダーミプソル リミテッド スキンケアのための組成物及び方法
NZ563270A (en) 2005-05-10 2010-11-26 Dermipsor Ltd Calcipotriol, polyethylene oxide topical compositions for the treatment of hyperproliferative epidermal diseases
US20090177002A1 (en) * 2006-03-15 2009-07-09 Asako Toyoda Method For Preparing Indene Derivatives, And Intermediates For Preparation Of Derivatives
EP2085380A1 (en) 2006-11-02 2009-08-05 Mercian Corporation Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
EP2393494A1 (en) 2009-01-27 2011-12-14 Berg Biosystems, LLC Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
KR101880032B1 (ko) 2009-08-14 2018-07-20 베르그 엘엘씨 탈모증 치료용 비타민 ｄ3 및 이의 유사체들
CN104829510B (zh) 2010-10-25 2016-05-04 帝人制药株式会社 23-炔-维生素d3衍生物
NZ714801A (en) 2013-05-29 2021-07-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
WO2017209934A1 (en) 2016-05-13 2017-12-07 Case Western Reserve University Autophagy activators for treating or preventing skin injury
GB202016614D0 (en) 2020-10-20 2020-12-02 King S College London Compounds

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GB1574685A (en) * 1977-03-24 1980-09-10 Wisconsin Alumni Res Found Vitamin d3 derivatives
NL7903929A (nl) * 1978-05-19 1979-11-21 Wisconsin Alumni Res Found Verbindingen met anti-vitamine d activiteit, farmaceutisch preparaat, dat een dergelijke verbinding bevat, alsmede werkwijze voor de toepassing van dergelijke verbindingen.
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4689180A (en) * 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4521410A (en) * 1984-05-03 1985-06-04 The General Hospital Corporation Vitamin D glycosyl orthoesters
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives

Also Published As

Publication number Publication date
HU201736B (en) 1990-12-28
DK19689D0 (da) 1989-01-17
FI890282A0 (fi) 1989-01-19
EP0326875B1 (de) 1992-03-25
CA1314906C (en) 1993-03-23
YU11889A (en) 1991-04-30
IE890156L (en) 1989-07-20
FI890282L (fi) 1989-07-21
PT89485B (pt) 1993-12-31
JPH0764805B2 (ja) 1995-07-12
KR960009118B1 (en) 1996-07-13
US4804502A (en) 1989-02-14
ATE74125T1 (de) 1992-04-15
GR3004785T3 (OSRAM) 1993-04-28
IL88988A (en) 1993-08-18
DK171966B1 (da) 1997-09-01
NO890240L (no) 1989-07-21
FI92193B (fi) 1994-06-30
NO890240D0 (no) 1989-01-19
ES2032613T3 (es) 1993-02-16
PH24442A (en) 1990-06-25
MC1997A1 (fr) 1990-01-26
DE58901003D1 (de) 1992-04-30
JPH029860A (ja) 1990-01-12
KR890011837A (ko) 1989-08-22
YU47204B (sh) 1995-01-31
ZA8922B (en) 1989-09-27
IL88988A0 (en) 1989-08-15
HUT49316A (en) 1989-09-28
PT89485A (pt) 1989-10-04
DK19689A (da) 1989-07-21
EP0326875A1 (de) 1989-08-09
NO174547B (no) 1994-02-14
IE60920B1 (en) 1994-08-24
FI92193C (fi) 1994-10-10
AU2864389A (en) 1989-07-20
NZ227642A (en) 1991-06-25
NO174547C (no) 1994-05-25
AU621851B2 (en) 1992-03-26

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