AR090037A1 - Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio - Google Patents
Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasioInfo
- Publication number
- AR090037A1 AR090037A1 ARP120104296A ARP120104296A AR090037A1 AR 090037 A1 AR090037 A1 AR 090037A1 AR P120104296 A ARP120104296 A AR P120104296A AR P120104296 A ARP120104296 A AR P120104296A AR 090037 A1 AR090037 A1 AR 090037A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- thieno
- pyrimidin
- piperidin
- Prior art date
Links
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
- 102000004257 Potassium Channel Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108020001213 potassium channel Proteins 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 31
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 11
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 8
- -1 tetrahydro-1,3-oxazinyl Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000002947 alkylene group Chemical group 0.000 abstract 7
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000003107 substituted aryl group Chemical group 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 abstract 4
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 abstract 2
- 229910003827 NRaRb Inorganic materials 0.000 abstract 2
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- JLOIWHWGPIRXBQ-UHFFFAOYSA-N 1-(5-methylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine Chemical compound C=12C(C)=CSC2=NC=NC=1N1CCC(N)CC1 JLOIWHWGPIRXBQ-UHFFFAOYSA-N 0.000 abstract 1
- VLCVHCJARZAQOT-UHFFFAOYSA-N 1-(6-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine Chemical compound C=12C(C=3C=CC=CC=3)=C(C)SC2=NC=NC=1N1CCC(N)CC1 VLCVHCJARZAQOT-UHFFFAOYSA-N 0.000 abstract 1
- ZCGQJNHNULHCGN-UHFFFAOYSA-N 1-(6-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-one Chemical compound C=12C(C=3C=CC=CC=3)=C(C)SC2=NC=NC=1N1CCC(=O)CC1 ZCGQJNHNULHCGN-UHFFFAOYSA-N 0.000 abstract 1
- WPZQFXGPJKULGO-UHFFFAOYSA-N 1-[5-(4-bromophenyl)thieno[2,3-d]pyrimidin-4-yl]piperidin-4-amine Chemical compound C1CC(N)CCN1C1=NC=NC2=C1C(C=1C=CC(Br)=CC=1)=CS2 WPZQFXGPJKULGO-UHFFFAOYSA-N 0.000 abstract 1
- OVUIZPTUHKPUQH-UHFFFAOYSA-N 1-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]piperidin-4-amine Chemical compound C1=CC(C)=CC=C1C1=CSC2=NC=NC(N3CCC(N)CC3)=C12 OVUIZPTUHKPUQH-UHFFFAOYSA-N 0.000 abstract 1
- JPDCBVOCAONAFB-UHFFFAOYSA-N 1-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]piperidin-4-one Chemical compound C1=CC(C)=CC=C1C1=CSC2=NC=NC(N3CCC(=O)CC3)=C12 JPDCBVOCAONAFB-UHFFFAOYSA-N 0.000 abstract 1
- MJILZRSAPALVKX-UHFFFAOYSA-N 1-phenylmethoxy-3-[[1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-yl]amino]propan-2-ol Chemical compound C=1C=CC=CC=1COCC(O)CNC(CC1)CCN1C(C1=2)=NC=NC=2SC=C1C1=CC=CC=C1 MJILZRSAPALVKX-UHFFFAOYSA-N 0.000 abstract 1
- NOWQHVUBAUZKBW-UHFFFAOYSA-N 2-[[1-[5-(4-bromophenyl)thieno[2,3-d]pyrimidin-4-yl]piperidin-4-yl]amino]cyclohexan-1-ol Chemical compound OC1CCCCC1NC1CCN(C=2C=3C(C=4C=CC(Br)=CC=4)=CSC=3N=CN=2)CC1 NOWQHVUBAUZKBW-UHFFFAOYSA-N 0.000 abstract 1
- AJFKKJXKBSDZIM-UHFFFAOYSA-N 2-benzyl-5-methyl-4-morpholin-4-ylthieno[2,3-d]pyrimidine-6-carbonitrile Chemical compound N=1C(N2CCOCC2)=C2C(C)=C(C#N)SC2=NC=1CC1=CC=CC=C1 AJFKKJXKBSDZIM-UHFFFAOYSA-N 0.000 abstract 1
- RXLPRZHHAKTOIY-UHFFFAOYSA-N CC1=CC=C(C=C1)C2=CSC3=NC=NC(=C23)N4CCC(CC4)NC(=O)O Chemical compound CC1=CC=C(C=C1)C2=CSC3=NC=NC(=C23)N4CCC(CC4)NC(=O)O RXLPRZHHAKTOIY-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003725 azepanyl group Chemical group 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000003106 haloaryl group Chemical group 0.000 abstract 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000005968 oxazolinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- 125000006008 trihaloethoxy group Chemical group 0.000 abstract 1
- 125000006004 trihaloethyl group Chemical group 0.000 abstract 1
- 125000004951 trihalomethoxy group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1119703.5A GB201119703D0 (en) | 2011-11-15 | 2011-11-15 | Compounds |
| GBGB1214250.1A GB201214250D0 (en) | 2012-08-09 | 2012-08-09 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR090037A1 true AR090037A1 (es) | 2014-10-15 |
Family
ID=47222145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104296A AR090037A1 (es) | 2011-11-15 | 2012-11-14 | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9290511B2 (Direct) |
| EP (1) | EP2780343A1 (Direct) |
| JP (1) | JP2014533259A (Direct) |
| KR (1) | KR20140094603A (Direct) |
| CN (1) | CN104011054B (Direct) |
| AR (1) | AR090037A1 (Direct) |
| AU (1) | AU2012338570A1 (Direct) |
| BR (1) | BR112014011671A2 (Direct) |
| CA (1) | CA2855346A1 (Direct) |
| IN (1) | IN2014MN01183A (Direct) |
| MX (1) | MX2014005935A (Direct) |
| RU (1) | RU2014124101A (Direct) |
| TW (1) | TWI498331B (Direct) |
| WO (1) | WO2013072694A1 (Direct) |
| ZA (1) | ZA201403503B (Direct) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105263926B (zh) | 2013-06-06 | 2018-05-11 | 安斯泰来制药株式会社 | 苯并噻吩化合物 |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| RU2545758C1 (ru) * | 2014-03-20 | 2015-04-10 | Общество с ограниченной ответственностью "Алион" | Бициклические пиримидины или их фармацевтически приемлемые соли-активаторы антиоксидантной программы и их применение в качестве цитопротекторов |
| USRE49687E1 (en) | 2014-09-09 | 2023-10-10 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| EP3302057A4 (en) | 2015-06-04 | 2018-11-21 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
| TWI703150B (zh) | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物 |
| FR3037958B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037959B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037957B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP7114076B2 (ja) | 2015-12-22 | 2022-08-08 | シャイ・セラピューティクス・エルエルシー | がん及び炎症性疾患の処置のための化合物 |
| JP6919977B2 (ja) | 2016-03-16 | 2021-08-18 | クラ オンコロジー，インク． | メニン−ｍｌｌの置換された阻害剤及びその使用方法 |
| MY199965A (en) | 2016-03-16 | 2023-11-30 | Univ Michigan Regents | Bridged bicyclic inhibitors of menin-mll and methods of use |
| CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
| MX390582B (es) | 2016-12-28 | 2025-03-20 | Dart Neuroscience Llc Star | Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2) |
| EA038388B1 (ru) * | 2017-01-16 | 2021-08-19 | Кура Онколоджи, Инк. | Замещенные ингибиторы менина-mll и способы применения |
| JP7628392B2 (ja) | 2017-03-24 | 2025-02-10 | クラ オンコロジー，インク． | 血液悪性腫瘍およびユーイング肉腫を処置するための方法 |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| EA201992780A1 (ru) | 2017-06-21 | 2020-06-02 | ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи | Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания |
| EP3668841A1 (en) * | 2017-08-14 | 2020-06-24 | Acesion Pharma ApS | Substituted benzimidazoles as potassium channel inhibitors |
| TW201920170A (zh) | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
| WO2019104285A1 (en) | 2017-11-27 | 2019-05-31 | Dart Neuroscience, Llc | Substituted furanopyrimidine compounds as pde1 inhibitors |
| CN108117556A (zh) * | 2018-01-15 | 2018-06-05 | 王山川 | 一种细胞周期检查点激酶1抑制剂的合成方法 |
| WO2020085493A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 新規なインダゾール化合物又はその塩 |
| WO2020132071A1 (en) | 2018-12-19 | 2020-06-25 | Shy Therapeutics. Llc | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease |
| ES2974634T3 (es) | 2018-12-21 | 2024-06-28 | Celgene Corp | Inhibidores de tienopiridinas de RIPK2 |
| GEP20247710B (en) | 2019-10-28 | 2024-12-25 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras g12c mutant |
| US12479834B2 (en) | 2019-11-29 | 2025-11-25 | Taiho Pharmaceutical Co., Ltd. | Phenol compound or salt thereof |
| WO2021106231A1 (en) * | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| WO2022194191A1 (en) * | 2021-03-16 | 2022-09-22 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as inhibitors of kras g12d |
| CN117561247A (zh) * | 2021-03-22 | 2024-02-13 | 阿塞西翁制药公司 | 新型钾通道抑制剂 |
| JP2024511801A (ja) * | 2021-03-26 | 2024-03-15 | スミトモ ファーマ オンコロジー， インコーポレイテッド | （フロピリミジン－４－イル）ピペラジン化合物及びその使用 |
| CN115006468B (zh) * | 2022-06-28 | 2023-06-06 | 西安外事学院 | 一种复方中草药生发液及制备方法 |
| US12466840B2 (en) | 2023-10-20 | 2025-11-11 | Merck Sharp & Dohme Llc | Small molecule inhibitors of KRAS proteins |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4008726A1 (de) | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
| BR9101256A (pt) * | 1990-03-30 | 1991-11-05 | Dowelanco | Composto,composicao fungicida,processo fungicida,composicao inseticida ou acaricida e processo inseticida ou acaricida |
| AU4618497A (en) | 1996-08-27 | 1998-03-19 | Novartis Ag | Herbicidal s-substituted 1,2,4,6-thiatriazines |
| WO2004011057A1 (en) | 1998-02-07 | 2004-02-05 | Advanced Cardiovascular Systems, Inc. | Perfusion dilatation catherer with expanded support coil |
| JP2001097979A (ja) | 1999-07-28 | 2001-04-10 | Takeda Chem Ind Ltd | 縮合複素環化合物、その製造法および用途 |
| NZ517404A (en) | 1999-09-17 | 2003-01-31 | Nissan Chemical Ind Ltd | Benzopyran derivative |
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| SE9904738D0 (sv) | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
| DE10031585A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
| TW589305B (en) | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
| US7041700B2 (en) | 2001-06-25 | 2006-05-09 | Nissan Chemical Industries, Ltd. | Substituted benzopyran derivatives against arrhythmia |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| AU2002333524A1 (en) * | 2001-09-11 | 2003-03-24 | Glaxosmithkline K.K. | Furo-and thienopyrimidine derivatives as angiogenesis inhibitors |
| US20040138238A1 (en) * | 2002-08-08 | 2004-07-15 | Dhanoa Dale S. | Substituted aminopyrimidine compounds as neurokinin antagonists |
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| US20050222175A1 (en) | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| GB0315950D0 (en) * | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| DK1641803T3 (da) | 2003-06-11 | 2009-06-29 | Xention Ltd | Thienopyrimidinderivater som kaliumkanalinhibitorer |
| US7594219B2 (en) | 2003-07-24 | 2009-09-22 | International Business Machines Corporation | Method and apparatus for monitoring compatibility of software combinations |
| TWI346112B (en) | 2004-02-25 | 2011-08-01 | Nissan Chemical Ind Ltd | Benzopyran compound |
| MXPA06011799A (es) * | 2004-04-12 | 2006-12-15 | Sankyo Co | Derivados de tienopiridina. |
| BRPI0511917A (pt) | 2004-06-10 | 2008-01-15 | Xention Discovery Ltd | composto ou sais farmaceuticamente aceitáveis do mesmo, processo para preparar um composto, composição farmacêutica, método para tratar ou prevenir um distúrbio que requer a inibição do canal de potássio, e, uso de um composto |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| JP5122293B2 (ja) | 2004-10-21 | 2013-01-16 | ダウ アグロサイエンシィズ エルエルシー | 殺真菌活性を有するチエノ−ピリミジン化合物 |
| JP5173429B2 (ja) * | 2004-12-09 | 2013-04-03 | ゼンション・リミテッド | 化合物 |
| US7576212B2 (en) * | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| US7576080B2 (en) | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
| CA2595882A1 (en) | 2005-01-26 | 2006-08-03 | Pharmacia & Upjohn Company Llc | Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation |
| EP1874780A1 (en) | 2005-03-25 | 2008-01-09 | Pharmacia & Upjohn Company LLC | 4-piperazinylthieno[2,3-d]pyrimidine compounds as platelet aggregation inhibitors |
| JP2008534571A (ja) | 2005-03-28 | 2008-08-28 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 血小板凝集阻害物質としての４−ピペラジニルチエノ［２，３−ｄ］ピリミジン化合物 |
| EP1866317A1 (en) | 2005-03-28 | 2007-12-19 | Pharmacia & Upjohn Company LLC | 4-piperazinothieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors |
| WO2006103544A2 (en) | 2005-03-28 | 2006-10-05 | Pharmacia & Upjohn Company Llc | 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors |
| US20060281768A1 (en) * | 2005-06-10 | 2006-12-14 | Gaul Michael D | Thienopyrimidine and thienopyridine kinase modulators |
| WO2006136402A1 (en) * | 2005-06-22 | 2006-12-28 | Develogen Aktiengesellschaft | Thienopyrimidines for pharmaceutical compositions |
| DE602005018972D1 (de) * | 2005-09-23 | 2010-03-04 | Equispharm Co Ltd | 5,6-dimethylthienoä2,3-diüpyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung für die bekämpfung von viren |
| WO2007056214A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc | N-alkyl-n-aryl-thienopyrimidin-r-amines and uses thereof |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| AU2007236116A1 (en) * | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having MnKl /Mnk2 inhibiting activity for pharmaceutical compositions |
| US8883781B2 (en) | 2006-06-12 | 2014-11-11 | Vertex Pharmaceuticals Incorporated | Thienopyrimidines useful as modulators of ion channels |
| DE102006030236A1 (de) | 2006-06-30 | 2008-01-03 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Direktoxidationsbrennstoffzelle für den konvektionsfreien Transport des Brennstoffs und Verfahren zum Betreiben der Brennstoffzelle |
| EP1947103A1 (en) | 2007-01-22 | 2008-07-23 | 4Sc Ag | Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments |
| GB0713602D0 (en) | 2007-07-12 | 2007-08-22 | Syngenta Participations Ag | Chemical compounds |
| BRPI0816922A2 (pt) * | 2007-09-14 | 2015-03-17 | Janssen Pharmaceutica Nv | Moduladores tieno e furo-pirimidina do receptor de histamina h4 |
| WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| MY156226A (en) | 2008-02-22 | 2016-01-29 | Otsuka Pharma Co Ltd | Benzodiazepine compound and pharmaceutical composition |
| US20100227853A1 (en) | 2008-04-18 | 2010-09-09 | Trustees Of Boston College | Inhibitors of cyclic amp phosphodiesterases |
| US7863291B2 (en) | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
| EP2331551B1 (en) * | 2008-08-26 | 2016-06-29 | Evotec International GmbH | Thienopyrimidines for pharmaceutical compositions |
| TWI334124B (en) * | 2008-08-28 | 2010-12-01 | Au Optronics Corp | Display drive circuit for flat panel display and driving method for gate lines |
| TWI389913B (zh) | 2008-09-08 | 2013-03-21 | Lg Life Sciences Ltd | 并合雜環化合物 |
| TW201024307A (en) | 2008-09-10 | 2010-07-01 | Kalypsys Inc | Aminopyrimidine inhibitors of histamine receptors for the treatment of disease |
| WO2010033127A1 (en) | 2008-09-22 | 2010-03-25 | Sionyx, Inc. | Response-enhanced monolithic-hybrid pixel |
| JP5792171B2 (ja) | 2009-09-04 | 2015-10-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 白血病を治療するための組成物および方法 |
| MX2012004560A (es) | 2009-10-29 | 2012-05-08 | Bristol Myers Squibb Co | Compuestos de quinuclidina como ligandos del receptor de acetilcolina nicotinico alfa-7. |
| NZ601508A (en) | 2009-12-30 | 2013-07-26 | Arqule Inc | Substituted naphthalenyl-pyrimidine compounds and the use thereof in the treatment of cancer |
| TW201219401A (en) * | 2010-09-14 | 2012-05-16 | Lexicon Pharmaceuticals Inc | Bicyclic inhibitors of Notum Pectinacetylesterase and methods of their use |
| JP2014503528A (ja) | 2010-12-14 | 2014-02-13 | エレクトロプホレトイクス リミテッド | カゼインキナーゼ１δ（ＣＫ１δ）阻害剤及びタウオパチーなどの神経変性疾患の治療におけるその使用 |
| EP3239154A1 (en) | 2011-01-10 | 2017-11-01 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
-
2012
- 2012-11-14 AR ARP120104296A patent/AR090037A1/es unknown
- 2012-11-15 MX MX2014005935A patent/MX2014005935A/es not_active Application Discontinuation
- 2012-11-15 CA CA2855346A patent/CA2855346A1/en not_active Abandoned
- 2012-11-15 JP JP2014540560A patent/JP2014533259A/ja active Pending
- 2012-11-15 TW TW101142693A patent/TWI498331B/zh not_active IP Right Cessation
- 2012-11-15 US US14/358,722 patent/US9290511B2/en not_active Expired - Fee Related
- 2012-11-15 KR KR1020147015757A patent/KR20140094603A/ko not_active Withdrawn
- 2012-11-15 IN IN1183MUN2014 patent/IN2014MN01183A/en unknown
- 2012-11-15 RU RU2014124101/04A patent/RU2014124101A/ru not_active Application Discontinuation
- 2012-11-15 AU AU2012338570A patent/AU2012338570A1/en not_active Abandoned
- 2012-11-15 BR BR112014011671A patent/BR112014011671A2/pt not_active IP Right Cessation
- 2012-11-15 WO PCT/GB2012/052842 patent/WO2013072694A1/en not_active Ceased
- 2012-11-15 EP EP12790948.9A patent/EP2780343A1/en not_active Withdrawn
- 2012-11-15 CN CN201280061286.3A patent/CN104011054B/zh not_active Expired - Fee Related
-
2014
- 2014-05-14 ZA ZA2014/03503A patent/ZA201403503B/en unknown
-
2016
- 2016-02-05 US US15/016,846 patent/US20160152634A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TWI498331B (zh) | 2015-09-01 |
| AU2012338570A1 (en) | 2014-07-03 |
| CN104011054B (zh) | 2016-08-24 |
| CA2855346A1 (en) | 2013-05-23 |
| IN2014MN01183A (Direct) | 2015-07-03 |
| NZ626199A (en) | 2015-04-24 |
| BR112014011671A2 (pt) | 2017-05-30 |
| TW201326178A (zh) | 2013-07-01 |
| KR20140094603A (ko) | 2014-07-30 |
| WO2013072694A1 (en) | 2013-05-23 |
| US20160152634A1 (en) | 2016-06-02 |
| MX2014005935A (es) | 2014-09-04 |
| US20140371203A1 (en) | 2014-12-18 |
| JP2014533259A (ja) | 2014-12-11 |
| US9290511B2 (en) | 2016-03-22 |
| RU2014124101A (ru) | 2015-12-27 |
| ZA201403503B (en) | 2016-09-28 |
| CN104011054A (zh) | 2014-08-27 |
| EP2780343A1 (en) | 2014-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR090037A1 (es) | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio | |
| AR087919A1 (es) | Heterociclos biciclicos como inhibidores de irak4 | |
| CO6251260A2 (es) | Derivados de bifenilo conformacionalmente restringido para uso como inhibidores del virus de la hepatitis c. | |
| AR106945A2 (es) | Compuestos de isoindolina y composiciones farmacéuticas de los mismos | |
| AR100809A1 (es) | Inhibidores de fosfatidilinositol 3-quinasa | |
| ES2612259T3 (es) | Inhibidores de cinasa | |
| AR060173A1 (es) | Derivados de piridina y de pirimidina como antagonistas del mglur2, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos para el tratamiento de trastornos del snc. | |
| CR9959A (es) | Derivados de pirazol | |
| ES2531274T3 (es) | Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas | |
| AR077695A1 (es) | Derivados de pirimidina como inhibidores del factor ixa | |
| AR099913A1 (es) | Derivados de indolizina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| AR100975A1 (es) | Inhibidores de fosfatidilinositol 3-quinasa | |
| AR092645A1 (es) | Derivados biciclicos inhibidores de autotaxina (atx) | |
| ECSP13012858A (es) | Derivados de piperidina puenteada | |
| AR103969A1 (es) | Inmunomoduladores | |
| AR103828A1 (es) | INHIBIDORES DEL FACTOR TRANSFORMADOR DEL CRECIMIENTO b | |
| AR059513A1 (es) | Derivados benzoil - piperidina como moduladores de 5ht/ d3 | |
| AR100807A1 (es) | Inhibidores de fosfatidilinositol 3-quinasa | |
| AR092742A1 (es) | Piridinonas antifibroticas | |
| AR085615A1 (es) | Derivados de fluoropiridinona utiles como agentes antibacterianos y composiciones farmaceuticas que los contienen | |
| AR100418A1 (es) | Compuestos y composiciones para inducir condrogénesis | |
| AR082799A1 (es) | Derivados de quinolina y quinoxalina como inhibidores de quinasa | |
| CO6270288A2 (es) | Composicion fungicida que comprende cantidades significativamente efectivas de un derivadio de amida de acido carboxilico o su sal | |
| AR071763A1 (es) | Pirazoles trisustituidos, composiciones farmaceuticas que los contienen, y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos | |
| AR084913A1 (es) | Derivados de aril-benzocicloalquil-amida |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |