CO6440596A2 - Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero de rapamicina - Google Patents
Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero de rapamicinaInfo
- Publication number
- CO6440596A2 CO6440596A2 CO11134794A CO11134794A CO6440596A2 CO 6440596 A2 CO6440596 A2 CO 6440596A2 CO 11134794 A CO11134794 A CO 11134794A CO 11134794 A CO11134794 A CO 11134794A CO 6440596 A2 CO6440596 A2 CO 6440596A2
- Authority
- CO
- Colombia
- Prior art keywords
- phosfoinositi
- kinase
- inhibitors
- objective
- rapamycin
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- 229960002930 sirolimus Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17352009P | 2009-04-28 | 2009-04-28 | |
| US25853209P | 2009-11-05 | 2009-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6440596A2 true CO6440596A2 (es) | 2012-05-15 |
Family
ID=42315845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO11134794A CO6440596A2 (es) | 2009-04-28 | 2011-10-11 | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero de rapamicina |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8362241B2 (enExample) |
| EP (1) | EP2424859B1 (enExample) |
| JP (1) | JP5697662B2 (enExample) |
| KR (1) | KR20120007540A (enExample) |
| CN (1) | CN102548984B (enExample) |
| AR (1) | AR076486A1 (enExample) |
| AU (1) | AU2010241723B2 (enExample) |
| BR (1) | BRPI1015262A2 (enExample) |
| CA (1) | CA2758986C (enExample) |
| CL (1) | CL2011002691A1 (enExample) |
| CO (1) | CO6440596A2 (enExample) |
| CR (1) | CR20110634A (enExample) |
| EA (1) | EA019700B1 (enExample) |
| IL (1) | IL215731A0 (enExample) |
| MA (1) | MA34207B1 (enExample) |
| MX (1) | MX2011011335A (enExample) |
| NZ (1) | NZ595572A (enExample) |
| PE (1) | PE20121159A1 (enExample) |
| SG (1) | SG175364A1 (enExample) |
| TW (1) | TW201103902A (enExample) |
| UY (1) | UY32582A (enExample) |
| WO (1) | WO2010126895A1 (enExample) |
| ZA (1) | ZA201108101B (enExample) |
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| FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
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| US9284270B2 (en) | 2011-02-14 | 2016-03-15 | The Governers Of The University Of Alberta | Boronic acid catalysts and methods of use thereof for activation and transformation of carboxylic acids |
| US20120258967A1 (en) * | 2011-03-09 | 2012-10-11 | Avila Therapeutics, Inc. | Pi3 kinase inhibitors and uses thereof |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
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| SG10201604682VA (en) | 2011-06-10 | 2016-07-28 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
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| FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
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| CN104744446B (zh) * | 2013-12-30 | 2019-06-25 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
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- 2010-04-27 AU AU2010241723A patent/AU2010241723B2/en active Active
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- 2010-04-27 NZ NZ595572A patent/NZ595572A/xx not_active IP Right Cessation
- 2010-04-27 MX MX2011011335A patent/MX2011011335A/es active IP Right Grant
- 2010-04-27 KR KR1020117028155A patent/KR20120007540A/ko not_active Withdrawn
- 2010-04-27 SG SG2011078748A patent/SG175364A1/en unknown
- 2010-04-27 EP EP10718364.2A patent/EP2424859B1/en active Active
- 2010-04-27 CA CA2758986A patent/CA2758986C/en active Active
- 2010-04-27 EA EA201101583A patent/EA019700B1/ru not_active IP Right Cessation
- 2010-04-27 US US12/768,602 patent/US8362241B2/en active Active
- 2010-04-27 WO PCT/US2010/032593 patent/WO2010126895A1/en not_active Ceased
- 2010-04-27 PE PE2011001861A patent/PE20121159A1/es not_active Application Discontinuation
- 2010-04-27 CN CN201080030184.6A patent/CN102548984B/zh not_active Expired - Fee Related
- 2010-04-27 JP JP2012508595A patent/JP5697662B2/ja active Active
- 2010-04-28 TW TW099113553A patent/TW201103902A/zh unknown
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- 2011-11-04 ZA ZA2011/08101A patent/ZA201108101B/en unknown
- 2011-11-25 MA MA34389A patent/MA34207B1/fr unknown
- 2011-11-28 CR CR20110634A patent/CR20110634A/es unknown
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|---|---|
| AU2010241723A1 (en) | 2011-11-17 |
| US20100273764A1 (en) | 2010-10-28 |
| EA019700B1 (ru) | 2014-05-30 |
| PE20121159A1 (es) | 2012-09-19 |
| CN102548984A (zh) | 2012-07-04 |
| ZA201108101B (en) | 2012-07-25 |
| CR20110634A (es) | 2012-01-06 |
| US8772480B2 (en) | 2014-07-08 |
| BRPI1015262A2 (pt) | 2016-05-03 |
| US8362241B2 (en) | 2013-01-29 |
| EP2424859A1 (en) | 2012-03-07 |
| MA34207B1 (fr) | 2013-05-02 |
| SG175364A1 (en) | 2011-11-28 |
| MX2011011335A (es) | 2011-11-18 |
| US20130079303A1 (en) | 2013-03-28 |
| UY32582A (es) | 2010-11-30 |
| KR20120007540A (ko) | 2012-01-20 |
| CN102548984B (zh) | 2015-11-25 |
| TW201103902A (en) | 2011-02-01 |
| AU2010241723B2 (en) | 2012-12-13 |
| JP2012525395A (ja) | 2012-10-22 |
| HK1167862A1 (en) | 2012-12-14 |
| CA2758986C (en) | 2014-05-27 |
| EP2424859B1 (en) | 2015-04-08 |
| CL2011002691A1 (es) | 2012-03-16 |
| NZ595572A (en) | 2013-07-26 |
| CA2758986A1 (en) | 2010-11-04 |
| IL215731A0 (en) | 2012-01-31 |
| AR076486A1 (es) | 2011-06-15 |
| JP5697662B2 (ja) | 2015-04-08 |
| WO2010126895A1 (en) | 2010-11-04 |
| EA201101583A1 (ru) | 2012-05-30 |
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