HRP20210455T1 - Anti-orai1 antitijelo - Google Patents

Anti-orai1 antitijelo Download PDF

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HRP20210455T1
HRP20210455T1 HRP20210455TT HRP20210455T HRP20210455T1 HR P20210455 T1 HRP20210455 T1 HR P20210455T1 HR P20210455T T HRP20210455T T HR P20210455TT HR P20210455 T HRP20210455 T HR P20210455T HR P20210455 T1 HRP20210455 T1 HR P20210455T1
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Croatia
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amino acid
seq
positions
diseases
acid residues
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HRP20210455TT
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Tomoaki Komai
Takako Kimura
Daichi BABA
Yoshikuni ONODERA
Kento TANAKA
Takashi Kagari
Anri AKI
Nobumi NAGAOKA
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Daiichi Sankyo Company, Limited
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Publication of HRP20210455T1 publication Critical patent/HRP20210455T1/hr

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Claims (13)

1. Antitijelo ili antigen-vezujući fragment antitijela koji se specifično vezuje za aminokiselinsku sekvencu predstavljenu pomoću SEQ ID NO: 2, pri čemu antitijelo sadrži: a) sekvencu varijabilnog regiona teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 136 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 62 i sekvencu varijabilnog regiona lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 126 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56; b) sekvencu varijabilnog regiona teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 136 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 62 i sekvencu varijabilnog regiona lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 126 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 58; c) sekvencu varijabilnog regiona teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 136 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 62 i sekvencu varijabilnog regiona lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 126 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 60; d) sekvencu varijabilnog regiona teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 136 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 64 i sekvencu varijabilnog regiona lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 126 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56; e) sekvencu varijabilnog regiona teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 136 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 66 i sekvencu varijabilnog regiona lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 126 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56; ili f) sekvencu varijabilnog regiona teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 136 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 43 i sekvencu varijabilnog regiona lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 126 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56.
2. Antitijelo ili antigen-vezujući fragment antitijela prema patentnom zahtjevu 1, pri čemu se antitijelo sastoji od: a) sekvence teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 465 ili 20 do 466 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 62 i sekvence lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 234 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56; b) sekvence teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 465 ili 20 do 466 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 70 i sekvence lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 234 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56; c) sekvence teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 465 ili 20 do 466 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 62 i sekvence lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 234 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 58; d) sekvence teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 465 ili 20 do 466 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 62 i sekvence lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 234 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 60; e) sekvence teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 465 ili 20 do 466 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 64 i sekvence lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 234 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56; f) sekvence teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 465 ii 20 do 466 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 66 i sekvence lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 234 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56; ili g) sekvence teškog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 20 do 465 ili 20 do 466 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 43 i sekvence lakog lanca koja se sastoji od aminokiselinskih ostataka sa položaja 21 do 235 u aminokiselinskoj sekvenci predstavljenoj pomoću SEQ ID NO: 56.
3. Antigen-vezujući fragment antitijela prema patentnom zahtjevu 1, pri čemu je antigen-vezujući fragment odabran od grupe koja se sastoji od Fab, F(ab')2, Fab' i Fv.
4. Antitijelo prema patentnom zahtjevu 1, pri čemu je antitijelo scFv.
5. Farmaceutska kompozicija koja sadrži najmanje bilo koje antitijelo ili antigen-vezujući fragment antitijela prema patentnim zahtjevima 1 do 4.
6. Farmaceutska kompozicija prema patentnom zahtjevu 5, pri čemu je farmaceutska kompozicija terapijski i/ili profilaktički agens za odbacivanja transplanta, bolesti povezane sa imunološkim sustavom, alergijske bolesti, inflamatorne bolesti, ili karcinome ili antitrombocitni ili antitrombotički aktivator.
7. Farmaceutska kompozicija prema patentnom zahtjevu 6, pri čemu su odbacivanja transplanta reakcije odbacivanja i reakcije domaćin protiv kalema na transplantaciju organa ili tkiva kao što su srce, bubreg, jetra, koštana srž, ili koža, i bolest kalem protiv domaćina uzrokovana transplantacijom hematopoetskih stanica (kao što su koštana srž, periferna krv ili krv iz pupčane vrpce).
8. Farmaceutska kompozicija prema patentnom zahtjevu 6, pri čemu su bolesti u vezi sa imunološkim sustavom bolesti vezivnog tkiva ili mišićno-koštanog sustava (kao što je reumatoidni artritis, ankilozirajući spondilitis, sustavni lupus eritematozus, skleroderma, polimiozitis ili dermatomiozitis), hematološke bolesti (kao što je aplastična anemija ili idiopatska trombocitopenijska purpura), gastrointestinalne bolesti (kao što je Kronova bolest ili ulcerativni kolitis), neurološke bolesti (kao što je multipla skleroza ili mijastenija gravis), oftamološke bolesti (kao što je uveitis), vaskularne bolesti (kao što je Behçetova bolest ili Wegenerova granulomatoza), epidermalne bolesti (kao što je psorijaza, pemphigus ili leukoderma) i endokrine bolesti (kao što je dijabetes melitus tip 1, autoimuni tiroiditis, Gravesova bolest ili Hashimotova bolest), alergijske bolesti su atopijski dermatitis, astma, anafilaksa, anafilaktoidna reakcija, alergija na hranu, rinitis, otitis media, reakcija na lijek, reakcija na ubod insekta, reakcija na biljke, alergija na lateks, konjuktivitis i urtikarija, i inflamatorne bolesti su inflamatorne bubrežne bolesti (kao što je glomerulonefritis ili nefroza), inflamatorne plućne bolesti (kao što je kronična opstruktivna bolest pluća, cistična fibroza ili intersticijalna pneumonija), inflamatorne bolesti crijeva (kao što je ulcerativni kolitis ili ileitis), inflamatorne bolesti jetre (kao što je autoimunski hepatitis ili virusni hepatitis), inflamatorne bolesti srca (kao što je miokarditis, ishemijska bolest srca ili ateroskleroza), inflamatorne bolesti kože (kao što je kontaktni dermatitis ili ekcem), inflamatorne bolesti oka (kao što je trahom ili endoftalmitis), inflamatorne bolesti centralnog živčanog sustava (kao što je meningitis, encefalomijelitis ili autoimuni encefalitis), inflamatorne bolesti zgloba (kao što je artritis ili osteoartritis), i sustavne upale (kao što je sepsa, krvarenje, preosjetljivost ili simptomi šoka koji se pripisuju kemoterapiji karcinoma).
9. Farmaceutska kompozicija prema patentnom zahtjevu 6, pri čemu su karcinomi, rak dojke, rak pluća, rak kože i leukemija, i slučajevi u kojima je antitrombocitna ili antitrombotička aktivnost korisna za liječenje i/ili prevenciju su infarkt miokarda, moždani udar, ishemijske bolesti srca, i tromboze, a slučajevi u kojima je inhibicija aktivacije stanice koja eksprimira Orail korisna za liječenje i/ili prevenciju su leukemija mastocita, mastocitoza, bazofilna leukemija, endometrioza, Stormorken sindrom, tubularna agregatna miopatija, reumatoidni artritis, ankilozirajući spondilitis i atopijski dermatitis.
10. Polinukleotid koji kodira antitijelo ili antigen-vezujući fragment antitijela prema bilo kojem od patentnih zahtjeva 1 do 4.
11. Vektor koji sadrži polinuklotid prema patentnom zahtjevu 10.
12. Transformirana stanica domaćina koja sadrži polinuklotid prema patentnom zahtjevu 10 ili vektor prema patentnom zahtjevu 11.
13. Postupak za proizvodnju antitijela ili antigen-vezujućeg fragmenta antitijela prema bilo kojem od patentnih zahtjeva 1 do 4, koji obuhvaća korak kultiviranja stanice domaćina prema patentnom zahtjevu 12 i pročišćavanje antitijela iz proizvoda kulture.
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