AR109953A2 - Fosfolipasas, ácidos nucleicos que las codifican y métodos para prepararlas y usarlas - Google Patents
Fosfolipasas, ácidos nucleicos que las codifican y métodos para prepararlas y usarlasInfo
- Publication number
- AR109953A2 AR109953A2 ARP170102871A ARP170102871A AR109953A2 AR 109953 A2 AR109953 A2 AR 109953A2 AR P170102871 A ARP170102871 A AR P170102871A AR P170102871 A ARP170102871 A AR P170102871A AR 109953 A2 AR109953 A2 AR 109953A2
- Authority
- AR
- Argentina
- Prior art keywords
- sequence
- nucleic acid
- seq
- amino acid
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04011—Phosphoinositide phospholipase C (3.1.4.11)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- General Preparation And Processing Of Foods (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Edible Oils And Fats (AREA)
- Hematology (AREA)
Abstract
Enzimas fosfolipasas específicas de fosfatidilinositol C (PI-PLC), anticuerpos que se unen específicamente a las mismas y métodos para prepararlas y usarlas. También se proveen métodos y productos industriales que comprenden el uso de estas fosfolipasas. En determinadas formas de realización, se proveen métodos para hidratar fosfolípidos no hidratables (NHP) en una matriz lipídica. Los métodos permiten la migración de los NHP a una interfase de aceite / agua, lo que permite la reacción de los NHP y/o su remoción de entre los lípidos. En determinadas formas de realización, se provee un método para remover los NHP, los fosfolípidos hidratables y las lecitinas de los aceites vegetales, con el objeto de producir un aceite o un producto graso desgomado que puede usarse en la producción de alimentos y/o en aplicaciones no alimenticias. En determinadas formas de realización, se proveen métodos que comprenden la hidratación de los NHP que es seguida por un tratamiento enzimático y por la remoción de diversos fosfolípidos y diversas lecitinas. Los métodos provistos en la presente pueden ponerse en práctica con aceites crudos o desgomados con agua. Reivindicación 1: Un ácido nucleico, sintético o recombinante, aislado, caracterizado porque comprende o consiste en una secuencia de ácidos nucleicos: (a) que codifica un polipéptido que tiene una actividad enzimática de fosfolipasa C específica de fosfatidilinositol (PI-PLC), y (i) que tiene al menos 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, o más de identidad de secuencia con la SEQ ID Nº 5 y que codifica un polipéptido que tiene al menos uno o más, o todos, los cambios de aminoácidos (mutaciones) que consisten en N176F, Q191G, Y205L, N244T, Y252R, Y276F, S282H, L284F y R291N, o cualquier combinación de los mismos, en donde la numeración de los cambios de aminoácidos comienza con el aminoácido 31 de la SEQ ID Nº 6; (ii) que codifica un polipéptido que tiene una secuencia de aminoácidos como se establece en la SEQ ID Nº 6 y que tiene al menos uno de los cambios de aminoácidos o sustituciones (mutaciones) que consisten en N176F, Q191G, Y205L, N244T, Y252R, Y276F, S282H, L284F, y R291N, o cualquier combinación de los mismos, en donde la numeración de los cambios de aminoácidos comienza con el aminoácido 31 de la SEQ ID Nº 6; o (iii) un ácido nucleico que comprende o consiste en la secuencia SEQ ID Nº 7, SEQ ID Nº 9 o SEQ ID Nº 10; o (iv) que tiene al menos 98%, 99%, o más, o 100% de identidad de secuencia con la SEQ ID Nº 7, SEQ ID Nº 9 o SEQ ID Nº 10; (b) la secuencia de ácidos nucleicos de (a) que codifica un polipéptido que tiene la actividad enzimática de PI-PLC pero carece de una secuencia señal o una secuencia de aminoácidos de la proproteína nativa; (c) la secuencia de ácidos nucleicos de (a) o (b) que codifica un polipéptido que tiene la actividad enzimática de PI-PLC pero carece de una secuencia promotora nativa; (d) el ácido nucleico de (c) que además comprende una secuencia promotora heteróloga u otra secuencia reguladora de la transcripción; (e) la secuencia de ácidos nucleicos de cualquiera de (a) o (d) que además comprende un ácido nucleico que codifica una secuencia de aminoácidos heteróloga o además comprende una secuencia de nucleótidos heteróloga; (f) el ácido nucleico de (e), en donde el ácido nucleico que codifica la secuencia de aminoácidos heteróloga comprende, o consiste en, una secuencia que codifica una secuencia señal heteróloga (directriz), o una marca o un epitope, o la secuencia de nucleótidos heteróloga comprende una secuencia promotora heteróloga; (g) una secuencia de ácidos nucleicos totalmente complementaria con la secuencia de nucleótidos de cualquiera de (a) a (f).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US25231309P | 2009-10-16 | 2009-10-16 |
Publications (1)
Publication Number | Publication Date |
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AR109953A2 true AR109953A2 (es) | 2019-02-06 |
Family
ID=43876450
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100103698A AR078583A1 (es) | 2009-10-16 | 2010-10-08 | Fosfolipasas, acidos nucleicos que las codifican y metodos para prepararlas y usarlas |
ARP170102871A AR109953A2 (es) | 2009-10-16 | 2017-10-13 | Fosfolipasas, ácidos nucleicos que las codifican y métodos para prepararlas y usarlas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100103698A AR078583A1 (es) | 2009-10-16 | 2010-10-08 | Fosfolipasas, acidos nucleicos que las codifican y metodos para prepararlas y usarlas |
Country Status (13)
Country | Link |
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US (2) | US9394529B2 (es) |
EP (1) | EP2488542B1 (es) |
CN (1) | CN102712671B (es) |
AR (2) | AR078583A1 (es) |
BR (1) | BR112012008957A2 (es) |
CA (2) | CA3185815A1 (es) |
EA (1) | EA022979B1 (es) |
ES (1) | ES2590037T3 (es) |
IN (1) | IN2012DN03226A (es) |
MX (1) | MX339648B (es) |
PL (1) | PL2488542T3 (es) |
UA (1) | UA109884C2 (es) |
WO (1) | WO2011046812A1 (es) |
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US10487316B2 (en) | 2019-11-26 |
EP2488542A1 (en) | 2012-08-22 |
BR112012008957A2 (pt) | 2017-09-19 |
CA2777699C (en) | 2023-03-14 |
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CA2777699A1 (en) | 2011-04-21 |
EA022979B1 (ru) | 2016-04-29 |
PL2488542T3 (pl) | 2016-12-30 |
EP2488542A4 (en) | 2013-07-31 |
WO2011046812A1 (en) | 2011-04-21 |
CN102712671B (zh) | 2016-11-09 |
EA201200593A1 (ru) | 2012-12-28 |
US20120210467A1 (en) | 2012-08-16 |
UA109884C2 (uk) | 2015-10-26 |
MX2012004469A (es) | 2012-08-08 |
AR078583A1 (es) | 2011-11-16 |
CN102712671A (zh) | 2012-10-03 |
CA3185815A1 (en) | 2011-04-21 |
EP2488542B1 (en) | 2016-06-08 |
IN2012DN03226A (es) | 2015-10-23 |
MX339648B (es) | 2016-06-02 |
ES2590037T3 (es) | 2016-11-17 |
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