AR081393A2 - Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento - Google Patents

Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento

Info

Publication number
AR081393A2
AR081393A2 ARP110101646A ARP110101646A AR081393A2 AR 081393 A2 AR081393 A2 AR 081393A2 AR P110101646 A ARP110101646 A AR P110101646A AR P110101646 A ARP110101646 A AR P110101646A AR 081393 A2 AR081393 A2 AR 081393A2
Authority
AR
Argentina
Prior art keywords
nasal
co2r
alkyl
methyl
topical
Prior art date
Application number
ARP110101646A
Other languages
English (en)
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26799441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR081393(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of AR081393A2 publication Critical patent/AR081393A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Una composicion farmacéutica topica oftálmica, otica o nasal que comprende una cantidad efectiva antimicrobiana de uno o más compuestos de la formula (1) donde A es CH, CF, CCI, C-OCH3, o N; X1 es H, halogeno, NH2, o CH3; R1 es alquilo C1-3, FCH2CH2; ciclopropilo o fenilo, opcionalmente mono-, di- o trisustituido por halogeno o A y R1 juntos pueden formar un puente de formula C-O-CH2-CH(CH3); R2 es H, alquilo C1-3 (opcionalmente sustituido por OH, halogeno, o NH2) o 5-metil-2-oxo-1,3-dioxol-4-il-metilo; y B es seleccionado del grupo de formulas (2) donde: Y es O o CH2; R3 es alcoxilo C2-5, CH2-CO-C6H5, CH2CH2CO2R', R'O2C-CH=C-CO2R', CH=CH-CO2R' o CH2CH2CN, donde R' es H o alquilo C1-3, R4 es H, alquilo C1-3, alcoxilo C2-5 CH2-CO-C6H5, CH2CH2CO2R', R'O2C-CH=C-CO2R', CH=CH-CO2R' o CH2CH2CN, o 5-metil-2-oxo-1,3-dioxol-4-il-metilo; donde: R' es H o alquilo C1-3; y sus hidratos y sales farmacéuticamente utiles; y un vehículo farmacéuticamente aceptable para los mismos; y el uso de la misma para la manufactura de un medicamento. Reivindicacion 2: Una composicion topica de acuerdo con la reivindicacion 1, donde la composicion comprende además una cantidad efectiva antiinflamatoria de un agente antiinflamatorio esteroidal o no esteroidal. Reivindicacion 3: Una composicion topica de acuerdo con la reivindicacion 1, donde el compuesto de la formula (1) comprende moxifloxacina. Reivindicacion 4: Una composicion topica de acuerdo con la reivindicacion 3, donde el agente antiinflamatorio comprende dexametasona. Reivindicacion 7: Un método de tratamiento o prevencion de infecciones oftálmicas, oticas o nasales e inflamacion, que comprende la aplicacion topica de una cantidad terapéuticamente efectiva de la composicion de la reivindicacion 2 al tejido oftálmico, otico o nasal afectado.
ARP110101646A 1998-09-30 2011-05-12 Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento AR081393A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10250498P 1998-09-30 1998-09-30
US10250698P 1998-09-30 1998-09-30

Publications (1)

Publication Number Publication Date
AR081393A2 true AR081393A2 (es) 2012-08-29

Family

ID=26799441

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP990104866A AR020661A1 (es) 1998-09-30 1999-09-27 Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
ARP110101646A AR081393A2 (es) 1998-09-30 2011-05-12 Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP990104866A AR020661A1 (es) 1998-09-30 1999-09-27 Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento

Country Status (18)

Country Link
EP (5) EP2796138B1 (es)
JP (5) JP2002525317A (es)
KR (1) KR101463243B1 (es)
CN (2) CN100374114C (es)
AR (2) AR020661A1 (es)
AT (2) ATE254458T1 (es)
AU (1) AU762827B2 (es)
BR (1) BRPI9914151B1 (es)
CA (3) CA2342211C (es)
CY (3) CY1111404T1 (es)
DE (2) DE69943287D1 (es)
DK (5) DK2796138T3 (es)
ES (4) ES2526521T3 (es)
HK (4) HK1150769A1 (es)
PT (5) PT1117401E (es)
TR (2) TR200704370T2 (es)
TW (1) TWI222361B (es)
WO (1) WO2000018386A2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR020661A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
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DE19937116A1 (de) 1999-08-06 2001-02-08 Bayer Ag Moxifloxacin Kochsalzformulierung
BR0014203A (pt) 1999-09-24 2002-05-21 Alcon Inc Formulações de suspensão tópicas contendo ciprofloxacina e dexametasona
DE19962470A1 (de) 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
WO2001089495A2 (en) * 2000-05-19 2001-11-29 Alcon Laboratories, Inc. Antibiotic compositions containing quinolone derivatives for treatment of the eye, ear and nose
AU2001276928A1 (en) 2000-07-26 2002-02-05 Alcon Universal Ltd. Improved process for manufacturing compositions containing ciprofloxacin and hydrocortisone
WO2002040028A1 (fr) * 2000-11-16 2002-05-23 Wakamoto Pharmaceutical Co., Ltd. Gouttes pour les yeux en gel antibacterien
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TWI544934B (zh) * 2008-06-09 2016-08-11 愛爾康研究有限公司 含有氟喹諾酮抗生素藥物之經改良藥學組成物
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RU2472507C1 (ru) * 2012-02-01 2013-01-20 Закрытое акционерное общество "Брынцалов-А" Водный состав на основе моксифлоксацина для парентерального введения
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US20150164882A1 (en) 2013-07-22 2015-06-18 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions for intraocular administration and methods for fabricating thereof
US20160279055A1 (en) 2013-07-22 2016-09-29 Imprimis Pharmaceuticals, Inc. Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof
CN104224802B (zh) * 2014-09-19 2017-12-12 南京优科生物医药研究有限公司 一种盐酸莫西沙星滴耳剂及其制备方法
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Also Published As

Publication number Publication date
TWI222361B (en) 2004-10-21
JP2013018799A (ja) 2013-01-31
JP2014144982A (ja) 2014-08-14
ES2207307T3 (es) 2004-05-16
HK1038691A1 (en) 2002-03-28
WO2000018386A2 (en) 2000-04-06
ES2519190T3 (es) 2014-11-06
PT2301541E (pt) 2014-10-29
EP2796138A1 (en) 2014-10-29
EP1117401A2 (en) 2001-07-25
ATE501732T1 (de) 2011-04-15
HK1150769A1 (en) 2012-01-13
EP1117401B1 (en) 2003-11-19
BR9914151A (pt) 2001-06-26
JP2002525317A (ja) 2002-08-13
AU762827B2 (en) 2003-07-03
CY1115759T1 (el) 2017-01-25
CN1184968C (zh) 2005-01-19
ATE254458T1 (de) 2003-12-15
JP2012067141A (ja) 2012-04-05
TR200100883T2 (tr) 2001-10-22
HK1150756A1 (en) 2012-01-13
EP1384478B1 (en) 2011-03-16
DE69912972D1 (de) 2003-12-24
HK1059572A1 (en) 2004-07-09
EP2269602B1 (en) 2014-11-19
DK2796138T3 (en) 2016-12-05
TR200704370T2 (tr) 2007-11-21
CN1650863A (zh) 2005-08-10
HK1038691B (zh) 2004-04-23
ES2526521T3 (es) 2015-01-13
ES2602956T3 (es) 2017-02-23
DE69912972T2 (de) 2004-04-22
CY1111404T1 (el) 2015-08-05
PT2796138T (pt) 2016-09-22
BRPI9914151B8 (es) 2021-05-25
EP1384478A1 (en) 2004-01-28
CA2342211C (en) 2009-05-26
BRPI9914151B1 (pt) 2017-10-03
KR20010075138A (ko) 2001-08-09
AU1310100A (en) 2000-04-17
CA2774207A1 (en) 2000-04-06
CY1115916T1 (el) 2017-01-25
DK1384478T3 (da) 2011-05-23
EP2301541B1 (en) 2014-08-20
DK1117401T3 (da) 2004-02-23
WO2000018386A3 (en) 2000-06-08
DE69943287D1 (de) 2011-04-28
AR020661A1 (es) 2002-05-22
PT1384478E (pt) 2011-05-12
EP2269602A1 (en) 2011-01-05
CA2342211A1 (en) 2000-04-06
DK2269602T3 (en) 2014-12-15
JP5563041B2 (ja) 2014-07-30
EP2796138B1 (en) 2016-08-17
JP2009007375A (ja) 2009-01-15
KR101463243B1 (ko) 2014-12-17
DK2301541T3 (da) 2014-09-01
PT1117401E (pt) 2004-03-31
PT2269602E (pt) 2014-12-29
CA2659064A1 (en) 2000-04-06
CN1320035A (zh) 2001-10-31
EP2301541A1 (en) 2011-03-30
CN100374114C (zh) 2008-03-12

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