DK115791A - Heparinfragmenter som inhibitorer af proliferering af glatte muskelceller - Google Patents

Heparinfragmenter som inhibitorer af proliferering af glatte muskelceller Download PDF

Info

Publication number
DK115791A
DK115791A DK115791A DK115791A DK115791A DK 115791 A DK115791 A DK 115791A DK 115791 A DK115791 A DK 115791A DK 115791 A DK115791 A DK 115791A DK 115791 A DK115791 A DK 115791A
Authority
DK
Denmark
Prior art keywords
prolification
hepar
infrastructures
inhibitors
muscle cells
Prior art date
Application number
DK115791A
Other languages
English (en)
Other versions
DK115791D0 (da
Inventor
Brian K Brandley
Lun H Lam
Roger A Laine
Original Assignee
Glycomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomed Inc filed Critical Glycomed Inc
Publication of DK115791D0 publication Critical patent/DK115791D0/da
Publication of DK115791A publication Critical patent/DK115791A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK115791A 1988-12-15 1991-06-14 Heparinfragmenter som inhibitorer af proliferering af glatte muskelceller DK115791A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28554688A 1988-12-15 1988-12-15
US07/400,661 US5032679A (en) 1988-12-15 1989-08-31 Heparin fragments as inhibitors of smooth muscle cell proliferation
PCT/US1989/005559 WO1990006755A1 (en) 1988-12-15 1989-12-14 Heparin fragments as inhibitors of smooth muscle cell profileration

Publications (2)

Publication Number Publication Date
DK115791D0 DK115791D0 (da) 1991-06-14
DK115791A true DK115791A (da) 1991-08-06

Family

ID=26963247

Family Applications (1)

Application Number Title Priority Date Filing Date
DK115791A DK115791A (da) 1988-12-15 1991-06-14 Heparinfragmenter som inhibitorer af proliferering af glatte muskelceller

Country Status (8)

Country Link
US (1) US5032679A (da)
EP (1) EP0448637A4 (da)
JP (1) JPH04503950A (da)
AU (1) AU634199B2 (da)
BR (1) BR8907831A (da)
CA (1) CA2005739A1 (da)
DK (1) DK115791A (da)
WO (1) WO1990006755A1 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827826A (en) * 1986-03-03 1998-10-27 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compositions of human endothelial cell growth factor
US5380716A (en) * 1988-12-15 1995-01-10 Glycomed, Inc. Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
US5340932A (en) * 1989-08-18 1994-08-23 Ajorca S.A. Substances with heparin-like structure and their method of production
EP0493533A4 (en) * 1989-10-27 1992-10-28 Case Western Reserve University Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
US5250519A (en) * 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
AU1680692A (en) * 1991-03-29 1992-11-02 Glycomed Incorporated Modulation of tpa activity by heparin fragments
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
WO1993006792A1 (en) * 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
WO1993019734A1 (en) * 1992-04-02 1993-10-14 Baker Norton Pharmaceuticals, Inc. Method and composition for treating antigen-induced and exercise-induced asthma
US5460807A (en) * 1992-08-19 1995-10-24 Merrell Dow Pharmaceuticals Inc. Antiproliferative oligomers
US5958883A (en) * 1992-09-23 1999-09-28 Board Of Regents Of The University Of Washington Office Of Technology Animal models of human amyloidoses
US6395494B1 (en) * 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5354774A (en) * 1992-12-24 1994-10-11 Yale University Inhibition of smooth muscle cell proliferation by 8-methoxypsoralen photoactivated by visible light
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
ATE179712T1 (de) * 1993-03-01 1999-05-15 Glycan Pharm Inc Analoge für spezifische oligosaccharid-protein- wechselwirkungen und ihre verwendungen
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
DE69435137D1 (de) * 1993-05-13 2008-10-16 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US6197789B1 (en) 1995-06-07 2001-03-06 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation
IL115745A (en) * 1994-11-07 2000-11-21 American Home Prod Acylated benzylglycosides and pharmaceutical compositions containing them
US5565432A (en) * 1994-11-07 1996-10-15 American Home Products Corporation Smooth muscle cell proliferation inhibitors
US5665591A (en) * 1994-12-06 1997-09-09 Trustees Of Boston University Regulation of smooth muscle cell proliferation
US5643892A (en) * 1995-06-07 1997-07-01 Baker Norton Pharmaceuticals, Inc. Method of treating chronic progressive vascular diseases
WO1997001568A1 (en) * 1995-06-29 1997-01-16 Pharmacia & Upjohn Ab New anticoagulants
US5980865A (en) 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
DE69833822D1 (de) * 1998-10-01 2006-05-11 Giovanni Gambaro Substanzen zur Vorbeugung von krankhafter TGF-beta Überexpression und Methoden derer Ermittlung
US6235725B1 (en) 1998-10-30 2001-05-22 Baker Norton Pharmaceuticals, Inc. Methods and compositions for the prevention of tolerance to medications
US6451767B1 (en) 1998-11-24 2002-09-17 Wyeth Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6339064B1 (en) 1998-11-24 2002-01-15 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US6340670B1 (en) 1998-11-24 2002-01-22 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US7132402B2 (en) 1998-11-24 2006-11-07 Wyeth Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6187755B1 (en) 1998-11-24 2001-02-13 American Home Products Corporation Benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6258784B1 (en) 1998-11-24 2001-07-10 American Home Products Corp. Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6664243B1 (en) 1998-11-24 2003-12-16 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US7081448B2 (en) 1998-11-24 2006-07-25 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US6291434B1 (en) 1998-11-24 2001-09-18 American Home Products Corp. Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6362170B1 (en) 1998-11-24 2002-03-26 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
DE29900874U1 (de) 1999-01-20 1999-07-22 Knoll AG, 67061 Ludwigshafen Organprotektive Lösungen
US7572287B2 (en) * 2001-10-25 2009-08-11 Boston Scientific Scimed, Inc. Balloon expandable polymer stent with reduced elastic recoil
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
EP1731131A1 (en) * 2004-03-29 2006-12-13 Kringle Pharma Inc. Hgf production accelerator containing heparin-like oligosaccharide
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU4827490A (en) 1990-07-10
WO1990006755A1 (en) 1990-06-28
AU634199B2 (en) 1993-02-18
BR8907831A (pt) 1991-10-22
EP0448637A1 (en) 1991-10-02
JPH04503950A (ja) 1992-07-16
CA2005739A1 (en) 1990-06-15
DK115791D0 (da) 1991-06-14
US5032679A (en) 1991-07-16
EP0448637A4 (en) 1991-10-30

Similar Documents

Publication Publication Date Title
DK115791D0 (da) Heparinfragmenter som inhibitorer af proliferering af glatte muskelceller
FI955467A (fi) Soluadheesion inhibiittoreina toimivia Sialyl Lex-analogeja
DK125796A (da) I form af små molekyler foreliggende inhibitorer for rotamaseaktivitet
FI980033A0 (fi) Solujen kiinnittymisen inhibiittoreita
DK0810218T3 (da) 6-benzyl-2H-pyridazin-3-onderivater samt fremstilling og anvendelsen deraf som inhibitorer af prostaglandin-G/H-syntase I og II (COX I og COX II)
DK633189D0 (da) Anvendelse af peptidisostere som retrovirale proteasehaemmere
BR8907457A (pt) Inibidores de interleucina-1
DK9987A (da) Ethanolaminderivater
NO933699D0 (no) Sulfaterte polysakkarider som hemmere av glatt muskelcelleproliferasjon
NO922167D0 (no) Aminodukter som korrosjonshemmere
DK293088D0 (da) Inhibitorer af dopamin-beta-hydroxylase
DK328288D0 (da) Anvendelse af dioxopiperidinderivater som analgetika
NO911459D0 (no) Anvendelse av metallion-komplekser som belegginhibitorer.
DK4687D0 (da) Anvendelse af esterforbindelser som temporaert mikrobicid
DK0830345T3 (da) Styryl-benzimidazol-derivater som inhibitorer af glatmuskel-celleproliferation
DK316289A (da) Anvendelse af difluormethyl-thiadiazolyl-oxyeddikesyreamider som selektive herbicider
DK80990D0 (da) Sulfonylderivater af thien-triazol-diazepin
FR2596641B1 (fr) Ligament artificiel
DK104389A (da) Anvendelse af imidazolderivater
FI893507A (fi) Uusien S-adenosyyli-metioniini-dekarboksylaasi-inhibiittoreiden valmistus
DK116087D0 (da) 2-oeheterocyclylmethylsulfinylaathienoimidazol-forbindelser og deres anvendelse som antiulcusmidler
DK104489D0 (da) Anvendelse af triazolderivater
NO864987D0 (no) Heteroaromatiske acetylener brukbare som antihypertensive midler.
NO912276L (no) Heparinfragmenter som hemmere av proliferasjon av glatte muskelceller.
DK293787D0 (da) Ekspression af en amyloglucosidase