AR084845A1 - Moleculas de anticuerpos que se unen a il-17a e il-17f - Google Patents
Moleculas de anticuerpos que se unen a il-17a e il-17fInfo
- Publication number
- AR084845A1 AR084845A1 ARP120100115A ARP120100115A AR084845A1 AR 084845 A1 AR084845 A1 AR 084845A1 AR P120100115 A ARP120100115 A AR P120100115A AR P120100115 A ARP120100115 A AR P120100115A AR 084845 A1 AR084845 A1 AR 084845A1
- Authority
- AR
- Argentina
- Prior art keywords
- disease
- arthritis
- fibrosis
- antibody
- autoimmune
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Surgery (AREA)
Abstract
Se provee además la secuencia de ADN que lo codifica, un vector de clonación que comprende la secuencia de ADN, una célula huésped que comprende el vector, un proceso para la producción del anticuerpo divulgado.Reivindicación 1: Un anticuerpo de neutralización que se une a IL-17A humano y IL-17F humano caracterizado porque tiene una cadena liviana en donde el dominio variable de la cadena liviana comprende la secuencia dada en la SEC ID Nº 7. Reivindicación 15: Una composición farmacéutica caracterizado porque comprende un anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 hasta 8, en combinación con uno o más de un excipiente, diluyente o vehículo aceptable desde el punto de vista farmacéutico. Reivindicación 18: Un anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 hasta 8 o una composición farmacéutica de acuerdo con la reivindicación 15 o la reivindicación 16, para usar en el tratamiento o la profilaxis de un estado patológico seleccionado del grupo que consiste en infecciones (viral, bacterianas, fúngicas y parasíticas), shock endotóxico asociado con infección, artritis, artritis reumatoide, artritis soriática, artritis idiopática sistémica de aparición en la juventud (JIA), lupus eritematoso sistémico (SLE), asma, enfermedad obstructiva de las vías aéreas (COAD), enfermedad pulmonar obstructiva crónica (EPOC), lesión aguda de pulmón, enfermedad inflamatoria pélvica, Enfermedad de Alzheimer, Enfermedad de Crohn, enfermedad de inflamación intestinal, síndrome de intestino irritable, colitis ulcerativa, Enfermedad de Castelman, espondilitis anquilosante y otras espondiloartropatías, dermatomiositis, miocarditis, uveítis, exoftalmos, tiroiditis autoinmune, Enfermedad de Peyronie, enfermedad celíaca, enfermedad de vesícula biliar, enfermedad de Pilonidal, peritonitis, psoriasis, dermatitis atópica, vasculitis, adhesiones quirúrgicas, accidente cerebrovascular, enfermedades autoinmunes, Diabetes tipo 1, artritis de lyme, meningoencefalitis, trastornos inflamatorios mediados por el sistema inmunológico del sistema nervioso central y periférico tales como esclerosis múltiple y síndrome de Guillain-Barr, otros trastornos autoinmunes, pancreatitis, traumatismo (cirugía), enfermedad de injerto versus huésped, rechazo a los trasplantes, trastornos de fibrosis incluyendo fibrosis pulmonar, fibrosis hepática, fibrosis renal, escleroderma o esclerosis sistémica, cáncer (tanto tumores sólidos tales como melanomas, hepatoblastomas, sarcomas, carcinomas de células escamosas, cánceres de células de transición, cánceres de ovario como enfermedades hematológicas y en particular leucemia mielógena aguda, leucemia mielógena crónica, leucemia linfática crónica, cáncer gástrico y cáncer de colon), enfermedad cardíaca incluyendo enfermedades isquémicas tales como infarto de miocardio así como también ateroesclerosis, coagulación intravascular, reabsorción ósea, osteoporosis, periodontosis e hipocloridia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161432814P | 2011-01-14 | 2011-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084845A1 true AR084845A1 (es) | 2013-06-26 |
Family
ID=45496193
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100115A AR084845A1 (es) | 2011-01-14 | 2012-01-12 | Moleculas de anticuerpos que se unen a il-17a e il-17f |
| ARP220103527A AR128047A2 (es) | 2011-01-14 | 2022-12-21 | Moléculas de anticuerpos que se unen a il-17a e il-17f |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220103527A AR128047A2 (es) | 2011-01-14 | 2022-12-21 | Moléculas de anticuerpos que se unen a il-17a e il-17f |
Country Status (37)
| Country | Link |
|---|---|
| US (5) | US8580265B2 (es) |
| EP (2) | EP2663577B1 (es) |
| JP (2) | JP6028737B2 (es) |
| KR (1) | KR101950306B1 (es) |
| CN (1) | CN103384682B (es) |
| AR (2) | AR084845A1 (es) |
| AU (1) | AU2012206431B2 (es) |
| BR (1) | BR112013017951B1 (es) |
| CA (1) | CA2823812C (es) |
| CL (1) | CL2013002044A1 (es) |
| CO (1) | CO6781516A2 (es) |
| CY (2) | CY1119055T1 (es) |
| DK (1) | DK2663577T3 (es) |
| EA (1) | EA037071B1 (es) |
| ES (1) | ES2632583T3 (es) |
| FI (1) | FIC20220002I1 (es) |
| FR (1) | FR22C1000I2 (es) |
| HR (1) | HRP20171034T1 (es) |
| HU (1) | HUS2200001I1 (es) |
| IL (1) | IL227347B (es) |
| LT (2) | LT2663577T (es) |
| MA (1) | MA34907B1 (es) |
| ME (1) | ME02734B (es) |
| MX (1) | MX341489B (es) |
| MY (1) | MY162790A (es) |
| NL (1) | NL301159I2 (es) |
| NO (1) | NO2021053I1 (es) |
| PL (1) | PL2663577T3 (es) |
| PT (1) | PT2663577T (es) |
| RS (1) | RS56298B1 (es) |
| SG (2) | SG10201510762YA (es) |
| SI (1) | SI2663577T1 (es) |
| TN (1) | TN2013000292A1 (es) |
| TW (1) | TWI511978B (es) |
| UA (1) | UA110358C2 (es) |
| WO (1) | WO2012095662A1 (es) |
| ZA (1) | ZA201306080B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0620729D0 (en) * | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
| GB0807413D0 (en) * | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
| SG185354A1 (en) | 2010-05-20 | 2012-12-28 | Ablynx Nv | Biological materials related to her3 |
| LT2663577T (lt) | 2011-01-14 | 2017-07-25 | Ucb Biopharma Sprl | Antikūnas, surišantis il-17a ir il-17f |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| MX2019001355A (es) | 2012-05-10 | 2023-01-17 | Bioatla Llc | Anticuerpos monoclonales multiespecíficos. |
| GB201310544D0 (en) | 2013-06-13 | 2013-07-31 | Ucb Pharma Sa | Obtaining an improved therapeutic ligand |
| CA2929662C (en) * | 2013-11-18 | 2023-05-02 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Il-17a binding agent and uses thereof |
| KR20160124165A (ko) | 2014-02-21 | 2016-10-26 | 제넨테크, 인크. | 항-il-13/il-17 이중특이적 항체 및 그의 용도 |
| JP2017521479A (ja) | 2014-05-15 | 2017-08-03 | ラニ セラピューティクス， エルエルシー | ポリペプチドおよび／またはタンパク質を含む固体塊の薬学的組成物およびそれを製造するための方法 |
| TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| CN107407677B (zh) | 2015-01-28 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 多发性硬化的基因表达标志和治疗 |
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