BR112015017920A8 - Molécula de ácido nucleico codificando uma proteína transportadore de acila (acp)-acila tioesterase variante, cassete de expressão, vetor, tioesterase (te) variante de proteína transportadora de acila-acila (acp), célula hospedeira, produto de óleo, método para produzir uma planta, alga ou microalga, que produz um óleo com um perfil de ácido graxo desejado, e método para produzir um óleo - Google Patents

Molécula de ácido nucleico codificando uma proteína transportadore de acila (acp)-acila tioesterase variante, cassete de expressão, vetor, tioesterase (te) variante de proteína transportadora de acila-acila (acp), célula hospedeira, produto de óleo, método para produzir uma planta, alga ou microalga, que produz um óleo com um perfil de ácido graxo desejado, e método para produzir um óleo

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Publication number
BR112015017920A8
BR112015017920A8 BR112015017920A BR112015017920A BR112015017920A8 BR 112015017920 A8 BR112015017920 A8 BR 112015017920A8 BR 112015017920 A BR112015017920 A BR 112015017920A BR 112015017920 A BR112015017920 A BR 112015017920A BR 112015017920 A8 BR112015017920 A8 BR 112015017920A8
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BR
Brazil
Prior art keywords
acyl
oil
variant
acp
producing
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BR112015017920A
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English (en)
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BR112015017920A2 (pt
Inventor
Davis David
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Solazyme Inc
Terravia Holdings Inc
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Publication date
Application filed by Solazyme Inc, Terravia Holdings Inc filed Critical Solazyme Inc
Publication of BR112015017920A2 publication Critical patent/BR112015017920A2/pt
Publication of BR112015017920A8 publication Critical patent/BR112015017920A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

MOLÉCULA DE ÁCIDO NUCLEICO CODIFICANDO UMA PROTEÍNA TRANSPORTADORE DE ACILA (ACP)-ACILA TIOESTERASE VARIANTE, CASSETE DE EXPRESSÃO, VETOR, TIOESTERASE (TE) VARIANTE DE PROTEÍNA TRANS- PORTADORA DE ACILA-ACILA (ACP), CÉLULA HOSPEDEIRA, PRODUTO DE ÓLEO, MÉTODO PARA PRODUZIR UMA PLANTA, ALGA OU MICROALGA, QUE PRODUZ UM ÓLEO COM UM PERFIL DE ÁCIDO GRAXO DESEJADO, E MÉTODO PARA PRODUZIR UM ÓLEO. A presente invenção refere-se a tioesterases variantes e a sua utilização em plantas, por exemplo para aumentar a atividade enzimática e promover uma maior produção de ácidos graxos de comprimento de cadeia médio (por exemplo, 8 a 14 carbonos) e a proporções desejadas. São ainda aqui revelados métodos de fabrico de químicos renováveis através do fabrico de novos óleos de triglicerídeos seguido de modificação química dos óleos. Óleos contendo comprimentos de cadeia de ácido graxo de C8, C10, C12 ou C14 são também revelados e são úteis como matéria-prima nos métodos aqui descritos.
BR112015017920A 2013-01-29 2014-01-29 Molécula de ácido nucleico codificando uma proteína transportadore de acila (acp)-acila tioesterase variante, cassete de expressão, vetor, tioesterase (te) variante de proteína transportadora de acila-acila (acp), célula hospedeira, produto de óleo, método para produzir uma planta, alga ou microalga, que produz um óleo com um perfil de ácido graxo desejado, e método para produzir um óleo BR112015017920A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361758223P 2013-01-29 2013-01-29
US13/797,733 US9567615B2 (en) 2013-01-29 2013-03-12 Variant thioesterases and methods of use
PCT/US2014/013676 WO2014120829A1 (en) 2013-01-29 2014-01-29 Variant thioesterases and methods of use

Publications (2)

Publication Number Publication Date
BR112015017920A2 BR112015017920A2 (pt) 2017-11-21
BR112015017920A8 true BR112015017920A8 (pt) 2018-01-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015017920A BR112015017920A8 (pt) 2013-01-29 2014-01-29 Molécula de ácido nucleico codificando uma proteína transportadore de acila (acp)-acila tioesterase variante, cassete de expressão, vetor, tioesterase (te) variante de proteína transportadora de acila-acila (acp), célula hospedeira, produto de óleo, método para produzir uma planta, alga ou microalga, que produz um óleo com um perfil de ácido graxo desejado, e método para produzir um óleo

Country Status (10)

Country Link
US (1) US9567615B2 (pt)
EP (1) EP2951294A1 (pt)
JP (1) JP2016508717A (pt)
KR (1) KR20150113973A (pt)
CN (2) CN105164252B (pt)
AU (1) AU2014212439A1 (pt)
BR (1) BR112015017920A8 (pt)
CA (1) CA2899209A1 (pt)
MX (1) MX2015009730A (pt)
WO (1) WO2014120829A1 (pt)

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BR112017001404A2 (pt) 2014-07-24 2017-11-21 Terravia Holdings Inc tioesterases variantes e métodos de utilização
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