AR076486A1 - Inhibidores de fosfoinositida 3 kinasa y composiciones farmaceuticas que los contienen. - Google Patents
Inhibidores de fosfoinositida 3 kinasa y composiciones farmaceuticas que los contienen.Info
- Publication number
- AR076486A1 AR076486A1 ARP100101435A ARP100101435A AR076486A1 AR 076486 A1 AR076486 A1 AR 076486A1 AR P100101435 A ARP100101435 A AR P100101435A AR P100101435 A ARP100101435 A AR P100101435A AR 076486 A1 AR076486 A1 AR 076486A1
- Authority
- AR
- Argentina
- Prior art keywords
- nrara
- alkyl
- crcrc
- nra
- orb
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 40
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 11
- 125000005843 halogen group Chemical group 0.000 abstract 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 10
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 5
- 125000005842 heteroatom Chemical group 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 5
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004043 oxo group Chemical group O=* 0.000 abstract 4
- -1 -OCHF2 Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
- 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17352009P | 2009-04-28 | 2009-04-28 | |
| US25853209P | 2009-11-05 | 2009-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076486A1 true AR076486A1 (es) | 2011-06-15 |
Family
ID=42315845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101435A AR076486A1 (es) | 2009-04-28 | 2010-04-28 | Inhibidores de fosfoinositida 3 kinasa y composiciones farmaceuticas que los contienen. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8362241B2 (enExample) |
| EP (1) | EP2424859B1 (enExample) |
| JP (1) | JP5697662B2 (enExample) |
| KR (1) | KR20120007540A (enExample) |
| CN (1) | CN102548984B (enExample) |
| AR (1) | AR076486A1 (enExample) |
| AU (1) | AU2010241723B2 (enExample) |
| BR (1) | BRPI1015262A2 (enExample) |
| CA (1) | CA2758986C (enExample) |
| CL (1) | CL2011002691A1 (enExample) |
| CO (1) | CO6440596A2 (enExample) |
| CR (1) | CR20110634A (enExample) |
| EA (1) | EA019700B1 (enExample) |
| IL (1) | IL215731A0 (enExample) |
| MA (1) | MA34207B1 (enExample) |
| MX (1) | MX2011011335A (enExample) |
| NZ (1) | NZ595572A (enExample) |
| PE (1) | PE20121159A1 (enExample) |
| SG (1) | SG175364A1 (enExample) |
| TW (1) | TW201103902A (enExample) |
| UY (1) | UY32582A (enExample) |
| WO (1) | WO2010126895A1 (enExample) |
| ZA (1) | ZA201108101B (enExample) |
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| JP5599783B2 (ja) | 2008-05-30 | 2014-10-01 | アムジエン・インコーポレーテツド | Ｐｉ３キナーゼの阻害薬 |
| CA2755285C (en) | 2009-03-20 | 2014-02-11 | Yunxin Y. Bo | Inhibitors of pi3 kinase |
| UY32582A (es) * | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| US9216981B2 (en) | 2010-12-02 | 2015-12-22 | Medpacto, Inc. | Purinylpyridinylamino-2,4-difluorophenyl sulfonamide derivative, pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition with inhibitory activity against Raf kinase, containing same as active ingredient |
| EP2675816A4 (en) * | 2011-02-14 | 2014-08-13 | Univ Alberta | BORIC ACID CATALYSTS AND USE METHOD FOR THE ACTIVATION AND TRANSFORMATION OF CARBOXYLIC ACIDS |
| WO2012122383A2 (en) * | 2011-03-09 | 2012-09-13 | Avila Therapeutics, Inc. | Pi3 kinase inhibitors and uses thereof |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| EA031153B1 (ru) | 2011-06-10 | 2018-11-30 | Мерк Патент Гмбх | Применение пиримидиновых соединений с btk ингибирующей активностью |
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| CN103102349B (zh) * | 2011-11-14 | 2017-03-15 | 北京赛林泰医药技术有限公司 | 蛋白激酶抑制剂及其组合物和用途 |
| EP2780341B1 (en) * | 2011-11-14 | 2019-02-13 | Chia Tai Tianqing Pharmaceutical Group Co.,Ltd | Kinase modulating compounds, compositions containing the same and use thereof |
| FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
| EP2617718A1 (en) | 2012-01-20 | 2013-07-24 | Sanofi | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent |
| US9221778B2 (en) | 2012-02-13 | 2015-12-29 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
| US9249119B2 (en) * | 2012-02-14 | 2016-02-02 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
| US9382223B2 (en) | 2012-02-22 | 2016-07-05 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
| WO2013178337A1 (en) | 2012-05-31 | 2013-12-05 | Sanofi | Process for preparation of dronedarone by grignard reaction |
| EP2882726A4 (en) * | 2012-08-09 | 2016-04-06 | Neuropore Therapies Inc | ARYL AND HETEROARYL-SUBSTITUTED BENZENE DERIVATIVES AS MODULATORS OF PI-3 KINASE SIGNALING PATHWAYS |
| FR2994572B1 (fr) * | 2012-08-17 | 2015-04-17 | Centre Nat Rech Scient | Pyrido[3,2-d]pyrimidines trisubstituees, leurs procedes de preparation et leurs utilisation en therapeutique |
| AU2014219075C1 (en) | 2013-02-19 | 2018-09-06 | Amgen Inc. | Cis-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| WO2014151863A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| WO2014177915A1 (en) | 2013-05-01 | 2014-11-06 | Piramal Enterprises Limited | Cancer combination therapy using imidazo[4,5-c]quinoline derivatives |
| MA53572A1 (fr) | 2013-06-10 | 2021-10-29 | Amgen Inc | Procédés de production et formes cristallines d'un inhibiteur mdm2 |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| CN104418849B (zh) * | 2013-09-02 | 2020-04-21 | 广东东阳光药业有限公司 | 取代的氨基嘧啶类化合物及其使用方法和用途 |
| AU2014324873B2 (en) * | 2013-09-25 | 2018-11-08 | Vertex Pharmaceuticals Incorporated | A selective inhibitor of phosphatidylinositol 3-kinase-gamma |
| EA202092456A3 (ru) | 2013-11-11 | 2021-09-30 | Эмджен Инк. | Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака |
| CN104744446B (zh) * | 2013-12-30 | 2019-06-25 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| MY186839A (en) | 2014-06-19 | 2021-08-25 | Takeda Pharmaceuticals Co | Heteroaryl compounds for kinase inhibition |
| JP6469238B2 (ja) * | 2015-09-18 | 2019-02-13 | 科研製薬株式会社 | ビアリール誘導体及びそれを含有する医薬 |
| CN109071543B (zh) * | 2016-02-03 | 2021-07-16 | 三进制药株式会社 | 抑制raf激酶和血管内皮生长因子受体的吡啶衍生物，其制备方法，含有其的药物组合物及其用途 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
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| CN116283467B (zh) * | 2023-01-18 | 2024-06-11 | 四川大学 | 一种合成二芳基烷基甲烷的方法 |
| GB202415232D0 (en) | 2024-10-16 | 2024-11-27 | Nacamed As | Composition |
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2010
- 2010-04-26 UY UY0001032582A patent/UY32582A/es not_active Application Discontinuation
- 2010-04-27 CN CN201080030184.6A patent/CN102548984B/zh not_active Expired - Fee Related
- 2010-04-27 US US12/768,602 patent/US8362241B2/en active Active
- 2010-04-27 AU AU2010241723A patent/AU2010241723B2/en active Active
- 2010-04-27 PE PE2011001861A patent/PE20121159A1/es not_active Application Discontinuation
- 2010-04-27 KR KR1020117028155A patent/KR20120007540A/ko not_active Withdrawn
- 2010-04-27 WO PCT/US2010/032593 patent/WO2010126895A1/en not_active Ceased
- 2010-04-27 MX MX2011011335A patent/MX2011011335A/es active IP Right Grant
- 2010-04-27 EP EP10718364.2A patent/EP2424859B1/en active Active
- 2010-04-27 BR BRPI1015262A patent/BRPI1015262A2/pt not_active IP Right Cessation
- 2010-04-27 JP JP2012508595A patent/JP5697662B2/ja active Active
- 2010-04-27 SG SG2011078748A patent/SG175364A1/en unknown
- 2010-04-27 CA CA2758986A patent/CA2758986C/en active Active
- 2010-04-27 EA EA201101583A patent/EA019700B1/ru not_active IP Right Cessation
- 2010-04-27 NZ NZ595572A patent/NZ595572A/xx not_active IP Right Cessation
- 2010-04-28 TW TW099113553A patent/TW201103902A/zh unknown
- 2010-04-28 AR ARP100101435A patent/AR076486A1/es not_active Application Discontinuation
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- 2011-10-28 CL CL2011002691A patent/CL2011002691A1/es unknown
- 2011-11-04 ZA ZA2011/08101A patent/ZA201108101B/en unknown
- 2011-11-25 MA MA34389A patent/MA34207B1/fr unknown
- 2011-11-28 CR CR20110634A patent/CR20110634A/es unknown
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- 2012-11-19 US US13/681,230 patent/US8772480B2/en active Active
Also Published As
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|---|---|
| JP5697662B2 (ja) | 2015-04-08 |
| AU2010241723B2 (en) | 2012-12-13 |
| ZA201108101B (en) | 2012-07-25 |
| IL215731A0 (en) | 2012-01-31 |
| AU2010241723A1 (en) | 2011-11-17 |
| EP2424859B1 (en) | 2015-04-08 |
| US20100273764A1 (en) | 2010-10-28 |
| CN102548984A (zh) | 2012-07-04 |
| EA201101583A1 (ru) | 2012-05-30 |
| WO2010126895A1 (en) | 2010-11-04 |
| EP2424859A1 (en) | 2012-03-07 |
| KR20120007540A (ko) | 2012-01-20 |
| CL2011002691A1 (es) | 2012-03-16 |
| PE20121159A1 (es) | 2012-09-19 |
| BRPI1015262A2 (pt) | 2016-05-03 |
| MX2011011335A (es) | 2011-11-18 |
| US8362241B2 (en) | 2013-01-29 |
| UY32582A (es) | 2010-11-30 |
| EA019700B1 (ru) | 2014-05-30 |
| CA2758986C (en) | 2014-05-27 |
| HK1167862A1 (en) | 2012-12-14 |
| CN102548984B (zh) | 2015-11-25 |
| CR20110634A (es) | 2012-01-06 |
| SG175364A1 (en) | 2011-11-28 |
| CA2758986A1 (en) | 2010-11-04 |
| US20130079303A1 (en) | 2013-03-28 |
| MA34207B1 (fr) | 2013-05-02 |
| CO6440596A2 (es) | 2012-05-15 |
| TW201103902A (en) | 2011-02-01 |
| NZ595572A (en) | 2013-07-26 |
| JP2012525395A (ja) | 2012-10-22 |
| US8772480B2 (en) | 2014-07-08 |
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